OPKO Health Inc.

Proxy Solicitation & Information Statement • Apr 30, 2020

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant Filed by a party other than the Registrant

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Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material under 240.14a-12

OPKO Health, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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*** Exercise Your Right to Vote *** Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on June 25, 2020.

	Meeting Information
OPKO HEALTH, INC.	Meeting Type: Annual Meeting
	For holders as of: April 27, 2020
	Date: June 25, 2020 Time: 10:00 a.m. Eastern Time
	Location: Meeting live via the Internet-please visit www.virtualshareholdermeeting.com/OPK2020.
	The company will be hosting the meeting live via the Internet this year. To attend the meeting via the Internet please visit www.virtualshareholdermeeting.com/OPK2020 and be sure to have the information that is printed in the box marked by the arrow -> XXXX XXXX XXXX XXXX (located on the following page).
SMCF VILLAN VE BLVD.	You are receiving this communication because you hold shares in the company named above.
137	This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may yiew the proxy materials online at www.broxwote.com or

We encourage you to access and review all of the important
information contained in the proxy materials before voting.

easily request a paper copy (see reverse side).

See the reverse side of this notice to obtain
proxy materials and voting instructions.

OPKO HEALTH
ATTN: KATE IN
4400 BISCAYN MAMI, FL 331

Before You Vote

How to Access the Proxy Materials

Proxy Materials Available to VIEW or RECEIVE: NOTICE AND PROXY STATEMENT How to View Online: Have the information that is printed in the box marked by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> following page) and visit: www.proxyvote.com How to Request and Receive a PAPER or E-MAIL Copy: If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request: I) BY INTERNET: www.proxyvote.com 2) BY TELEPHONE: 1-800-579-1639 3) BY E-MAIL*: sendmaterial@proxyvote.com If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked * by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment

advisor. Please make the request as instructed above on or before June 11, 2020 to facilitate timely delivery.

How To Vote

Please Choose One of the Following Voting Methods

Vote By Internet:
Before The Meeting.
Go to www.proxyvote.com Have the information that is printed in the box marked by the arrow ->>>XXX XXXX XXXX XXXX (located on the following page) available and follow the instructions
During The Meeting:
Go to www.virtualshareholdermeeting.com/OPK2020. Have the information that is printed in the box marked by the arrow -> XXXX XXXX XXXX {{located on the following page) available and follow the instructions.
Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.

E97656-P37502

Voting Items THE BOARD OF DIRECTORS RECOMMENDS A VOTE
PORTETION OF DIRECTORS RECOMMENDS AND ANDS FORE
DIRECTOR THE SACHON OF ENDENT OF THE NOLANDS FOR THE COLLE
AS THE COMPANY'S INDEPENDE 1-Election of nine directors.

NOMINEES

01)	Phillip Frost, M.D.	06)	Richard A. Lerner, M.D.
02)	Jane H. Hsiao, Ph.D., MBA		John A. Paganelli
03)	Steven D. Rubin	08)	Richard C. Pfenniger, Jr.
04)	Robert S. Fishel, M.D.		09) Alice Lin-Tsing Yu, M.D., Ph.D.
05)	Richard M. Krasno, Ph.D.

1. A non-binding advisory vote to approve the compensation paid to named executive officers of the Company ("Say on Pay").

2. To ratify the appointment of Enst & Young LP as the Company's independent registered public accounting firm for the fiscal year ending of the first ling of the first ling

3. In their discretion, the proxy holders are authorized to vote upon such other matters as may propely come before the meeting or any