OPKO Health Inc.

Major Shareholding Notification • Jul 25, 2020

FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person		2. Date of Event Requiring		3. Issuer Name and Ticker or Trading Symbol
Hernandez	Rulfo	F	Statement (Month/Day/Year) 07/22/2020		OPKO Health, Inc. [OPK]
(Last) 4400 Biscayne Blvd.	(First)	(Middle)			4. Relationship of Reporting Person(s) to Issuer			5. If Amendment, Date Original
					(Check all applicable)		Filed(Month/Day/Year)
(Street)					_ Director _ 10% Owner			6. Individual or Joint/Group Filing (Check
Miami	FL	33137			____ Other (specify X Officer (give title below) below) CAO, Treasurer			Applicable Line)
(City)	(State)	(Zip)						X Form filed by One Reporting Person ____ Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)			2. Amount of Securities Beneficially Owned (Instr. 4)		3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock		87		D

Table II - Derivative Securities Beneficially Owned ( e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative	5. Ownership Form of Derivative	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	Security	Security: Direct (D) or Indirect (I) (Instr. 5)
Stock Option (Right to Buy)	(1)	06/11/2024	Common Stock	40,000	\$9.1	D
Stock Option (Right to Buy)	(2)	03/17/2025	Common Stock	60,000	\$14.42	D
Stock Option (Right to Buy)	(3)	03/31/2026	Common Stock	75,000	\$10.41	D
Stock Option (Right to Buy)	(4)	06/20/2028	Common Stock	50,000	\$4.46	D
Stock Option (Right to Buy)	(5)	06/30/2029	Common Stock	100,000	\$2.47	D
Stock Option (Right to Buy)	(6)	06/03/2030	Common Stock	100,000	\$2.27	D

Explanation of Responses:

• (1) This option will vest in four equal annual installments beginning June 12, 2015.
• (2) This option will vest in four equal annual installments beginning March 18, 2016.
• (3) This option will vest in four equal annual installments beginning April 1, 2017.
• (4) This option will vest in four equal annual installments beginning June 21, 2019.
• (5) This option will vest in four equal annual installments beginning July 1, 2020.
• (6) This option will vest in four equal annual installments beginning June 4, 2021.

Rulfo F. Hernandez 07/24/2020 **Signature of Reporting Person Date

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure. Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.