Quarterly Report • Nov 29, 2024
Quarterly Report
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January - September 2024

Delivering mitochondrial health
Positive Interim Analysis of the FALCON Study Paves the Way for KL1333 Development

* APM Alternative performance measures, see definition on page 20.
The interim analysis results from the FALCON study were a key highlight in the third quarter of 2024. Following two recent setbacks in the field, the positive interim readout created significant momentum within the mitochondrial community as well as among strategic partners and investors with expertise in the space. During the quarter, the team focused on managing the surge of interest in the program while also preparing for the final phase of the study.
Abliva's FALCON study is a Phase 2 trial targeting adults with multisystemic mitochondrial disease caused by mutations in their mitochondrial DNA. All participants experience fatigue and myopathy, the two primary endpoints of the study. Patients are treated for 48 weeks with either KL1333 (60% of patients) or placebo (40% of patients). Following discussions with the FDA, the study was designed as a pivotal trial, meaning the data, if positive, should be sufficient to support a marketing approval application based on the two primary endpoints, with just one endpoint required for regulatory registration.
The interim analysis (IA) represented a key de-risking milestone for the program. The IA included data from the first cohort of patients who had received KL1333 or placebo for at least 24 weeks. The independent Data Monitoring Committee reviewed the results and concluded that the safety profile supported continued development of the drug candidate. Additionally, both primary endpoints had met the required futility thresholds, allowing the study to proceed. The committee also confirmed that the full study will include 180 patients.
This positive interim readout is significant, marking the first successful outcome in a field that has faced multiple setbacks, including the recent negative results from US-based Reneo and Astellas' decision to exit the space (both of whom pursued a different mode of action to ours). Moreover, the analysis further solidifies our position as the company with the most advanced program targeting primary mitochondrial disease patients with mtDNA mutations – estimated to represent approximately 80% of the adult mitochondrial disease population. Commercial projections suggest that the potential market exceeds USD 1 billion in peak sales, with the patient population likely accessible through a well-established network of specialized treating physicians at a limited number of medical centers.

"The interim analysis represented a key de-risking milestone for the program"
This month, the program reached a significant milestone with the completion of the 48-week dosing in the final patient in Wave 1, marking the end of the first phase of the study. When the trial began, we had only administered doses for 10 days; now, we have demonstrated that KL1333 maintains a strong safety profile even after long-term dosing, with no drug-related serious adverse events (SAEs) reported to date.
We are now continuing preparatory activities for the second and final wave of the study, starting subject to financing. The team has been actively preparing for the study's expansion, including coordinating the documentation needed to support around forty sites across ten countries. Enthusiasm for the study with sites remains high, and we look forward to commencing Wave 2 as soon as possible.
The interim analysis generated significant anticipation and has brought heightened attention to both the company and the program. The team has been carefully evaluating various strategic options to ensure the best outcome for shareholders while pursuing an efficient path to market and patient access. This process takes time, and we remain focused on its importance. The strategic discussions are progressing well, and we are encouraged by the interest shown in this important program.
Best wishes,
Ellen Donnelly CEO

Primary mitochondrial disease affects the ability of cells to convert energy. It can manifest itself very differently depending on the organs impacted and the number of dysfunctional mitochondria in that organ. Historically viewed as clinical syndromes, our knowledge about the various mutations underlying mitochondrial disease has increased, improving our ability to identify and treat these patients. It is estimated that 1 in 5,000 people have primary mitochondrial disease.
Primary mitochondrial disease often presents in early childhood and can lead to severe symptoms, such as stunted growth, muscle weakness, pronounced fatigue, heart failure and rhythm disturbances, diabetes, movement disorders, stroke-like episodes, deafness, blindness, limited mobility of the eyes and epileptic seizures.
| PROGRAM | DISEASE | DISCOVERY | PRECLINICAL | PHASE 1 | PHASE 2*** | MARKET |
|---|---|---|---|---|---|---|
| KL1333* | Mitochondrial disease (mtDNA**) |
|||||
| NV354* | Mitochondrial disease (Neurology) |
|||||
| Early programs |
Mitochondrial disease |
*KL1333 and NV354 have Orphan Drug Designation (ODD) in the U.S. and Europe, and KL1333 has Fast Track designation in the U.S. **mtDNA-related mitochondrial disorders caused by mutation(s) in mitochondrial DNA (as opposed to nuclear DNA). ***Given that mitochondrial disease is an orphan disease, a Phase 2 study in these patients, if successful, can have the potential for market approval.
At Abliva, we are focused on becoming the leading company in mitochondrial medicine, developing therapeutics for mitochondrial disease, orphan indications of high unmet medical need. We intend to build a fully integrated research, development, and commercial organization, developing innovative therapeutics and taking them directly to the patients.
Abliva's long-term goal is to become the leading global company focused on the discovery of therapeutics for mitochondrial disease. We will do this with our clear strategy, strong portfolio of assets, research and development organization, and team with decades of experience in mitochondrial medicine and drug development.
Over the next few years, we will focus on the delivery of our portfolio to the market. We aim to:
Primary mitochondrial disease is a rare orphan disease where the energy metabolism in the cells, by the powerhouses of our cells – the mitochondria – is impaired. This causes deterioration that leads to multifaceted disorders and great suffering for patients. Mitochondrial medicine has become an area of ever-increasing focus for the pharmaceutical industry as there are currently no effective treatment options. Through Abliva's research and development, we have an opportunity to improve the health and quality of life of these patients.
Abliva's in-house R&D capabilities have been instrumental in creating and delivering a portfolio that includes several projects with mechanisms of action suitable for a wide range of different types of mitochondrial disease.
KL1333 is being developed as a treatment for primary mitochondrial disease patients suffering from multiple debilitating symptoms, including consistent fatigue and myopathy. KL1333 has completed several key Phase 1 studies that enabled the start of a potentially registrational Phase 2 study in 2022. KL1333 is protected by a composition of matter patent and Orphan Drug Designation (ODD) in the US and in Europe. It has also received Fast Track Designation in the US. The commercial opportunity is significant with even conservative estimates exceeding USD 1 billion per year in annual sales1).
NV354 is being developed for mitochondrial disease with neurologic complications, including Leigh syndrome, MELAS (Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes), and LHON (Leber's hereditary optic neuropathy). NV354 has completed preclinical development and is supported by a strong group of patents as well as ODD in the US and Europe.
Further, Abliva has efforts ongoing to identify additional portfolio opportunities focused on the regulation and stabilization of cellular energy production.
Abliva is committed to taking advantage of rare disease opportunities, successfully attaining ODD for both KL1333 and NV354. ODD provides significant benefits, including
regulatory assistance, cost reduction, advantageous pricing, and an additional layer of market exclusivity (10 years in the EU, 7 in the US). The outlook for reaching the market is also better than for traditional medicines2,3). KL1333 has also secured Fast Track designation in the US, streamlining development and marketing application reviews.
Seeking scientific advice from regulators in the US, UK, and Europe has been invaluable, resulting in a shift toward a single, potentially registrational, Phase 2 study for KL1333, expediting its path to market.
The key to the success of any company is the people who work there, and we are committed to attracting and retaining bright and innovative scientists, clinicians, and drug development experts. We will continue to support development opportunities for our colleagues and ensure that they have the tools and resources available to deliver on our goals. We will continue to complement our core team with a network of specialists, physicians, advisors, and others who will bring their expertise to our programs.
Abliva is a public company traded on NASDAQ Stockholm (ABLI, Small cap). We appreciate the continued commitment of our shareholders and look to attract new investors as we advance our portfolio and build the company. The investment of Hadean Ventures in 2020 was the first step to bringing specialist investors into the company, and, since that time, they have been joined by life science specialist IP Group plc and Norwegian institutional investor Oslo Pensjonsforsikring AS. We continue to attract new specialist and institutional investors as we grow the company and commercialize our portfolio.
1) Gorman et al., Prevalence of Nuclear and Mitochondrial DNA Mutations Related to Adult Mitochondrial Disease, 2015.
2) Jayasundra et al. Orphanet J of Rare Dis. Estimating the clinical cost of drug development for orphan versus non-orphan drugs. 2019.3) EvaluatePharma, Orphan Drug Report 2019.
| DISEASE | DISCOVERY | PRECLINICAL | PHASE 1 | PHASE 2*** | MARKET | |
|---|---|---|---|---|---|---|
| KL1333* | Mitochondrial disease (mtDNA**) |
*KL1333 has Orphan Drug Designation (ODD) in the U.S. and Europe and Fast Track designation in the U.S. **mtDNA-related mitochondrial disorders caused by mutation(s) in mitochondrial DNA (as opposed to nuclear DNA). ***Given that mitochondrial disease is an orphan disease, a Phase 2 study in these patients, if successful, can have the potential for market approval.
• In July, Abliva announced a positive outcome of the interim analysis of the 24-week data in Wave 1 of the FALCON study, increasing the probability of a positive readout upon completion of the full study.
Abliva's lead candidate, KL1333, has been designed to treat debilitating fatigue and myopathy (muscle weakness) in genetically confirmed adult patients with primary mitochondrial disease. Diagnoses can include MELAS-MIDD and KSS-CPEO spectrum disorders as well as MERRF syndrome. The drug candidate is intended for long-term oral treatment.
KL1333 has the ability to restore the ratio of NAD+ and NADH, and thus leads to the formation of new mitochondria and improved energy levels.
FALCON is a Phase 2, global, randomized, placebo-controlled, potentially registrational study evaluating the safety and efficacy of KL1333 in adult patients with primary mitochondrial disease who
experience consistent, debilitating fatigue and myopathy (muscle weakness), the most common and impairing symptoms.
A total of 180 patients with mitochondrial DNA mutations who meet the eligibility criteria are randomized 3:2 to receive KL1333 (50mg-100mg) or placebo twice daily for 48 weeks. The two alternative primary endpoints assess consistent fatigue (using the PROMIS Fatigue Mitochondrial Disease Short Form) and myopathy (using the 30 second Sit-to-Stand test), only one of which must be positive to file for marketing approval.
An interim analysis evaluating 24-week data from the first wave of patients confirmed the strong safety profile of KL1333, and both primary endpoints passed futility, meaning that both have the potential to demonstrate benefit in the final analysis of the study.
KL1333 has received Orphan Drug Designation in both the US and EU and Fast Track Designation in the US. Upon approval, the drug is expected to see significant uptake with an estimated patient population of up to 1:5,000 people1 . Considering typical orphan drug pricing, this translates into a blockbuster opportunity of over USD 1 billion in peak sales.
1) Gorman et al.,Prevalence of Nuclear and Mitochondrial DNA Mutations Related to Adult Mitochondrial Disease, 2015

*NV354 has Orphan Drug Designation (ODD) in the U.S. and Europe.
**Given that mitochondrial disease is an orphan disease, a Phase 2 study in these patients, if successful, can have the potential for market approval.
• Given the prioritization of KL1333, no costintensive operational activities are planned for NV354 at this time.
The drug candidate was discovered due to its ability to increase mitochondrial function in cells from mitochondrial Leigh syndrome patients. Leigh syndrome usually debuts at one to two years of age and includes psychomotor regression, low muscle tone, and developmental delays. The disease is fatal, and children with early-onset Leigh syndrome usually die before adulthood.
In Leigh syndrome and related mitochondrial diseases, the first step in energy production (complex 1) does not work properly. NV354, a succinate prodrug, bypasses this deficiency and restores the energy to the cell.
NV354 is being developed for mitochondrial disease with neurologic complications, in particular at insufficient activity in the mitochondrial protein complex I. The resulting deficiency in energy conversion contributes to clinical signs and symptoms in many types of mitochondrial disease, including neurologic complications seen in Leigh syndrome, MELAS, and LHON. There are also expansion opportunities outside of mitochondrial disease, including neurologic conditions where mitochondrial dysfunction has been confirmed.
Given the orphan drug designation and the high unmet medical need, NV354 is expected to have an expedited path to market and the potential for significant commercial sales.

The consolidated turnover during the third quarter of 2024 was SEK 0 (0). Other operating revenues for the third quarter were SEK 0 (0). During the first nine months of 2024 the consolidated turnover was SEK 0 (0). Other operating revenues for the first nine months amounted to SEK 290,000 (2,783,000) and pertain to exchangerate gains.
The operating loss for the third quarter was SEK 19,861,000 (32,938,0000) and for the first nine months the operating loss amounted SEK 63,769,000 (70,442,00). The net loss before tax for the third quarter amounted to SEK 19,541,000 (32,942,00). For the fist nine months the loss before tax was 63,473,000 ( 70,260,000).
The operating loss was affected by other external expenses, which for the first nine months were SEK 48,297,000 (48,829,000). Expenses related to development projects, as a part of external expenses, have affected the result with SEK 39,061,000 (36,983,000) relates to project in clinical phase. The cost for Projects in the clinical phase are higher, compared to the same period last year, due to predetermined payment schedules to suppliers. Personnel expenses during the first nine months amounts to KSEK 14,314,000 (14,451,000) and are less compared to last year due to fewer employees. Depreciation and impairment of intangible and tangible assets for the first nine months amount to SEK 1,448,000 (9,945,000), comparative figures from 2023 includes impairment of patents of in total SEK 7,797,000. Other operating expenses amount to SEK 0(0).
Financial items for the nine months amounted to SEK 295,000 (182,000) and refers mainly to accrued interest for short term placements.
| 1 Jul, 2024 | 1 Jul, 2023 | 1 Jan, 2024 | 1 Jan, 2023 | 1 Jan, 2023 | |
|---|---|---|---|---|---|
| (SEK 000) Note |
30 Sep, 2024 | 30 Sep, 2023 | 30 Sep, 2024 | 30 Sep, 2023 | 31 Dec, 2023 |
| Net sales | - | - | - | - | 137 |
| Other operating income | - | - | 290 | 2,783 | 1,345 |
| - | - | 290 | 2,783 | 1,482 | |
| Operating expenses | |||||
| Other external expenses | -14,258 | -18,789 | -48,297 | -48,829 | -68,819 |
| Personnel cost | -4,907 | -4,646 | -14,314 | -14,451 | -18,785 |
| Depreciation and write-down of tangible and intangible assets | -474 | -8,520 | -1,448 | -9,945 | -10,426 |
| Other operating expenses | -222 | -983 | - | - | - |
| -19,861 | -32,938 | -64,059 | -73,226 | -98,030 | |
| Operating income | -19,861 | -32,938 | -63,769 | -70,442 | -96,548 |
| Profit/loss from financial items | |||||
| Result from other securities and receivables related to non current assets | - | - | - | - | 34 |
| Financial income | 332 | 13 | 334 | 243 | 1,072 |
| Financial costs | -12 | -17 | -39 | -62 | -76 |
| 320 | -4 | 295 | 182 | 1,030 | |
| Profit/loss before tax | -19,541 | -32,942 | -63,474 | -70,260 | -95,518 |
| Income tax 2 |
- | -13 | 1 | -13 | 9 |
| Profit/loss for the period | -19,541 | -32,954 | -63,473 | -70,273 | -95,509 |
| Other comprehensive income | |||||
| Items that may be reclassified to profit or loss | |||||
| Translation differences on foreign subsidiaries | -45 | -8 | 4 | 18 | -30 |
| Total comprehensive income for the period | -19,586 | -32,963 | -63,469 | -70,255 | -95,539 |
| Loss for the period attributable to: | |||||
| Parent company shareholders | -19,541 | -32,954 | -63,473 | -70,273 | -95,509 |
| Non-controlling interests | - | - | - | - | - |
| -19,541 | -32,954 | -63,473 | -70,273 | -95,509 | |
| Total comprehensive income for the period | |||||
| Parent company shareholders | -19,586 | -32,963 | -63,469 | -70,255 | -95,539 |
| Non-controlling interests | - | - | - | - | - |
| -19,586 | -32,963 | -63,469 | -70,255 | -95,539 | |
| Earnings per share before and after dilution(SEK) based on average number of shares | -0.01 | -0.03 | -0.05 | -0.07 | -0.09 |
| Average number of shares before and after dilution | 1,477,717,869 1,056,299,165 1,264,478,582 1,056,299,165 1,056,299,165 |
The equity/assets ratio was 91 (88) percent as of 30 September 2024, and equity was SEK 87,707,000 (95,749,000). Long term liabilities refers to long term part and tax liability of the rigth of use asset leases and amount to 109,000 (534,000). Short term Liabilties amounted SEK 9,026,000 (12,719,000) as of 30 September 2024, and mainly refers to activities realted to the FALCON study. Other short-term recivables amounts to SEK 16,950,000 (22,985,000) and refer to the investment of surplus liquidity. Cash and cash equivalents amounted to SEK 46,812,000 (58,637,000) as of 30 September 2024. In total, short-term recivables and cash and cash equivalents amount to 63,762,000 an increase of SEK 6,098,000 compared to the beginning of the year. Total assets as of 30 September 2024 were SEK 96,842,000 (109,003,000).
Abliva holds unlisted securities. These assets should be measured at fair value and are classified as "financial assets measured at fair value through other comprehensive income."
The holding corresponds to about 10% in one of Abliva's R&D partner companies, which conducts development activities. A prudent assessment is that book value corresponds to the market value.
Other financial assets and liabilities are valued at amortized cost. The carrying amount of these assets and liabilities is estimated to correspond to fair value.
| (SEK 000) Note |
30 Sep, 2024 30 Sep, 2023 31 Dec, 2023 | ||
|---|---|---|---|
| ASSETS | |||
| Non-current assets | |||
| Intangible assets 1 |
|||
| Patents | 10,294 | 10,026 | 10,505 |
| Other Intangible assets | 840 | 975 | 941 |
| 11,134 | 11,000 | 11,446 | |
| Tangible assets | |||
| Equipment | 6 | 27 | 20 |
| Right of use asset leases | 475 | 856 | 761 |
| 481 | 883 | 781 | |
| Financial assets | |||
| Other long-term securities | 13,101 | 13,101 | 13,101 |
| Deferred tax | 9 | - | 9 |
| 13,110 | 13,101 | 13,110 | |
| Total non-current assets | 24,725 | 24,984 | 25,337 |
| Current assets | |||
| Other receivables | 3,116 | 1,032 | 1,051 |
| Prepaid expenses and accrued income | 5,239 | 1,365 | 3,447 |
| Other short term recivables | 16,950 | 22,985 | - |
| Cash and cash equivalents | 46,812 | 58,637 | 57,664 |
| 72,117 | 84,019 | 62,162 | |
| TOTAL ASSETS | 96,842 | 109,003 | 87,499 |
| Consolidated Statement of (SEK 000) |
Note | 30 Sep, 2024 30 Sep, 2023 31 Dec, 2023 | ||
|---|---|---|---|---|
| EQUITY AND LIABILITIES | ||||
| 80,594 | 52,815 | 52,815 | ||
| 957,613 | 906,047 | 905,972 | ||
| Financial Equity attributable to the shareholders of the parent company Share capital Position Additional paid in capital Translation reserve Retained earnings* Total equity attributable to the shareholders of the parent Total equity Long-term liabilities Deferred tax liabilities Other longtrem liabilities Short-term liabilities Accounts payable Other liabilities |
807 | 224 | 803 | |
| -951,307 | -863,336 | -888,872 | ||
| 87,707 | 95,749 | 70,718 | ||
| 87,707 | 95,749 | 70,718 | ||
| - | 13 | - | ||
| 109 | 521 | 424 | ||
| 109 | 534 | 424 | ||
| 2,613 | 6,044 | 9,348 | ||
| 712 | 717 | 699 | ||
| Accrued expenses and deferred income | 5,701 | 5,958 | 6,310 | |
| 9,026 | 12,719 | 16,357 | ||
| Total liabilities | 9,135 | 13,253 | 17,205 | |
| TOTAL EQUITY AND LIABILITIES | 96,842 | 109,003 | 87,499 |
Total equity includes funds from the April 19th completed preferential rights issue with net SEK 39,840,000 less expenses SEK 6,163,000 wherof SEK 2,136,000 constituted compensation to the guarantors. In addition, net 39,209,000 SEK is included reduced by issue costs of 2,791,000 SEK regarding funds from convertibles that were converted on August 14 following a positive outcome from the Interim Analysis on July 18, 2024
| Additional | Non- | ||||||
|---|---|---|---|---|---|---|---|
| Share- | paid in Translation | Retained | controlling | Total | |||
| (SEK 000) | capital | capital | reserve | earnings | Total | interests | equity |
| Opening balance, 1 January 2023 | 52,815 | 905,221 | 833 | -794,581 | 164,287 | 0 | 164,287 |
| Comprehensive profit/loss for the period | - | - | - | - | - | - | - |
| Profit/loss for the period | - | - | - | -95,509 | -95,509 | - | -95,509 |
| Other comprehensive income | - | - | - | - | - | - | - |
| Translation differences | - | - | -30 | - | -30 | - | -30 |
| Other comprehensive profit/loss for the period, net after tax | - | - | -30 | - | -30 | - | -30 |
| Total comprehensive profit/loss | - | - | -30 | -95,509 | -95,539 | - | -95,539 |
| Transactions with shareholders | |||||||
| Share-based payment | - | - | - | 1,218 | 1,218 | - | 1,218 |
| New share Issue, Employee stock options | - | 752 | - | - | 752 | - | 752 |
| Total transactions with shareholders | - | 752 | - | 1,218 | 1,970 | - | 1,970 |
| Closing balance, 31 December 2023 | 52,815 | 905,972 | 803 | -888,872 | 70,718 | 0 | 70,718 |
| Opening balance, 1 January 2023 | 52,815 | 905,221 | 833 | -794,581 | 164,287 | 0 | 164,287 |
| Comprehensive profit/loss for the period | |||||||
| Profit/loss for the period | - | - | -627 | -69,646 | -70,273 | - | -70,273 |
| Other comprehensive income | |||||||
| Translation differences | - | - | 18 | - | 18 | - | 18 |
| Other comprehensive profit/loss for the period, net after tax | - | - | 18 | - | 18 | - | 18 |
| Total comprehensive profit/loss | - | - | -609 | -69,646 | -70,255 | - | -70,255 |
| Transactions with shareholders | |||||||
| New share Issue, Employee stock options | - | 827 | - | - | 827 | - | 827 |
| Share-based payment | - | - | - | 891 | 891 | - | 891 |
| Total transactions with shareholders | - | 827 | - | 891 | 1,718 | - | 1,718 |
| Closing balance, 30 September 2023 | 52,815 | 906,047 | 224 | -863,336 | 95,750 | 0 | 95,749 |
| Opening balance, 1 January 2024 | 52,815 | 905,972 | 803 | -888,872 | 70,718 | 0 | 70,718 |
| Comprehensive profit/loss for the period | |||||||
| Profit/loss for the period | - | - | - | -63,473 | -63,473 | - | -63,473 |
| Other comprehensive income | |||||||
| Translation differences | - | - | 4 | - | 4 | - | 4 |
| Other comprehensive profit/loss for the period, net after tax | - | - | 4 | - | 4 | - | 4 |
| Total comprehensive profit/loss | - | - | 4 | -63,473 | -63,469 | - | -63,469 |
| Transactions with shareholders | |||||||
| Rights Issue | 14,654 | 25,186 | - | - | 39,840 | - | 39,840 |
| Convertible loans | 13,125 | 26,084 | - | - | 39,209 | - | 39,209 |
| Share-based payment | - | - | - | 1,038 | 1,038 | - | 1,038 |
| New share Issue, Employee stock options | - | 371 | - | - | 371 | - | 371 |
| Total transactions with shareholders | 27,779 | 51,641 | - | 1,038 | 80,458 | - | 80,458 |
| Closing balance, 30 September 2024 | 80,594 | 957,613 | 807 | -951,307 | 87,707 | 0 | 87,707 |
Equity attributable to the shareholders of the parent company
Operating cash flow for the third quarter was SEK 37,140,000 (4,945,000) wherof SEK 16,950,000 relates to investment of surplus liquidity. For the first nine months the operating cash flow amounted SEK -89,180,000 (-8,054,000). The cash flow effect related to investments in intangibles equals SEK -836,000 (-332,000) for the first nine months. The cash flow effect related to investments in financing activities equals SEK 79,138,000 (576,000) for the first nine months and refers mainly to the preferential rights issue that affected cash flow positively by SEK 39,840,000, the warrant programs for management and board that affected cash flow positively by SEK 371,000 and the conversion of the convertible that effected the cash flow positively by SEK 39,209,000. Cash flow for the third quarter equals positive SEK 1,601,000 (-5,148,000). Cashflow for the first nine months equals negative SEK -10,878,000 (-7,810,000).
| (SEK 000) | 1 Jul, 2024 | 1 Jul, 2023 | 1 Jan, 2024 | 1 Jan, 2023 | 1 Jan, 2023 |
|---|---|---|---|---|---|
| 30 Sep, 2024 30 Sep, 2023 30 Sep, 2024 30 Sep, 2023 31 Dec, 2023 | |||||
| Cash flow from operating activities | |||||
| Operating income | -19,861 | -32,938 | -63,769 | -70,442 | -96,547 |
| Adjustments for non-cash items: | |||||
| Depreciation | 474 | 8,520 | 1,449 | 9,945 | 10,426 |
| Currency differences on intercompany items | -94 | -13 | -3 | 43 | -58 |
| Impaired Value | -34 | - | -33 | -10 | -7 |
| Share-based payments | 664 | 327 | 1,038 | 891 | 1,218 |
| Result from other securities and receivables related to non current assets | - | - | - | - | 34 |
| Interest received | 332 | 13 | 334 | 243 | 1,072 |
| Interest paid | -12 | -17 | -39 | -62 | -76 |
| Paid taxes | - | - | - | - | - |
| Net cash from operating activities before changes in working capital | -18,531 | -24,108 | -61,023 | -59,391 | -83,938 |
| Changes in working capital | |||||
| Increase/decrease of other current assets | -19,691 | 19,784 | -20,806 | 58,042 | 78,923 |
| Increase/decrease of other short-term liabilities | 1,082 | -621 | -7,351 | -6,705 | -2,787 |
| Changes in working capital | -18,609 | 19,163 | -28,157 | 51,337 | 76,136 |
| Cash flow from operating activities | -37,140 | -4,945 | -89,180 | -8,054 | -7,802 |
| Investing activities | |||||
| Acquisition of intangible assets | -372 | -118 | -836 | -332 | -1,290 |
| Acquisition of tangible assets | - | - | - | - | - |
| Cash flow from investing activities | -372 | -118 | -836 | -332 | -1,290 |
| Financing activities | |||||
| New share issue | 39,209 | - | 79,420 | 827 | 752 |
| Amoritization lease | -96 | -85 | -282 | -251 | -338 |
| Cash flow from financing activities | 39,113 | -85 | 79,138 | 576 | 414 |
| Cash flow for the period | 1,601 | -5,148 | -10,878 | -7,810 | -8,678 |
| Cash and cash equivalents at the beginning of the period | 45,253 | 63,770 | 57,664 | 66,392 | 66,392 |
| Effect of exchange rate changes on cash | -43 | 14 | 25 | 55 | -50 |
| Cash and cash equivalents at end of period | 46,812 | 58,637 | 46,812 | 58,637 | 57,664 |
Company earnings after tax for the third quarter amounts to SEK -18,907,000 (-56,322,000). Earnings after tax for the first nine months amount to SEK -62,447,000 (-93,309,000). Most of the Group's operations are conducted within the parent company. Accordingly, no further specific information regarding the parent company is presented.
| (SEK 000) | 1 Jul, 2024 | 1 Jul, 2023 | 1 Jan, 2024 | 1 Jan, 2023 | 1 Jan, 2023 | |
|---|---|---|---|---|---|---|
| Note 30 Sep, 2024 30 Sep, 2023 30 Sep, 2024 30 Sep, 2023 31 Dec, 2023 | ||||||
| Net sales | - | - | - | - | 137 | |
| Other operating income | - | - | 238 | 2,575 | 1,508 | |
| - | - | 238 | 2,575 | 1,645 | ||
| Operating expenses | ||||||
| Other external expenses | -16,014 | -20,327 | -53,564 | -53,849 | -75,410 | |
| Personnel cost | -2,561 | -2,723 | -8,290 | -8,888 | -11,803 | |
| Depreciation and write-down of tangible and intangible assets | -378 | -8,425 | -1,163 | -9,660 | -10,046 | |
| Other operating expenses | -285 | -1,133 | - | - | - | |
| -19,238 | -32,609 | -63,017 | -72,396 | -97,259 | ||
| Operating income | -19,238 | -32,609 | -62,779 | -69,821 | -95,614 | |
| Profit/loss from financial items | ||||||
| Result from other securities and receivables related to non current assets | - | -23,725 | - | -23,725 | -23,691 | |
| Interest income and other similar profit items | 332 | 13 | 333 | 243 | 1,072 | |
| Interest expenses and other similar loss items | -1 | - | -1 | -6 | -5 | |
| 331 | -23,713 | 332 | -23,488 | -22,624 | ||
| Profit/loss before tax | -18,907 | -56,322 | -62,447 | -93,309 | -118,238 | |
| Income tax | 2 | - | - | - | - | - |
| Profit/loss for the period | -18,907 | -56,322 | -62,447 | -93,309 | -118,238 |
| (SEK 000) | 1 Jul, 2024 | 1 Jul, 2023 | 1 Jan, 2024 | 1 Jan, 2023 | 1 Jan, 2023 |
|---|---|---|---|---|---|
| Note 30 Sep, 2024 30 Sep, 2023 30 Sep, 2024 30 Sep, 2023 31 Dec, 2023 | |||||
| Profit/loss for the period | -18,907 | -56,322 | -62,447 | -93,309 | -118,238 |
| Other comprehensive income | - | - | - | - | - |
| Total comprehensive profit/loss for the period | -18,907 | -56,322 | -62,447 | -93,309 | -118,238 |
| (SEK 000) Note |
30 Sep, 2024 30 Sep, 2023 31 Dec, 2023 | ||
|---|---|---|---|
| ASSETS | |||
| Non-current assets | |||
| Intangible assets | 1 | ||
| Patents | 10,294 | 10,026 | 10,505 |
| Other intangible assets | 840 | 975 | 941 |
| 11,134 | 11,000 | 11,446 | |
| Tangible assets | |||
| Equipment | 6 | 27 | 20 |
| 6 | 27 | 20 | |
| Financial assets | |||
| Shares in subsidiaries | 3 1,671 |
13,100 | 1,465 |
| Other long-term placement | 13,100 | 1,465 | 13,101 |
| 14,771 | 14,565 | 14,566 | |
| Total non-current assets | 25,911 | 25,593 | 26,032 |
| Current assets | |||
| Short term receivables | |||
| Receivables from group companies | - | - | - |
| Other receivables | 3,095 | 1,010 | 1,031 |
| Prepaid expenses and accrued income | 5,233 | 1,311 | 3,425 |
| 8,328 | 2,321 | 4,456 | |
| Other short term recievables | 16,950 | 22,985 | - |
| Cash and bank balances | 45,156 | 57,053 | 55,826 |
| Total current assets | 70,434 | 82,359 | 60,282 |
| TOTAL ASSETS | 96,345 | 107,952 | 86,314 |
| (SEK 000) Note |
30 Sep, 2024 30 Sep, 2023 31 Dec, 2023 | ||
|---|---|---|---|
| Equity | |||
| Restricted equity | |||
| Share capital | 80,594 | 52,815 | 52,815 |
| Statutory reserve | 1,856 | 1,856 | 1,856 |
| Development expenditure reserve** | - | - | - |
| 82,450 | 54,671 | 54,671 | |
| Unrestricted equity | |||
| Share premium reserve | 227,054 | 175,488 | 225 |
| Retained earnings | -159,343 | -41,104 | 134,159 |
| Profit/loss for the period | -62,447 | -93,309 | -118,238 |
| 5,264 | 41,074 | 16,145 | |
| Total equity | 87,714 | 95,745 | 70,816 - |
| Short-term liabilities | |||
| Accounts payable | 2,595 | 6,021 | 9,345 |
| Liabilities subsidiary | 1,904 | 1,649 | 1,620 |
| Other liabilities | 300 | 349 | 319 |
| Accrued expenses and deferred income | 3,832 | 4,188 | 4,213 |
| 8,631 | 12,206 | 15,498 | |
| TOTAL EQUITY AND LIABILITIES | 96,345 | 107,952 | 86,314 |
| (SEK 000) | Patents | Other | Total |
|---|---|---|---|
| ACCUMULATED COST | |||
| Opening balance 1 Jan. 2024 | 21,612 | 2,864 | 24,476 |
| Additions | 837 | - | 837 |
| Impaired value | -5 | - | -5 |
| Closing balance 30 Sep. 2024 | 22,444 | 2,864 | 25,308 |
| ACCUMULATED DEPRECIATION | |||
| Opening balance 1 Jan. 2024 | -11,107 | -1,923 | -13,030 |
| Depreciation for the period | -1,043 | -101 | -1,144 |
| Closing balance 30 Sep. 2024 | -12,150 | -2,024 | -14,174 |
| Residual value 30 Sep. 2024 | 10,294 | 840 | 11,134 |
| (SEK 000) | Patents | Other | Total |
|---|---|---|---|
| ACCUMULATED COST | |||
| Opening balance 1 Jan. 2023 | 36,086 | 2,864 | 38,950 |
| Additions | 1,459 | - | 1,459 |
| Impaired value | -15,933 | - | -15,933 |
| Closing balance 31 Dec. 2023 | 21,612 | 2,864 | 24,476 |
| ACCUMULATED DEPRECIATION | |||
| Opening balance 1 Jan. 2023 | -17,158 | -1,789 | -18,947 |
| Depreciation for the period | -1,290 | -134 | -1,424 |
| Impaired value | 7,341 | - | 7,341 |
Closing balance 31 Dec. 2023 -11,107 -1,923 -13,030 Residual value 31 Dec. 2023 10,505 941 11,446
The group's total loss carry-forwards amounts to SEK 991,773,000 as of 30 September 2024 (921,798,000). The parent company's total loss carry-forwards amounts to SEK 1,017,931,000 as of 30 September 2024 (919,355,000). Because the company is loss making, management cannot judge when deductible loss carry-forwards will be utilized.
Shares and participations in group companies relates to the holly owned american subsidiary Abliva Inc., Boston and the Swedish subsidiary Abliva Incentive AB, holding option program for the CEO and warrant program for managment and key personnel.
In November 2023, Abliva and Owl Therapeutics of San Antonio, Texas, entered into a licensing and collaboration agreement for the drug candidate NeuroSTAT®.
Transactions between the company and its subsidiarie, which are related parties to the company, have been eliminated on consolidation, and accordingly, no disclosures are made regarding these transactions.
Apart from remuneration to senior executives no transactions with related parties have occured.
Financial information reported to the chief operating decision maker (CEO) as the basis for allocating resources and judging the group's profit or loss is not divided into different operating segments. Accordingly, the group consists of a single operating segment.
The average number of employees of the group for the period January to September 2024 was 6 (8), of which 4 (6) are women.
For further information, see page 2.
There have been no important events after the reporting period.
The Company has two option programs and four warrant programs.
The general meeting on 8 March, 2023, decided on a fouryear incentive stock option program 2023/2027 for the Company's CEO. The incentive stock option program entitles the holder to a new share in Abliva AB up to a maximum of 17,500,000 ordinary shares. The redemption price amounts to SEK 0.27. The program is vested at 25% per year on 1 April, 2024, 1 April, 2025, 1 April, 2026 and 1 April, 2027. Latest redemption date is 31 December, 2027.
The general meeting on 23 May, 2024, decided on a fouryear incentive stock option program 2024/2030 for the Company's CEO. The incentive stock option program entitles the holder to a new share in Abliva AB up to a maximum of 25,000,000 ordinary shares. The redemption price amounts to SEK 0.19. The program is vested at 25% per year on 1 June, 2025, 1 June, 2026, 1 June, 2027 and 1 June, 2028. Latest redemption date is 1 June, 2030.
At the general meeting on 8 March, 2023, it was decided on a warrant program 2023/2027 to management and other and key employees of a maximum of 23.5 million warrants at a price of SEK 0.06 per warrant, corresponding to a subscription price of SEK 0.67 per share. In total, approx. 8.8 million options have been subscribed in the warrant program for management and other and key employees. One warrant entitles the holder to one new share in Abliva AB. Unsubscribed options have been cancelled. Redemption date is 1 June - 31 December 2027.
On 5 May the AGM resolved on a warrant program 2023/2027 for certain board members of a maximum of 4.5 million warrants at a price of SEK 0.05 per warrant and a subscription price of SEK 0.5767 per share. All options have been subscribed. One warrant entitles the holder to one new share in Abliva AB. Redemption date is June 1 - December 31, 2027. Incentive programs/share warrants mation Performed by the Independent Auditor of the Entity.
At the general meeting on 23 May, 2024, it was decided on a warrant program 2024/2028 to management and other and key employees of a maximum of 15.0 million warrants at a price of SEK 0.03 per warrant, corresponding to a subscription price of SEK 0.48 per share. In total, approx. 9.4 million options have been subscribed in the warrant program for management and other and key employees. One warrant entitles the holder to one new share in Abliva AB. Redemption date is 1 June - 31 December 2028.
On 23 May the AGM resolved on a warrant program 2024/2028 for certain board members of a maximum of 4.0 million warrants at a price of SEK 0.03 per warrant and a subscription price of SEK 0.48 per share. In total, 3 million options have been subscribed in the warrant program for certain board members. One warrant entitles the holder to one new share in Abliva AB. Redemption date is June 1 - December 31, 2028.
In case of full utilization of all incentive programs the maximum dilution amounts to 4.06 per cent on a fully diluted basis. The dilution effects have been calculated as the number of additional shares and votes in relation to the number of existing shares and votes plus the number of additional shares and votes. The dilution is only expected to have a marginal effect on the Company's key performance indicator "Earnings (loss) per share".
For further information please see www.abliva.com and the Annual report 2023 note 11.
This Interim Report has been subject to review by the company's auditors in accordance with the Standard on Review Engagements (ISRE) 2410, Review of Interim Financial Infor-
Year-End Report 2024 February 21, 2025 Q1 January-March Report 2025 May 22, 2025 Q2 January-June Report 2025 August 22, 2025 Q2 January-September Report 2025 November 21, 2025 Year-End Report 2025 February 20, 2026
The interim reports and the Annual Year Report are available www.abliva.com
A research company such as Abliva AB (publ) is subject to high operational and financial risks because the projects the company conducts are in different developmental phases, where a number of parameters influence the likelihood of commercial success. Briefly, operations are associated with risks relating to factors including drug development, competition, technological progress, patents, regulatory requirements, capital requirements, currencies and interest rates. The Board of Directors works continuously to secure the business operation's need for financing. For a more detailed description of the risks and uncertainty factors that Abliva is facing, please refer to the risk analysis on pages 16-19 in the Annual Report for 2023.
The Board continuously monitors and evaluates the company's funding need and financial position given ongoing development. The company announced the outcome from a preferential rights issue in April 2024 of approximately SEK 39.8 million after transaction costs. In July, the conversion of a convertible loan of approximately SEK 39.1 million after transaction costs was announced. The Board acknowledges that when the company starts recruiting patients into Wave 2 of the FALCON study, there is a need for capital for the next 12 months. The Board has initiated a process to ensure adequate funding (equity, loan, grants and/or part¬nerships) to enable execution of the company's strategy. If the company is not successful in securing additional financing, there is a risk that Wave 2 of the program will be further delayed, and then there is a significant uncertainty for continued operations. The interim report is prepared on the basis of a going concern assumption.
Abliva is not involved in any disputes.
Abliva prepares its consolidated accounts in accordance with International Financial Reporting Standards (IFRS) issued by the International Accounting Standards Board (IASB) and interpretation statements from the IFRS Interpretations Committee, as endorsed by the EU for application within the EU. This Interim Report has been prepared in accordance with IAS 34 Interim Financial Reportin..
The parent company applies the Swedish Annual Accounts Act and RFR's (the Swedish Financial Reporting Board) recommendation RFR 2 Accounting for Legal Entities. Application of RFR 2 implies that, as far as possible, the parent company applies all IFRS endorsed by the EU within the limits of the Swedish Annual Accounts Act and the Swedish Pension Obligations Vesting Act, and considering the relationship between accounting and taxation.
The group and parent company have applied the accounting principles described in the Annual Report for 2023. New or amended standards or interpretations of standards effective as of January 1, 2024 have not had any significant impact on Ablivas financial statements.
Alternative Performance Measures (APM) are key figures not defined in financial reports prepared according to IFRS. Of the below key figures, only the key figure Earnings per share before and after dilution is mandatory and defined according to IFRS. Of the other key figures, net sales, earnings per share before and after dilution, cash flow from operating activities and cash flow for the period are defined according to IFRS.
| The following key figures are used: | Definition | Reason for use |
|---|---|---|
| Net revenues | Revenue from goods and services sold that are part of the company's normal operations |
|
| Other operating income | Income from secondary activities in ordinary activities such as grants received |
|
| Operating income | Net sales and other revenues minus expenses for other external costs, personnel costs, depreciation and impairment and other expenses |
Measures the result in the operations |
| Profit/loss before tax | Operating income after profit/loss from finacial items and allocations | Measures the result in the business after profit/loss from financial items and allocations |
| Earnings per share before dilution(SEK) based on average number of shares |
Profit/loss for the period divided by average number of shares before dilution at the end of the period |
|
| Earnings per share after dilution(SEK) based on average number of shares |
Profit/loss for the period divided by average number of shares after dilution at the end of the period |
|
| Cash flow from operating activities | Cash flow from operating activities, including cash flow from working capital, ie changes in current liabilities and current receivables |
Measures total cash flow generated in the business |
| Cash flow for the period | The company's total cash flow from operating activities, investment activities and financing activities |
Measures total cash flow generated in the business including investment activities and financing activities |
| Average number of shares before and after dilution |
Average number of shares before and after dilution | Measures the average number of shares during the period before and after dilution. As the Group's earnings are negative, there is no dilution |
| Equity Ratio % | Equity as a percentage of total assets | Shows how much of the company's assets are financed with equity and shows the company's ability to pay |
| Liquidity Ratio (%) | Current assets divided by current liabilities | Shows on the company's short-term ability to pay |
This Interim Report gives a true and fair view of the parent company and group's operations, financial position and results of operations, and states the significant risks and uncertainty factors facing the parent company and group companies.
Lund, Sweden, November 29, 2024
David Laskow-Pooley David Bejker Roger Franklin Chair of the Board Board member Board member
Denise Goode Jan Törnell Ellen Donnelly
Board member Board member Chief Executive Officer



David Laskow-Pooley David Bejker



For more information concerning this report, please contact CEO Ellen Donnelly. Telephone: +46 (0)46-275 62 20.
The information was submitted for publication, through the agency of the contact person set out above, at 6:00 p.m. CET on November 29, 2024.
This Interim Report is published in Swedish and English. In the event of any difference between the English version and the Swedish original, the Swedish version shall prevail.
We have reviewed the condensed interim report for Abliva AB (publ) as at September 30, 2024 and for the nine months period then ended. The Board of Directors and the Managing Director are responsible for the preparation and presentation of this interim report in accordance with IAS 34 and the Swedish Annual Accounts Act. Our responsibility is to express a conclusion on this interim report based on our review.
We conducted our review in accordance with the International Standard on Review Engagements, ISRE 2410 Review of Interim Financial Statements Performed by the Independent Auditor of the Entity. A review consists of making inquiries, primarily of persons responsible for financial and accounting matters, and applying analytical and other
review procedures. A review is substantially less in scope than an audit conducted in accordance with International Standards on Auditing and other generally accepted auditing standards in Sweden. The procedures performed in a review do not enable us to obtain assurance that we would become aware of all significant matters that might be identified in an audit. Accordingly, we do not express an audit opinion.
Based on our review, nothing has come to our attention that causes us to believe that the interim report is not prepared, in all material aspects, in accordance with IAS 34 and the Swedish Annual Accounts Act regarding the Group, and in accordance with the Swedish Annual Accounts Act regarding the Parent Company.
We draw attention to the information provided in the section "Financing" on page 19, where it is stated that a continued
execution of the FALCON study is dependent on additional capital. Should the measures planned by the board of directors not occur to the extent expected there is a material uncertainty that may cast significant doubt on the Company's ability to continue as a going concern. Our opinion is not modified in respect of this matter
Uppsala, November 29, 2024.
Ernst & Young AB
Authorized Public Accountant
Candidate drug. A particular compound which is selected during the preclinical phase. The candidate drug is subsequently tested in humans in clinical studies.
Clinical study. The examination of healthy or unhealthy humans to study the safety and efficacy of a pharmaceutical or treatment method. Clinical trials are divided into different phases, termed Phase 1, Phase 2, Phase 3. Phase 2 is usually divided into an early phase (Phase 2a) and a later phase (Phase 2b). See also "phase (1,2 and 3)".
(The) FALCON study. Abliva's global potentially registrational Phase 2 clinical trial with the drug candidate KL1333. The study will evaluate the efficacy of KL1333 on fatigue and muscle weakness in adult patients with primary mitochondrial diseases caused by inherited mutations in the mitochondrial DNA.
Fatigue. Extreme tiredness. Often includes muscle fatigue with exercise intolerance.
FDA. The United States Federal Food and Drug Administration.
Indication. A disease condition requiring treatment, such as traumatic brain injury or fatty liver, NASH.
Hypotonia. An abnormally low level of tension, important for posture, in the resting muscle
Interim analysis. The analysis of data in a clinical trial comparing intervention groups before the formal completion of the trial, typically before patient recruitment is complete. Can be used for various purposes, such as assessing the statistical strength of the study to meet the predetermined endpoints.
KSS. Mitochondrial disease, Kearns-Sayre's syndrome. The disease debuts before the age of 20 and is characterized by eye related symptoms with pigment retention in the retina and paralysis of the outer eye muscles, as well as the effects on the cardiac retinal system and the cerebellum with disorders in the coordination of muscle movements (ataxia).
Leigh syndrome. Leigh syndrome is a serious condition with characteristic changes to the brain that usually affects small children. This disease is caused by faults in energy-producing mitochondria and is also known as subacute (fast onset) necrotizing (tissue destroying) encephalomyopathy (a disease of the brain and muscles).
LHON. Mitochondrial disease, Leber Hereditary Optic Neuropathy. Affects the retina and the optic nerve, but in rare cases symptoms can be found in other parts of the central nervous system. There is no cure, but treatments are focused primarily on compensating for the visual impairment.
MELAS. MELAS is an acronym of mitochondrial encephalomyopathy (brain and muscle disease) with lactic acidosis (increased lactic acid levels in the blood) and strokelike episodes.
MERRF. (Myoclonic epilepsy with ragged-red fibers). Primary mitochondrial disease with symptoms such as epilepsy, involuntary muscle twitching and difficulty coordinating muscle movements, but the disease can affect many functions. When examined under a microscope, muscle tissue has characteristic changes.
MIDD. Maternally Inherited Diabetes and Deafness
Mitochondria. That part of each cell that provides effective energy production in the form of conversion of oxygen and nutrients in the body into chemical energy.
Mitochondrial medicine. Field of research and development of pharmaceuticals that protect the mitochondria.
Mitochondrial myopathy. Primary mitochondrial disease which affects the muscles.
mtDNA. Mitochondrial DNA. Mitochondria's own genome that is inherited only on the maternal line. Separate from the cells' genome (nuclear DNA = nDNA) inherited by both parents.
NAD+/NADH. A coenzyme involved in metabolism. NAD+ and NADH have central roles in cell- and mitochondrial metabolism and energy production.
ODD. Orphan Drug Designation. Facilitates development and commercialization, and may, upon receiving marketing authorization, provide orphan drug status with seven or ten years of market exclusivity (in the US and Europe, respectively).
PEO/CPEO. Mitochondrial disease. Progressive External Ophthalmoplegia/Chronic Progressive External Ophthalmoplegia.
Phase (1,2 and 3). The various stages of trials on the efficacy of a pharmaceutical in humans. See also "clinical trial." Phase 1 examines the safety on healthy human subjects, Phase 2 examines efficacy in patients with the relevant disease and Phase 3 is a large-scale trial that verifies previously achieved results. In the development of new pharmaceuticals, different doses are trialed and safety is evaluated in patients with relevant disease, Phase 2 is often divided between Phase 2a and Phase 2b.
Preclinical. That stage of drug development that occurs before a candidate drug is trialed on humans.
Primary mitochondrial disease. Metabolic disease that affects the ability of cells to convert energy. An estimated 12 in every 100,000 people are affected. Often presents in early childhood and leads to severe symptoms, such as mental retardation, heart failure and rhythm disturbances, dementia, movement disorders, severe diabetes, stroke-like episodes, deafness, blindness, limited mobility of the eyes, vomiting and seizures.
Psychomotor regression. When the development of the ability to perform will-driven movements is initially normal but deteriorates during infancy or early childhood.
Succinate. Endogenous substance that plays an important role in mitochondrial energy production. Succinate is used by mitochondrial protein complex II.
TBI. Traumatic Brain Injury. An injury to the brain where some nerve cells are subjected to immediate damage. The injury then continues to exacerbate several days after the incident, which significantly impacts the final extent of damage.
Abliva discovers and develops medicines for the treatment of mitochondrial disease. This rare and often very severe disease occurs when the cell's energy provider, the mitochondria, do not function properly. The company has prioritized two projects. KL1333, a powerful regulator of the essential co-enzymes NAD+ and NADH, has entered late-stage development. NV354, an energy replacement therapy, has completed preclinical development. Abliva is based in Lund, Sweden.
Primary mitochondrial disease affects the ability of cells to convert energy. It can manifest itself very differently depending on the organs impacted and the number of dysfunctional mitochondria in that organ. Historically viewed as clinical syndromes, our knowledge about the various mutations underlying mitochondrial disease has increased, improving our ability to identify and treat these patients. It is estimated that 125 people per million have primary mitochondrial disease.
Abliva's discovery projects focus on gaining a deeper understanding of the mechanisms underlying mitochondrial disease in order to enable us to design new molecules and develop the next-generation compounds targeting primary mitochondrial disease.
Stock exchange Abliva is listed on Nasdaq Stockholm, Sweden (ticker: ABLI).
Medicon Village, SE-223 81 Lund Phone: +46 46 275 62 20 (switchboard) [email protected]
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