Nyxoah SA

Declaration of Voting Results & Voting Rights Announcements • Oct 2, 2020

PRESS RELEASE REGULATED INFOMATION

Information on the total number of voting rights and shares

Mont-Saint-Guibert (Belgium), 2nd October 2020, 14:30 (CEST) – In accordance with article 15 of the Act of 2 May 2007 on the disclosure of large shareholdings, Nyxoah S.A. publishes the below information following the issue of 650,250 new shares on 29 September 2020 pursuant to the exercise of the "Over-allotment Warrant" that was conditionally issued on 7 September 2020 and confirmed on 21 September 2020:

• Share capital: EUR 3,792,010.34
• Total number of securities carrying voting rights: 22,074,109 (all ordinary shares)
• Total number of voting rights (= denominator): 22,074,109 (all relating to ordinary shares)
• Number of rights to subscribe to securities carrying voting rights not yet issued:
• o 161 "2013 ESOP Warrants" issued on 3 May 2013 and 23 December 2014, entitling their holders to subscribe for a total number of 80,500 securities carrying voting rights (all ordinary shares);
• o 482 "2016 ESOP Warrants" issued on 3 November 2016, entitling their holders to subscribe for a total number of 241,000 securities carrying voting rights (all ordinary shares);
• o 319 "2018 ESOP Warrants" issued on 12 December 2018, entitling their holders to subscribe for a total number of 159,500 securities carrying voting rights (all ordinary shares); and
• o 550,000 "2020 ESOP Warrants" issued on 21 February 2020, entitling their holders to subscribe for a total number of 550,000 securities carrying voting rights (all ordinary shares).

- ENDS -

For further information, please contact:

Nyxoah

Rémi Renard, VP Therapy Development and Education remi.renard@nyxoah.com +32 472 12 64 40

For media enquiries, please contact: Consilium Strategic Communications

Amber Fennell, Ashley Tapp, Lindsey Neville, Taiana De Ruyck Soares Nyxoah@consilium-comms.com +44 (0)20 3709 5700

About Nyxoah

Nyxoah is a healthtech company focused on the development and commercialization of innovative solutions and services for sleep disordered breathing conditions. Nyxoah's lead solution is the Genio® system, a CE-validated, user-centered, next generation hypoglossal neurostimulation therapy for OSA, the world's most common sleep disordered breathing condition that is associated with increased mortality risk1 and comorbidities including cardiovascular diseases, depression and stroke.

Following successful completion of the BLAST OSA study in patients with moderate to severe OSA, the Genio® system received its European CE Mark in March 2019. The Company is currently conducting the BETTER SLEEP study in Australia and New Zealand for therapy indication expansion, and a postmarketing EliSA study in Europe to confirm the long-term safety and efficacy of the Genio® system.

For more information, please visit www.nyxoah.com.

Caution – CE marked since 2019. Investigational device in the United States. Limited by U.S. federal law to investigational use in the United States.

¹ Young T. et al: Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort, Sleep. 2008 Aug 1; 31(8): 1071–1078.