Schrodinger, Inc. — Director's Dealing 2021

May 6, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Schrodinger, Inc. (SDGR)
CIK: 0001490978
Period of Report: 2021-05-04

Reporting Person: SHAW DAVID E (10% Owner)
Reporting Person: Schrodinger Equity Holdings, LLC (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-05-04	Common Stock, par value $0.01 per share	S	7820	$68.8396	Disposed	7755060	Indirect
2021-05-04	Common Stock, par value $0.01 per share	S	17865	$69.8766	Disposed	7737195	Indirect
2021-05-04	Common Stock, par value $0.01 per share	S	3073	$70.8395	Disposed	7734122	Indirect
2021-05-04	Common Stock, par value $0.01 per share	S	920	$71.5627	Disposed	7733202	Indirect
2021-05-04	Common Stock, par value $0.01 per share	S	322	$72.7578	Disposed	7732880	Indirect
2021-05-05	Common Stock, par value $0.01 per share	S	11641	$68.7393	Disposed	7721239	Indirect
2021-05-05	Common Stock, par value $0.01 per share	S	11750	$69.7366	Disposed	7709489	Indirect
2021-05-05	Common Stock, par value $0.01 per share	S	6509	$70.3172	Disposed	7702980	Indirect
2021-05-05	Common Stock, par value $0.01 per share	S	100	$71.335	Disposed	7702880	Indirect
2021-05-06	Common Stock, par value $0.01 per share	S	6409	$66.0882	Disposed	7696471	Indirect
2021-05-06	Common Stock, par value $0.01 per share	S	17971	$66.8873	Disposed	7678500	Indirect
2021-05-06	Common Stock, par value $0.01 per share	S	3630	$67.6571	Disposed	7674870	Indirect
2021-05-06	Common Stock, par value $0.01 per share	S	1990	$69.2097	Disposed	7672880	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock, par value $0.01 per share	4264	Indirect

Footnotes

F1: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F2: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.32 to $69.30, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

F4: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.385 to $70.36, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F5: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.41 to $71.40, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F6: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.48 to $71.66, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.705 to $72.81, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F8: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.09 to $69.07, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F9: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.10 to $70.09, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F10: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.10 to $71.005, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F11: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.42 to $66.38, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F12: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.42 to $67.41, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F13: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.42 to $68.015, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F14: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.88 to $69.52, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F15: David E. Shaw is President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the sole member of D. E. Shaw Technology Development, LLC.