OPKO Health Inc.

Director's Dealing • Mar 30, 2024

3/29/24, 9:32 AM

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

(Print or Type Responses)

Ownership Submission

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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person John A. Paganelli			2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. OPK	5. Relationship of Reporting Person(s) to Issuer (Check all applicable)
(Last) OPKO Health, Inc. 4400 Biscayne Blvd.	(First)	(Middle)	3. Date of Earliest Transaction (Month/Day/Year) 03/28/2024	Director 10% Owner Officer (give title below) Other (specify below)
(Street) Miami, FL 33137 (City) (Zip) (State)			4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security	2. Transaction	2A. Deemed	3. Transaction		4. Securities Acquired			5. Amount of Securities Beneficially		7. Nature
(Instr. 3)	Date	Execution Date, if Code						(A) or Disposed of (D) Owned Following Reported		Ownership of Indirect
	(Month/Day/Year) any		(Instr. 8)		' (Instr. 3, 4 and 5)			Transaction(s)	Horm:	Beneficial
		(Month/Day/Year)						Instr. 3 and 4)		Direct (D) Ownership
									। or Indirect (Instr. 4)
						(A) or			(1)
			Code		Amount	(D)	Price		(Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)

Ownership Submission

1. Title of Security (Instr. 3)	2 Derivative Conversion Date Price of Derivative	3. Transaction or Exercise (Month/Day/Year) any	3A. Deemed Execution Date, if Transaction Number (Month/Day/Year) (Instr. 8)	4 Code	5. of Derivative Securities		6. Date Exercisable and Expiration Date (Month/Day/Year)	7. Title and Amount of Underlying Securities (Instr. 3 and 4)		Security (Instr. 5)	8. Price of 9. Number of Derivative Derivative Securities Beneficially Owned	10. Form of	11. Nature Ownership of Indirect Beneficial Derivative Ownership
	Security				Acquired (A) or Disposed							Following Reported Transaction(s) (I)	Security: Direct (D) or Indirect	(Instr. 4)
					of (D) (Instr. 3, 4, and 5)							(Instr. 4)	(Instr. 4)
				Code	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	\$ 1.20							03/28/2025 03/27/2034	Common 30,000 Stock			30,000	D

Explanation of Responses:

Signatures

Steven D. Rubin, Attorney-in-Fact 03/29/2024

** Signature of Reporting Person

Reminder: Report on a separate line for each class of securities beneficially owned directly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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