SYNLOGIC, INC. — Director's Dealing 2015

Oct 6, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Mirna Therapeutics, Inc. (MIRN)
CIK: 0001527599
Period of Report: 2015-10-05

Reporting Person: Sofinnova Venture Partners VIII, L.P. (10% Owner)
Reporting Person: Sofinnova Management VIII, L.L.C. (10% Owner)
Reporting Person: HEALY JAMES (10% Owner)
Reporting Person: AKKARAJU SRINIVAS (10% Owner)
Reporting Person: Mehra Anand (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-10-05	Common Stock	C	1244269	—	Acquired	1244269	Direct
2015-10-05	Common Stock	C	583559	—	Acquired	1827828	Direct
2015-10-06	Common Stock	J	289841	—	Acquired	2117669	Direct
2015-10-06	Common Stock	P	857142	$7	Acquired	2974811	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2015-10-05	Series C Preferred Stock	$	C	1244269	Disposed		Common Stock (1244269)	Direct
2015-10-05	Series D Preferred Stock	$	C	583559	Disposed		Common Stock (583559)	Direct

Footnotes

F1: Each share of Series C and Series D Preferred Stock automatically converted on a one-to-one basis into Common Stock immediately prior to the consummation of the Issuer's initial public offering.

F2: The shares are held by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual Managers, or the Managing Members, of SM VIII are Michael Powell, James Healy, Srinivas Akkaraju and Anand Mehra. The Managers share voting and dispositive power with regard to the shares held directly by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares owned by SVP VIII except to the extent of any pecuniary interest therein.

F3: The shares were issued for no additional consideration pursuant to an accruing paid-in-kind dividend on shares of Series C and Series D Preferred Stock of the Company.

F4: The expiration date is not relevant to the conversion of the securities.

F5: Due to a clerical error, the Reporting Persons' Form 3 which previously reported the holding of these shares understated his total by one (1) share.