ADHERIUM LIMITED — Director's Dealing 2022

Nov 3, 2022

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Adherium Limited
ABN	24 605 352 510

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Louis Panaccio
Date of last notice	2 March 2022

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Indirect
Nature of indirect interest	Issue of placement securities to		the	Director’s
(including registered holder)	nomineeVilmosPty	Ltd	atf	Panaccio
Note: Provide details of the circumstances giving rise to the relevantinterest.	Investment Trust
Date of change	28 October 2022
No. of securities held prior to change	Nil
Class	Ordinary fully paid shares		and	unlisted
	options
Number acquired	20,000,000 ordinary fully paid shares and
	10,000,000 options over fully		paid	ordinary
	shares, each with a $0.01 exercise price and 31
	March 2024 expiry date
Number disposed	Nil
Value/Consideration
Note: If consideration is non-cash, provide details and estimatedvaluation	$100,000 cash

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

No. of securities held after change	(a) Indirect interest in 20,000,000 fully paidordinary shares(b) Indirect interest in 10,000,000 optionsover fully paid ordinary shares, each with a$0.01 exercise price and 31 March 2024expiry date
Nature of changeExample: on-market trade, off-market trade, exercise of options,issue of securities under dividend reinvestment plan, participation inbuy-back	Participation in placement offer with theapproval of shareholders under listing rule10.11

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

==> picture [434 x 305] intentionally omitted <==

----- Start of picture text ----- Detail of contract Not applicableNature of interestName of registered holder(if issued securities)Date of changeNo. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changedInterest acquiredInterest disposedValue/ConsiderationNote: If consideration is non-cash, provide detailsand an estimated valuationInterest after change----- End of picture text -----

Part 3 –[+] Closed period

==> picture [434 x 98] intentionally omitted <==

----- Start of picture text ----- Were the interests in the securities or contracts detailed Noabove traded during a [+] closed period where prior writtenclearance was required?If so, was prior written clearance provided to allow the trade Not applicableto proceed during this period?If prior written clearance was provided, on what date was this Not applicableprovided?----- End of picture text -----

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011