abrdn Healthcare Investors

Regulatory Filings • Aug 29, 2006

N-Q 1 a06-18737_1nq.htm QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS

| UNITED
STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 |
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| FORM N-Q |

*QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY*

Investment Company Act file number
H&Q Healthcare
Investors
(Exact name of
registrant as specified in charter)
30 Rowes Wharf, Boston,
MA	02110
(Address of principal
executive offices)	(Zip code)
(Name and address of
agent for service)
Registrant's telephone number, including area code:	617-772-8500
Date of fiscal year end:	September 30
Date of reporting period:	6/30/06

Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-% (ss.ss. 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b-15 under the Investment Company Act of 1940 (17CFR 270.3b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.

A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget (“OMB”) control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. ss.3507.

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*Item 1. Schedule of Investments.*

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*H&Q HEALTHCARE INVESTORS*

*SCHEDULE OF INVESTMENTS*

June 30, 2006

(Unaudited)

SHARES		VALUE
	CONVERTIBLE SECURITIES AND WARRANTS – 15.1% of
Net Assets
	Convertible Preferred (Restricted) – 15.0%
	Drug Discovery Technologies –
1.5 %
2,380,953	Agilix
Corporation Series B (a) (b)	$ 141,809
375,000	Ceres, Inc.
Series C (a)	2,250,000
32,193	Ceres, Inc.
Series C-1 (a)	193,158
280,105	Ceres, Inc.
Series D (a)	1,680,630
324,717	Cougar
Biotechnology Inc. Series A (a)	1,462,493
1,398,732	Galileo
Pharmaceuticals, Inc. Series F-1 (a)	140
300,000	Zyomyx, Inc.
Series A New (a)	30,000
300	Zyomyx, Inc.
Series B New (a)	30
	Emerging Biopharmaceuticals –
4.1 %
1,117,381	Agensys, Inc.
Series C (a)	3,300,300
2,586,207	Corus Pharma,
Inc. Series C (a)	1,500,000
1,818,182	Raven
biotechnologies, Inc. Series B (a)	1,509,091
2,809,157	Raven
biotechnologies, Inc. Series C (a)	2,331,600
4,083,022	Raven
biotechnologies, Inc. Series D (a)	1,200,000
2,123,077	TargeGen, Inc.
Series C (a)	2,760,000
47,407	Therion
Biologics Corporation Series A (a)	474
240,000	Therion
Biologics Corporation Series B (a)	2,400
407,712	Therion
Biologics Corporation Series C (a)	4,077
305,784	Therion
Biologics Corp. warrants (expiration 9/26/06) (a)	0
33,332	Therion
Biologics Corporation Series C-2 (a)	334
24,999	Therion
Biologics Corp. warrants (expiration 8/18/08) (a)	0
36,092	Therion
Biologics Corporation Sinking Fund (a)	361
2,555,000	Xanthus Life
Sciences, Inc. Series B (a)	2,555,000
	Healthcare Services – 4.5 %
1,577,144	CardioNet, Inc.
Series C (a) (b)	5,520,004
52,882	CardioNet
warrants (expiration 5/01/11) (a) (b)	0
484,829	CytoLogix
Corporation Series A (a) (b)	399,984
227,130	CytoLogix
Corporation Series B (a) (b)	187,382
160,000	I-trax, Inc.
Series A (a)	5,708,055
5,384,615	PHT Corporation
Series D (a) (b)	4,200,000
1,204,495	PHT Corporation
Series E (a) (b)	939,506
	Medical Devices and Diagnostics
– 4.9 %
4,852,940	Concentric
Medical, Inc. Series B (a) (b) (c)	6,794,116
1,744,186	Concentric
Medical, Inc. Series C (a) (b)	2,441,860
683,000	Concentric
Medical, Inc. Series D (a) (b)	956,200
222,222	EPR, Inc. Series
A (a)	2,222
3,669,024	Labcyte, Inc.
Series C (a)	1,920,000
160,000	Masimo
Corporation Series D	1,760,000
1,632,653	OmniSonics
Medical Technologies, Inc. Series B (a) (b)	1,962,775
1,547,988	OmniSonics
Medical Technologies, Inc. Series C (a) (b)	1,616,100
65,217	TherOx, Inc. Series H (a)	247,825

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SHARES
	Medical Devices and Diagnostics – continued
149,469	TherOx,
Inc. Series I (a)	$ 577,100
4,220	Therox
warrants (expiration 1/26/10) (a)	0
8,141	Therox
warrants (expiration 6/09/09) (a)	0
		$ 56,155,026

PRINCIPAL AMOUNT
	Convertible Notes (Restricted) – 0.1%
	Healthcare Services – 0.1%
$ 316,964	CardioNet, Inc. Cvt. Note, 8.00% due 2006 (b)	316,964
168,337	CytoLogix Corporation Cvt. Note, 6.75% (b) (d)	168,337
		$ 485,301
	TOTAL CONVERTIBLE SECURITIES
AND WARRANTS (Cost
$67,638,219)	$ 56,640,327

SHARES
	COMMON STOCKS AND WARRANTS – 78.0%
	Biopharmaceuticals
– 31.3%
577,778	Akorn, Inc. (a)	2,299,556
202,223	Akorn Inc. warrants (expiration 3/07/11) (a)	0
373,750	Alexza Pharmaceuticals, Inc. (a)	2,739,588
74,000	Amgen, Inc. (a)	4,827,020
50,000	Biogen Idec Inc. (a)	2,316,500
103,000	Celgene Corp. (a)	4,885,290
360,620	Corcept Therapeutics Inc. (a)	1,460,511
433,486	Cubist Pharmaceuticals, Inc. (a)	10,915,178
73,800	Endo Pharmaceuticals Holdings (a)	2,433,924
174,500	Forest Laboratories, Inc. (a)	6,751,405
64,500	Genentech, Inc. (a)	5,276,100
159,268	Genzyme Corporation (a)	9,723,311
247,075	Gilead Sciences, Inc. (a)	14,616,957
450,175	Idenix Pharmaceuticals Inc. (a)	4,231,645
778,450	Insmed Inc. (a)	1,245,520
1,048,756	Inspire Pharmaceuticals, Inc. (a)	4,876,715
158,690	MedImmune, Inc. (a)	4,300,499
408,000	MGI Pharma, Inc. (a)	8,772,000
147,760	Myriad Genetics Inc. (a)	3,730,940
124,080	PDL BioPharma Inc. (a)	2,284,313
205,000	Pfizer, Inc.	4,811,350
278,300	Schering-Plough Corporation	5,296,049
690,556	Tercica, Inc. (a)	3,653,041
97,050	United Therapeutics Corp. (a)	5,606,578
		117,053,990

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SHARES		VALUE
	Drug Delivery – 2.2%
822,533	DepoMed, Inc. (a)	$ 4,828,269
197,940	Noven Pharmaceuticals,
Inc. (a)	3,543,126
		8,371,395
	Drug Discovery Technologies –
2.6%
277,273	Avalon Pharmaceuticals,
Inc. (a)	939,955
36,080	Cougar Biotechnology
Inc. (Restricted) (a)	162,501
213,513	Senomyx, Inc. (a)	3,080,993
290,600	ZymoGenetics, Inc. (a)	5,512,682
300,000	Zyomyx, Inc.
(Restricted) (a)	3,000
		9,699,131
	Emerging Biopharmaceuticals –
10.5%
466,448	ACADIA Pharmaceuticals,
Inc. (a)	3,936,821
972,841	Ariad Pharmaceuticals,
Inc. (a)	4,387,513
540,592	Barrier Therapeutics,
Inc. (a)	3,535,472
164,930	DOV Pharmaceutical,
Inc. (a)	349,652
465,050	Exelixis, Inc. (a)	4,673,752
387,577	Kosan Biosciences, Inc. (a)	1,550,308
119,650	Momenta
Pharmaceuticals, Inc. (a)	1,520,751
62,073	Myogen, Inc. (a)	1,800,117
102,176	Myogen, Inc. warrants
(expiration 9/29/09) (a)	2,166,131
599,790	Neurogen Corporation (a)	3,070,925
471,278	Nitromed, Inc. (a)	2,276,273
626,580	Seattle Genetics, Inc. (a)	2,882,268
109,954	Telik, Inc. (a)	1,814,241
238,199	Theravance, Inc. (a)	5,449,993
226,760	Therion Biologics
Corporation (Restricted) (a)	2,268
		39,416,485
	Generic Pharmaceuticals – 6.5%
109,700	Barr Pharmaceuticals,
Inc. (a)	5,231,593
828,524	Impax Laboratories,
Inc. (a)	5,178,275
119,700	K-V Pharmaceutical Co. (a)	2,233,602
237,500	Taro Pharmaceuticals
Industries Ltd. (a)	2,519,875
283,469	Teva Pharmaceutical
Industries, Ltd. (e)	8,954,786
		24,118,131
	Healthcare Services – 9.3%
131,000	Allscripts Healthcare
Solutions, Inc. (a)	2,299,050
222,222	Aveta, Inc.
(Restricted) (a)	2,999,997
26,125	DakoCytomation, Inc.
(Restricted) (f)	271,962
200,000	Eclipsys Corporation (a)	3,632,000
404,334	Emageon, Inc. (a)	5,899,233
416,500	Emdeon Corporation (a)	5,168,765

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SHARES		VALUE
	Healthcare
Services – continued
141,000	Medco Health Solutions, Inc. (a)	$ 8,076,480
198,905	National Medical Health Card Systems, Inc. (a)	2,744,889
306,208	Syntiro Healthcare Services (Restricted) (a)	306
80,000	UnitedHealth Group Inc.	3,582,400
		34,675,082
	Medical
Devices and Diagnostics – 15.6%
189,330	Adeza Biomedical Corporation (a)	2,654,407
852,150	Align Technology, Inc. (a)	6,297,388
347,000	American Medical Systems Holdings Inc (a)	5,777,550
447,722	Conor Medsystems, Inc. (a)	12,352,650
109,200	Conor Medsystems, Inc. (Restricted) (a)	2,862,187
120,000	DJO Incorporated. (a)	4,419,600
73,000	Gen-Probe, Inc. (a)	3,940,540
137,120	Genomic Health Inc. (a)	1,613,902
100,980	IDEXX Laboratories, Inc. (a)	7,586,627
160,000	Masimo Corporation (Restricted)	1,600
830,292	Medwave, Inc. (a) (b)	2,100,639
207,573	Medwave Inc. warrants (expiration 8/21/11) (a) (b)	0
932,315	Orthovita, Inc. (a)	3,934,369
208,529	Songbird Hearing, Inc. (Restricted) (a)	2,085
546,875	VNUS Medical Technologies, Inc. (a)	4,582,813
		58,126,357
	TOTAL COMMON STOCKS AND
WARRANTS (Cost
$261,284,050)	$ 291,460,571

PRINCIPAL AMOUNT
	SHORT-TERM
INVESTMENTS – 3.8%
$ 3,600,000	American Express Corp.; 5.25% due 07/11/06	3,594,750
5,000,000	General Electric Capital Corp.; 5.21% due 07/07/06	4,995,658
5,600,000	United Parcel Service American Inc.; 4.95% due
07/05/06	5,596,920
	TOTAL
SHORT-TERM INVESTMENTS (Cost
$14,187,328)	$ 14,187,328
	TOTAL INVESTMENTS – 96.9% (Cost $343,109,597)	$ 362,288,226
	OTHER ASSETS IN EXCESS OF LIABILITIES – 3.1%	11,664,152
	NET ASSETS -
100%	$ 373,952,378

(a) Non-income producing security.

(b) Affiliated issuers in which the Fund holds 5% or more of the voting securities (Total Market Value of $27,745,677).

(c) Includes 321,000 non-voting shares.

(d) Variable maturity.

(e) American Depositary Receipt.

(f) Foreign security.

The accompanying notes are an integral part of these financial statements.

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HQH

Investment Securities Valuation - Investments traded on national securities exchanges or in the over-the-counter market that are National Market System securities are valued at the last sale price or, lacking any sales, at the mean between the last bid and asked prices. Other over-the-counter securities are valued at the most recent bid prices as obtained from one or more dealers that make markets in the securities. Exchange-traded investments for which market quotations are not readily available are valued at fair value as determined in good faith by the Trustees of the Fund. The fair value of venture capital and other restricted securities is determined in good faith by the Trustees. However, because of the uncertainty of fair valuations these estimated values may differ significantly from the values that would have been used had a ready market for these securities existed, and the differences could be material. Each such fair value determination is based on a consideration of relevant factors. Factors the Trustees consider may include (i) the existence of any contractual restrictions on the disposition of securities; (ii) information obtained from the issuer which may include an analysis of the company’s financial statements, the company’s products or intended markets or the company’s technologies; and (iii) the price of a security negotiated at arm’s length in an issuer’s completed subsequent round of financing. Short-term investments with maturity of 60 days or less are valued at amortized cost.

Venture Capital and Other Restricted Securities - The following table details the acquisition date, cost, carrying value per unit, and value of the Fund’s venture capital and other restricted securities at June 30, 2006, as determined by the Trustees of the Fund. The Fund may invest up to 40% of its net assets in venture capital and other restricted securities. The values of these securities represent 17% of the Fund’s net assets at June 30, 2006. With the exception of Conor Medsystems, Inc. Restricted Common, the Fund on its own does not have the right to demand that such securities be registered. Subject to certain conditions, the Fund has the right to request registration of Conor Medsystems, Inc. Restricted Common.

	Acquisition		Carrying — Value
Security (f)	Date	Cost	per Unit	Value
Agensys, Inc.
Series C Cvt. Pfd.	2/14/02, 9/27/05	$ 3,307,024	$ 2.95	$ 3,300,300
Agilix
Corporation
Series B Cvt. Pfd.	11/8/01	2,566,969	0.06	141,809
Aveta, Inc.
Restricted Common	12/21/05	2,999,997	13.50	2,999,997
CardioNet, Inc.
Series C Cvt. Pfd.	5/3/01 - 3/25/03	5,551,696	3.50	5,520,004
Convertible Note	8/15/05	316,964	1.00	316,964
Ceres, Inc.
Series C Cvt. Pfd.	12/23/98	1,502,620	6.00	2,250,000
Series C-1 Cvt. Pfd.	3/31/01	111,488	6.00	193,158
Series D Cvt. Pfd.	3/14/01	1,668,122	6.00	1,680,630
Concentric
Medical, Inc.
Series B Cvt. Pfd.	5/7/02, 1/24/03	3,329,210	1.40	6,794,116
Series C Cvt. Pfd.	12/19/03	1,500,000	1.40	2,441,860
Series D Cvt. Pfd.	9/30/05	957,768	1.40	956,200
Conor
Medsystems, Inc.
Restricted Common	10/23/03-8/6/04	653,127	27.59	2,862,187
Corus Pharma,
Inc.
Series C Cvt. Pfd.	4/8/04	3,006,929	0.58	1,500,000
Cougar
Biotechnology Inc.
Series A Cvt. Pfd.	3/30/06	1,462,499	4.50	1,462,493
Restricted Common	3/30/06	162,501	4.50	162,501
CytoLogix
Corporation
Series A Cvt. Pfd.	1/13/98-7/21/99	1,622,895	0.83	399,984
Series B Cvt. Pfd.	1/11/01	760,284	0.83	187,382
Convertible Note	5/29/02	168,337	1.00	168,337
Dako A/S
Restricted Common	6/14/04	1,102,920	10.41	271,962
EPR, Inc.
Series A Cvt. Pfd.	3/9/94	1,000,409	0.01	2,222
Galileo
Pharmaceuticals, Inc.
Series F-1 Cvt. Pfd.	8/18/00	3,002,895	0.00	140
I-trax, Inc.
Series A Cvt. Pfd.	3/18/04	4,003,650	35.68	5,708,055
Labcyte, Inc.
Series C Cvt. Pfd.	7/18/05	1,923,506	0.52	1,920,000
Masimo
Corporation
Series D Cvt. Pfd.	8/14/96	1,120,657	11.00	1,760,000
Restricted Common	3/31/98	0	0.01	1,600
OmniSonics
Medical Technologies, Inc.
Series B Cvt. Pfd.	5/24/01	2,409,023	1.20	1,962,775
Series C Cvt. Pfd.	10/1/03	1,800,336	1.04	1,616,100

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			Carrying
	Acquisition		Value
Security (f)	Date	Cost	per Unit	Value
PHT Corporation
Series D Cvt. Pfd.	7/23/01	$ 4,205,754	$ 0.78	$ 4,200,000
Series E Cvt. Pfd.	9/12/03 - 10/14/04	941,669	0.78	939,506
Raven
biotechnologies, Inc.
Series B Cvt. Pfd.	12/12/00	3,001,725	0.83	1,509,091
Series C Cvt. Pfd.	11/26/02	2,331,600	0.83	2,331,600
Series D Cvt. Pfd.	6/23/05	1,205,415	0.29	1,200,000
Songbird
Hearing, Inc.
Restricted Common	12/14/00	3,004,861	0.01	2,085
Syntiro
Healthcare Services
Restricted Common	2/5/97	1,200,325	0.001	306
TargeGen, Inc.
Series C Cvt. Pfd.	8/30/05	2,763,495	1.30	2,760,000
Therion
Biologics Corporation
Series A Cvt. Pfd.	8/20/96-10/16/96	444,850	0.10	474
Series B Cvt. Pfd.	6/22/99	901,393	0.01	2,400
Series C Cvt. Pfd.	9/26/01-10/15/01	1,529,348	0.10	4,077
Series C-2 Units	8/13/03	59,998	0.01	334
Sinking Fund Cvt. Pfd.	10/18/94-8/20/96	721,291	0.01	361
Restricted Common	7/12/90-1/25/96	511,365	0.01	2,268
TherOx, Inc.
Series H Cvt. Pfd.	9/11/00	3,002,506	3.80	247,825
Series I Cvt. Pfd.	7/8/05	579,407	3.86	577,100
Xanthus Life
Sciences, Inc.
Series B Cvt. Pfd.	12/5/03, 3/23/06	2,556,320	1.00	2,555,000
Zyomyx, Inc.
Series A New Cvt. Pfd.	1/12/04	299,700	0.10	30,000
Series B New Cvt. Pfd.	2/19/99, 1/12/04	468	0.10	30
New Restricted Common	2/19/99 - 7/22/04	3,602,065	0.01	3,000
		$ 80,875,381		$ 62,946,233	(g)

(f) See Schedule of Investments and corresponding footnotes for more information on each issuer.

(g) Represents 17% of the Fund’s net assets as of June 30, 2006.

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Federal Income Tax Cost - At June 30, 2006, the total cost of securities for Federal income tax purposed was $343,109,597. The net unrealized gain on securities held by the Fund was $19,178,629, including gross unrealized gain of $76,334,481 and gross unrealized loss of $57,155,852.

Affiliate Transactions – An affiliate issuer is a company in which the Fund holds 5% or more of the voting securities. Transactions with such companies during the nine months ended June 30, 2006 were as follows:

Issuer	Value on October 1, 2005	Purchases	Sales	Income	Value on June 30, 2006
Agilix
Corporation	$ 571,429	$ —	$ —	$ —	$ 141,809
CardioNet, Inc.	5,820,004	—	—	18,112	5,836,968
Concentric
Medical, Inc.	10,192,176	—	—	—	10,192,176
CytoLogix
Corporation	755,703	—	—	8,522	755,703
Medwave, Inc.	—	2,275,000	—	—	2,100,639
OmniSonics
Medical Technologies, Inc.	3,981,225	—	—	—	3,578,875
PHT Corporation	5,139,506	—	—	—	5,139,506
	$ 26,460,043	$ —	$ —	$ 26,634	$ 27,745,676

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*Item 2. Controls and Procedures.*

(a.) The registrant’s principal executive officer and principal financial officer have concluded, based on their evaluation of the registrant’s disclosure controls and procedures as conducted within 90 days of the filing date of this report, that these disclosure controls and procedures are adequately designed and are operating effectively to ensure that information required to be disclosed by the registrant on Form N-Q is (i) accumulated and communicated to the investment company’s management, including its certifying officers, to allow timely decisions regarding required disclosure; and (ii) recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms.

(b.) There were no changes in the registrant’s internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act that occurred during the registrant’s last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting.

*Item 3. Exhibits.*

Separate certifications for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the Act (17 CFR 270.30a-2(a)). Filed herewith.

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*SIGNATURES*

Pursuant to the requirements of the Securities and Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)
By (Signature and Title)	/s/ Daniel Omstead
	Daniel Omstead, President
Date	8/29/06

Pursuant to the requirements of the Securities and Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)*
	Kathleen Eckert, Treasurer
Date	8/29/06

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