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BB Biotech AG

Quarterly Report Oct 25, 2024

833_10-q_2024-10-25_1ace6aa3-8bd5-4606-b6da-648a6efaceb9.pdf

Quarterly Report

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Interim Report as at 30.09.2024

Table of contents

Business Report 3–11
Performance/Multi-year comparison 3
Shareholder letter 7
Portfolio at a glance 10
Financial Report 12–23
Consolidated interim financial statements 12
Selected explanatory notes to the consolidated interim financial statements 16
Report of the statutory auditors 23
About us 24–34
Company profile 24
Investment strategy 25
Investment process 27
Board of Directors 29
Investment Manager 29
Shareholder information 30
Facts & figures 31
Corporate calendar 32
Contact 33

Performance/Multi-year comparison

Indexed performance since launch

BB Biotech AG (SIX)-CHF

Rolling performance

SHARE NAV NBI TR
30.09.2023 – 30.09.2024 (8.1%) 5.2% 12.3%
30.09.2022 – 30.09.2023 (17.1%) (12.8%) (1.7%)
30.09.2021 – 30.09.2022 (33.7%) (22.7%) (21.3%)
30.09.2020 – 30.09.2021 31.1% 24.5% 21.9%
30.09.2019 – 30.09.2020 15.9% 21.0% 26.4%

Annual performance

SHARE NAV NBI TR
2023 (18.1%) (7.4%) (4.8%)
2022 (24.3%) (11.0%) (9.1%)
2021 8.3% (11.5%) 3.0%
2020 19.3% 24.3% 15.8%
2019 18.5% 23.4% 23.0%

Cumulated performance

30.09.2024

SHARE NAV NBI TR
(11.1%) 0.3% 10.5%
(8.1%) 5.2% 12.3%
(49.5%) (29.1%) (13.1%)
(23.2%) 6.8% 33.9%
60.4% 43.8% 56.5%
1 660% 1 865% 1 331%

1 09.11.1993

Annualized performance 30.09.2024

SHARE NAV NBI TR
1 year (8.1%) 5.2% 12.3%
3 years (20.4%) (10.8%) (4.6%)
5 years (5.2%) 1.3% 6.0%
10 years 4.8% 3.7% 4.6%
since inception 1) 9.7% 10.1% 9.0%

1 09.11.1993

BB BIOTECH AG (XETRA)-EUR

Rolling performance

SHARE NAV NBI TR
30.09.2023 – 30.09.2024 (4.7%) 8.2% 15.4%
30.09.2022 – 30.09.2023 (17.3%) (12.9%) (2.1%)
30.09.2021 – 30.09.2022 (26.1%) (13.9%) (11.7%)
30.09.2020 – 30.09.2021 29.6% 24.5% 21.8%
30.09.2019 – 30.09.2020 17.5% 22.0% 27.3%

Cumulated performance

30.09.2024

SHARE NAV NBI TR
YTD (11.0%) (1.0%) 9.0%
1 year (4.7%) 8.2% 15.4%
3 years (41.7%) (18.8%) (0.2%)
5 years (11.2%) 23.4% 54.7%
10 years 105% 84% 100%
since inception 1) 1 524% 1 712% 1 498%

1 10.12.1997

Annual performance

SHARE NAV NBI TR
2023 (15.2%) (1.3%) 1.3%
2022 (19.0%) (6.7%) (4.5%)
2021 13.3% (7.8%) 7.4%
2020 18.1% 24.8% 16.1%
2019 23.4% 28.1% 27.6%

Annualized performance 30.09.2024

SHARE NAV NBI TR
1 year (4.7%) 8.2% 15.4%
3 years (16.5%) (6.7%) (0.1%)
5 years (2.4%) 4.3% 9.1%
10 years 7.5% 6.3% 7.2%
since inception 1) 10.9% 11.4% 10.9%

1 10.12.1997

Multi-year comparison

30.09.2024 2023 2022 2021 2020
2 016.6 2 368.4 3 058.1 4 274.1 4 107.9
2 229.0 2 323.2 2 686.1 3 283.5 3 887.5
55.4 55.4 55.4 55.4 55.4
710.3 906.3 1 482.0 2 101.0 2 315.6
16.2 (206.6) (357.8) (404.8) 691.2
36.40 42.75 55.20 77.15 74.15
38.80 45.50 56.70 74.05 68.00
(11.1%) (18.1%) (24.3%) 8.3% 19.3%
49.35/36.40 60.70/35.60 78.15/51.00 92.20/73.40 74.70/45.44
52.00/38.30 60.50/37.10 75.40/49.60 86.20/67.80 69.00/43.04
(3.8%) 7.5% 20.5% 19.5% 9.2%
N.A. 2.00 2.85 3.85 3.60
113.3% 113.7% 112.8% 108.6% 106.8%
1.34% 1.34% 1.27% 1.22% 1.25%

1 All figures in CHF %, total return-methodology

2 Based on market capitalization

Shareholder letter

Dear Shareholders

In the third quarter of 2024, stock markets remained volatile, with several major equity indices reaching new all-time highs. A key event during this period was the US Federal Reserve's decision in September to lower interest rates by 50 bps, marking its first rate cut in four years. This shift signals a potential further easing of monetary policy heading into 2025, with markets anticipating rates to gradually decrease to around 3.5% by the end of 2025. Historically, lower interest rates have been correlated with increased capital flows into sectors such as biotech, as investors seek growth opportunities. This dynamic positions the biotech industry for potential capital inflows as market conditions improve.

The Nasdaq Biotech Index increased by 5.1% in USD during the third quarter. As in the second quarter of 2024 the healthcare sector generally did not keep up with broader equity indices in the third quarter.

For BB Biotech AG, the share price return in the third quarter of 2024 was –9.2% in CHF and – 6.7% in EUR. Its third-quarter performance was driven by a widening of BB Biotech's Net Asset Value discount, from a high single-digit to a low double-digit percentage discount at the end of the third quarter, and by the negative development of the underlying stocks in the portfolio during the same time frame. The portfolio's total return was –6.6% in CHF, –4.4% in EUR, and –0.6% in USD. The company's net loss for the third quarter of 2024 amounted to CHF 157 mn and a net profit of CHF 16 mn was generated in the first nine months of 2024, in contrast to a net loss of CHF 48 mn during the third quarter in 2023 and a net loss of CHF 316 mn in the first nine months of 2023.

For the first nine months of 2024, the total return for BB Biotech's shares was –11.1% in CHF and –11.0% in EUR. The portfolio performance was +0.3% in CHF, –1.0% in EUR, and –0.2% in USD. All results reported for the first nine months of 2024 include the dividend payment of CHF 2.00 per share in late March 2024.

Portfolio update Q3 2024

In the third quarter, portfolio adjustments focused on capitalizing on gains from larger, longterm holdings in line with BB Biotech's S-curve investment strategy. This allowed us to reallocate capital into selectively identified companies with strong growth trajectories, further advancing our continuous portfolio rejuvenation. By rotating investments strategically, we aim to enhance exposure to promising novel assets while staying aligned with our long-term objectives.

At the end of Q3 2024, BB Biotech's portfolio consisted of 31 positions.

As the third quarter concluded, our investment level decreased slightly but remained near the upper limit of our target range at 112.3%. This sustained high level of investment reflects the management team's continued confidence, with an increasing proportion of holdings featuring de-risked business models and attractive valuations.

Portfolio milestones in the third quarter of 2024

Biotechnology markets remained volatile, with notable fluctuations across our investments. Several portfolio companies, including Edgewise Therapeutics, Ionis Pharmaceuticals, Rivus Pharmaceuticals, Relay Therapeutics, Wave Life Sciences, and Vertex Pharmaceuticals, delivered positive news, while Exelixis and Neurocrine Biosciences experienced at least market-perceived setbacks. Below, we summarize key milestones from Q3:

  • Ionis Pharmaceuticals reported positive results from a completed Phase I/II study in Angelman syndrome, a significant and proprietary orphan disease opportunity. Phase III development is planned for H1 2025.
  • Vertex Pharmaceuticals received FDA acceptance of its suzetrigine NDA for acute pain, with a PDUFA date of January 30, 2025. If approved, it will be the first novel pain medication with a new mechanism of action in two decades.
  • Alnylam Pharmaceuticals presented groundbreaking results from the HELIOS B Phase III outcomes trial of vutrisiran in ATTR Cardiomyopathy at the ESC Congress in August. With an unprecedented risk reduction of over 30% in all-cause mortality, the therapy is poised to become a multi-billion-dollar blockbuster.
  • Neurocrine Biosciences shared top-line Phase II data for NBI-568, a muscarinic receptor agonist, in schizophrenia, which fell short of market expectations. Nevertheless, phase III is set to begin in early 2025.
  • Celldex Therapeutics announced positive Phase II results for barzolvolimab in chronic inducible urticaria (CIndU). Phase III development began in July 2024 for chronic spontaneous urticaria (CSU).
  • Biohaven reported somewhat unexpected positive pivotal results for troriluzole in spinocerebellar ataxia and plans to submit an NDA to the FDA in Q4 2024.
  • Relay Therapeutics provided positive interim data for RLY-2608 in HR+/HER2 metastatic breast cancer, with a pivotal second-line trial expected to begin in 2025.
  • Exelixis reported results from a trial investigating Cabometyx (cabozantinib) in combination with atezolizumab, which showed a positive trend towards improved overall survival – one of the trial's primary endpoints. However, the results did not achieve statistical significance, leading to market-perceived disappointment.
  • Rivus Pharmaceuticals, our only private holding, presented positive Phase IIa data for HU6 in obesity-related heart failure at HFSA. The company has also completed enrollment in the Phase IIb M-ACCEL trial with more than 220 patients with readout expected in H1 2025.
  • Edgewise Therapeutics, our newest holding, reported positive early healthy volunteer and patient data for EDG-7500. Our investment thesis of separating obstruction gradient reduction from ejection fraction reduction has been validated. We expect additional repeat dose patient data early next year to confirm the potential in hypertrophic cardiomyopathy (HCM) and beyond.
  • Wave Life Sciences reported promising interim results for WVE-N531 in boys with Duchenne muscular dystrophy, with feedback on accelerated approval expected in Q1 2025. As a result, we expect the company to advance other exon-skipping assets into the clinic.

Financing and M&A

In the third quarter, several biotech companies raised capital following positive pipeline developments, including Ionis Pharmaceuticals, Relay Therapeutics, and Wave Life Sciences. We typically directly support our portfolio companies in such transactions with capital injections, participating in Relay Therapeutics's offerings due to key data that aligned with our investment thesis. Ionis Pharmaceuticals's capital increase was perceived as unexpected, as the company was already well capitalized. While Wave Life Sciences's DMD program showed promise, our focus remains on its AIMers RNA editing platform and A1ATD program, with ongoing updates expected. M&A activity has significantly slowed in 2024 compared to 2023 but may rebound after the U.S. presidential election in November.

Outlook for the remainder of 2024

In September, the US Federal Reserve implemented its first interest rate cut in four years, signaling a shift that could benefit growth sectors like biotech by easing funding conditions. This change, coupled with potential policy shifts, will be important to monitor throughout the remainder of 2024.

The US presidential election and possible shifts in the control of Congress may influence healthcare policy and drug pricing. While healthcare has not been central to campaign discussions, medical costs – particularly drug pricing – remain a key concern for voters. Despite being politically supported by the Biden Administration, the Inflation Reduction Act (IRA) negotiations have had limited impact on cost savings thus far. Key challenges remain, including eligibility timelines for small molecules and biologics, and the orphan drug exemptions. Addressing these issues will likely require bipartisan cooperation. Additionally, as of 2025, Medicare Part D's USD 2 000 out-of-pocket cap could improve drug adherence and compliance, benefiting the broader healthcare system.

Many of our portfolio companies have strengthened their financial positions, and we are confident that they are positioned for positive clinical news, upcoming approvals, and launches in the months ahead. This view is reinforced by improving capital markets and a gradually reawakening IPO market, signaling renewed investor interest. Within the small and mid-cap space, we have seen multiple positive clinical milestones across the industry and within our portfolio, leading to notable share price inflections, enabling companies to secure funding and move onto new growth trajectories.

BB Biotech remains optimistic about the sector's prospects. Major patent cliffs are looming for big pharma through the end of the decade and beyond; this will likely drive further M&A activity as organic pipelines struggle to replace lost revenues, generating ongoing consolidation. With our strengthened fundamentals, upcoming clinical milestones, and supportive market dynamics, we are well-positioned to capitalize on opportunities and navigate challenges through the remainder of 2024.

We thank you for your continued trust. As we work through a challenging market environment, we remain committed to executing our strategy and delivering long-term value for our shareholders.

The Board of Directors of BB Biotech AG

Dr. Thomas von Planta Chairman Laura Hamill Member Camilla Soenderby Member

Dr. Clive Meanwell Vice-Chairman Dr. Pearl Huang Member Prof. Dr. Mads Krogsgaard Thomsen Member

Portfolio at a glance

Securities as at September 30, 2024

Company Number
of
securities
Change
since
31.12.2023
Local
currency
Share
price
Market
value
in CHF
mn
In % of
securities
In % of
shareholders'
equity
In % of
company
Argenx SE 630 000 (195 000) USD 542.08 288.8 11.5% 13.0% 1.1%
Ionis Pharmaceuticals 7 850 000 (740 000) USD 40.06 265.9 10.6% 11.9% 5.0%
Vertex Pharmaceuticals 510 000 (130 000) USD 465.08 200.6 8.0% 9.0% 0.2%
Revolution Medicines 4 858 760 (187 940) USD 45.35 186.3 7.4% 8.4% 2.9%
Alnylam Pharmaceuticals 800 000 (59 700) USD 275.03 186.1 7.4% 8.3% 0.6%
Neurocrine Biosciences 1 860 000 (550 000) USD 115.22 181.2 7.2% 8.1% 1.8%
Intra-Cellular Therapies 2 470 000 (570 000) USD 73.17 152.8 6.1% 6.9% 2.3%
Agios Pharmaceuticals 3 735 915 (264 085) USD 44.43 140.4 5.6% 6.3% 6.6%
Incyte 2 150 000 USD 66.10 120.2 4.8% 5.4% 1.1%
Moderna 1 600 000 (291 075) USD 66.83 90.4 3.6% 4.1% 0.4%
Celldex Therapeutics 3 071 615 655 319 USD 33.99 88.3 3.5% 4.0% 4.6%
Biohaven 2 040 853 965 853 USD 49.97 86.2 3.4% 3.9% 2.2%
Arvinas 2 380 000 (114 531) USD 24.63 49.6 2.0% 2.2% 3.5%
Relay Therapeutics 7 375 000 1 450 000 USD 7.08 44.2 1.8% 2.0% 4.6%
Essa Pharma 7 879 583 USD 6.06 40.4 1.6% 1.8% 17.8%
Exelixis 1 600 000 (400 000) USD 25.95 35.1 1.4% 1.6% 0.6%
Rivus Pharmaceuticals 1) USD 34.9 1.4% 1.6%
Edgewise Therapeutics 1 428 929 1 428 929 USD 26.69 32.2 1.3% 1.4% 1.5%
Immunocore 1 205 464 239 810 USD 31.13 31.7 1.3% 1.4% 2.4%
Beam Therapeutics 1 518 121 825 000 USD 24.50 31.5 1.3% 1.4% 1.8%
Black Diamond Therapeutics 8 517 839 USD 4.35 31.3 1.3% 1.4% 15.1%
Wave Life Sciences 4 094 458 (400 000) USD 8.20 28.4 1.1% 1.3% 2.8%
Macrogenics 9 929 963 USD 3.29 27.6 1.1% 1.2% 15.8%
Sage Therapeutics 4 460 693 955 693 USD 7.22 27.2 1.1% 1.2% 7.3%
Annexon 5 157 290 5 157 290 USD 5.92 25.8 1.0% 1.2% 4.9%
Crispr Therapeutics 610 000 (270 000) USD 46.98 24.2 1.0% 1.1% 0.7%
Scholar Rock Holding 2 132 725 USD 8.01 14.4 0.6% 0.6% 2.7%
Fate Therapeutics 4 839 779 USD 3.50 14.3 0.6% 0.6% 4.2%
Esperion Therapeutics 9 944 064 5 750 000 USD 1.65 13.9 0.6% 0.6% 5.1%
Generation Bio Co. 3 918 856 310 576 USD 2.47 8.2 0.3% 0.4% 5.9%
Molecular Templates 1 279 820 250 000 USD 1.41 1.5 0.1% 0.1% 19.4%
Molecular Templates –
Prefunded Warrant
134 667 134 667 USD 1.41 0.2 0.0% 0.0%
Molecular Templates –
Warrants, 2.4.29
769 334 769 334 USD 0.00 0.0 0.0% 0.0%
Radius Health –
Contingent Value Right
8 733 538 USD 0.00 0.0 0.0% 0.0%
Total securities 2 503.8 100.0% 112.3%
Other assets 2.4 0.1%
Other payables (277.2) (12.4%)
Net Asset Value 2 229.0 100.0%

1 Unlisted company

Exchange rate as at 30.09.2024: USD/CHF: 0.8456

Consolidated balance sheet

in CHF 1 000 Notes 30.09.2024 31.12.2023
Current assets
Cash and cash equivalents 2 246 501
Receivables from brokers 1 829
Securities 3 2 503 832 2 634 714
Other assets 109 110
2 506 187 2 637 154
Total assets 2 506 187 2 637 154
Current liabilities
Short-term borrowings from banks 4 274 300 304 900
Payables to brokers 5 436
Other short-term liabilities 2 858 3 491
Tax liabilities 74 110
277 232 313 937
Total liabilities 277 232 313 937
Shareholders' equity
Share capital 5 11 080 11 080
Treasury shares 5 (37 321) (36 508)
Retained earnings 2 255 196 2 348 645
2 228 955 2 323 217
Total liabilities and shareholders' equity 2 506 187 2 637 154
Net asset value per share in CHF 40.65 42.35

The notes are an integral part of the condensed consolidated interim financial statements.

The condensed consolidated interim financial statements were approved by the Board of Directors of BB Biotech AG on October 22, 2024.

Consolidated statement of comprehensive income

in CHF 1 000 Notes 01.01.–30.09.2024 01.01.–30.09.2023 01.07.–30.09.2024 01.07.–30.09.2023
Operating income
Gains from securities 3 44 460
Interest income 32 17
Foreign exchange gains 600 100
Other income 6 5 1
44 498 622 1 100
Operating expenses
Losses from securities 3 (285 455) (148 448) (39 135)
Finance expenses (4 202) (4 219) (1 197) (1 669)
Foreign exchange losses (51) (41)
Administrative expenses 6 (20 896) (23 276) (6 572) (6 981)
Other expenses (3 049) (3 350) (893) (690)
(28 198) (316 300) (157 151) (48 475)
Profit/(loss) before tax 7 16 300 (315 678) (157 150) (48 375)
Income taxes (57) (45) (19) (15)
Profit/(loss) for the
period
16 243 (315 723) (157 169) (48 390)
Total comprehensive
profit/(loss) for the
period
16 243 (315 723) (157 169) (48 390)
Earnings per share in CHF 8 0.30 (5.76) (2.87) (0.89)
Diluted earnings per share
in CHF
8 0.30 (5.76) (2.87) (0.89)

The notes are an integral part of the condensed consolidated interim financial statements.

Consolidated statement of changes in equity

in CHF 1 000 Share
capital
Treasury
shares
Retained
earnings
Total
Balances at January 1, 2023 11 080 (36 508) 2 711 563 2 686 135
Dividend (CHF 2.85 per share) (156 311) (156 311)
Total comprehensive income for the period (315 723) (315 723)
Balances at September 30, 2023 11 080 (36 508) 2 239 529 2 214 101
Balances at January 1, 2024 11 080 (36 508) 2 348 645 2 323 217
Dividend (CHF 2.00 per share) (109 692) (109 692)
Trade with treasury shares (813) (813)
Total comprehensive income for the period 16 243 16 243
Balances at September 30, 2024 11 080 (37 321) 2 255 196 2 228 955

The notes are an integral part of the condensed consolidated interim financial statements.

Consolidated statement of cash flows

in CHF 1 000 Notes 01.01.–30.09.2024 01.01.–30.09.2023
Cash flows from operating activities
Proceeds from sales of securities 3 390 279 303 675
Purchase of securities 3 (218 544) (56 602)
Interest receipts 32 17
Payments for services (24 595) (27 810)
Income taxes paid (69) (76)
Total cash flows from operating activities 147 103 219 204
Cash flows from financing activities
Dividend (109 692) (156 311)
Purchase of treasury shares 5 (813)
Repayment of borrowings 4 (30 600) (60 900)
Interest payments (4 202) (4 219)
Total cash flows from financing activities (145 307) (221 430)
Foreign exchange difference (51) 600
Change in cash and cash equivalents 1 745 (1 626)
Cash and cash equivalents at the beginning of the period 501 1 948
Cash and cash equivalents at the end of the period 2 246 322

The notes are an integral part of the condensed consolidated interim financial statements.

Notes to the consolidated financial statements

1. The Company and its principal activity

(the Company) is listed on the SIX Swiss Exchange as well as in the «Prime Standard Segment» of the German Exchange and has its registered office in Schaffhausen, Schwertstrasse 6. Its principal activity is to invest in companies active in the biotechnology industry for the purpose of capital appreciation. The investments are held through its wholly owned subsidiaries. BB Biotech AG

Company Capital
in CHF 1 000
Capital and
voting interest
in %
Biotech Focus N.V., Curaçao 11 100
Biotech Growth N.V., Curaçao 11 100
Biotech Invest N.V., Curaçao 11 100
Biotech Target N.V., Curaçao 11 100

2. Accounting policies

The condensed consolidated interim financial statements of the Company and its subsidiary companies (the Group) have been prepared in accordance with International Accounting Standards (IAS) 34 «Interim Financial Reporting,» as well as the provisions of the rules of the SIX Swiss Exchange for Investment Companies and should be read in conjunction with the consolidated annual financial statements for the year ended December 31, 2023. The preparation of the condensed consolidated interim financial statements requires management to make assumptions and estimates that have an impact on the balance sheet values and items of the statement of comprehensive income in the current financial period. In certain circumstances, the actual values may diverge from these estimates.

The condensed consolidated interim financial statements have been prepared in accordance with the accounting policies set out in the consolidated annual financial statements.

The following amended standards, valid since January 1, 2024, have been applied in these condensed consolidated interim financial statements:

  • IFRS 16 (amended, effective January 1, 2024) Lease Liability in a Sale and Leaseback
  • IFRS 7/IAS 7 (amended, effective January 1, 2024) Disclosures Supplier Finance Arrangements
  • IAS 1 (amended, effective January 1, 2024) Classification of Liabilities as Current or Noncurrent
  • IAS 1 (amended, effective January 1, 2024) Non-current Liabilities with Covenants

The following amended standard was approved, but will only be applicable for the Group prospectively and was not early adopted in these condensed consolidated interim financial statements:

IAS 21 (amended, effective January 1, 2025) – Lack of Exchangeability

The Board of Directors do not expect that the adoption of the above-mentioned standard will have a material impact on the financial statements of the Group in future periods.

The following exchange rates have been used for the preparation of these condensed consolidated interim financial statements:

Currency 30.09.2024 31.12.2023
USD 0.84560 0.84140
ANG 0.47506 0.47270
EUR 0.94157 0.92887
GBP 1.11350 1.07160

3. Financial assets

Fair Values

The following table presents the Group's assets that are measured at fair value (in CHF 1 000):

30.09.2024 Level 1 Level 2 Level 3 Total
Assets
Securities
- Shares 2 468 778 34 894 2 503 672
- Derivative instruments 160 160
Total assets 2 468 778 160 34 894 2 503 832
31.12.2023
Assets
Securities
- Shares 2 619 989 14 725 2 634 714
- Derivative instruments
Total assets 2 619 989 14 725 2 634 714

The table below summarizes the transactions in level 3 instruments (in CHF 1 000):

01.01.–30.09.2024 01.01.–30.09.2023
Opening balance 14 725 16 179
Purchases 15 139
Unrealized gains/(losses) included in gains/losses from securities 5 030 (161)
Closing balance 34 894 16 018
Gains/(losses) on level 3 instruments included in gains/losses from securities 5 030 (161)

There were no transfers between level 1, 2 and 3 during the reporting period.

The fair value of the level 2 instruments at initial recognition represents the transaction price (purchase of warrants / prefunded warrants of Molecular Templates in April 2024 at TCHF 316), which was paid as part of a financing round together with other investors. The

valuation as of September 30, 2024, is based on a model that takes current market conditions into account.

The fair value of level 3 instruments at initial recognition represents the transaction price (purchase of preferred stocks of Rivus Pharmaceuticals in August 2022 for TCHF 16 875 and August 2024 for TCHF 15 139), which was paid in financing rounds together with other investors. For the valuation as at September 30, 2024, it is deemed to be appropriate to use the latest transaction price in USD, as it is a reasonable approximation of fair value at the valuation date given the fact that no events occurred which significantly impact the fair value.

In August 2022, Radius Health – Contingent Value Rights were allocated from a corporate action. The valuation as of 2024, is 8 733 538 September 30, CHF 0.

For assets and liabilities carried at amortised cost, their carrying values are a reasonable approximation of fair value.

Securities

The changes in value of securities at fair value through profit or loss by investment category are as follows (in CHF 1 000):

Listed
shares
Unlisted
shares
Derivative
instruments
Total
Opening balance as at 01.01.2023 at fair values 3 035 170 16 179 3 051 349
Purchases 201 147 201 147
Sales (451 169) (451 169)
Gains/(losses) from securities (165 158) (1 454) (166 613)
Realized gains 28 749 28 749
Realized losses (46 543) (46 543)
Unrealized gains 276 764 276 764
Unrealized losses (424 128) (1 454) (425 582)
Closing balance as at 31.12.2023 at fair values 2 619 989 14 725 2 634 714
Opening balance as at 01.01.2024 at fair values 2 619 989 14 725 2 634 714
Purchases 197 653 15 139 316 213 108
Sales (388 450) (388 450)
Gains/(losses) from securities 39 586 5 030 (156) 44 460
Realized gains 60 709 60 709
Realized losses
Unrealized gains 371 445 5 030 376 475
Unrealized losses (392 568) (156) (392 724)
Closing balance as at 30.09.2024 at fair values 2 468 778 34 894 160 2 503 832

Securities comprise the following:

Company Number
31.12.2023
Change Number
30.09.2024
Market price in
original currency
30.09.2024
Valuation
CHF mn
30.09.2024
Valuation
CHF mn
31.12.2023
Argenx SE 825 000 (195 000) 630 000 USD 542.08 288.8 264.1
Ionis Pharmaceuticals 8 590 000 (740 000) 7 850 000 USD 40.06 265.9 365.6
Vertex Pharmaceuticals 640 000 (130 000) 510 000 USD 465.08 200.6 219.1
Revolution Medicines 5 046 700 (187 940) 4 858 760 USD 45.35 186.3 121.8
Alnylam Pharmaceuticals 859 700 (59 700) 800 000 USD 275.03 186.1 138.5
Neurocrine Biosciences 2 410 000 (550 000) 1 860 000 USD 115.22 181.2 267.2
Intra-Cellular Therapies 3 040 000 (570 000) 2 470 000 USD 73.17 152.8 183.2
Agios Pharmaceuticals 4 000 000 (264 085) 3 735 915 USD 44.43 140.4 75.0
Incyte 2 150 000 2 150 000 USD 66.10 120.2 113.6
Moderna 1 891 075 (291 075) 1 600 000 USD 66.83 90.4 158.2
Celldex Therapeutics 2 416 296 655 319 3 071 615 USD 33.99 88.3 80.6
Biohaven 1 075 000 965 853 2 040 853 USD 49.97 86.2 38.7
Arvinas 2 494 531 (114 531) 2 380 000 USD 24.63 49.6 86.4
Relay Therapeutics 5 925 000 1 450 000 7 375 000 USD 7.08 44.2 54.9
Essa Pharma 7 879 583 7 879 583 USD 6.06 40.4 43.8
Exelixis 2 000 000 (400 000) 1 600 000 USD 25.95 35.1 40.4
Edgewise Therapeutics 1 428 929 1 428 929 USD 26.69 32.2
Immunocore 965 654 239 810 1 205 464 USD 31.13 31.7 55.5
Beam Therapeutics 693 121 825 000 1 518 121 USD 24.50 31.5 15.9
Black Diamond Therapeutics 8 517 839 8 517 839 USD 4.35 31.3 20.1
Wave Life Sciences 4 494 458 (400 000) 4 094 458 USD 8.20 28.4 19.1
Macrogenics 9 929 963 9 929 963 USD 3.29 27.6 80.4
Sage Therapeutics 3 505 000 955 693 4 460 693 USD 7.22 27.2 63.9
Annexon 5 157 290 5 157 290 USD 5.92 25.8
Crispr Therapeutics 880 000 (270 000) 610 000 USD 46.98 24.2 46.4
Scholar Rock Holding 2 132 725 2 132 725 USD 8.01 14.4 33.7
Fate Therapeutics 4 839 779 4 839 779 USD 3.50 14.3 15.2
Esperion Therapeutics 4 194 064 5 750 000 9 944 064 USD 1.65 13.9 10.6
Generation Bio Co. 3 608 280 310 576 3 918 856 USD 2.47 8.2 5.0
Molecular Templates 1 029 820 250 000 1 279 820 USD 1.41 1.5 3.2
Listed shares 2 468.7 2 620.0
Rivus Pharmaceuticals USD 34.9 14.7
Unlisted shares 34.9 14.7
Total shares 2 503.6 2 634.7
Molecular Templates –
Prefunded Warrant
134 667 134 667 USD 1.41 0.2
Molecular Templates –
Warrants, 2.4.29
769 334 769 334 USD 0.00 0.0
Radius Health –
Contingent Value Right
8 733 538 8 733 538 USD 0.00 0.0
Total derivative instruments 0.2
Total securities 2 503.8 2 634.7

4. Short-term borrowings from banks

At September 30, 2024, a short-term loan is outstanding with interest payable at 1.55% p.a. (December 31, 2023: at 2.10% p.a.). CHF 274.3 mn CHF 304.9 mn

5. Shareholders' equity

The share capital of the Company consists of fully paid registered shares (December 31, 2023: ) with a par value of each (December 31, 2023: ). 55.4 mn 55.4 mn CHF 0.20 CHF 0.20

Treasury shares

The Company can buy and sell treasury shares in accordance with the Company's articles of association and Swiss company law and in compliance with the listing rules of the SIX Swiss Exchange. During the period from to 2024, the Company has bought 20 000 treasury shares and has not sold any treasury shares (01.01.–30.09.2023: no transactions). As at September 30, 2024, the Company holds treasury shares ( : ). The treasury shares as at September 30, 2024, were treated as a deduction from the consolidated shareholders' equity using cost values of (December 31, 2023: ). January 1, 2024, September 30, 574 000 December 31, 2023 554 000 shares TCHF 37 321 TCHF 36 508

Share buyback 2 line (bought for cancellation) nd

In April 2022, the Board of Directors has approved the repurchase of a maximum of own registered shares with a nominal value of each. The share buy-back program will run from April 13, 2022 until April 11, 2025 at the latest. Until September 30, 2024, 20 000 shares had been repurchased under this share buy-back program (December 31, 2023: no shares). The repurchase will take place via second trading line for the purpose of a subsequent capital reduction. 5 540 000 CHF 0.20

6. Administrative expenses

Administrative expenses comprise the following:

in CHF 1 000 01.01.–30.09.2024 01.01.–30.09.2023
Investment manager
– Management fees 19 295 21 685
Personnel
– Board of Directors remuneration 1 250 1 260
– Wages and salaries 251 237
– Social insurance contributions and duties 100 95
20 896 23 276

The remuneration model of BB Biotech AG is determined by the Board of Directors.

Since 2014 the remuneration paid to the investment manager is based upon a 1.1% p.a. all-in fee on the average market capitalization without any additional fixed or performance-based elements of compensation. The compensation of the Board of Directors consists since 2014 of a fixed compensation.

7. Segment reporting

The sole operating segment of the Group reflects the internal management structure and is evaluated on an overall basis. Revenue is derived by investing in a portfolio of companies active in the biotechnology industry for the purpose of capital appreciation. The following results correspond to the sole operating segment of investing in companies active in the biotechnology industry.

The geographical analysis of the profit/(loss) before tax is as follows – all income from financial assets are attributed to a country based on the domiciliation of the issuer of the instrument.

Profit/(loss) before tax in CHF 1 000 01.01.–30.09.2024 01.01.–30.09.2023
Netherlands 97 442 85 895
British Virgin Islands 13 009
Singapore 11 727 (5 432)
Canada (3 380) 3 928
Switzerland (9 726) (32)
Curaçao (24 613) (26 686)
Great Britain (32 457) 1 818
USA (35 702) (375 169)
16 300 (315 678)

8. Earnings per share

01.01.–30.09.2024 01.01.–30.09.2023
Total comprehensive profit/(loss) for the period (in CHF 1 000) 16 243 (315 723)
Weighted average number of shares in issue 54 842 000 54 846 000
Earnings per share in CHF 0.30 (5.76)
Income used to determine diluted earnings per share (in CHF 1 000) 16 243 (315 723)
Weighted average number of shares in issue following the dilution 54 842 000 54 846 000
Diluted earnings per share in CHF 0.30 (5.76)

9. Assets pledged

At 2024, securities in the amount of (December 31, 2023: ) are collateral for a credit line of ( 2023: ). At , a short-term loan is outstanding 2023: ). September 30, CHF 2 503.8 mn CHF 2 634.7 mn CHF 700 mn December 31, CHF 700 mn September 30, 2024 CHF 274.3 mn (December 31, CHF 304.9 mn

10. Transactions with the Investment Manager and related party transactions

Detailed information regarding the remuneration model for the Board of Directors and the investment manager are mentioned under note «6. Administrative Expenses».

11. Commitments, contingencies and other offbalance sheet transactions

The Group had no commitments or other off-balance sheet transactions open at September 30, 2024 and December 31, 2023.

The operations of the Group are affected by legislative, fiscal and regulatory developments for which provisions are made where deemed necessary. The Board of Directors concludes that as at September 30, 2024, no proceedings existed which could have any material effect on the financial position of the Group (December 31, 2023: none).

12. Subsequent events

There have been no events subsequent to , which would affect the condensed consolidated interim financial statements. September 30, 2024

Report on the review of condensed consolidated interim financial statements

Introduction

In accordance with the terms of our engagement, we have reviewed the condensed consolidated interim financial statements (consolidated balance sheet, consolidated statement of comprehensive income, consolidated statement of changes in equity, consolidated statement of cash flows and selected explanatory notes) of for the period ended 30 September 2024. BB Biotech AG

These condensed consolidated interim financial statements in accordance with International Accounting Standard 34 «Interim Financial Reporting» and article 14 of the Directive on Financial Reporting of the SIX Swiss Exchange are the responsibility of the Board of Directors whereas our responsibility is to issue a report on these condensed consolidated interim financial statements based on our review.

Scope of Review

We conducted our review in accordance with the Swiss Auditing Standard 910 (SAS 910) «Engagements to Review Financial Statements» and the International Standard on Review Engagements (ISRE) 2410 «Review of interim financial information performed by the independent auditor of the entity». This Standard requires that we plan and perform the review to obtain moderate assurance as to whether the condensed consolidated interim financial statements are free of material misstatements. A review is limited primarily to inquiries of company personnel and analytical procedures applied to financial data and thus provides less assurance than an audit. We have not performed an audit and accordingly, we do not express an audit opinion.

Conclusion

Based on our review, nothing has come to our attention that causes us to believe that the accompanying condensed consolidated interim financial statements do not give a true and fair view of all material respects of the net assets, the financial position and results of operations in accordance with International Accounting Standard 34 Interim Financial Reporting and article 14 of the Directive on Financial Reporting of the SIX Swiss Exchange.

Deloitte AG

Marcel Meyer

Audit expert Auditor in charge Severin Holder Audit expert

Zurich, 23 October 2024

Deloitte AG, Pfingstweidstrasse 11, CH-8005 Zurich Phone: +41 (0)58 279 60 00, Fax: +41 (0)58 279 66 00, www.deloitte.ch

Company profile

Excellence in Biotech Investments

The access to fast growing biotechnology companies

invests in companies in the fast growing market of biotechnology and is one of the world's largest investors in this sector with 30 years of experience. The shares of are listed on the SIX Swiss Exchange and the Frankfurt Stock Exchange. Its investments are focused on listed companies that are developing and commercializing novel drugs that offer sound value for the healthcare system. BB Biotech BB Biotech

The competent Board of Directors with its long-standing experience set the investment strategy and guidelines. Investment decisions are taken by the experienced investment management team of Bellevue Asset Management AG based on their extensive investment research.

Biotechnology is one of the most attractive of any sector today with estimated long-term annual growth in the double-digits. Mega trends such as increasing life expectancy and a Westernized diet and lifestyle are powerful growth drivers. These mega trends have led to a tremendous increase in healthcare costs, which, in turn, only amplifies the need for more efficient and effective drugs.

Investment strategy

invests in fast-growing biotechnology companies that are developing and marketing innovative drugs. It focuses on biotech companies whose products address areas of significant unmet medical needs and thus have above-average sales and profit-growth potential. BB Biotech

Besides profitable large cap companies, is building up its investments in promising small and mid cap companies. BB Biotech

Diversified portfolio with focus on small and mid cap biotech companies

The team of investment experts is concentrating not only on established target areas such as oncology, orphan diseases and neurological indications, but also on the technologies of tomorrow that could lead to novel treatment methods with attractive therapeutic profiles and substantial economic rewards. These future technologies include RNA platforms and cell and gene therapies. An overall weighted average cost of capital (WACC) of at least 15% is applied to the discounted cash flow models of our portfolio, aligned with our mid-to long term investment objectives.

The asset classes available to are direct investments in the shares of listed companies, equity interests in unlisted companies, corporate bonds, and options on a range of underlying assets. invests almost exclusively in stocks for liquidity and risk/ return reasons. At least 90% of its shareholdings must be in listed companies, while always holding more than 50% of its assets in equity investments. Corporate bonds are an alternative primarily when stock market trends are negative. Options on the stocks of portfolio companies can be bought and sold at opportune times and as a means of hedging currency exposure. BB Biotech BB Biotech

We are focussing on the technologies of tomorrow.

Multi-stage due diligence process based on bottom-up fundamental analysis

Exhaustive, multi-stage due diligence precedes the selection of individual investments. We must have a thorough understanding of every company we invest in. Before an investment is made, the team analyzes a company's financial statements in detail and assesses its competitive environment, R&D pipeline, and patent portfolio as well as its customers' perceptions of its products and services.

Close contact with company executives is of high importance to us in this due diligence process, but also afterwards, as we believe that it takes strong leaders to achieve strong results.

relies on the long-standing experience of its distinguished Board of Directors and on the fundamental analysis of the experienced Investment Management Team of Bellevue Asset Management AG when making its investment decisions. It can also turn to an extensive international network of physicians and specialists in individual sub-segments of the biotech industry for further support and advice. BB Biotech

The Investment Management Team creates detailed financial models for all portfolio holdings and they must provide compelling arguments that these holdings have the potential to double in value over a four-year time frame. The team is guided by its convictions, not by benchmark considerations. Upside potential is driven in most cases by the power of innovation, the launch of new products for serious or significant illnesses, and successful company management. Each investment case is constantly monitored and evaluated within the scope of our stringent and disciplined risk management process and corrective action will be taken if and when necessary.

We follow our own conviction, not a benchmark.

High conviction portfolio consisting of a maximum of 35 positions

investment portfolio will usually consist of between 20 to 35 biotechnology companies. There are estblished large cap companies as well as small and mid cap companies in the portfolio. Smaller positions will be taken in innovative biotech companies with promising R&D pipelines. From a regional perspective, the US biotech sector has displayed a high level of innovation and so this regional bias is also reflected in portfolio. The predominance of the US biotech industry can be traced to the country's stellar research clusters, industry-friendly regulatory frameworks and myriad financing options, among other factors. BB Biotech's BB Biotech's

New investments in small and mid cap companies will have a weighting of between 0.5% and a maximum of 4% to ensure that both upside potential and R&D risks are adequately addressed. Because it is a holding company, has the flexibility to increase portfolio weightings considerably over time as a position increases in value. Smaller positions may become a top holding as their business develops and milestones such as positive Phase III outcomes, drug approvals, the successful marketing of products, and a sustainable flow of profits are achieved. All positions and their valuations are continually monitored, taking into account their growth potential and other aspects, and will be reduced if and when appropriate. BB Biotech

Investment process

During the investment selection process, relies on the well established experience of its Board of Directors and the fundamental analyses by the experienced management team of Bellevue Asset Management AG, with access to a network of physicians and specialists for the sectors in question. BB Biotech

Investment process

Source: Bellevue Asset Management

Using a multi-stage process, the universe of around companies is systematically analyzed and evaluated. The use of artificial intelligence is being explored to deepen our knowledge and understanding. A detailed financial model is created for each investment, which must convincingly demonstrate the potential to double in value over a four-year period. This potential to double in value is based on innovative strength, new products for serious diseases and outstanding management. Each investment is systematically reviewed for sustainability risks and breaches of elementary human rights. Bellevue Asset Management AG is a signatory of UN Principles for Responsible Investment. Besides upholding strict exclusion criteria – such as serious controversies that violate universal norms regarding the environment, human rights or good corporate governance – environmental, social and governance factors are integrated into the fundamental analysis of every company through an ESG integration process in which the associated financial risks or opportunities are evaluated with respect to future stock market performance. The Investment Management Team strive to have an active and constructive dialogue with the management or other relevant stakeholders of the portfolio companies regarding environmental, social and governance aspects – and via proxy voting we use our voting rights actively at the general meetings. 1 000

With all of investments focusing on biotechnology as a subsector of the healthcare industry, the UN's Sustainable Development Goal number 3: «Good Health and Well-being», is at the core of investment strategy and our portfolio companies. The investments of provide companies with capital in order to allow for drug development to ensure and improve healthy lives and well-being. Therapies to address high unmet medical needs such as for patients suffering from rare disorders, cancer, neurological diseases and chronic cardiovascular and metabolic disorders etc. are key investment selection criteria. BB Biotech´s BB Biotech's BB Biotech AG

Sustainability at portfolio level

Our investment process fully implements Bellevue Asset Management's formal ESG investment guidelines and therewith all investments are systematically reviewed for sustainability risks and breaches of elementary human rights (as defined, for example, by UN Global Compact principles). Besides upholding strict exclusion criteria – such as serious controversies that violate universal norms regarding the environment, human rights or good corporate governance – environmental, social and governance factors are integrated into the fundamental analysis of every company through an ESG integration process in which the associated financial risks or opportunities are evaluated with respect to future price development. ESG ratings compiled by the global leading ESG research provider MSCI ESG Research are referenced in this process, all the while exercising the necessary prudence and, in some cases, questioning the ESG score. BB Biotech

Before making a positive investment decision, intensive contact is established with the target company's management, since we are convinced that a superior performance can only be achieved with well managed companies.

After being incorporated into portfolio, intense personal contact is maintained with members of the management of the relevant holdings. This closely knit monitoring of the portfolio companies enables to utilize all strategic options on a timely basis, including the early disposal of an equity interest should the fundamental situation significantly deteriorate. BB Biotech's BB Biotech

Board of Directors

The Board of Directors of BB Biotech consists of the following members:

  • Dr. Thomas von Planta (Chairman)
  • Dr. Clive Meanwell (Vice-Chairman)
  • Laura Hamill
  • Dr. Pearl Huang
  • Camilla Soenderby
  • Prof. Dr. Mads Krogsgaard Thomsen

Investment Manager

Bellevue Asset Management AG

Investment Manager is Bellevue Asset Management AG. Bellevue Asset Management AG is subject to supervision by the Swiss Financial Market Supervisory Authority (FINMA) and it has been issued a license as an authorized manager of collective investment schemes. Bellevue Asset Management AG is wholly owned by Bellevue Group AG, an independent Swiss financial boutique listed on the SIX Swiss Exchange. Bellevue Asset Management provides administrative services in connection with the investment activities and organizational operations of . This basically comprises the following services: BB Biotech's BB Biotech AG

  • Portfolio Management
  • Investor Relations
  • Marketing & Communications
  • Finance
  • Administration

Investment Management Team

Bellevue Asset Management AG has a team of proven biotech specialists with a successful track record who manage the investments in the biotech sector's most attractive players. The team's academic expertise and extensive experience, its long history of collaboration and interest in all fields of medicine as well as in biochemistry and business fundamentals ensure an inspiring and constructive interdisciplinary dialog within the team and with the Board of Directors as well as with external experts such as physicians and analysts.

The following experts are member of the Investment Management Team:

  • Dr. Daniel Koller (Head)
  • Dr. Maurizio Bernasconi (Deputy Head)
  • Dr. Christian Koch (Deputy Head)
  • Dr. Can Buldun-Gora
  • Dr. Samuel Croset
  • Dr. Leonidas Georgiou
  • Dr. Stephen Taubenfeld
  • Dallas Webb
  • Dr. Olivia Woolley

Shareholder information

The Company publishes its Net Asset Value daily via the major stock market information services and on its website . The portfolio composition is published at least every three months within quarterly reports. www.bbbiotech.com

Official listing and share structure as at September 30, 2024

Foundation: November 9, 1993; Schaffhausen, Switzerland
CHF 4.75
Switzerland: December 27, 1993
Germany: December 10, 1997
Issue price adj. November 15, 1993:
Official listing:
Share structure: CHF 11.08 mn nominal, 55 400 000 registered shares
with a par value of CHF 0.20 each
Shareholders, free-float: Institutional and private investors, 100% free-float
Security number Switzerland: 3 838 999
Security number Germany: A0NFN3
ISIN: CH0038389992

Quotes and reports

NAV: in CHF
– Datastream: S:BINA
in EUR – Datastream: D:BBNA
– Reuters: BABB – Reuters: BABB
– Telekurs: BIO resp. 85, BB1
– Finanz & Wirtschaft (CH)
Stock price: in CHF – Bloomberg: BION SW Equity in EUR – Bloomberg: BBZA GY Equity
(SIX) – Datastream: S:BIO (Xetra) – Datastream: D:BBZ
– Reuters: BION.S – Reuters: BION.DE
– Telekurs: BIO
– Finanz & Wirtschaft (CH)
– Neue Zürcher Zeitung (CH)

Facts & figures

BB Biotech

Foundation November 9, 1993, Schaffhausen, Switzerland
Issue price adj. 15.11.1993 CHF 4.75
Official Listing Switzerland: December 27, 1993
Germany: December 10, 1997
Share structure CHF 11.08 mn nominal, 55 400 000 registered shares
with a par value of CHF 0.20 each
Shareholders, free-float as at 30.09.2024 Institutional and private investors
100% free-float
Security number Switzerland 3 838 999
Security number Germany A0NFN3
ISIN CH0038389992
Ticker Bloomberg Switzerland: BION SW
Germany: BBZA GY
Ticker Reuters Switzerland: BION.S
Germany: BION.DE
Type / asset class Investment company / equity
Investment style Long only, long term
Index membership SPI Index, SPI ESG Index
Benchmark Nasdaq Biotech Index (NBI) TR
Management Fee All-in-Fee: 1.1% p.a.

Analyst coverage

Institute Analyst
Baader Helvea Leonildo Delgado
Edison Joanne Collins
Kepler Cheuvreux Nicolas Pauillac
Oddo BHF Oussame Denguir
Panmure Liberum Callum Stokeld
Pareto Securities Marietta Miemietz
SEB Martin Parkhoi

Corporate calendar

Portfolio as at December 31, 2024 January 24, 2025, 7.00 AM CET
February 21, 2025, 7.00 AM CET
March 19, 2025, 3.00 PM CET
Annual Report 2024
Annual General Meeting 2025
Interim Report as at March 31, 2025 April 25, 2025, 7.00 AM CET
Interim Report as at June 30, 2025 July 25, 2025, 7.00 AM CET
Interim Report as at September 30, 2025 October 24, 2025, 7.00 AM CET

Contact

Investor Relations

Dr. Silvia Siegfried-Schanz

Phone +41 44 267 72 66 E-Mail [email protected]

Claude Mikkelsen

Phone +44 755 704 85 77 E-Mail [email protected]

Maria-Grazia Alderuccio

Phone +41 44 267 67 14 E-Mail [email protected]

BB Biotech AG

Schwertstrasse 6 CH-8200 Schaffhausen Phone +41 52 624 08 45 E-Mail [email protected] www.bbbiotech.com

Bellevue Asset Management AG

Seestrasse 16 CH-8700 Küsnacht Phone +41 44 267 67 00 E-Mail [email protected] www.bellevue.ch

The interim report is published in English. A translated German version is also available. In case of any deviations the English shall prevail over the German text. BB Biotech

«For reasons of readability, the masculine form is used for gender-specific designations and personal nouns in this interim report. Corresponding terms apply to all genders in line with equal treatment. The abbreviated language form is only for editorial reasons and does not contain any value judgements. All genders may feel equally addressed by this content. We thank you for your understanding.»

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