Biotage

Major Shareholding Notification • Nov 4, 2010

Press release Biotage AB

Contact: SE-753 18 Uppsala Torben Jörgensen, President and CEO Tel+46 18 56 59 00 Tel: +46 707 49 05 84, torben.jorgensen@biotage.com www.biotage.com

Kungsgatan 76

Uppsala November 4, 2010

Biotage AB (publ) – disclosure notice of substantial holding of shares

Biotage AB (publ) has as of 4 November 2010 bought back an aggregate of 8,848,632 shares under the re-purchase program resolved at the Annual General Meeting with the shareholders on 29 April 2010. The Company`s aggregated holding of own shares corresponds to 10 percent of the total amount of shares and votes in the Company.

The total amount of shares outstanding, including shares held in treasury, amounts to 88,486,320.

The Board of Directors intends to propose the forthcoming Annual General Meeting to resolve that the re-purchased shares shall be cancelled.

Biotage discloses the information provided herein pursuant to the Swedish Securities Markets Act and/or the Swedish Financial Instruments Trading Act. The information was submitted for publication at 12.00 am on 4 November 2010.

About Biotage

Biotage offers solutions, knowledge and experience in the areas of analytical chemistry and medicinal chemistry. The customers include the world's largest pharmaceutical and biotech companies, and leading academic institutes. The company is headquartered in Uppsala and has subsidiaries in the US, UK and Japan. Biotage has 269 employees and had sales of 394.1 MSEK in 2009. Biotage is listed on the NASDAQ OMX Nordic Stockholm stock exchange. Website: www.biotage.com