OPKO Health Inc.

Major Shareholding Notification • Jan 18, 2024

1/17/24, 4:13 PM Ownership Submission

FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See
Instruction 1(b). Check this box to	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549
indicate that a transaction was made pursuant to a contract,	STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
Instruction 10.

(Print or Type Responses)

1. Name and Address of Reporting Person * Jane H. Hsiao, Ph.D.			2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [ OPK ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director _____ 10% Owner
(Last) OPKO Health, Inc. 4400 Biscayne Blvd.	(First) (Middle)		3. Date of Earliest Transaction (Month/Day/Year) 01/17/2024	__ X __ Officer (give title below) _____ Other (specify below) Vice Chairman & CTO
(Street) Miami, FL 33137 (City) (State) (Zip)			4. If Amendment, Date Original Filed 6. Individual or Joint/Group Filing (Month/Day/Year) (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security	2. Transaction	2A. Deemed	3. Transaction		4. Securities Acquired			5. Amount of Securities	6.	7. Nature
(Instr. 3)	Date	Execution Date, if	Code		(A) or Disposed of (D)			Beneficially Owned Following	Ownership	of Indirect
	(Month/Day/Year)	any	(Instr. 8)		(Instr. 3, 4 and 5)			Reported Transaction(s)	Form:	Beneficial
		(Month/Day/Year)						(Instr. 3 and 4)	Direct (D)	Ownership
									or Indirect	(Instr. 4)
						(A) or			(I)
			Code	V	Amount	(D)	Price		(Instr. 4)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)

1. Title of	2.	3. Transaction	3A. Deemed	4.		5. Number		6. Date Exercisable		7. Title and		8. Price of	9. Number of	10.	11. Nature
Derivative	Conversion	Date	Execution Date, if	Transaction		of and Expiration Date					Amount of Derivative		Derivative	Ownership	of Indirect
Security	or Exercise	(Month/Day/Year)	any	Code		Derivative (Month/Day/Year)				Underlying Security			Securities	Form of	Beneficial
(Instr. 3)	Price of		(Month/Day/Year)	(Instr. 8)		Securities					Securities (Instr. 5)		Beneficially	Derivative	Ownership
	Derivative					Acquired		(Instr. 3 and 4)		Owned	Security:	(Instr. 4)
	Security					(A) or							Following	Direct (D)
						Disposed							Reported	or Indirect
						of (D)							Transaction(s)	(I)
					(Instr. 3, 4,								(Instr. 4)	(Instr. 4)
						and 5)
											Amount
								Date	Expiration		or
									Exercisable	Date	Title	Number
				Code V		(A)	(D)				of Shares

Explanation of Responses:

1. The securities are owned directly by Hsu Gamma Investment, L.P. Dr. Hsiao is the general partner of Hsu Gamma Investment, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.

Signatures

Steven D. Rubin, Attorney-in-Fact 01/17/2024

Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

• * If the form is filed by more than one reporting person, see Instruction 4(b)(v).
• ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

**

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