ACHIEVE LIFE SCIENCES, INC. — Director's Dealing 2010

Dec 3, 2010

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ONCOGENEX PHARMACEUTICALS, INC. (OGXI)
CIK: 0000949858
Period of Report: 2010-12-01

Reporting Person: Cormack Scott Daniel (Director, President and CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2010-12-01	Common Stock	M	5000	$3.889	Acquired	18067	Direct
2010-12-01	Common Stock	S	5000	$16.02	Disposed	13067	Direct
2010-12-03	Common Stock	M	5000	$3.889	Acquired	18067	Direct
2010-12-03	Common Stock	G	5000	$0.00	Disposed	13067	Direct
2010-12-03	Common Stock	G	5000	$0.00	Acquired	35680	Indirect

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2010-12-01	Stock options	$3.889	M	3709	Disposed	2010-12-16	Common (3709)	Direct
2010-12-01	Stock Options	$3.889	M	1291	Disposed	2011-01-14	Common (1291)	Direct
2010-12-03	stock Options	$3.889	M	5000	Disposed	2011-01-14	Common (5000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	8092	Indirect

Footnotes

F1: Scott D. Cormack and his spouse are the trustees and beneficiaries of the Trycor Investment Trust No. 1

F2: These shares were exercised and sold under the 10b5 Sales Plan