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Pentixapharm Holding AG
Regulatory Filings • Feb 14, 2025
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Corporate | 13 February 2025 14:10
First-In-Human Data about the Treatment of Muscle-Invasive Bladder Cancer with Pentixapharm’s Lu177-PentixaTher to be Presented at ASCO-GU 2025
Pentixapharm Holding AG / Key word(s): Conference
First-In-Human Data about the Treatment of Muscle-Invasive Bladder Cancer with Pentixapharm’s Lu177-PentixaTher to be Presented at ASCO-GU 2025
13.02.2025 / 14:10 CET/CEST
The issuer is solely responsible for the content of this announcement.
Berlin, Germany, February 13, 2025 – Data from the first-in-human radioligand-therapy for muscle invasive bladder cancer (MIBC) using Pentixapharm’s Lu177-PentixaTher compound will be shown at the American Society of Clinical Oncology’s Genitourinary Cancers Symposium (ASCO-GU 2025) in San Francisco, CA.
The presentation features a case study of a late-stage MIBC patient who was initially treated with three cycles of neoadjuvant combination chemotherapy followed by intravesical administration of Pentixapharm’s radiopharmaceutical that targets the CXCR4 receptor. Imaging with Ga68-PentixaFor PET/CT had revealed intravesical CXCR4 expression prior to therapy, so a subsequent Lu177-PentixaTher instillation was used to target residual tumor cells. Pathological examination after transurethral resection confirmed a complete response, suggesting a potential for bladder preservation.
Instillation therapy in bladder cancer opens the potential for localized treatment with enhanced precision and minimized systemic exposure, thereby reducing the risk of adverse effects.
This early data adds to the growing body of evidence supporting CXCR4 as a therapeutic target across multiple oncology indications. To date, more than 100 patients have been treated with PentixaTher, providing a basis for a Pentixapharm-sponsored clinical development program. In November of last year, a first patient was enrolled in an investigator initiated Phase I/II trial in patients with acute myeloid and lymphoblastic leukemia (AML/ALL) in Nantes, France.
Presentation Details:
- Presenter: Dr. Ralph Wirtz
- Session: Poster Session B
- Date: February 14, 2025
- Time: 11:30 AM – 12:45 PM (PT)
- Location: ASCO-GU 2025, San Francisco, CA
About Pentixapharm
Pentixapharm is a clinical-stage biotech company discovering and developing novel targeted radiopharmaceuticals with offices in Berlin and Würzburg, Germany. It is committed to developing ligand-based first-in-class radiopharmaceutical approaches with a clear commercial pathway for diagnostic and therapeutic programs. Its pipeline features CXCR4-targeted compounds as well as early-stage radionuclide-antibody conjugates addressing hematological and solid cancers, as well as cardiovascular, endocrine, and inflammatory diseases.
For more information, please contact:
Pentixapharm Holding AG
Phillip Eckert, Investor Relations
Tel. +49 30 94893232
13.02.2025 CET/CEST Dissemination of a Corporate News, transmitted by EQS News – a service of EQS Group.
The issuer is solely responsible for the content of this announcement.
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| Language: | English |
| Company: | Pentixapharm Holding AG |
| Robert-Rössle-Straße 10 | |
| 13125 Berlin | |
| Germany | |
| E-mail: | [email protected] |
| Internet: | https://www.pentixapharm.com/ |
| ISIN: | DE000A40AEG0 |
| WKN: | A40AEG |
| Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange |
| EQS News ID: | 2086021 |
| End of News | EQS News Service |
2086021 13.02.2025 CET/CEST