Wave Life Sciences Ltd. — Director's Dealing 2025

Dec 11, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Wave Life Sciences Ltd. (WVE)
CIK: 0001631574
Period of Report: 2025-12-08

Reporting Person: Francis Chris (N/A)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-12-08	Ordinary Shares	M	28125	$3.14	Acquired	53125	Direct
2025-12-08	Ordinary Shares	S	28125	$14.50	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	107400	$3.87	Acquired	132400	Direct
2025-12-08	Ordinary Shares	S	107400	$14.556	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	45882	$4.75	Acquired	70882	Direct
2025-12-08	Ordinary Shares	S	45882	$14.5	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	9375	$3.14	Acquired	34375	Direct
2025-12-08	Ordinary Shares	S	9375	$15	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	37500	$3.14	Acquired	62500	Direct
2025-12-08	Ordinary Shares	S	37500	$14.08	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	17900	$3.87	Acquired	42900	Direct
2025-12-08	Ordinary Shares	S	17900	$15	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	122349	$4.75	Acquired	147349	Direct
2025-12-08	Ordinary Shares	S	122349	$14.195	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	50000	$10.48	Acquired	75000	Direct
2025-12-08	Ordinary Shares	S	50000	$16	Disposed	25000	Direct
2025-12-08	Ordinary Shares	M	22500	$2.83	Acquired	47500	Direct
2025-12-08	Ordinary Shares	S	22500	$14.08	Disposed	25000	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-12-08	Share Option (right to buy)	$3.14	M	75000	Disposed	2032-01-01	Ordinary Shares (75000)	Direct
2025-12-08	Share Option (right to buy)	$3.87	M	125300	Disposed	2034-02-05	Ordinary Shares (125300)	Direct
2025-12-08	Share Option (right to buy)	$4.75	M	168231	Disposed	2033-02-17	Ordinary Shares (168231)	Direct
2025-12-08	Share Option (right to buy)	$10.48	M	50000	Disposed	2031-02-01	Ordinary Shares (50000)	Direct
2025-12-08	Share Option (right to buy)	$2.83	M	22500	Disposed	2023-07-25	Ordinary Shares (22500)	Direct

Footnotes

F1: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 5, 2025.

F2: The share option represented a right to purchase a total of 150,000 ordinary shares that vest as to 25% of the shares on January 1, 2023 and vests as to an additional 6.25% of the shares quarterly thereafter until January 1, 2026.

F3: The share option represented a right to purchase a total of 286,400 ordinary shares that vest as to 25% of the shares on February 5, 2025, and vests as to an additional 6.25% of the shares quarterly thereafter until February 5, 2028.

F4: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $14.50 to $14.78 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

F5: The share option represented a right to purchase a total of 244,700 ordinary shares that vest as to 25% of the shares on February 17, 2024 and vests as to an additional 6.25% of the shares quarterly thereafter until February 17, 2027.

F6: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $14.08 to $15.00 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

F7: These share options are fully vested.