OPKO Health Inc.

Major Shareholding Notification • Mar 30, 2024

3/29/24, 10:00 AM

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person Prem A. Lachman, M.D.			2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [ OPK	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) x Director 10% Owner
(Last) OPKO Health, Inc. 4400 Biscayne Blvd.	(First)	(Middle)	3. Date of Earliest Transaction (Month/Day/Year) 03/28/2024	Officer (give title below) Other (specify below)
Miami, FL 33137 (City)	(Street) (State)	(Zip)	4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security	2. Transaction	2A. Deemed	3. Transaction	4. Securities Acquired			5. Amount of Securities Beneficially		7. Nature
(Instr. 3)	Date	Execution Date, if Code					(A) or Disposed of (D) Owned Following Reported		' Ownership of Indirect
	(Month/Day/Year) any		(Instr. 8)	(Instr. 3, 4 and 5)			Transaction(s)	Form:	Beneficial
		(Month/Day/Year)					(Instr. 3 and 4)		Direct (D) Ownership
								। or Indirect (Instr. 4)
					(A) or			(1)
			Code	Amount	(D)	Price		(Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)

+ , - / 0 1 2 A + ? + 3 0 4 - 5 6 0 B 1 = 5 0 4 > - 1 = 3 7 0 8 9 4 - : 1 4 C D 0 8 - > ; F ; < = > 4 + ? @ E 4 - 8 0 1 2 3 0 4 - 5 6 0 7 0 8 9 4 - : 7 1 8 b [ T - 1 = c + A _ ; ^ - X G 1 Z 9 :		, 4 6 = > 8 - 1 = ? J 6 0 C D 1 = G H 3 6 : I 0 4 @ 6 = ; F	+ 3 0 K 0 L N + 0 8 9 - 1 = 3 6 0 M - 2 , 4 6 = > 8 - 1 : B 1 L 0 1 = G H 3 6 : I 0 4 @ ; < = > 4 + O @	=				P + U + 3 6 0 C D 4 8 - > 6 R / 0 = L V Q 9 K R 0 4 C D T - 4 6 1 = 3 6 0 1 1 2 ; F 1 = G H 3 6 : I 0 4 @ 7 3 0 4 - 5 6 0 ; 7 0 8 9 4 - 0 > J 8 S 9 - 4 0 L ; J @ 1 4 3 - > T 1 0 L 1 2 ; 3 @ ; < = > 4 + ? M N M 6 = L P @ 3 6 0 C D T - 4 6 1 = , C D 0 4 8 - > 6 R / 0 3 6 0		+ , - / 0 6 = L J K 1 9 = O + E 4 - 8 0 2 W = L 0 4 / : - = X 3 0 4 - 5 6 0 8 9 4 - 0 > 7 0 8 9 4 - < = > 4 + ? 6 = L N @ ; < = > 4 + P J K 1 9 = 1 4 - / 0 Q 9 K R 0 4 1 2 7 G 6 4 0 >		1 2 Y + Q 9 K R 0 4 1 2 * _ + 0 3 0 4 - 5 6 0 [ \ = 0 4 > G - T : 7 0 8 9 4 - 0 > ] 1 4 K 2 @ Z 0 = 2 - 8 6 / : 3 0 4 - 5 6 0 [ \ = 0 L 7 0 8 9 4 - : ` ] 1 / \ - = X 3 - 4 0 8 ; 3 @ ^ 0 T 1 4 L 1 4 < = L - 4 0 8 , 4 6 = > 8 - 1 = ; > @ ; < @ ; < = > 4 + N @ ; < = > 4 + N @	* + Q 6 9 4 0 1 2 < = L - 4 0 8 Z 0 = 2 - 8 6 /	[ \ = 0 4 > G - T ; < = > 4 + N @
			B 1 L 0 a					; J @ ; 3 @
	^ 0 K - = L 4 ` ^	d e f g h i j @ T 1 4 = 6 > 0 T 4 0 / - = 2 1	k l m n o p f l i o q r k s i h j t u o p 7 0 5 = 3 + ^ 9 R - = M J 1 4 = 0 : v - ] 6 8 4 0 6 8 G / 6 > 1 2 0 8 9 4 - 0 > R = 2 - 8 6 / : 1					_ ? H A Y \ = 0 L - 4 0 8 / : 1 4	B 1 K K 1 = ? H A O P ? H A V ? N ? M 7 1 8 b N - = L 4 0 8 / : +			? M 3
	x < 2 G 0 2 1 x x < = 0 - 1	4 K - > 2 / 0 L R : K 1 4 0 G 6 = 1 6 / K - > 6 0 K 0 = > 1 4 K - >	7 - X = 6 9 4 0 1 2 ^ 0 T 1 4 - = X E 0 4 > 1 = w 0 4 T 1 - = X T 0 4 > 1 = M y z < = > 4 9 8 - 1 = N ; R - 1 = 2 6 8 > 1 = - 9 0 ] L 4 6 / B - K - =					3 6 0 @ 5 + 6 / a - 1 6 = > + { z	O W + 7 B _ 6 = L * P W + 7 B V O 2 ; 6 @	+

w7-X=6.94012^0T14.-=XE04>1=^0K-=L4^T14.=6>0T4.0/-= 214068G xxx<=.0Q1.0]-/0.G481T-0>12.G->]14KM=0|oupli}~luopflij~olgojklimkiluhjklijhko

36.0/6>120894-.0>R=2-86/:1\=0L-408./:14-=L408./:+<2.G0214K->2/0LR:K140.G6=104T1.-=XT04>1=Myz<=>.498-1=N;R@5+ -16/K->.60K0=>14K->-1=268.>1=.-90]L46/B-K-=6/a-16.=>+{z*OW+7B*_

6=L*PW+7BVO2;6@+2\G-8K9>.R0K6=96/:>-X=0L+<2>T680->=92-80=.Myz<=>.498-1=U214T80L94+ j~pmluhoiljuotkjluopflitgopj~omlukpfghtuoijghktou