OPKO Health Inc.

Major Shareholding Notification • May 8, 2023

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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Check this box if no longer subject to

Section 16. Form 4 or

Form 5 obligations may

continue. See Instruction 1(b). STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the

Investment Company Act of 1940

Nabel, M.D., Ph.D	1. Name and Address of Reporting Person Gary	J.	2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [OPK]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) ____ 10% Owner X Director
(Last) 4400 Biscayne Blvd.	(First)	(Middle)	Officer (give title below)____ Other (specify below) X Chief Innovation Officer
(Street) Miami	FL	33137	4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person ____ Form filed by More than One Reporting Person
(City)	(State)	(Zip)	Rule 10b5-1(c) Transaction Indication Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)					5. Amount of Securities Beneficially Owned Following Reported Transaction(s)	6. Ownership Form:	7. Nature of Indirect Beneficial
		Code	V	Amount	(A) or (D)	Price		or Indirect (I) (Instr. 4)	Ownership (Instr. 4)
05/05/2023		P		19,285	A	\$1.78	94,756	D
05/05/2023		P		3,185	A	\$1.793	97,941	D
05/05/2023		P		27,777	A	\$1.8	125,718	D
05/05/2023		P		27,624	A	\$1.81	153,342	D
05/05/2023		P		79,334	A	\$1.82	232,676	D
							4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)	(Instr. 3 and 4)	Direct (D)

Common Stock	05/05/2023	P	19,475	A	\$1.829	252,151	D
Common Stock	05/05/2023	P	10,928	A	\$1.83	263,079	D
Common Stock	05/05/2023	P	28,538	A	\$1.82	19,886,052	I	See Footnote (1)
Common Stock	05/05/2023	P	26,407	A	\$1.85	19,912,459	I	See Footnote (1)
Common Stock	05/05/2023	P	54,945	A	\$1.82	19,912,459	I	See Footnote (2)
Common Stock	05/05/2023	P	34,338	A	\$1.838	114,338	I	See Footnote (3)
Common Stock	05/05/2023	P	54,346	A	\$1.8399	168,684	I	See Footnote (3)
Common Stock	05/05/2023	P	20,009	A	\$1.8472	188,693	I	See Footnote (3)
Common Stock	05/05/2023	P	54,054	A	\$1.85	242,747	I	See Footnote (3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of	2.	3. Transaction	3A. Deemed	4.		5. Number		6. Date Exercisable and			7. Title and	8. Price of	9. Number of	10.	11. Nature
Derivative	Conversion	Date	Execution Date, if	Transaction		of		Expiration Date			Amount of	Derivative	Derivative	Ownership	of Indirect
Security	or Exercise	(Month/Day/Year)	any	Code		Derivative		(Month/Day/Year)			Underlying	Security	Securities	Form of	Beneficial
(Instr. 3)	Price of		(Month/Day/Year)	(Instr. 8)		Securities					Securities	(Instr. 5)	Beneficially	Derivative	Ownership
	Derivative					Acquired					(Instr. 3 and 4)		Owned	Security:	(Instr. 4)
	Security					(A) or							Following	Direct (D)
							Disposed of						Reported	or Indirect
						(D)							Transaction(s)	(I)
						(Instr. 3, 4,							(Instr. 4)	(Instr. 4)
						and 5)
											Amount
											or
								Date	Expiration		Number
				Code	V	(A)	(D)	Exercisable	Date	Title	of Shares

Explanation of Responses:

• (1) Shares held by the GJN 2021 TRUST for the benefit of the Reporting Person's spouse and descendants, and for which the Reporting Person's spouse serves as co-trustee together with an independent trustee. The Reporting Person's spouse and the independent trustee serve as investment advisors of the trust. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
• (2) Shares held by the EGN 2021 TRUST for the benefit of the Reporting Person and his descendants, and for which an independent trustee has been appointed. The Reporting Person and the independent trustee serve as investment advisors of the trust. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
• (3) Shares held by the Nabel Family Investments LLC, of which the Reporting Person is the manager with sole investment power and has an approximately 48% interest through the parent trust, the 2009 Nabel Family Children's Trust of which the Reporting Person has sole control, and sole investment power. The Reporting Per disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Steven D. Rubin, Attorney-in-Fact 05/08/2023

**Signature of Reporting Person Date

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