OPKO Health Inc.

Director's Dealing • Aug 11, 2021

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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Check this box if no longer subject to

Section 16. Form 4 or

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continue. See

Instruction 1(b).

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

Hsiao, Ph.D.	1. Name and Address of Reporting Person Jane	H	2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [OPK]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) ____ 10% Owner
(Last)	(First) (Middle) OPKO Health, Inc. 4400 Biscayne Blvd.		3. Date of Earliest Transaction (Month/Day/Year) 08/09/2021	X Director Officer (give title below)____ Other (specify below) X Vice Chairman & CTO
(Street) Miami FL 33137 (City) (State) (Zip)			4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person ____ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s)	6. Ownership Form:	7. Nature of Indirect Beneficial
			Code	V	Amount	(A) or (D)	Price	(Instr. 3 and 4)	Direct (D) or Indirect (I) (Instr. 4)	Ownership (Instr. 4)
Common Stock	08/09/2021		P		10	A	\$3.73	(1) 27,599,870	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of	2.	3. Transaction	3A. Deemed	4.		5. Number		6. Date Exercisable and			7. Title and	8. Price of	9. Number of	10.	11. Nature
Derivative	Conversion	Date	Execution Date, if	Transaction		of		Expiration Date	Amount of		Derivative	Derivative	Ownership	of Indirect
Security	or Exercise	(Month/Day/Year)	any	Code		Derivative		(Month/Day/Year)		Underlying		Security	Securities	Form of	Beneficial
(Instr. 3)	Price of		(Month/Day/Year)	(Instr. 8)		Securities					Securities	(Instr. 5)	Beneficially	Derivative	Ownership
	Derivative					Acquired					(Instr. 3 and 4)		Owned	Security:	(Instr. 4)
	Security					(A) or							Following	Direct (D)
							Disposed of						Reported	or Indirect
						(D)							Transaction(s)	(I)
						(Instr. 3, 4,							(Instr. 4)	(Instr. 4)
						and 5)
											Amount
											or
								Date	Expiration		Number
				Code	V	(A)	(D)	Exercisable	Date	Title	of Shares

Explanation of Responses:

(1) Includes 3,124,713 shares received as a pro rata distribution from The Frost Group, LLC ("The Frost Group"), of which the reporting person was a member. The Frost Group effected a pro rata distribution of its 20,091,062 shares of the Issuer, pursuant to which the reporting person now has direct beneficial ownership of her pro rata share of the securities formerly held by The Frost Group. The reporting person previously reported that the shares were owned directly by The Frost Group.

Jane H. Hsiao, Ph.D. 08/10/2021

**Signature of Reporting Person Date

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