Zymeworks Inc. — Director's Dealing 2025

Jan 21, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Zymeworks Inc. (ZYME)
CIK: 0001937653
Period of Report: 2025-01-16

Reporting Person: EcoR1 Capital, LLC (Director, 10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-01-16	Common Stock	P	121681	$13.885	Acquired	15700413	Indirect
2025-01-17	Common Stock	P	19748	$13.8747	Acquired	15720161	Indirect

Footnotes

F1: The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

F2: Qualified Fund purchased 114,344 of the shares purchased in this transaction.

F3: After this transaction, Qualified Fund held 14,714,552 shares of the Issuer's Common Stock.

F4: Qualified Fund purchased 18,557 of the shares purchased in this transaction.

F5: After this transaction, Qualified Fund held 14,733,109 shares of the Issuer's Common Stock.