Ion Beam Applications, SA

Major Shareholding Notification • Dec 27, 2021

IBA – TRANSPARENCY NOTIFICATION

(Article 14, paragraph 1 of the law of 2 May 2007 on the disclosure of major holdings)

Louvain-la-Neuve, Belgium, December 27th, 2021, 18.30

Summary of the notification

IBA (Ion Beam Application), the world's leading provider of proton therapy solutions for the treatment of cancer, announces that it has to issue a transparency notification, in accordance with Article 14, al. 1 of the Transparency Law of May 2, 2007 on disclosure of major holdings, further to the notification received on December 27th, 2021.

In its notification, Ion Beam Applications SA has notified, that following an acquisition of voting rights, its total holding in IBA SA has crossed upwards the 2% threshold.

Content of the notification

• Reason for the notification: Acquisition or disposal of voting securities or voting rights
• Notification by : A parent undertaking or a controlling person
• Persons subject to the notification requirement: Ion Beam Applications SA, Chemin du Cyclotron 3, 1348 Louvain-la-Neuve IBA Investments SCRL, Chemin du Cyclotron 3, 1348 Louvain-la-Neuve
• Date on which the threshold is crossed: 03/12/2021
• Threshold crossed (in %): 2%
• Denominator: 38.339.545

• Notified details: (extract of the received notification form)

A) Droits de vote	Notification precedente a droits de vote	Après la transaction
Détenleurs de droits de vote		e droits de vote		% de droits de vote
		Attaches a des thes	Non liés a des titres	Attachés à des thres	Non lies a dos samo
lon Beam Applications SA	400 603	743 050		1.04%
IBA Investments SCRI.	-51 973	51.073		0.14%
SQUS-10711	452,476	795 032		2,07%
TOTAL		795.032	0	2,07%	0.00%

TOTAL (A & B)	# de droits de vote	% de droits de vote
	CALCULER	795.032	2,07%

• Full chain of controlled undertakings through which the holding is effectively held

IBA Investments SCRL is the subsidiary of Ion Beam Applications SA, wholly owned by the latter. IBA isn't a controlled entity.

For further information, please contact:

IBA

Valérie Van Impe Paralegal +32 10 203 180 legal@iba-group.com

About IBA

IBA (Ion Beam Applications) is a global medical technology company focused on bringing integrated and innovative solutions for the diagnosis and treatment of cancer. The company is the worldwide technology leader in the field of proton therapy, considered to be the most advanced form of radiation therapy available today. IBA's proton therapy solutions are flexible and adaptable, allowing customers to choose from universal full-scale proton therapy centers as well as compact, single room solutions. In addition, IBA also has a radiation dosimetry business and develops particle

accelerators for the medical world and industry. Headquartered in Belgium and employing about 1,500 people worldwide, IBA has installed systems across the world.

IBA is listed on the pan-European stock exchange NYSE EURONEXT (IBA: Reuters IBAB.BR and Bloomberg IBAB.BB). More information can be found at: www.iba-worldwide.com