OPKO Health Inc.

Proxy Solicitation & Information Statement • May 1, 2018

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant Filed by a party other than the Registrant

Check the appropriate box:

Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material under 240.14a-12

OPKO Health, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box)

No fee required

Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11

• (1) Title of each class of securities to which transaction applies:
• (2) Aggregate number of securities to which transaction applies:
• (3) Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):
• (4) Proposed maximum aggregate value of transaction:

(5) Total Fee paid:

Fee paid previously with preliminary materials.

• Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.
• (1) Amount Previously Paid:
• (2) Form, Schedule or Registration Statement No.:
• (3) Filing Party:

(4) Date Filed:

*** Exercise Your Right to Vote *** Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on June 21, 2018.

	Meeting Information
OPKO HEALTH, INC.	Meeting Type: Annual Meeting
	For holders as of: April 23, 2018
	Date: June 21, 2018 Time: 10:00 am. Eastern Time
	Location: Meeting live via the Internet-please visit www.virtualshareholdermeeting.com/OPK2018.
H. INC. WANAN	The company will be hosting the meeting live via the Internet this year. To attend the meeting via the Internet please visit www.virtualshareholdermeeting.com/OPK2018 and be sure to have the information that is printed in the box marked by the arrow -> XXXX XXXX XXXX XXXX (located on the following page). The Company will also be hosting a listen-only conference call. Please note that you will not be able to vote or revoke your proxy via the listen-only conference call.
NE BI VO 3137	You are receiving this communication because you hold shares in the company named above.
	This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at www.proxyrote.com or easily request a paper copy (see reverse side).

We encourage you to access and review all of the important
information contained in the proxy materials before voting.

See the reverse side of this notice to obtain
proxy materials and voting instructions.

の 18816841
1771678
480000500
1840,0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000

Before You Vote

How to Access the Proxy Materials

	Proxy Materials Available to VIEW or RECEIVE:
	NOTICE AND PROXY STATEMENT ANNUAL REPORT
	How to View Online:
	Have the information that is printed in the box marked by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> following page) and visit: www.proxyvote.com
	How to Request and Receive a PAPER or E-MAIL Copy:
If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request:
	I) BY INTERNET: www.proxyvote.com
	2) BY TELEPHONE: 1-800-579-1639
	3) BY E-MAIL*: sendmaterial@proxyvote.com
* If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before June 7, 2018 to facilitate timely delivery.
- How To Vote -
Please Choose One of the Following Voting Methods

Vote By Internet:
Before The Meeting: Go to www.boxyote.com. Have the is printed in the box marked by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> following page) available and follow the instructions.
Dunng The Meeting: Go to www.virtualshareholdermeeting.com/OPK2018. Have the is printed in the box marked by the arrow -> XXXX XXXX XXXX (located on the following page) available and follow the instructions.
Please note that you will not be able to vote or revolv conference call o cake place sinutaneously with the webcast of the Annual Meeting.
Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.

E47293-P09823

THE BOAT 11.

Election of nine directors.

nominees

01) (02) (3) 04)	Phillip Frost, M.D. Jane H. Hsiao, Ph.D., MBA Steven D. Rubin Robert S. Fishel, M.D. 05) Richard M. Krasno, Ph.D.	07)	06) Richard A. Lerner, M.D. John A. Paganelli 08) Richard C. Pfenniger, Jr. 09) Alice Lin-Tsing Yu, M.D., Ph.D.

• 1. A non-binding advisory vote to approve the compensation paid to named executive officers of the Company ("Say on Pay").
• 1. To ratify the appointment of Ernst & Young LP as the Company's independent registered public accounting firm for the fiscal year ending for the fiscal year ending for the
• 1. In their discretion, the proxy holders are authorized to vote upon such other matters as may propely come before the meeting or any