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Structure Therapeutics Inc. Director's Dealing 2025

Dec 10, 2025

31940_dirs_2025-12-10_730fed69-e01a-4b52-8c7d-c1bc8ef9ba68.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Structure Therapeutics Inc. (GPCR)
CIK: 0001888886
Period of Report: 2025-12-08

Reporting Person: FMR LLC (N/A)

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2025-12-08 American Depositary Shares $ S 709 Disposed Ordinary Shares (2127) Indirect
2025-12-08 American Depositary Shares $ S 183 Disposed Ordinary Shares (549) Indirect
2025-12-08 American Depositary Shares $ S 475 Disposed Ordinary Shares (1425) Indirect
2025-12-08 American Depositary Shares $ S 1414 Disposed Ordinary Shares (4242) Indirect
2025-12-08 American Depositary Shares $ S 1320 Disposed Ordinary Shares (3960) Indirect
2025-12-08 American Depositary Shares $ S 8337 Disposed Ordinary Shares (25011) Indirect
2025-12-08 American Depositary Shares $ S 2159 Disposed Ordinary Shares (6477) Indirect
2025-12-08 American Depositary Shares $ S 5589 Disposed Ordinary Shares (16767) Indirect
2025-12-08 American Depositary Shares $ S 16635 Disposed Ordinary Shares (49905) Indirect
2025-12-08 American Depositary Shares $ S 15535 Disposed Ordinary Shares (46605) Indirect

Holdings (Non-Derivative)

Security Shares Ownership
Ordinary Shares 36909 Indirect
Ordinary Shares 434298 Indirect

Holdings (Derivative)

Security Exercise Price Expiration Underlying Shares Ownership
American Depositary Shares $ Ordinary Shares (4546674) 1515558 Indirect

Footnotes

F1: Reported securities are American Depositary Shares, each of which represents three Ordinary Shares of the Issuer. Any one American Depositary Share may be converted into three Ordinary Shares, and any three Ordinary Shares into one American Depositary Share, at any time at the election of the holder upon notice.

F2: The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $92.29 to $92.93. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

F3: The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $93.27 to $94.26. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

F4: The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $94.28 to $94.88. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

F5: The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $60.32 to $61.31. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.

F6: The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $61.32 to $61.64. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information.