Mereo BioPharma Group plc

Major Shareholding Notification • Jun 5, 2020

National Storage Mechanism | Additional information

RNS Number : 1608P

Mereo BioPharma Group plc

05 June 2020

TR-1: Standard form for notification of major holdings

NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible)i
1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii:			Mereo BioPharma Group Plc
1b. Please indicate if the issuer is a non-UK issuer  (please mark with an "X" if appropriate)
Non-UK issuer
2. Reason for the notification (please mark the appropriate box or boxes with an "X")
An acquisition or disposal of voting rights						X
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify)iii:
3. Details of person subject to the notification obligationiv
Name			OrbiMed Advisors LLC
City and country of registered office (if applicable)			Delaware, USA
4. Full name of shareholder(s) (if different from 3.)v
Name			OrbiMed Private Investment VII, LP OrbiMed Partners Master Fund Limited OrbiMed Genesis Master Fund, LP
City and country of registered office (if applicable)			Delaware, USA Bermuda Cayman Islands
5. Date on which the threshold was crossed or reachedvi:			3 June 2020
6. Date on which issuer notified (DD/MM/YYYY):			5 June 2020
7. Total positions of person(s) subject to the notification obligation
	% of voting rights attached to shares (total of 8. A)	% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)		Total of both in % (8.A + 8.B)	Total number of voting rights of issuervii
Resulting situation on the date on which threshold was crossed or reached	9.39%			9.39%	213,652,487
Position of previous notification (if applicable)

8. Notified details of the resulting situation on the date on which the threshold was crossed or reachedviii
A: Voting rights attached to shares
Class/type of shares ISIN code (if possible)		Number of voting rightsix					% of voting rights
Direct (Art 9 of Directive 2004/109/EC) (DTR5.1)		Indirect (Art 10 of Directive 2004/109/EC) (DTR5.2.1)			Direct (Art 9 of Directive 2004/109/EC) (DTR5.1)		Indirect (Art 10 of Directive 2004/109/EC) (DTR5.2.1)
Ordinary shares GB00BZ4G2K23				20,061,437					9.39%
SUBTOTAL 8. A		20,061,437					9.39%
B 1: Financial Instruments according to Art. 13(1)(a) of Directive 2004/109/EC (DTR5.3.1.1 (a))
Type of financial instrument		Expiration datex	Exercise/ Conversion Periodxi			Number of voting rights that may be acquired if the instrument is exercised/converted.			% of voting rights
			SUBTOTAL 8. B 1
B 2: Financial Instruments with similar economic effect according to Art. 13(1)(b) of Directive 2004/109/EC (DTR5.3.1.1 (b))
Type of financial instrument	Expiration datex		Exercise/ Conversion Period xi		Physical or cash settlementxii			Number of voting rights	% of voting rights
					SUBTOTAL 8.B.2

9. Information in relation to the person subject to the notification obligation (please mark the applicable box with an "X")
Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuerxiii
Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entityxiv (please add additional rows as necessary)				x
Namexv	% of voting rights if it equals or is higher than the notifiable threshold	% of voting rights through financial instruments if it equals or is higher than the notifiable threshold	Total of both if it equals or is higher than the notifiable threshold
OrbiMed Private Investments VII, LP	5.01%
OrbiMed Partners Master Fund Limited	3.13%
OrbiMed Genesis Master Fund, LP	1.25%
10. In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held
11. Additional informationxvi
10,699,433 ordinary shares are held of record by OrbiMed Private Investments VII, LP ("OPI VII").  OrbiMed Capital GP VII LLC ("GP VII") is the general partner of OPI VII, and OrbiMed Advisors LLC ("OrbiMed Advisors") is the managing member of GP VII.  By virtue of such relationships, GP VII and OrbiMed Advisors may be deemed to have voting power and investment power over the securities held by OPI VII and as a result, may be deemed to have an interest in such securities. 6,687,146 ordinary shares are held of record by OrbiMed Partners Master Fund Limited ("OPM").  OrbiMed Capital LLC ("OrbiMed Capital") is the investment advisor of OPM.  OrbiMed Capital is a relying advisor of OrbiMed Advisors. 2,674,858 ordinary shares are held of record by OrbiMed Genesis Master Fund, LP ("Genesis").  OrbiMed Genesis GP LLC ("Genesis GP") is the general partner of Genesis.  OrbiMed Advisors is the managing member of Genesis GP. By virtue of such relationships, Genesis GP and OrbiMed Advisors may be deemed to have voting power and investment power over the securities held by Genesis and as a result, may be deemed to have an interest in such securities. OrbiMed Advisors and OrbiMed Capital exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and Jonathan T. Silverstein.

Place of completion	New York, NY USA
Date of completion	5 June 2020

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