Apontis Pharma AG

Investor Presentation • Aug 11, 2022

APONTIS PHARMA

The Single Pill Company

H1 2022 Results

Disclaimer

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APONTIS PHARMA Executive Team

Thomas Milz

Chief Product Officer

• Business Development
• Market Access
• Medical & Regulatory Affairs
• Product Development

Karlheinz Gast

Chief Executive Officer

• Strategy
• Marketing & Sales
• Human Resources
• Investor Relations

Thomas Zimmermann

Chief Finance Officer

• Finance
• Supply Chain
• IT
• Compliance

"Drug non-compliance is a stealth epidemic exacting a heavy toll on the healthcare system – our broad portfolio of Single Pills is designed to help tackle this epidemic"

APONTIS PHARMA with successful first half-year 2022

Financial Highlights H1 2022

Successful H1 2022 strengthens financial position

APONTIS PHARMA with successful first half-year 2022

New Single Pill launches, pipeline progress and extended cooperation

Launch	Marketing	Marketing	Development	Development	Co-Promotion	Divesture
of	authorization	authorization	agreement	agreement	agreement	of
Tonotec Lipid	granted	application	with	with	with	gynecology
and	for	submitted	Develco	Midas	AstraZeneca	products
		for	for	for	prolonged	(legacy)
AmloAtor	RosuASS	Caramlo HCT	2 Single Pills	2 Single Pills	2023

Further expansion of our Single Pill portfolio

APONTIS PHARMA with successful first half-year 2022

Business Execution

Full publications	Expansion	7.770 physicians	+10 sales reps	Limited physician
of	of promotional	trained	to support	access
START-study	activities to	on	Single Pills	related to
in	rehabilitation	START-study	and	additional
peer-reviewed	hospitals	Single Pill	AstraZeneca	COVID-19-work,
journals		treatment	co-operation	e.g., vaccination

Further expansion of our Single Pill portfolio

APONTIS PHARMA: Dynamic continuation of growth course

Key performance indicators H1 2022

(in EUR million)

Revenues

• Single Pills +27%
• Co-Marketing +2%
• Others +19% (influenced by the selling of the Gyn products)

Gross Profit

• Decline in gross profit margin impacted by Ulunar (Novartis): contract changed from Co-marketing to distribution model. Changed treatment of post-milestone payments in 2022 (impact EURm 0.5).

EBITDA/Net Result

• Higher sales in H1 compared to previous period and IPO costs of EURm 3.5 last year main driver of profitability increase.
• Gross profit impact related to changed Co-Marketing contract
• Income from divestment of Gyn products in the amount of approx. EUR 0.6 Mio.
• Repayment of shareholder loan in 2021: EUR 0.4 Mio lower interest expense.

Momentum for Single Pills continues

• Growth in Single Pills driven in particular by Atorimib, Tonotec, Tonotec HCT and LosAmlo
• 4 out of 7 single pills with high double-digit growth
• Two new Single Pills launched
• Caramlo below prior year due to tender and high wholesaler stockpiling in December 2021 (EURk 500)
• Growth in co-marketing/co-promotion driven by Copromotion of AstraZeneca's product Trixeo
• Ulunar sales declined with 12% lower than expected
• Jalra/Icandra at prior year level due to supply constraints at Novartis
• Others benefit from
• Normal cough season after COVID-19 restrictions fall end of Q1 2021
• Sale of complete inventories with divestment of gynecology business

Note: Rounding differences may occur. Source: Company data

Solid Financial Position: Well-Funded for Planned Activities

€ thousand	ACT	PY Dec 21	∆	Growth
Total equity and capitalization difference	42 858	41 413	1 445	3%
A. Total working capital	- 2 976	- 1 290	- 1 686	131%
I. Trade net working capital	3 624	5 177	- 1 553	-30%
1. Inventories	4 080	4 598	- 518	-11%
2. Receivables and other assets	4 258	3 581	677	19%
3. Accounts payables	- 4 714	- 3 002	- 1 712	57%
II. Prepaid expenses	514	443	70	16%
III. Other liabilities	- 836	- 724	- 112	16%
IV. Other accruals	- 6 277	- 6 186	- 91	1%
B. Long-term assets	15 884	14 886	998	7%
I. Intangible fixed assets	15 547	14 691	855	6%
II. Tangible fixed assets	16	19	- 3	-15%
III. Deferred tax assets	322	176	146	83%
C. Net cash	29 949	27 817	2 132	8%
I. Pension accruals	- 2 502	- 2 423	- 79	3%
II. Financial assets	779	784	- 5	-1%
III. Tax accruals	- 551	- 384	- 167	43%
IV. Cash	32 223	29 840	2 383	8%

• Total working capital negative.
• Inventories with normal monthly fluctuation.
• Receivables higher in June due to high portion of sales end of month.
• Increase in fixed assets driven by further milestone payments for development projects.
• Increase net cash driven by profit and lower working capital.
• Equity increased due to profit. Purchase of own shares (EURm 0.9); equity ratio at 73.1%.

Strong cash generation in H1 2022 based on sales development and lower working capital

€ thousand	ACT	PY H1 21	∆	Growth
Cash BoP	29 840	8 059	21 781	270%
Operating flow	4 953	2 660	2 292	86%
Net profit	2 351	- 2 197	4 548	107%
Depreciation & amortization	859	761	98	13%
Accruals	144	- 470	614	31%
Inventories & receivables	- 230	- 2 945	2 715	-92%
Payables	1 824	3 275	- 1 451	-44%
Taxes	167	94	73	77%
Interests	17	381	- 364	-96%
Other	- 180	3 761	- 3 942	-105%
Investing flow	- 1 697	- 328	- 1 369	417%
Financing flow	- 872	20 121	- 20 994	-104%
Cash EoP	32 223	30 512	1 711	6%
Change in cash and cash equivalents	2 383	22 453	- 20 070	-89%

• Higher sales in H1 compared to previous period and IPO costs last year main driver of profitability increase.
• Inventory build-up was higher in H1 2021 compared to H2 2022.
• Investing cash flow for milestone payments.
• Financing cash flow represents the buy-back of shares.

Single Pill Portfolio and Pipeline

APONTIS PHARMA: The Single Pill Strategy – Repeating Success

APONTIS expertise and market access meets demand for Single Pill development of commonly prescribed drugs available only as loose combinations

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The Development of a Single Pill: Many Steps – One Goal

Short-term Pipeline: Accelerating the Development of Single Pills

1 Field of application	AmloAtor	RosuASS	Tonotec Lipid	Rosazimib (AP – D 01)	Caramlo HCT (AP – T 01)	Caramlo Lipid (AP – T 02)
Planned market launch	Launched in May 2022	Launched in July 2022	Launched in May 2022	Q2 2023	Q3 2023	Q4 2023
Update August 2022					Q1 2024	Q3 2024
Status	§ Launched in Germany	§ Launched in Germany	§ Launched in Germany	§ Application for Marketing Authorization submitted	§ Application for Marketing Authorization submitted	§ Development ongoing § Application for Marketing Authorization expected in Q4 2022
Competitive environment	§ No other Single Pill provider with this combination	§ No other Single Pill provider with this combination	§ No other Single Pill provider with this combination	§ Other Single Pill provider with this combination	§ No other Single Pill provider with this combination	§ No other Single Pill provider with this combination
Min. patient potential²	510k	100k	230k	60k	180k	140k
Total development cost	EURm 0.3 (exclusive licensing agreement)	EURm 0.4 (semi-exclusive licensing agreement)	EURm 1.9	EURm 0.0 (exclusive licensing agreement)	EURm 1.3	EURm 2.5
Mid-term annual revenue potential	EURm 3.2	EURm 2.5	EURm 5.0	EURm 3.0	EURm 9.0	EURm 3.0

Notes: (1) Main application essential hypertension; (2) Patient potential: Number of patients with same substance class combination in loose form Source: Patient INSIGHTS Analytics (PIA). A web-based pharma tool from INSIGHT Health GmbH & Co. KG; Company information

Licensed-in

own development

16

Mid-term Development Pipeline: Continuous Market Opportunities

Development candidates (n = 13) (Exclusive) In-Licensing agreements (n = 17)

AP - T 11 to be discussed 25 3,0-4,0

Product	Patient potential Revenue potential Product Projekt status Projekt status (narrow-Germany) (narrow-Germany) (in k, substance level) (in EURm, peak sales)	Patient potential (narrow-Germany) (substance level)	Revenue potential (narrow-Germany) (in EURm, peak sales)
AP - D 05	30 projects in progress AP - D 01 (Rosazimib) MAA submitted in development 680 8,0-10,0	70	2,5
AP - D 06	AP - D 02 in negotiation in development 585 7,5-9,5	10	1,0
AP - D 07	AP - D 03 in advanced negotiation in development 610 19,0	65	8,0-10,0
AP - D 09	AP - D 04 in negotiation in negotiation 260 7,3	10	2,0-3,0
AP - D 10	AP - D 08 in negotiation in negotiation 425 6,0-8,0	40	6,0-8,0
AP - T 01 (Caramlo HCT)	• 3 in registration AP - D 11 in negotiation MAA submitted 155 6,0-8,0	590	8,0-10,0
AP - T 02 (Caramlo Lipid)	AP - D 12 in negotiation MAA submitted 115 6,0 AP - D 13 in negotiation	880 95	7,7 1,7
AP - T 03	• 4 in development in development 20 11,6 AP - D 14 in negotiation	60	4,0
AP - T 04	to be discussed 150 5,0-6,0 AP - D 15 to be discussed	90	4,0-5,0
AP - T 05	to be discussed 35 3,0-4,0 AP - D 16 to be discussed	100	0,8 -1,6
AP - T 06	• 10 in negotiation AP - D 17 to be discussed to be discussed 30 5,0	120	2,5-3,5
AP - T 09	AP - D 18 in negotiation in negotiation 125 4,5-5,5	70	2,0-3,0
AP - T 12	• 13 in discussion AP - T 07 in negotiation in negotiation 15 5,0-6,0	95	2,5-3,5
	AP - T 08 in negotiation	95	7,5-8,5
	AP - T 10 in negotiation	30	2,4

Single Pill Outlook

Scientific

New publications at the Congress of the European Cardiology Society (ESC) by end of August 2022 START:

• Additional Data from START Data Base to support Single Concept

SECURE (prospective study):

• Comparison of Single Pill Iltria® (Ramipril/ Atorvastatin/ASA) vs. usual care

Commercial

Expansion of Marketing and Sales activities

• Increasing number of scientific events and digital activities
• Higher number of salesforce calls in second half of 2022 expected
• Increasing acceptance of substitution activities as a result of new launches

Potential COVID-19 impact on access to physicians for patients and sales force, and on new launches caused by regulatory delays in the approval process

FY22 Forecast confirmed

Notes: * EURk 500 stock in trade increase at wholesaler with approx. EURk 325 gross profit impact Source: Company information, audited financials

Vision: To Establish the Single Pill as the Gold Standard. For a better life. Together. Every day.

• Increasing acceptance of the Single Pill concept by physicians
• Greater awareness of Single Pill company APONTIS PHARMA driven by growing portfolio
• Strong support from key opinion leaders and scientific experts and call for action for Single Pill concept based on convincing study results (retrospective and prospective)

Increasing importance of Single Pill concept underpins strategy of APONTIS PHARMA

THANK YOU FOR YOUR ATTENTION!

ir@apontis-pharma.de T: +49 2173 89 55 4900 F: +49 2173 89 55 1521

Alfred-Nobel-Str. 10 40789 Monheim am Rhein Germany

apontis-pharma.de