Kalaris Therapeutics, Inc.

Developing next-gen, long-acting anti-VEGF therapies for prevalent retinal diseases.

KLRS | US

Overview

Corporate Details

ISIN(s):: US0198181036
LEI:
Country:: United States of America
Address:: 628 MIDDLEFIELD ROAD, 94301 PALO ALTO
Website:: https://kalaristx.com/
Sector:: Manufacturing
Industry:: Manufacture of pharmaceuticals, medicinal chemical and botanical products

Description

Kalaris Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing and commercializing treatments for prevalent retinal diseases. The company's lead product candidate is TH103, a fully humanized, recombinant fusion protein designed as a next-generation anti-VEGF agent for intravitreal delivery. Co-developed by Dr. Napoleone Ferrara, known for his work on Avastin and Lucentis, TH103 acts as a soluble decoy receptor. A key feature is its high affinity for heparan sulfate proteoglycans (HSPG), which may act as a molecular anchor to extend its intraocular retention. This mechanism aims to reduce the frequency of injections for patients with neovascular retinal diseases, such as age-related macular degeneration.

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Insider Transactions

Date	Insider Name	Position	Type	Shares	Value
No insider transactions recorded for this company.

Peer Companies

Company	Country	Ticker
Kidswell Bio Corporation Biopharma R&D of biosimilars, biologics, and cell therapies, with a pediatric focus.	Japan	4584
Kinarus Therapeutics Holding AG A specialty pharma firm developing and selling medicines for rare and specialty diseases.	Switzerland	KNRS
Kiniksa Pharmaceuticals International, plc Develops and commercializes immune-modulating therapies for debilitating diseases with unmet needs.	United States of America	KNSA
KIORA PHARMACEUTICALS INC Developing advanced small molecule therapies for vision-threatening retinal diseases.	United States of America	KPRX
KISSEI PHARMACEUTICAL CO.,LTD. Develops innovative drugs for urology, renal diseases, and rare or intractable diseases.	Japan	4547
Klaria Pharma Holding AB Develops oral films for non-invasive drug delivery as an alternative to injections and sprays.	Sweden	KLAR
Klotho Neurosciences, Inc. Advancing gene and cell therapies for neurodegenerative disorders, cancer, and chronic diseases.	United States of America	KLTO
KOA SHOJI HOLDINGS CO.,LTD. Imports APIs and manufactures generic drugs for Japan's pharmaceutical industry.	Japan	9273
KOBAYASHI PHARMACEUTICAL CO.,LTD. Manufactures OTC pharma, personal care, and household goods for niche consumer markets.	Japan	4967
Kodiak Sciences Inc. Developing durable biologics to treat high-prevalence retinal diseases and prevent blindness.	United States of America	KOD