3/18/24, 4:15 PM

FORM 4		OMB APPROVAL
		OMB Number:	3235
Check this box if no longer subject to		Estimated average burden hours per response
Section 16. Form 4 or
Form 5 obligations may continue. See Instruction 1(b). Check this box to	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549
indicate that a transaction was made	STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

(Print or Type Responses)

1. Name and Address of Reporting Person Phillip Frost, M.D., ET AL			2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. OPK	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director
Last) OPKO Health, Inc. 4400 Biscayne Blvd.	(Middle) (First)		3. Date of Earliest Transaction (Month/Day/Year) 03/18/2024	X Officer (give title below) Other (specify below) CEO & Chairman
(Street) Miami, FL 33137 (City) (State)		(Zip)	4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security	2. Transaction	2A. Deemed	3. Transaction 4. Securities Acquired (A) 5. Amount of Securities					7. Nature
(Instr. 3)	Date	Execution Date, if Code	or Disposed of (D)			Beneficially Owned Following		Ownership of Indirect
	(Month/Day/Year) any		(Instr. 8)	(Instr. 3, 4 and 5)			Reported Transaction(s)	Form:	Beneficial
		(Month/Day/Year)						(Instr. 3 and 4)		Direct (D) Ownership
						(A)			or Indirect (Instr. 4)
						Or			(1)
			Code		Amount	(D)	Price		(Instr. 4)

0.5

3235-0287

Ownership Submission

Common Stock	03/18/2024	P	500,000	A	ಳ 0.8742 (1)	210,968,225	I	See Footnote (2)
Common Stock						3,068,951	D
Common Stock						30,127,177	I	See Footnote (3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. . puts. calls. warrants. options. convertible securities)

1000 1 1 11000 Section 11 Cellery 2001 01 000 100 0000 10000 10000
10	11. Nature

Form of	Beneficial
	Derivative Ownership
Security:	(Instr. 4)
Direct (D)
or Indirect

(Instr. 4)





Derivative Derivative Securities Following Reported	8. Price of 9. Number of Ownership of Indirect Beneficially Transaction(s) (I)

Reporting Owners

	Relationships
Reporting Owner Name / Address	Director	10% Owner Officer		Other
Phillip Frost, M.D., ET AL OPKO Health, Inc. 4400 Biscayne Blvd. Miami, FL 33137	X	X	CEO & Chairman
Frost Gamma Investments Trust OPKO Health, Inc. 4400 Biscayne Blvd. Miami, FL 33137		X

Explanation of Responses:

1. The price reported is a verge price. These shares were purchased in multiple transactions at prices ranging from \$0.8655 to \$1.8788, including freson undertakes to provide to OPKO Health, Inc. (the "Company"), any security holder of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4.
1. The securities are held by Frost Gamma Investments of which Philip Frost M.D., is the truste. Frost Gamma L. Is the sole and exclusive beneficiary of Frost Camma hvestments Trust. Dr. Frost is one of tvo limited partner of Frost Gamma L.P. is Frost Camma, Inc., and the sole sharelotder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole sharen of Frost-Nevada Corporation. The reporting of these securities, except to the extent of any people stall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
1. These securities are held by Frost Nevada Investments Trust, of which the rustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of the extent of any pecumary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Signatures

Phillip Frost, M.D., Individually and as Trustee 03/18/2024

Date " Signature of Reporting Person

Reminder: Report on a separate line for each class of securities beneficially owned directly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 18tf(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Persons who respond to the collection of in this form are not required to respond unless the form displays a currently walld Off I will of

JOINT FILER INFORMATION

Name: Frost Gamma Investments Trust

Address: 4400 Biscayne Blvd. Miami, FL 33137

Designated Filer: Phillip Frost, M.D.

Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK)

Date of Earliest Transaction: March 18, 2024

Relationship to Issuer: 10% Owner

FROST GAMMA INVESTMENTS TRUST

By: /s/ Phillip Frost, M.D., as Trustee Phillip Frost, M.D., Trustee

AI Terminal

OPKO Health Inc.

6963_rns_2024-03-18_ed9c9ee2-6411-44cd-b5fc-2579229d17a4.pdf