ACHIEVE LIFE SCIENCES, INC. — Director's Dealing 2008

Aug 22, 2008

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ONCOGENEX PHARMACEUTICALS, INC. (OGXI)
CIK: 0000949858
Period of Report: 2008-08-21

Reporting Person: JACOBS CINDY (Exec. VP & Chief Med. Officer)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2008-08-21	Stock Option (right to buy)	$4.1077	A	27203	Acquired	2012-09-12	Common Stock (27203)	Direct

Footnotes

F1: 20,402 options are exercisable as of 8/21/2008, the remaining 6,801 will become exercisble on 9/12/2008.

F2: Received in exchange for a stock option to acquire 125,000 shares of OncoGenex Technologies Inc. ("OncoGenex Technologies")
common stock for CAD$0.95 per share in connection with an arrangement between OncoGenex Technologies and OncoGenex
Pharmaceuticals, Inc.