OPKO Health Inc.

Director's Dealing • May 30, 2025

		OMB APPROVAL
Washington, D.C. 20549	OMB Number: Estimated average burden hours per response	3235-0287 0.5
2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [ OPK ]
3. Date of Earliest Transaction (Month/Day/Year) 05/27/2025		_____ Other (specify below) Vice Chairman & CTO
		UNITED STATES SECURITIES AND EXCHANGE COMMISSION STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940 __ X __ Director	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _ 10% Owner X __ Officer (give title below)

4400 Biscayne Blvd.
Miami, FL 33137	(Street)		4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person
(City)	(State)	(Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)	2. Transaction Date (Month /Day/Year)	2A. Deemed Execution Date, if any (Month/Day /Year)	3. Transaction Code (Instr. 8)		Disposed of (D) (Instr. 3, 4 and 5)	4. Securities Acquired (A) or		5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form:	7. Nature of Indirect Beneficial
			Code	V		Amount (A) or (D)	Price		Direct (D) or Indirect (I) (Instr. 4)	Ownership (Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
( e.g. , puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month /Day/Year)	3A. Deemed Execution Date, if any (Month/Day /Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number 10. of Derivative Form of Securities Beneficially Security:	Ownership Derivative	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares		Owned Direct (D) Following or Indirect Reported (I) Transaction (Instr. 4) (s) (Instr. 4)
Stock Option (Right to Buy)	\$ 1.31	05/27/2025		A		500,000		(1)	05/26/2035	Common Stock	500,000	\$ 0	500,000	D

Explanation of Responses:

1. This option will vest in four equal annual installments beginning May 27, 2026.

Steven D. Rubin, Attorney-in-Fact 05/29/2025

Signature of Reporting Person ** Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

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^* If the form is filed by more than one reporting person, see Instruction 4(b)(v).