ARECOR THERAPEUTICS PLC

Environmental & Social Information • Apr 12, 2022

National Storage Mechanism | Additional information

RNS Number : 0350I

Arecor Therapeutics PLC

12 April 2022

Arecor Therapeutics plc

("Arecor" or the "Group")

ARECOR ANNOUNCES ORAL PRESENTATION AT ATTD 2022 OF

PHASE I CLINICAL TRIAL OF AT278 ULTRA-CONCENTRATED ULTRA-RAPID ACTING INSULIN FOR DIABETES

Cambridge, UK, 12 April 2022: Arecor Therapeutics plc (AIM: AREC), a globally focused biopharmaceutical company advancing today's therapies to enable healthier lives, today announces that its abstract titled "AT278 (U500) - PK/PD and safety of rapid-acting concentrated insulin aspart", has been selected for oral presentation at the upcoming 15th International Conference on Advanced Technologies and Treatments For Diabetes (ATTD) meeting which will be held from 27-30 April 2022 in Barcelona.

The presentation will take place at 17:20 on Thursday 28 April during the Oral Presentations Session 2 in Hall 118 of the Conference Centre.

Oral Presentation:          AT278 (U500) - PK/PD and safety of rapid-acting concentrated insulin aspart

Presenting Author:         Dr Eva Svehlikova

Session:                             Oral Presentations Session 2

Date and Time:                Thursday, 28 April 2022, at 17:20 Central European Time

AT278 is an ultra-concentrated (500U/mL) novel formulation of insulin that has been designed to significantly accelerate insulin absorption post injection to enable more effective and convenient management of blood glucose levels in people with high daily insulin requirements.

In addition, a poster titled 'Adjusting insulin therapy to faster insulin analogs leads to improved glucose control: An in-silico analysis' will be presented at ATTD by Dr Jenny Diaz from the University of Virginia.  The in-silico analysis suggests that the faster PK/PD profile of Arecor's AT247, an investigational ultra-rapid acting (100U/mL) insulin formulation, has the potential to significantly improve glucose control in closed loop systems.

Sarah Howell, Chief Executive Officer at Arecor, said: "We are very excited to be able to share these ground-breaking data for AT278 and AT247 at the ATTD conference. AT278 has the potential to be the first and perhaps only concentrated (500U/mL) rapid acting insulin available to patients, having clearly demonstrated faster insulin absorption with an accelerated pharmacokinetic (PK) and pharmacodynamic (PD) profile compared to gold-standard insulin NovoRapid® despite a 5-fold increase in concentration, in this first Phase I clinical study. In addition, in partnership with the University of Virginia, we are excited to be able to share results from their in-silico analysis demonstrating the potential for AT247 to enable a fully closed loop artificial pancreas, which would be a life-changing treatment option for people living with Type 1 diabetes."

About the ATTD

The International Conference on Advanced Technologies and Treatments of Diabetes (ATTD) was established in 2008 and has held annual meetings since then. The purpose of the ATTD meeting is to highlight innovative technologies in diabetes treatment. It brings together developers of new technologies with the diabetes professionals and caretakers as well as acquainting clinicians with techniques for new treatments.

-ENDS-

For more information, please contact:

Arecor Therapeutics plc	www.arecor.com
Dr Sarah Howell, Chief Executive Officer	Tel: +44 (0) 1223 426060 Email: info@arecor.com
Susan Lowther, Chief Financial Officer	Tel: +44 (0) 1223 426060 Email: info@arecor.com
Mo Noonan, Communications	Tel: +44 (0) 7876 444977 Email: mo.noonan@arecor.com
Panmure Gordon (UK) Limited (NOMAD and Broker)
Freddy Crossley, Emma Earl (Corporate Finance) Rupert Dearden (Corporate Broking)	Tel: +44 (0) 20 7886 2500
Consilium Strategic Communications
Chris Gardner, David Daley, Angela Gray	Tel: +44 (0) 20 3709 5700 Email: arecor@consilium-comms.com

Notes to Editors

About Arecor

Arecor Therapeutics plc is a globally focused biopharmaceutical group transforming patient care by bringing innovative medicines to market through the enhancement of existing therapeutic products. By applying our innovative proprietary formulation technology platform, Arestat™, we are developing an internal portfolio of proprietary products in diabetes and other indications, as well as working with leading pharmaceutical and biotechnology companies to deliver enhanced formulations of their therapeutic products. The Arestat™ platform is supported by an extensive patent portfolio. 

For further details please see our website, www.arecor.com

About AT278

AT278 is Arecor's ultra-concentrated, ultra-rapid acting insulin designed to accelerate the absorption of insulin post injection, to enable more effective management of blood glucose levels to the increasing number of people with diabetes with high daily insulin requirements (>200 units/day), whilst maintaining the convenience and compliance benefits of being able to deliver these high insulin doses in a lower injection volume via a single injection.  A truly rapid acting concentrated insulin is a critical step towards the advancement and miniaturisation of the next generation of insulin delivery devices.   

About AT247

AT247 is an ultra-rapid insulin that aims to accelerate insulin absorption, post injection, to enable more effective management of blood glucose levels for people living with diabetes, particularly around difficult to manage mealtimes.  Early clinical evidence suggests that AT247 may facilitate a fully closed loop artificial pancreas, a potentially life changing treatment option for people living with diabetes, and a US Phase I clinical trial is currently underway investigating the potential of the product when delivered by continuous subcutaneous infusion via insulin pump. 

This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the London Stock Exchange. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

Reach is a non-regulatory news service. By using this service an issuer is confirming that the information contained within this announcement is of a non-regulatory nature. Reach announcements are identified with an orange label and the word “Reach” in the source column of the News Explorer pages of London Stock Exchange’s website so that they are distinguished from the RNS UK regulatory service. Other vendors subscribing for Reach press releases may use a different method to distinguish Reach announcements from UK regulatory news.

RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy.

END

NRAKZGMDLMVGZZM