OPKO Health Inc.

Director's Dealing • Nov 23, 2022

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

OMB APPROVAL

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Check this box if no longer subject to Section 16. Form 4 or

Instruction 1(b).

Form 5 obligations may continue. See STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person PHILLIP M.D. FROST ET AL			2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [OPK]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X X Director 10% Owner
(Last) OPKO Health, Inc. 4400 Biscayne Blvd.	(First)	(Middle)	3. Date of Earliest Transaction (Month/Day/Year) 11/22/2022	Officer (give title below)____ Other (specify below) X CEO & Chairman
(Street) Miami (City)	FL (State)	33137 (Zip)	4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) ____ Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s)	6. Ownership Form:	7. Nature of Indirect Beneficial
		(Month/Day/Year)	Code	V	Amount	(A) or (D)	Price	(Instr. 3 and 4)	Direct (D) or Indirect (I) (Instr. 4)	Ownership (Instr. 4)
Common Stock								3,068,951	D
Common Stock	11/22/2022		P		34,247	A	\$1.475	198,565,941	I	See Footnote (1)
Common Stock	11/22/2022		P		58,006	A	\$1.48	198,623,947	I	See Footnote (1)
										See

Common Stock	11/22/2022	P	1,200	A	\$1.4825	198,625,147	I	Footnote (1)
Common Stock	11/22/2022	P	93,500	A	\$1.485	198,718,647	I	See Footnote (1)
Common Stock	11/22/2022	P	11,551	A	\$1.49	198,730,198	I	See Footnote (1)
Common Stock	11/22/2022	P	75,496	A	\$1.5	198,805,694	I	See Footnote (1)
Common Stock	11/22/2022	P	6,345	A	\$1.505	198,812,039	I	See Footnote (1)
Common Stock	11/22/2022	P	19,655	A	\$1.51	198,831,694	I	See Footnote (1)
Common Stock						30,127,177	I	See Footnote (2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of		2.	3. Transaction	3A. Deemed	4.		5. Number		6. Date Exercisable and			7. Title and	8. Price of	9. Number of	10.	11. Nature
Security	Derivative	Conversion or Exercise	Date (Month/Day/Year)	Execution Date, if any	Transaction Code		of Derivative		Expiration Date (Month/Day/Year)		Amount of Underlying		Derivative Security	Derivative Securities	Ownership Form of	of Indirect Beneficial
(Instr. 3)		Price of Derivative		(Month/Day/Year)	(Instr. 8)		Acquired	Securities			Securities (Instr. 3 and 4)	(Instr. 5)	Beneficially Owned	Derivative Security:	Ownership (Instr. 4)
		Security					(A) or							Following	Direct (D)
							(D)	Disposed of						Reported Transaction(s)	or Indirect (I)
							(Instr. 3, 4, and 5)							(Instr. 4)	(Instr. 4)
												Amount
									Date	Expiration		or Number
					Code	V	(A)	(D)	Exercisable	Date	Title	of Shares

	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
FROST PHILLIP M.D. ET AL OPKO Health, Inc. 4400 Biscayne Blvd. Miami, FL 33137	X	X	CEO & Chairman
Frost Gamma Investments Trust 4400 Biscayne Blvd. Miami, FL 33137		X

Explanation of Responses:

• (1) The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
• (2) These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole

and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Phillip Frost, M.D., Individually and as Trustee 11/23/2022

**Signature of Reporting Person Date

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JOINT FILER INFORMATION

Name: Frost Gamma Investments Trust

Address: 4400 Biscayne Blvd. Miami, FL 33137

Designated Filer: Phillip Frost, M.D.

Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK)

Date of Earliest Transaction: November 22, 2022

Relationship to Issuer: 10% Owner

FROST GAMMA INVESTMENTS TRUST

By: /s/ Phillip Frost, M.D., as Trustee Phillip Frost, M.D., Trustee