SAREUM HOLDINGS PLC

Director's Dealing • Nov 23, 2021

National Storage Mechanism | Additional information

RNS Number : 3042T

Sareum Holdings PLC

23 November 2021

SAREUM HOLDINGS PLC

("Sareum" or the "Company")

Notification of transaction by Person Discharging Managerial Responsibilities ('PDMR')

Cambridge, UK, 23 November 2021 - Sareum Holdings plc (AIM: SAR), the specialist drug development company delivering targeted small molecule therapeutics to improve the treatment of cancer and autoimmune diseases, announces that Dr Stephen Parker, Non-Executive Chairman, purchased 277,777 ordinary shares of 0.025 pence each in the capital of the Company at a price of 3.6 pence per share on 23 November 2021.

The notification below, which has been made in accordance with the requirements of the Market Abuse Regulation, provides further details.

1	Details of the person discharging managerial responsibilities / person closely associated
a)	Name	Stephen Parker
2	Reason for the notification
a)	Position/status	Non-Executive Chairman
b)	Initial notification /Amendment	Initial notification
3	Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a)	Name	Sareum Holdings plc
b)	LEI	213800PKERN2DY8FFM72
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a)	Description of the financial instrument, type of instrument	Ordinary shares of 0.025p each in the share capital of Sareum Holdings plc
Identification code	GB00B02RFS12
b)	Nature of the transaction	Purchase of shares
c)	Price(s) and volume(s)
		Price(s)	Volume(s)
		3.6 pence	277,777
d)	Aggregated information
- Aggregated volume	277,777 ordinary shares
- Price	3.6 pence per share
e)	Date of the transaction	23 November 2021
f)	Place of the transaction	London Stock Exchange (AIM)

For further information, please contact: 

Sareum Holdings plc Tim Mitchell, CEO	01223 497 700
Strand Hanson Limited (Nominated Adviser) James Dance / James Bellman	020 7409 3494
Peel Hunt LLP (Joint Corporate Broker) James Steel	020 7418 8900
Hybridan LLP (Joint Corporate Broker) Claire Noyce	020 3764 2341
MEDiSTRAVA Consulting (Financial PR) Mark Swallow / David Dible	020 7638 9571

About Sareum

Sareum is a specialist drug development company delivering targeted small molecule therapeutics to improve the treatment of cancer and autoimmune diseases. The Company aims to generate value through licensing its candidates to international pharmaceutical and biotechnology companies at the preclinical or early clinical trials stage.

Sareum is advancing internal programmes focused on distinct dual tyrosine kinase 2 (TYK2) / Janus kinase 1 (JAK1) inhibitors through preclinical development as therapies for autoimmune diseases, including the 'cytokine storm' immune system overreaction to Covid-19 and other viral infections, (SDC-1801) and cancer immunotherapy (SDC-1802).

Sareum also has an economic interest in SRA737, a clinical-stage oral, selective Checkpoint kinase 1 (Chk1) inhibitor that targets cancer cell replication and DNA damage repair mechanisms. Preliminary Phase 2 and comprehensive preclinical data suggest SRA737 may have broad application in combination with other oncology and immune-oncology drugs in genetically defined patients.

SRA737 was discovered and initially developed by scientists at The Institute of Cancer Research in collaboration with Sareum, and with funding from Sareum and Cancer Research UK. SRA737 was licensed by CRT Pioneer Fund (CPF) to Sierra Oncology Inc. Sierra continues to explore options that would enable the development of SRA737 to advance.

Sareum Holdings plc is listed on the AIM market of the London Stock Exchange, trading under the ticker SAR. For further information, please visit the Company's website at www.sareum.com 

- Ends -

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