OPKO Health Inc.

Proxy Solicitation & Information Statement • May 1, 2021

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant Filed by a party other than the Registrant

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Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material under 240.14a-12

OPKO Health, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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OPKO Health, Inc. Important Notice Regarding the Availability of Proxy Materials

Stockholders Meeting to be held on June 24, 2021 For Stockholders as of April 26, 2021

This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting.

To view the proxy materials, and to obtain directions to attend meeting, go to: www.proxydocs.com/OPK

To vote your proxy while visiting this site, you will need the 12 digit control number in the box below.

Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet.

For a convenient way to view proxy materials and VOTE go to www.proxydocs.com/OPK

Have the 12 digit control number located in the shaded box above available when you access the website and follow the instructions.

If you want to receive a paper or e-mail copy of the proxy material, you must request one. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year's meeting, you must make this request on or before June 14, 2021.

To order paper materials, use one of the following methods.

* If requesting material by e-mail, please send a blank
e-mail with the 12 digit control number (located and one)
in the subject line. No other requested the OR
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When requesting via the Internet or telephone you will need the 12 digit control number located in the shaded box above.

OPKO Health, Inc.

Meeting Type: Annual Meeting of Stockholders Date: Thursday, June 24, 2021 Time: 10:00 AM, Eastern Time Place: Annual Meeting to be held live via the Internet - please visit www.proxydocs.com/OPK for more details.

You must register to attend the meeting online and/or participate at www.proxydocs.com/OPK

SEE REVERSE FOR FULL AGENDA

OPKO Health, Inc.

Annual Meeting of Stockholders

THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE ELECTION OF EACH OF THE NOMINEES FOR DIRECTOR, "FOR" THE SAY ON PAY PROPOSAL, AND "FOR" RATFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS THE COMPANY'S INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM.

PROPOSAL

1.

• Election of twelve directors. 1.01 Phillip Frost, M.D.
  • 1.02 Jane H. Hsiao, Ph.D., MBA
  • 1.03 Steven D. Rubin
  • 1.04 Jon R. Cohen, M.D.
  • 1.05 Robert S. Fishel, M.D.
  • 1.06 Richard M. Krasno, Ph.D.
  • 1.07 Prem A. Lachman, M.D.
  • 1.08 Richard A. Lerner, M.D.
  • 1.09 Roger J. Medel, M.D.
  • 1.10 John A. Paganelli
  • 1.11 Richard C. Pfenniger, Jr.
  • 1.12 Alice Lin-Tsing Yu, M.D., PhD.
• 1. A non-binding advisory vote to approve the compensation paid to named executive officers of the Company ("Say on Pay").
• 1. To ratify the appointment of Emst & Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2021.
• 1. In their discretion, the proxy holders are authorized to vote upon such other matters as may properly come before the meeting or any postponement or adjournment thereof.