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ER - Acadia Pharmaceuticals and Saniona Announce Initial Positive Results from ACP-711 (formerly SAN711) Phase 1 Study

Company: Saniona Date: 2025-03-03 Language: English Register to download
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# **PRESS RELEASE**

**03 March 2025 15:04:00 CET**

# **Acadia Pharmaceuticals and Saniona Announce Initial Positive Results from ACP-711 (formerly SAN711) Phase 1 Study**

**SAN DIEGO, CA and COPENHAGEN, Denmark – March 3, 2025 -- Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) and Saniona (OMX: SANION), today announced the successful completion of the two originally planned cohorts in its Phase 1 multiple-ascending-dose MAD study (EUCT: 2024- 514514-12-00) of ACP-711, formerly SAN711, in healthy volunteers.**

In the study, ACP-711 was safe and generally well tolerated across all dosing cohorts. There were no serious adverse events, and all participants completed the study. Most adverse events were mild. No safety laboratory concerns, cardiovascular concerns, or abnormal neurological findings were observed.

Given the favorable safety and tolerability profile and the prioritization of essential tremor as the lead indication, Acadia Pharmaceuticals and Saniona are seeking regulatory approval to evaluate ACP-711 in elderly healthy volunteers and to test higher repeated doses. To enable this extension, the study has been temporarily paused until regulatory approval.

## *About Acadia Pharmaceuticals*

Acadia is advancing breakthroughs in neuroscience to elevate life. Since our founding we have been working at the fore front of healthcare to bring vital solutions to people who need them most. We developed and commercialized the first and only FDA-approved drug to treat hallucinations and delusions associated with Parkinson's disease psychosis and the first and only approved drug in the United States and Canada for the treatment of Rett syndrome. Our clinical-stage development efforts are focused on Prader-Willi syndrome, Alzheimer's disease psychosis and multiple other programs targeting neuroscience and neuro-rare diseases. For more information, visit us at **[Acadia.com](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Facadia.com%2F&esheet=54207187&newsitemid=20250214260863&lan=en-US&anchor=Acadia.com&index=1&md5=27dd255185cf9225be4fa578e52ae67e)** and follow us on **[LinkedIn](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Facadia-pharmaceuticals&esheet=54207187&newsitemid=20250214260863&lan=en-US&anchor=LinkedIn&index=2&md5=7965be2383a4048f76c541b98af94db8)** and **[X](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fx.com%2FacadiaPharma&esheet=54207187&newsitemid=20250214260863&lan=en-US&anchor=X&index=3&md5=adc0a8baf80c0ea5f229c7a0e9d24064)**.

## *About Saniona*

Saniona (OMX: SANION) is a clinical-stage biopharmaceutical company leading the way in ion channel modulation for the treatment of neurological disorders. Saniona's internal pipeline includes SAN2219, targeting acute repetitive seizures; SAN2355, addressing refractory focal onset seizures; and SAN2465, positioned for major depressive disorders. Saniona has two strategic development collaborations. ACP-711 (formerly SAN711) is being prepared for Phase 2 for essential tremor in collaboration with Acadia Pharmaceuticals and tesofensine is out licensed for obesity to Medix, which has submitted a market authorization application (MAA) in Mexico. In addition, Saniona oversees two clinical programs poised for collaboration. Tesomet™ is ready for Phase 2b, targeting rare eating disorders, while SAN903 is ready for Phase 1 for inflammatory bowel disease. Saniona partners include Acadia Pharmaceuticals, Boehringer Ingelheim GmbH, Productos Medix S.A de S.V, AstronauTx Limited, and Cephagenix ApS. Saniona is based in Copenhagen and listed on Nasdaq Stockholm Main Market. For more information, visit **[www.saniona.com](http://www.saniona.com/)**.

## *Acadia's Forward-Looking Statement*

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include all statements other than statements of historical fact and can be identified by terms such as "intends," "may," "will," "should," "can," "could," "would," "expects," "plans," "anticipates," "believes," "estimates," "projects," "predicts," "potential" and similar expressions (including the negative thereof) intended to identify forwardlooking statements. Forward-looking statements contained in this press release, include, but are not limited to, statements about: (I) our clinical development plans related to ACP-711 and (ii) the safety profile of ACP-711. Forward-looking statements are subject to known and unknown risks, uncertainties, assumptions, and other factors that may cause our actual results, performance or achievements to differ materially and adversely from those anticipated or implied by our forward-looking statements. Given the risks and uncertainties, you should not place undue reliance on these forward-looking statements. For a discussion of these and other risks, uncertainties, assumptions, and other factors that may cause our actual results, performance or achievements to differ, please refer to our quarterly report on Form 10-K for the year ended December 31, 2024, filed with the Securities and Exchange Commission on February 27, 2025, as well as our subsequent filings with the Securities and Exchange Commission from time to time. The forward-looking statements contained herein are made as of the date hereof, and we undertake no obligation to update them after this date, except as required by law.

## *Saniona's Forward-Looking Statement*

This press release contains certain forward-looking information that reflects Saniona's current views of future events and financial and operational performance. Words such as "intends", "anticipates", "expects", "can", "plans", "estimates" and similar expressions regarding indications or forecasts of future developments or trends, and which are not based on historical facts, constitute forward-looking information. Forward-looking information is inherently associated with both known and unknown risks and uncertainties because it is dependent on future events and circumstances. Forward-looking information is not a guarantee of future results or developments, and actual results may differ materially from results referred to in forward-looking information. Forward looking information in the press release is only applicable on the date of issue of the press release. Saniona does not commit to publishing updates or revision of any forward-looking statements as a result of new information, future events or similar circumstances other than those required by applicable legislation.

## *Acadia Investor and Media Contacts:*

Acadia Pharmaceuticals Inc. Al Kildani (858) 261-2872 **[ir@acadia-pharm.com](mailto:ir@acadia-pharm.com)**

Acadia Pharmaceuticals Inc. Deb Kazenelson (818) 395-3043 **[media@acadia-pharm.com](mailto:media@acadia-pharm.com)**

## *Saniona Contacts:*

Saniona AB (publ) Thomas Feldthus +45 2210 9957 **[thomas.feldthus@saniona.com](mailto:thomas.feldthus@saniona.com)**

*This information is information that Saniona AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact persons set out above, at 2025-03-03 15:04 CET.*

**Attachments [Acadia Pharmaceuticals and Saniona Announce Initial Positive Results from ACP-711 \(formerly](https://storage.mfn.se/c40453f9-1859-4eac-adce-cb9051cd90b0/acadia-pharmaceuticals-and-saniona-announce-initial-positive-results-from-acp-711-formerly-san711-phase-1-study.pdf)  [SAN711\) Phase 1 Study](https://storage.mfn.se/c40453f9-1859-4eac-adce-cb9051cd90b0/acadia-pharmaceuticals-and-saniona-announce-initial-positive-results-from-acp-711-formerly-san711-phase-1-study.pdf)**

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