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Valneva SE

Regulatory Filings Feb 12, 2013

1739_iss_2013-02-12_76b9c4bc-2260-4098-a3cf-1798e29d7ce4.pdf

Regulatory Filings

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VIVALIS ANNOUNCES A NEW EB66® CELL LINE RESEARCH LICENSE WITH A NORTH AMERICAN ANIMAL HEALTH VACCINE COMPANY

Nantes, Lyon (France) – 12 February 2013 − VIVALIS (NYSE Euronext: VLS) announced today that it has signed a research license agreement with the North American animal health vaccine company. The license allows for the assessment of several viruses in EB66 ® cells.

Franck Grimaud, CEO, and Majid Mehtali, CSO, co-managers of VIVALIS jointly stated, "Our development into the animal vaccines market with our EB66® cell line is advancing and intensifying as demonstrated by this new research license agreement. With this second agreement signed since the beginning of this year, we have shown that the EB66® cell line continues to stand as the cell line of choice for vaccine manufacturing over traditional manufacturing systems, in both human and animal health vaccines."

Terms of the agreement were not disclosed.

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Next financial press release: Q4 2012 Results February 14, 2013, after market closing

About VIVALIS (www.vivalis.com)

Vivalis (NYSE-Euronext: VLS) is a biopharmaceutical company that provides innovative cell-based solutions to the pharmaceutical industry for the manufacture of vaccines and recombinant proteins, and develops monoclonal antibodies for the prevention and treatment of pathologies with unmet medical needs. Vivalis' expertise and intellectual property are leveraged in two main areas:

1. EB66® Cell Line

Vivalis offers research and commercial licenses for its EB66® cell line, derived from duck embryonic stem cells, to pharmaceutical and biotechnology companies for the production of therapeutic and prophylactic viral vaccines, virosomes, VLPs and recombinant proteins, with a focus on monoclonal antibodies having enhanced cytotoxic activity. Clinical trials of EB66® produced vaccines are currently on-going in the USA and Japan. Through these programs, Vivalis receives a upfront payments, clinical stage milestone payments and royalties on licensees' net sales.

2. VIVA|Screen™ Human Antibody Discovery Platform

Customized solutions for the discovery, development and production of rare, fully human monoclonal antibodies are offered by Vivalis. Through these programs, Vivalis receives payments associated with the funding of discovery phase, upfront payments, clinical stage milestone payments, and royalties on net sales of licensed antibodies that are commercially developed and sold by our clients.

Based in Nantes and Lyon (France) and in Toyama (Japan), Vivalis was founded in 1999 by the Grimaud Group (ca. 1,700 employees), one of the worldwide leaders in animal genetic selection. Vivalis has established more than 30 partnerships and licenses with world leaders in this sector, including Sanofi Pasteur, GlaxoSmithKline, Transgene, Pfizer Animal Health, Kaketsuken, Kitasato Daiichi Sankyo Vaccine, Merial, Merck Animal Health and SAFC Biosciences. Vivalis is a member of the French ATLANTIC BIOTHERAPIES and LYON BIOPOLE bio-clusters and a member of the Japanese HOKURIKU INNOVATION CLUSTER FOR HEALTH SCIENCE in Toyama.

This document contains forward-looking statements and comments on the company's objectives and strategies. No guarantee can be given to any of the events anticipated by the forward which are subject to inherent risks, including risk factors described in the company's conditions, the financial markets or the markets in which the company operates. looking forward-looking statements contained in this document Document ancial looking document, E, changes in economic

Contacts

VIVALIS

Franck Grimaud, CEO Email: [email protected]

NewCap

Financial communications agency Axelle Vuillermet / Pierre Laurent Tel.: +33 (0) 1 44 71 Email: [email protected] 94 91

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