ADHERIUM LIMITED — Director's Dealing 2021

Dec 1, 2021

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Adherium Limited
ABN	24 605 352 510

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	James Ward-Lilley
Date of last notice	10 May 2021

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Indirect
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.	Issue of securities to the Director’s nomineeOshacroft LLP in lieu of cash payment ofDirector Fees
Date of change	26 November 2021
No. of securities held prior to change	(a) Direct interest in 10,000,000 $0.04unlisted options over fully paid ordinaryshares(b) Indirect interest in 2,167,412 ordinaryfully paid shares through Oshacroft LLP
Class	Ordinary fully paid shares
Number acquired	1,432,199 ordinary fully paid shares
Number disposed	Nil
Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation	Issue in lieu of cash payment of Director feesof $25,000 for the period 1 April 2021 to 30June 2021

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

No. of securities held after change (a) Direct interest in 10,000,000 $0.04 unlisted options over fully paid ordinary shares (b) Indirect interest in 3,599,611 ordinary fully paid shares through Oshacroft LLP Nature of change Issue in lieu of cash payment of Director Fees Example: on-market trade, off-market trade, exercise of options, amounting to $25,000 with the approval of issue of securities under dividend reinvestment plan, participation in buy-back shareholders under listing rule 10.11

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

==> picture [434 x 305] intentionally omitted <==

----- Start of picture text ----- Detail of contract Not applicableNature of interestName of registered holder(if issued securities)Date of changeNo. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changedInterest acquiredInterest disposedValue/ConsiderationNote: If consideration is non-cash, provide detailsand an estimated valuationInterest after change----- End of picture text -----

Part 3 –[+] Closed period

==> picture [434 x 98] intentionally omitted <==

----- Start of picture text ----- Were the interests in the securities or contracts detailed Noabove traded during a [+] closed period where prior writtenclearance was required?If so, was prior written clearance provided to allow the trade Not applicableto proceed during this period?If prior written clearance was provided, on what date was this Not applicableprovided?----- End of picture text -----

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011