ACHIEVE LIFE SCIENCES, INC. — Director's Dealing 2010

Nov 2, 2010

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ONCOGENEX PHARMACEUTICALS, INC. (OGXI)
CIK: 0000949858
Period of Report: 2010-11-01

Reporting Person: Cormack Scott Daniel (Director, President and CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2010-11-01	Common Stock	M	10000	$3.889	Acquired	18067	Direct
2010-11-01	Common Stock	S	5000	$15.45	Disposed	13067	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2010-11-01	Employee Stock Option (right to buy)	$3.889	M	10000	Disposed	2010-12-16	Common Stock (10000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	8092	Indirect
Common Stock	25680	Indirect

Footnotes

F1: Scott Cormack and his spouse are the trustees and beneficiaries of the Trycor Investment Trust No. 1.

F2: 5,000 of these shares were exercised and sold under the 10b5 Sales Plan.