OPKO Health Inc.

Major Shareholding Notification • Mar 14, 2024

3/13/24, 4:19 PM Ownership Submission

FORM 4
Check this box if no longer subject to Section 16. Form 4 or
Form 5 obligations may continue. See Instruction 1(b). Check this box to	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549
indicate that a transaction was made pursuant to a contract,	STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
instruction or written plan for the purchase or sale of equity securities of the issuer	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

(Print or Type Responses)

1. Name and Address of Reporting Person * Phillip Frost, M.D., ET	AL	2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [ OPK ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner
(Last) (First) OPKO Health, Inc. 4400 Biscayne Blvd.	(Middle)	3. Date of Earliest Transaction (Month/Day/Year) 03/13/2024	__ X __ Officer (give title below) _____ Other (specify below) CEO & Chairman
(Street) Miami, FL 33137 (City) (State)	(Zip)	4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security	2. Transaction	2A. Deemed	3. Transaction								4. Securities Acquired (A)			5. Amount of Securities	6.	7. Nature
(Instr. 3)	Date	Execution Date, if	Code								or Disposed of (D)			Beneficially Owned Following	Ownership	of Indirect
	(Month/Day/Year)	any	(Instr. 8)		(Instr. 3, 4 and 5)			Reported Transaction(s)	Form:	Beneficial
		(Month/Day/Year)						(Instr. 3 and 4)	Direct (D)	Ownership
						(A)			or Indirect	(Instr. 4)
						or			(I)
			Code	V	Amount	(D)	Price		(Instr. 4)

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3/13/24, 4:19 PM Ownership Submission

Common Stock	03/13/2024	P	500,000	A	\$ 0.9275 (1)	209,968,225	I	See Footnote (2)
Common Stock						3,068,951	D
Common Stock						30,127,177	I	See Footnote (3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned

	( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of	2.	3. Transaction	3A. Deemed	4.		5. Number		6. Date Exercisable			7. Title and	8. Price of	9. Number of	10.	11. Nature
Derivative	Conversion	Date	Execution Date, if	Transaction		of		and Expiration Date					Amount of	Derivative	Derivative	Ownership	of Indirect
Security	or Exercise	(Month/Day/Year)	any	Code			Derivative (Month/Day/Year)				Underlying	Security	Securities	Form of	Beneficial
(Instr. 3)	Price of		(Month/Day/Year)	(Instr. 8)		Securities						Securities		(Instr. 5)	Beneficially	Derivative	Ownership
	Derivative					Acquired					(Instr. 3 and 4)		Owned	Security:	(Instr. 4)
	Security					(A) or							Following	Direct (D)
						Disposed							Reported	or Indirect
						of (D)							Transaction(s)	(I)
						(Instr. 3, 4,							(Instr. 4)	(Instr. 4)
						and 5)
											Amount
								Date	Expiration		or
								Exercisable	Date	Title	Number
				Code	V	(A)	(D)				of Shares

Reporting Owners

	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Phillip Frost, M.D., ET AL OPKO Health, Inc. 4400 Biscayne Blvd. Miami, FL 33137	X	X	CEO & Chairman
Frost Gamma Investments Trust OPKO Health, Inc. 4400 Biscayne Blvd. Miami, FL 33137		X

Explanation of Responses:

• 1. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from \$0.9172 to \$0.9383, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the "Company"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4.
• 2. The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
• 3. These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Signatures

Phillip Frost, M.D., Individually and as Trustee 03/13/2024

** Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

JOINT FILER INFORMATION

Name: Frost Gamma Investments Trust

Address: 4400 Biscayne Blvd. Miami, FL 33137

Designated Filer: Phillip Frost, M.D.

Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK)

Date of Earliest Transaction: March 13, 2024

Relationship to Issuer: 10% Owner

FROST GAMMA INVESTMENTS TRUST

By: /s/ Phillip Frost, M.D., as Trustee Phillip Frost, M.D., Trustee