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ADALTA LIMITED Capital/Financing Update 2022

Feb 15, 2022

64247_rns_2022-02-15_c833b33b-c6ac-47ba-bdca-907201978552.pdf

Capital/Financing Update

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16 February 2022

ASX Announcement

Listing Rule 6.22.2 Adjustment to Option Exercise Prices

MELBOURNE Australia, 16 February 2022: AdAlta Limited (ASX:1AD) he clinical stage biotechnology company developing novel therapeutic products from its i-body platform, advises it has options on issue which, under Listing Rule 6.22.2 and their terms and conditions, require their exercise price to be adjusted as a consequence of the Nonrenounceable Rights Issue Offer that closed on 31 January 2022 (Entitlement Offer).

Listing Rule 6.22 confers on an option the right to a change to its exercise price if there is a pro rata issue (except a bonus issue). The reduction in exercise price to be applied is outlined in the formula in Listing Rule 6.22.2.

As a result of the recent Entitlement Offer, applying the formula in Listing Rule 6.22.2 requires a reduction in the exercise price of issued options of $0.0003 per option.

In accordance with Listing Rule 3.11.2, AdAlta advises that, effective from 22 February 2022, the exercise price of the following options will be amended in accordance with their terms and conditions and the Listing Rules:

Details Number of Expiry Date Original Amended
Options Exercise Price Exercise Price
Unlisted options 620,535 27/02/2022 $0.2385 $0.2382
Unlisted options 4,929,060 26/11/2025 $0.2485 $0.2482
Unlisted options 600,000 20/03/2023 $0.0835 $0.0832
Unlisted options 1,000,000 15/03/2025 $0.1750 $0.1747
Unlisted options 6,655,000 29/09/2025 $0.0850 $0.0847

The effect of the change in exercise prices is a reduction of $4,141 in the amount of capital that would be raised by the Company should all the above options be exercised.

Authorised for lodgement by:

Tim Oldham

CEO and Managing Director

February 2022

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Notes to Editors

About AdAlta

AdAlta Limited is a clinical stage drug development company headquartered in Melbourne, Australia. The Company is using its proprietary i-body technology platform to solve challenging drug targeting problems and generate a promising new class of single domain antibody protein therapeutics with the potential to treat some of today’s most challenging medical conditions.

The i-body technology mimics the shape and stability of a unique and versatile antigen binding domain that was discovered initially in sharks and then developed as a human protein. The result is a range of unique proteins capable of interacting with high selectivity, specificity and affinity with previously difficult to access targets such as G-protein coupled receptors (GPCRs) that are implicated in many serious diseases. i-bodies are the first fully human single domain antibody scaffold and the first based on the shark motif to reach clinical trials.

AdAlta has completed Phase I clinical studies for its lead i-body candidate, AD-214, that is being developed for the treatment of Idiopathic Pulmonary Fibrosis (IPF) and other human fibrotic diseases for which current therapies are sub-optimal and there is a high unmet medical need.

The Company is also entering collaborative partnerships to advance the development of its i-body platform. It has an agreement with GE Healthcare to co-develop i-bodies as diagnostic imaging agents against Granzyme B, a biomarker of response to immunooncology drugs, a program now in preclinical development. It also has a collaboration with Carina Biotech to co-develop precision engineered, i- body enabled CAR-T cell therapies to bring new hope to patients with cancer.

AdAlta’s strategy is to maximise the products developed using its next generation i-body platform by internally discovering and developing selected i-body enabled product candidates against GPCRs implicated in fibrosis, inflammation and cancer and partnering with other biopharmaceutical companies to develop product candidates against other classes of receptor, in other indications, and in other product formats.

Further information can be found at: https://adalta.com.au

For more information, please contact: Investors

Media

Tim Oldham, CEO & Managing Director IR Department Tel: +61 403 446 665 Tel: +61 411 117 774 E: [email protected] E: [email protected]