Regulatory Filings • Feb 28, 2011
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| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 |
|---|
| OMB Number: 3235-0578 Expires: April 30, 2013 Estimated average burden hours per response........5.6 |
| FORM N-Q |
*QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY*
| Investment Company Act file number | |
|---|---|
| H&Q Healthcare Investors | |
| (Exact name of registrant as specified in charter) | |
| 2 Liberty Square, 9 th Floor, Boston, MA | 02109 |
| (Address of principal executive offices) | (Zip code) |
| (Name and address of agent for service) | |
| Registrants telephone number, including area code: | 617-772-8500 |
| Date of fiscal year end: | September 30 |
| Date of reporting period: | 12/31/10 |
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*Item 1. Schedule of Investments.*
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*H&Q HEALTHCARE INVESTORS*
*SCHEDULE OF INVESTMENTS*
DECEMBER 31, 2010
(Unaudited)
| SHARES | VALUE | |
|---|---|---|
| CONVERTIBLE SECURITIES AND WARRANTS 9.7% of Net Assets | ||
| Convertible Preferred and Warrants (Restricted)(a) (b) 9.4% | ||
| Biotechnology/Biopharmaceuticals 0.7% | ||
| 2,470,798 | Euthymics Biosciences, Inc. Series A | $ 2,470,798 |
| 306,413 | MacroGenics, Inc. Series D | 199,812 |
| 75,217 | MacroGenics, Inc. Series D 18 Month Lock-up | 0 |
| 2,670,610 | ||
| Drug Discovery Technologies 1.3% | ||
| 2,380,953 | Agilix Corporation Series B (c) | 141,809 |
| 375,000 | Ceres, Inc. Series C | 2,437,500 |
| 32,193 | Ceres, Inc. Series C-1 | 209,255 |
| 280,105 | Ceres, Inc. Series D | 1,820,683 |
| 40,846 | Ceres, Inc. Series F | 265,499 |
| 8,170 | Ceres, Inc. warrants (expiration 9/05/15) | 0 |
| 4,874,746 | ||
| Healthcare Services 1.3% | ||
| 5,384,615 | PHT Corporation Series D (c) | 4,200,000 |
| 1,204,495 | PHT Corporation Series E (c) | 939,506 |
| 149,183 | PHT Corporation Series F (c) | 116,363 |
| 5,255,869 | ||
| Medical Devices and Diagnostics 6.1% | ||
| 3,424,756 | CardioKinetix, Inc. Series C (c) | 762,351 |
| 6,155,027 | CardioKinetix, Inc. Series D (c) | 800,154 |
| N/A | CardioKinetix, Inc. warrants (expiration 12/11/19) (c) (d) | 0 |
| N/A | CardioKinetix, Inc. warrants (expiration 06/03/20) (c) (d) | 0 |
| 4,852,940 | Concentric Medical, Inc. Series B (c) | 2,523,529 |
| 1,744,186 | Concentric Medical, Inc. Series C (c) | 906,977 |
| 683,000 | Concentric Medical, Inc. Series D (c) | 355,160 |
| 652,013 | Concentric Medical, Inc. Series E (c) | 339,047 |
| 1,724,230 | Eleme Medical, Inc. Series C (c) | 17,242 |
| 1,877,273 | Interlace Medical, Inc. Series C (c) | 9,799,365 |
| 3,669,024 | Labcyte, Inc. Series C | 1,920,000 |
| 3,109,861 | Magellan Biosciences, Inc. Series A | 3,109,861 |
| 142,210 | Magellan Biosciences, Inc. warrants (expiration 4/01/19) | 0 |
| 11,335 | Magellan Biosciences, Inc. warrants (expiration 5/06/19) | 0 |
| 1,547,988 | OmniSonics Medical Technologies, Inc. Series A-1 | 1,548 |
| 1,263,099 | OmniSonics Medical Technologies, Inc. Series B-1 | 1,263 |
| 13,823,805 | Palyon Medical Corporation Series A (c) | 2,211,809 |
| 65,217 | TherOx, Inc. Series H | 108,181 |
| 149,469 | TherOx, Inc. Series I | 247,939 |
| 4,220 | TherOx, Inc. warrants (expiration 1/26/11) | 0 |
| 8,141 | TherOx, Inc. warrants (expiration 2/06/11) | 0 |
| 921,875 | Xoft, Inc. Series D | 682,187 |
| 176,647 | Xoft, Inc. Series E | 130,719 |
| N/A | Xoft, Inc. warrants (expiration 6/12/14) (d) | 0 |
The accompanying notes are an integral part of these financial statements.
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| SHARES | VALUE | |
|---|---|---|
| Convertible Preferred and Warrants (Restricted)(a) (b) continued | ||
| Medical Devices and Diagnostics continued | ||
| N/A | Xoft, Inc. warrants (expiration 6/30/15) (d) | $ 0 |
| 23,917,332 | ||
| 36,718,557 | ||
| PRINCIPAL AMOUNT | ||
| Convertible Notes (Restricted) (a) 0.3% | ||
| Medical Devices and Diagnostics 0.3% | ||
| $ 354,118 | CardioKinetix, Inc., Cvt. Promissory Notes, 4.25% due 12/11/11 (c) | 354,118 |
| 221,217 | Eleme Medical, Inc., Cvt. Promissory Notes, 10.50% due 12/18/12 (c) | 2,212 |
| 562,597 | Eleme Medical, Inc., Subordinated Cvt. Promissory Notes, 10.50% due 12/18/12 (c) | 5,626 |
| 70,240 | Xoft, Inc., Cvt. Promissory Notes, 10.00% due 4/01/11 | 70,240 |
| 590,000 | Xoft, Inc., Cvt. Promissory Notes, 10.00% due 3/31/11 | 590,000 |
| 74,237 | Xoft, Inc., Cvt. Promissory Notes, 10.00% due 6/30/11 | 74,237 |
| 1,096,433 | ||
| 1,096,433 | ||
| TOTAL CONVERTIBLE SECURITIES AND WARRANTS (Cost $49,849,138) | 37,814,990 | |
| SHARES | ||
| COMMON STOCKS AND WARRANTS 83.6% | ||
| Biotechnology/Biopharmaceuticals 27.4% | ||
| 91,100 | Acorda Therapeutics, Inc. (b) | 2,483,386 |
| 88,415 | Alexion Pharmaceuticals, Inc. (b) | 7,121,828 |
| 41,141 | Allergan, Inc. | 2,825,152 |
| 318,600 | Amarin Corporation plc (b) | 2,615,706 |
| 72,500 | Amgen, Inc. (b) | 3,980,250 |
| 127,686 | Amylin Pharmaceuticals, Inc. (b) | 1,878,261 |
| 5,910,745 | Antisoma plc (b) (e) | 592,266 |
| 118,000 | Athersys, Inc. warrants (Restricted, expiration 6/08/12) (a) (b) | 0 |
| 118,400 | Baxter International, Inc. | 5,993,408 |
| 280,866 | Celgene Corporation (b) | 16,610,415 |
| 79,471 | Cephalon, Inc. (b) | 4,904,950 |
| 234,455 | Cubist Pharmaceuticals, Inc. (b) | 5,017,337 |
The accompanying notes are an integral part of these financial statements.
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| SHARES | VALUE | |
|---|---|---|
| Biotechnology/Biopharmaceuticals continued | ||
| 69,276 | Dendreon Corporation (b) | $ 2,419,118 |
| 923,940 | Elan Corporation plc (b) (f) | 5,294,176 |
| 56,068 | Genzyme Corporation (b) | 3,992,042 |
| 306,308 | Gilead Sciences, Inc. (b) | 11,100,602 |
| 140,420 | Human Genome Sciences, Inc. (b) | 3,354,634 |
| 134,874 | InterMune, Inc. (b) | 4,909,414 |
| 260,485 | Ironwood Pharmaceuticals, Inc. (b) | 2,696,020 |
| 148,216 | Martek Biosciences Corporation (b) | 4,639,161 |
| 584,478 | Neurocrine Biosciences, Inc. (b) | 4,465,412 |
| 126,850 | Seattle Genetics, Inc. (b) | 1,896,408 |
| 109,742 | Vertex Pharmaceuticals, Inc. (b) | 3,844,262 |
| 540,610 | XenoPort, Inc. (b) | 4,605,997 |
| 107,240,205 | ||
| Drug Delivery 0.7% | ||
| 208,000 | Alkermes, Inc. (b) | 2,554,240 |
| Drug Discovery Technologies 0.0% | ||
| 70 | Zyomyx, Inc. (Restricted) (a)(b) | 17 |
| Generic Pharmaceuticals 8.6% | ||
| 1,321,151 | Akorn, Inc. (b) | 8,019,387 |
| 202,223 | Akorn, Inc. warrants (Restricted, expiration 3/08/11) (a)(b) | 200,201 |
| 56,050 | Impax Laboratories, Inc. (b) | 1,127,165 |
| 421,078 | Mylan, Inc. (b) | 8,897,378 |
| 90,637 | Perrigo Company | 5,740,041 |
| 161,089 | Teva Pharmaceutical Industries, Ltd. (f) | 8,397,570 |
| 25,075 | Watson Pharmaceuticals, Inc. (b) | 1,295,124 |
| 33,676,866 | ||
| Healthcare Services 19.3% | ||
| 376,873 | Aetna, Inc. | 11,498,395 |
| 222,222 | Aveta, Inc. (Restricted) (a)(g) | 2,222,220 |
| 154,100 | Charles River Laboratories International, Inc. (b) | 5,476,714 |
| 211,650 | CVS Caremark Corporation | 7,359,071 |
| 17,433 | Express Scripts, Inc. (b) | 942,254 |
| 101,133 | Laboratory Corporation of America Holdings (b) | 8,891,613 |
| 85,292 | McKesson Corporation | 6,002,851 |
| 177,528 | Medco Health Solutions, Inc. (b) | 10,877,141 |
| 328,953 | Pharmaceutical Product Development, Inc. | 8,927,784 |
| 24,802 | UnitedHealth Group, Inc. | 895,600 |
| 218,633 | WellPoint, Inc. (b) | 12,431,472 |
| 75,525,115 | ||
| Medical Devices and Diagnostics 22.4% | ||
| 235,153 | Alere, Inc. (b) | 8,606,600 |
| 428,560 | Align Technology, Inc. (b) | 8,374,062 |
| 135,500 | Boston Scientific Corporation (b) | 1,025,735 |
The accompanying notes are an integral part of these financial statements.
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| SHARES | VALUE | |
|---|---|---|
| Medical Devices and Diagnostics continued | ||
| 20,653 | Covidien plc | $ 943,016 |
| 93,931 | Cynosure, Inc. (b) | 960,914 |
| 21,024 | Danaher Corporation | 991,702 |
| 509,696 | Hologic, Inc. (b) | 9,592,479 |
| 129,029 | IDEXX Laboratories, Inc. (b) | 8,931,387 |
| 156,209 | Illumina, Inc. (b) | 9,894,278 |
| 141,628 | Kinetic Concepts, Inc. (b) | 5,931,381 |
| 95,309 | Life Technologies Corporation (b) | 5,289,649 |
| 82,290 | Masimo Corporation | 2,392,170 |
| 160,000 | Masimo Laboratories, Inc. (Restricted) (a) (b) | 169,324 |
| 25,869 | Medtronic, Inc. | 959,481 |
| 830,292 | Medwave, Inc. (b) (c) | 1,744 |
| 207,573 | Medwave, Inc. warrants (Restricted, expiration 8/21/11) (a) (b) (c) | 0 |
| 93,008 | OmniSonics Medical Technologies, Inc. (Restricted) (a) (b) | 93 |
| 101,200 | Palomar Medical Technologies, Inc. (b) | 1,438,052 |
| 507,291 | PerkinElmer, Inc. | 13,098,253 |
| 36,000 | Quest Diagnostics, Inc. | 1,942,920 |
| 208 | Songbird Hearing, Inc. (Restricted) (a) (b) | 139 |
| 23,524 | St Jude Medical, Inc. (b) | 1,005,651 |
| 18,488 | The Cooper Companies, Inc. | 1,041,614 |
| 35,500 | Thermo Fisher Scientific, Inc. (b) | 1,965,280 |
| 71,980 | Thoratec Corporation (b) | 2,038,474 |
| 17,925 | Zimmer Holdings, Inc. (b) | 962,214 |
| 87,556,612 | ||
| Pharmaceuticals 5.2% | ||
| 292,726 | Forest Laboratories, Inc. (b) | 9,361,378 |
| 74,232 | Shire plc (f) | 5,372,912 |
| 246,973 | Warner Chilcott plc | 5,571,711 |
| 20,306,001 | ||
| TOTAL COMMON STOCKS AND WARRANTS (Cost $297,994,759) | 326,859,056 | |
| MUTUAL FUND 3.1% | ||
| 128,856 | iShares Nasdaq Biotechnology Index Fund | 12,037,728 |
| TOTAL MUTUAL FUND (Cost $11,396,462) | 12,037,728 |
The accompanying notes are an integral part of these financial statements.
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| PRINCIPAL AMOUNT | VALUE | |
|---|---|---|
| SHORT-TERM INVESTMENT 1.8% | ||
| $ 6,957,000 | Repurchase Agreement, State Street Bank and Trust Co., repurchase value $6,957,006 (collateralized by U.S. Treasury Bill 2.50%, 04/30/15, market value $7,096,500); 0.01% due 01/03/11 | $ 6,957,000 |
| TOTAL SHORT-TERM INVESTMENT (Cost $6,957,000) | 6,957,000 | |
| TOTAL INVESTMENTS BEFORE MILESTONE INTEREST 98.2% (Cost $366,197,359) | 383,668,774 | |
| INTEREST | ||
| MILESTONE INTEREST 1.6% | ||
| Biotechnology/Biopharmaceuticals 1.6% | ||
| 1 | Targegen Milestone Interest (a) (b) | 6,262,933 |
| TOTAL MILESTONE INTEREST | 6,262,933 | |
| TOTAL INVESTMENTS - 99.8% (Cost $372,060,705) | 389,931,707 | |
| OTHER ASSETS IN EXCESS OF LIABILITIES - 0.2% | 855,178 | |
| NET ASSETS - 100% | $ 390,786,885 |
| (a) | Security fair valued. |
|---|---|
| (b) | Non-income producing security. |
| (c) | Affiliated issuers in which the Fund holds 5% or more of the voting securities (total market value of $23,477,011). |
| (d) | Number of warrants to be determined at a future date. |
| (e) | Foreign Security. |
| (f) | American Depository Receipt. |
| (g) | Security exempt from registration under Rule 144A of the Securities Act of 1933, as amended. These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers. |
The accompanying notes are an integral part of these financial statements.
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*H&Q HEALTHCARE INVESTORS*
*NOTES TO FINANCIAL STATEMENTS*
December 31, 2010
(continued)
**Other Information****
Financial Accounting Standards Board Accounting Standards Codification No. 820, Fair Value Measurements and Disclosures , establishes a three-tier hierarchy to prioritize the assumptions, referred to as inputs, used in valuation techniques to measure fair value. The three-tier hierarchy of inputs is summarized in the three broad levels. Level 1 includes quoted prices in active markets for identical investments. Level 2 includes prices determined using other significant observable inputs (including quoted prices for similar investments, interest rates, credit risk, etc.) Level 3 includes prices determined using significant unobservable inputs (including the Funds own assumptions in determining the fair value of investments). These inputs or methodology used for valuing securities are not necessarily an indication of the risk associated with investing in those securities.
The following is a summary of the inputs used as of December 31, 2010 to value the Funds net assets:
| Assets at Value | Level 1 | Level 2 | Level 3 | Total |
|---|---|---|---|---|
| Convertible Securities and Warrants | ||||
| Biotechnology/Biopharmaceuticals | | | $ 2,670,610 | $ 2,670,610 |
| Drug Discovery Technologies | | | 4,874,746 | 4,874,746 |
| Healthcare Services | | | 5,255,869 | 5,255,869 |
| Medical Devices and Diagnostics | | | 25,013,765 | 25,013,765 |
| Common Stocks and Warrants | ||||
| Biotechnology/Biopharmaceuticals | $ 107,240,205 | | | 107,240,205 |
| Drug Delivery | 2,554,240 | | | 2,554,240 |
| Drug Discovery Technologies | | | 17 | 17 |
| Generic Pharmaceuticals | 33,476,665 | | 200,201 | 33,676,866 |
| Healthcare Services | 73,302,895 | | 2,222,220 | 75,525,115 |
| Medical Devices and Diagnostics | 87,387,056 | | 169,556 | 87,556,612 |
| Pharmaceuticals | 20,306,001 | | | 20,306,001 |
| Mutual Fund | 12,037,728 | | | 12,037,728 |
| Short-Term Investments | | $ 6,957,000 | | 6,957,000 |
| Milestone Interest | ||||
| Biotechnology/Biopharmaceuticals | | | 6,262,933 | 6,262,933 |
| Other Assets | | | 1,215,193 | 1,215,193 |
| Total | $ 336,304,790 | $ 6,957,000 | $ 47,885,110 | $ 391,146,900 |
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COMMAND=ROTATED_TABLE WIDTH="150%"
The following is a reconciliation of level 3 assets for which significant unobservable inputs were used to determine fair value.
| Level 3 Assets | Balance as of September 30, 2010 | Accrued discounts/premiums | Realized gain/loss and change in unrealized appreciation (depreciation) | Net purchases | Net sales | Net transfers in (out of) Level 3 | Balance as of December 31, 2010 | ||
|---|---|---|---|---|---|---|---|---|---|
| Convertible Securities and Warrants | |||||||||
| Biotechnologies/Biopharmaceuticals | $ 814,382 | | $ 12,478 | $ 1,843,750 | $ | | $ 2,670,610 | ||
| Drug Discovery Technologies | 4,874,746 | | | | | | 4,874,746 | ||
| Healthcare Services | 5,255,869 | | | | | | 5,255,869 | ||
| Medical Devices and Diagnostics | 20,020,123 | | 4,469,429 | 524,213 | | | 25,013,765 | ||
| Common Stocks and Warrants | |||||||||
| Biotechnologies/Biopharmaceuticals | 1,180 | | (1,180 | ) | | | | 0 | |
| Drug Discovery Technologies | 17 | | | | | | 17 | ||
| Generic Pharmaceuticals | 76,845 | | 123,356 | | | | 200,201 | ||
| Healthcare Services | 2,222,220 | | | | | | 2,222,220 | ||
| Medical Devices and Diagnostics | 97,193 | | 72,363 | | | | 169,556 | ||
| Milestone Interest | |||||||||
| Biotechnologies/Biopharmaceuticals | 6,225,114 | 37,819 | | | | 6,262,933 | |||
| Other Assets | 1,266,445 | | 36,190 | (87,442 | ) | 1,215,193 | |||
| Total | $ 40,854,134 | | $ 4,714,265 | $ 2,404,153 | $ (87,442 | ) | $ | $ 47,885,110 | |
| Net change in unrealized appreciation (depreciation) from investments still held as of December 31, 2010 | $ 4,690,695 |
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In January 2010, the Financial Accounting Standards Board (FASB) issued Accounting Standards Update 2010-06, Improving Disclosures about Fair Valuation Measurements (ASU 2010-06). ASU 2010-06 requires new disclosures regarding transfers in and out of Levels 1 and 2 effective for interim and annual reporting periods beginning after December 15, 2009. For the period ending December 31, 2010, there were no transfers between Levels 1 and 2. ASU 2010-06 will also require additional details regarding Level 3 transaction activity effective for interim and annual periods beginning after December 15, 2010. Management is currently evaluating the impact it will have on its financial statements.
**Investment Valuation****
Investments traded on national securities exchanges or in the over-the-counter market that are National Market System securities are valued at the last sale price or, lacking any sales, at the mean between the last bid and asked prices. Other over-the-counter securities are valued at the most recent bid prices as obtained from one or more dealers that make markets in the securities. Publicly traded investments for which market quotations are not readily available or whose quoted price may otherwise not reflect fair value, the fair value of convertible preferred, warrants or convertible note interests in private companies, milestone interests and other restricted securities are valued in good faith by the Hambrecht & Quist Capital Management LLC (the Adviser) pursuant to valuation policies and procedures approved by the Trustees. Such values are subject to regular oversight and ratification by the Trustees. Because of the uncertainty of fair valuations, these estimated values may differ significantly from the values that would have been used had a ready market for these securities existed, and the differences could be material. Each such fair value determination is based on a consideration of relevant factors. Factors the Adviser considers may include (i) the existence of any contractual restrictions on the disposition of securities; (ii) information obtained from the issuer, which may include an analysis of the companys financial statements, the companys products or intended markets or the companys technologies; (iii) the price of a security negotiated at arms length in an issuers completed subsequent round of financing; (iv) the price and extent of public trading in similar securities of the issuer or of comparable companies; or (v) a probability and time value adjusted analysis of contractual terms. Publicly traded warrants are valued using the Black-Scholes model, which incorporates both observable and unobservable inputs. Short-term investments with maturity of 60 days or less are valued at amortized cost, which approximates fair value.
**Private Companies and Other Restricted Securities****
The Fund may invest in private companies and other restricted securities if these securities would currently comprise 40% or less of net assets. The value of these securities represents 12% of the Funds net assets at December 31, 2010.
The following table details the acquisition date, cost, carrying value per unit, and value of the Funds private companies and other restricted securities at December 31, 2010. The Fund on its own does not have the right to demand that such securities be registered.
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| Acquisition | Carrying — Value | |||
|---|---|---|---|---|
| Security (j) | Date | Cost | per Unit | Value |
| Agilix Corporation | ||||
| Series B Cvt. Pfd. | 11/08/01 | $ 2,495,500 | $ 0.06 | $ 141,809 |
| Akorn, Inc. | ||||
| Warrants (expiration 3/08/11) | 3/07/06 | 0 | 0.99 | 200,201 |
| Athersys, Inc. | ||||
| Warrants (expiration 6/08/12) | 6/07/07 | 0 | 0.00 | 0 |
| Aveta, Inc. | ||||
| Common | 12/21/05 | 3,004,731 | 10.00 | 2,222,220 |
| CardioKinetix, Inc. | ||||
| Series C Cvt. Pfd. | 5/22/08 | 2,377,226 | 0.22 | 762,351 |
| Series D Cvt. Pfd. | 12/10/10 | 781,073 | 0.13 | 800,154 |
| Cvt. Promissory Notes | 12/10/09, 6/03/10 | 354,630 | 1.00 | 354,118 |
| Warrants (expiration 12/11/19) | 12/10/09, 2/11/10 | 177 | 0.00 | 0 |
| Warrants (expiration 6/03/20) | 6/03/10, 9/01/10 | 177 | 0.00 | 0 |
| Ceres, Inc. | ||||
| Series C Cvt. Pfd. | 12/23/98 | 1,502,732 | 6.50 | 2,437,500 |
| Series C-1 Cvt. Pfd. | 3/31/01 | 111,508 | 6.50 | 209,255 |
| Series D Cvt. Pfd. | 3/14/01 | 1,668,294 | 6.50 | 1,820,683 |
| Series F Cvt. Pfd. | 9/05/07 | 268,136 | 6.50 | 265,499 |
| Warrants (expiration 9/05/15) | 9/05/07 | 0 | 0.00 | 0 |
| Concentric Medical, Inc. | ||||
| Series B Cvt. Pfd. | 5/07/02, 1/24/03 | 3,330,988 | 0.52 | 2,523,529 |
| Series C Cvt. Pfd. | 12/19/03 | 1,500,818 | 0.52 | 906,977 |
| Series D Cvt. Pfd. | 9/30/05 | 958,007 | 0.52 | 355,160 |
| Series E Cvt. Pfd. | 12/18/08 | 655,011 | 0.52 | 339,047 |
| Elemé Medical, Inc. | ||||
| Series C Cvt. Pfd. | 7/15/08 | 3,253,243 | 0.01 | 17,242 |
| Convertible | 01/15/10 | 225,813 | 1.00 | 2,212 |
| Subordinated Cvt. Promissory Notes | 12/18/09, 6/04/10 | 569,455 | 1.00 | 5,626 |
| Euthymics Biosciences, Inc. | ||||
| Cvt. Pfd. | 7/14/10, 9/17/10 | 2,477,061 | 1.00 | 2,470,798 |
| Interlace Medical, Inc. | ||||
| Series C Cvt. Pfd. | 6/10/09 | 2,072,857 | 5.22 | 9,799,365 |
| Labcyte Inc. | ||||
| Series C Cvt. Pfd. | 7/18/05 | 1,924,893 | 0.52 | 1,920,000 |
| MacroGenics, Inc. | ||||
| Series D Cvt. Pfd. | 9/04/08 | 1,002,546 | 0.65 | 199,812 |
| Series D Cvt. Pfd. 18 Month Lock-up | 9/04/08 | 315,748 | 0.00 | 0 |
| Magellan Biosciences, Inc. | ||||
| Series A Cvt. Pfd. | 11/28/06 - 5/12/09 | 3,117,537 | 1.00 | 3,109,861 |
| Warrants (expiration 4/01/19) | 4/03/09 | 0 | 0.00 | 0 |
| Warrants (expiration 5/06/19) | 5/12/09 | 0 | 0.00 | 0 |
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| Acquisition | Carrying — Value | |||
|---|---|---|---|---|
| Security (j) | Date | Cost | per Unit | Value |
| Masimo Laboratories, Inc. | ||||
| Common | 3/31/98 | 0 | 1.06 | 169,324 |
| Medwave, Inc. | ||||
| Warrants (expiration 8/21/11) | 8/21/06 | 0 | 0.00 | 0 |
| OmniSonics Medical Technologies, Inc. | ||||
| Series A-1 Cvt. Pfd. | 10/01/03 | 1,801,555 | 0.001 | 1,548 |
| Series B-1 Cvt. Pfd. | 6/04/07, 11/15/07 | 961,365 | 0.001 | 1,263 |
| Common | 5/24/01, 7/02/07 | 2,409,096 | 0.001 | 93 |
| Palyon Medical Corporation | ||||
| Series A Cvt. Pfd. | 4/28/09 | 2,967,403 | 0.16 | 2,211,809 |
| PHT Corporation | ||||
| Series D Cvt. Pfd. | 7/23/01 | 4,205,754 | 0.78 | 4,200,000 |
| Series E Cvt. Pfd. | 9/12/03 - 10/14/04 | 941,669 | 0.78 | 939,506 |
| Series F Cvt. Pfd. | 7/21/08 | 122,580 | 0.78 | 116,363 |
| Songbird Hearing, Inc. | ||||
| Common | 12/14/00 | 3,004,861 | 0.67 | 139 |
| Targegen | ||||
| Milestone Interest | 07/20/10 | 5,863,346 | 6,262,933.00 | 6,262,933 |
| TherOx, Inc. | ||||
| Series H Cvt. Pfd. | 9/11/00 | 3,002,748 | 1.66 | 108,181 |
| Series I Cvt. Pfd. | 7/08/05 | 579,958 | 1.66 | 247,939 |
| Warrants (expiration 1/26/11) | 1/26/05 | 0 | 0.00 | 0 |
| Warrants (expiration 2/06/11) | 6/09/04 | 0 | 0.00 | 0 |
| Xoft, Inc. | ||||
| Series D Cvt. Pfd. | 3/23/07 | 2,958,518 | 0.74 | 682,187 |
| Series E Cvt. Pfd. | 6/20/08 | 592,532 | 0.74 | 130,719 |
| Cvt. Promissory Note | 6/12/09 | 598,183 | 1.00 | 590,000 |
| Cvt. Promissory Note | 7/1/10, 8/17/10 | 74,237 | 1.00 | 74,237 |
| Cvt. Promissory Note | 10/06/10 | 79,137 | 1.00 | 70,240 |
| Warrants (expiration 6/12/14) | 6/12/09 | 59 | 0.00 | 0 |
| Warrants (expiration 6/30/15) | 7/1/10, 8/17/10 | 7 | 0.00 | 0 |
| Zyomyx, Inc. | ||||
| Common | 2/19/99 - 7/22/04 | 3,902,233 | 0.25 | 17 |
| $ 68,033,402 | $ 46,669,917 |
(j) See Schedule of Investments and corresponding footnotes for more information on each issuer.
SEQ.=1,FOLIO='',FILE='C:\JMS\jkarthi\11-1181-1\task4522526\1181-1-bi-07.htm',USER='105429',CD='Feb 28 23:31 2011'
**Federal Income Tax Cost****
At December 31, 2010, the cost of securities for Federal income tax purposes was $372,060,705. The net unrealized gain on securities held by the Fund was $17,871,002, including gross unrealized gain of $62,389,167 and gross unrealized loss of $44,518,165.
**Affiliated Transactions****
An affiliate issuer is a company in which the Fund holds 5% or more of the voting securities. Transactions with such companies during the period ended December 31, 2010 were as follows:
| Issuer | Value on October 1, 2010 | Purchases | Sales | Income | Value on December 31, 2010 |
|---|---|---|---|---|---|
| Agilix Corporation | $ 141,809 | | $ | $ | $ 141,809 |
| CardioKinetix, Inc. | 3,068,236 | $ 426,954 | | 8,987 | 1,916,623 |
| Concentric Medical, Inc. | 4,124,713 | | | | 4,124,713 |
| Elemé Medical, Inc. | 1,684,430 | 27,019 | | 22,620 | 25,080 |
| Interlace Medical, Inc. | 2,065,000 | | | | 9,799,365 |
| Medwave, Inc. | 1,661 | | | | 1,744 |
| Palyon Medical Corporation | 2,211,809 | | | | 2,211,809 |
| PHT Corporation | 5,255,869 | | | | 5,255,869 |
| $ 18,553,527 | $ 453,973 | $ | $ 31,607 | $ 23,477,012 |
SEQ.=1,FOLIO='',FILE='C:\JMS\jkarthi\11-1181-1\task4522526\1181-1-bi-07.htm',USER='105429',CD='Feb 28 23:31 2011'
*Item 2. Controls and Procedures.*
(a.) The registrants principal executive officer and principal financial officer have concluded, based on their evaluation of the registrants disclosure controls and procedures as conducted within 90 days of the filing date of this report, that these disclosure controls and procedures are adequately designed and are operating effectively to ensure that information required to be disclosed by the registrant on Form N-Q is (i) accumulated and communicated to the investment companys management, including its certifying officers, to allow timely decisions regarding required disclosure; and (ii) recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commissions rules and forms.
(b.) There were no changes in the registrants internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act that occurred during the registrants last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrants internal control over financial reporting.
*Item 3. Exhibits.*
Separate certifications for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the Act (17 CFR 270.30a-2(a)). Filed herewith.
SEQ.=1,FOLIO='',FILE='C:\JMS\c900675\11-1181-1\task4439706\1181-1-ga.htm',USER='c900675',CD='Jan 22 18:42 2011'
*SIGNATURES*
Pursuant to the requirements of the Securities and Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
| (Registrant) | |
|---|---|
| By (Signature and Title) | /s/ Daniel R. Omstead |
| Daniel R. Omstead, President | |
| Date | 2/28/2011 |
Pursuant to the requirements of the Securities and Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.
| By (Signature and Title) | |
|---|---|
| Laura Woodward, Treasurer | |
| Date | 2/28/2011 |
SEQ.=1,FOLIO='',FILE='C:\JMS\105455\11-1181-1\task4517623\1181-1-jc.htm',USER='105455',CD='Feb 26 07:15 2011'
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