Opthea Ltd
Biopharma that discontinued its wet AMD therapy after its lead drug failed Phase 3 trials.
OPT | US
Overview
Corporate Details
- ISIN(s):
- US68386J2087
- LEI:
- Country:
- United States of America
- Address:
- LEVEL 4, 3141 SOUTH YARRA
- Website:
- https://opthea.com/
- Sector:
- Manufacturing
- Industry:
- Manufacture of pharmaceuticals, medicinal chemical and botanical products
Description
Opthea Ltd. is a clinical-stage biopharmaceutical company that was focused on developing novel therapies for vision-threatening retinal diseases. The company's primary development program centered on its lead candidate, sozinibercept (OPT-302), a first-in-class biologic inhibitor of VEGF-C and VEGF-D. Sozinibercept was being evaluated in combination with standard-of-care anti-VEGF-A therapies for the treatment of wet age-related macular degeneration (wet AMD), with the goal of delivering superior visual outcomes. However, in March 2025, the company announced that its pivotal Phase 3 clinical trials (COAST and ShORe) did not meet their primary endpoints, leading to the discontinuation of the development program and significant corporate restructuring.
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Filings
| Date | Filing | Language | Size | Actions | |
|---|---|---|---|---|---|
| No filings match the current criteria. | |||||
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Market Data
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Financials & KPIs
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Insider Transactions
| Date | Insider Name | Position | Type | Shares | Value |
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| No insider transactions recorded for this company. | |||||
