Mithra Pharmaceuticals S.A.

AGM Information • Mar 3, 2023

Resolutions taken by Mithra's Board of Directors

Liege, Belgium, 03 March 2023 – 21:15 CET – Meeting this Thursday 2 nd and Friday 3 rd March to discuss the approval of the 2022 annual results, R&D follow-up, and corporate governance topics, the Board of Directors of Mithra (Euronext Brussels: MITRA), a company dedicated to women's health, would like to update the market on the resolutions decided today.

Considering the recent news flow completed by the Company, the Board of Directors strengthened its confidence that the company will deliver on its promises moving forward:

• the positive safety profile of our product candidate Donesta® as outlined in a separate press release disclosed earlier today;
• the BCI scientific achievements revealing that the Preclinical studies confirm the broad potential of innovative and proprietary inhibitors of CSF-1R to treat different pathologies, including endometriosis, cancer and inflammatory disorders. These results reinforce Mithra's intent to acquire BCI Pharma's IP rights and finalize the acquisition option to develop new tyrosine kinase inhibitors for the treatment of endometriosis, female cancers and other diseases;
• the fact that Mithra's management is looking to optimize the potential of our CDMO;
• the perspectives in terms of business development for the US.

The Board of Directors also discussed the progress made on the selection of a new CEO. According to the mandate given a few months ago to a first-class head hunter in order to find a successor to Mr. Leon Van Rompay, the Company received pronounced interest for this position of international high profile candidates. Three candidates have been selected by the Nomination and Remuneration committee for presentation to the approval of the Board. Mithra's new CEO should be announced as soon as possible.

Mr. Van Rompay confirmed his willingness to remain CEO of Mithra up until the end of this process. Once it is completed, Mr. Van Rompay will continue assisting the Company for dedicated advices, like Mr. Fornieri is currently doing. The Board will be delighted to still have Mr. Van Rompay as a dedicated advisor, given his extensive experience in the pharmaceutical sector.

Additionally, the mandates of the Board members will expire at the end of the next Ordinary General Meeting. The selection process is ongoing and Mithra aims to add new profiles whose expertise and competence in the pharmaceutical and financial sector will contribute to ensure the quality and relevance of the directions taken in the development and commercialization of its products.

Christian Moretti, Chairman of Mithra's Board of Directors, commented:

"The Board of Directors has adopted constructive resolutions that will enable the company to build on the very encouraging progress made in recent weeks. These results once again attest to the many future possibilities that Mithra is able to offer."

François Fornieri, Co-founder and largest shareholder of Mithra, added:

"I have obtained insurance that the R&D results and especially BCI achievements are very promising for the Company. The new CEO will have to bring on its extensive potential. In this regards, I am pleased to learn that high profile candidates are being considered and are rapidly available to lead Mithra into a new era. The new CEO will have to help Mithra regain the investor confidence it had in the past and still deserves. I will continue my role as an advisor to the Company if the new CEO so wishes."

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For more information, please contact:

Benoît Mathieu (IRO) : +32 473 35 80 18 – investorrelations@mithra.com

About Mithra

Mithra (Euronext: MITRA) is a Belgian biotech company dedicated to transforming Women's Health by offering new choices through innovation, with a particular focus on contraception and menopause. Mithra's goal is to develop products offering better efficacy, safety and convenience, meeting women's needs throughout their life span. Mithra explores the potential of the unique native estrogen estetrol in a wide range of applications in women health and beyond. After having successfully launched the first estetrol-based product in 2021, the contraceptive pill Estelle® , Mithra is now focusing on its second product Donesta® , the next-generation hormone therapy. Mithra also offers partners a complete spectrum of solutions from early drug development, clinical batches and commercial manufacturing of complex polymeric products (vaginal ring, implants) and complex liquid injectables and biologicals (vials, pre-filled syringes or cartridges) at its technological platform Mithra CDMO. Active in more than 100 countries around the world, Mithra has an approximate headcount of 300 staff members and is headquartered in Liège, Belgium. www.mithra.com

ESTELLE® , DONESTA® and MYRING® are registered trademarks of Mithra Pharmaceuticals or one of its affiliates.

Important information

The contents of this announcement include statements that are, or may be deemed to be, "forward-looking statements". These forward-looking statements can be identified by the use of forward-looking terminology, including the words "believes", "estimates," "anticipates", "expects", "intends", "may", "will", "plans", "continue", "ongoing", "potential", "predict", "project", "target", "seek" or "should", and include statements the Company makes concerning the intended results of its strategy. By their nature, forward-looking statements involve risks and uncertainties and readers are cautioned that any such forward-looking statements are not guarantees of future performance. The Company's actual results may differ materially from those predicted by the forward-looking statements. The Company undertakes no obligation to publicly update or revise forward-looking statements, except as may be required by law.

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