Novonesis AS

Director's Dealing • Nov 7, 2025

Trading by management and close relations of management

In accordance with article 19 in Regulation (EU) No 596/2014 of 16 April 2014 on market abuse (the "Market Abuse Regulation") and commission delegated regulation (EU) 1052/2016 of 8 March 2016, Novonesis reports the following transactions under ISIN DK0060336014, Novonesis (Novozymes) B shares under the symbol NSIS B.

1. Details of the person discharging managerial responsibilities/person closely associated a) Name Morten Enggaard Rasmussen 2. Reason for the notification a) Position/status Executive Vice President of People & Stakeholder Relations b) Initial notification/ Amendment Initial notification 3. Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor a) Name Novozymes A/S b) LEI 529900T6WNZXD2R3JW38 4. Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted a) Description of the financial instrument, type of instrument Identification code B-Shares DK0060336014 b) Nature of the transaction Purchase of shares c) Price(s) and volume(s) Price(s) Volume(s) DKK 418.10 380 shares d) Aggregated information - Aggregated volume - Price Number of shares: 380 Average price, DKK: 418.10 Transaction value, DKK: 158,878.00 e) Date of transaction November 7, 2025 f) Place of the transaction Nasdaq XCSE

November 7, 2025

Company announcement no. 48

Contact information Investor relations

Tobias Bjorklund +45 3077 8682

tobb@novonesis.com

Anders Enevoldsen +45 5350 1453 adev@novonesis.com

Katrine Spedtsberg Poulsen kats@novonesis.com

About Novonesis

Novonesis is a global leading biosolutions company transforming the way we all produce, consume and live. In more than 30 industries our biosolutions are helping companies meet their business needs and the needs of our planet. Our 10,000 people worldwide work closely with our partners and customers to challenge conventional thinking and transform business with biology.

Novozymes A/S, part of Novonesis Group Krogshoejvej 36 2880 Bagsvaerd Denmark