ADHERIUM LIMITED — Director's Dealing 2022

Nov 3, 2022

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Adherium Limited
ABN	24 605 352 510

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	George Baran
Date of last notice	2 December 2021

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

	Direct or indirect i	nterest		Indirect	Indirect	Indirect
	Nature of indirect(including registerNote: Provide details ofinterest.	interested holder)the circumstanc	es giving rise to the relevant	Issue of placementMedical Limited. Thbeneficial interest in	securitiese DirectorTrudell Med	to Trudelhas a 33.33%ical Limited.	l
	Date of change			28 October 2022
	No. of securities h	eld prior to ch	ange	(a)Indirect interest	n 423080	272 fully pai
	Class			Ordinary fully paid shares and unlistedoptions
	Number acquired			527,500,000 ordinary fully paid shares and263,750,000 options over fully paid ordinaryshares, each with a $0.01 exercise price and 31March 2024 expiry date
	Number disposed			Nil
	Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation			$2,637,500 cash

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

No. of securities held after change	(a) Indirect interest in 950,580,272 fully paidordinary shares(b) Indirect interest in 263,750,000 optionsover fully paid ordinary shares, each with a$0.01 exercise price and 31 March 2024expiry date(c) Indirect interest in 10,485,950 options overfully paid ordinary shares, each with a$0.0219 exercise price and 29 January 2027expiry date
Nature of changeExample: on-market trade, off-market trade, exercise of options,issue of securities under dividend reinvestment plan, participation inbuy-back	Participation in placement offer

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Detail of contract	Not applicable	Not applicable	Not applicable	Not applicable
Nature of interest
Name of registered holder(if issued securities)
Date of change
No. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changed
Interest acquired
Interest disposed
Value/ConsiderationNote: If consideration is non-cash, provide detailsand an estimated valuation
	ote: If consideration is non-cash, provide details
	nd an estimated valuation
Interest after change	terest after chane

Part 3 –[+] Closed period

Part 3 –+Closed period
Were the interests in the securities or contracts detailedabove traded during a+closed period where prior writtenclearance was required?	No
If so, was prior written clearance provided to allow the tradeto proceed during this period?	Not applicable

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

If prior written clearance was provided, on what date was this Not applicable provided?

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 3