PRUDENTIAL FINANCIAL INC — Major Shareholding Notification 2018

Jan 26, 2018

DOCUMENT TYPE SC 13G/A TEXT SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment # 4 Name of Issuer: ASSEMBLY BIOSCIENCES, INC. ___________ Title of Class of Securities: Common Stock CUSIP Number: 045396108 1) NAME AND I.R.S. IDENTIFICATION NO. OF REPORTING PERSON Prudential Financial, Inc. 22-3703799 2.) MEMBER OF A GROUP: (a) N/A (b) N/A 3) SEC USE ONLY: 4) PLACE OF ORGANIZATION: New Jersey NUMBER OF SHARES BENEFICIALLY OWNED BY REPORTING PERSON WITH: 5) Sole Voting Power: 3,600 See Exhibit A 6) Shared Voting Power: 2,120,300 See Exhibit A 7) Sole Dispositive Power: 3,600 See Exhibit A 8) Shared Dispositive Power: 2,120,300 See Exhibit A 9) AGGREGATE AMOUNT BENEFICIALLY OWNED: 2,123,900 See Exhibit A 10) AGGREGATE AMOUNT IN ROW (9) EXCLUDES SHARES: Not Applicable 11) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9): 10.6 See Exhibit A 12) TYPE OF REPORTING PERSON: HC ITEM 1(a). NAME OF ISSUER: ASSEMBLY BIOSCIENCES, INC. ITEM 1(b). ADDRESS OF ISSUER'S EXECUTIVE OFFICES: 11711 N. MERIDIAN STREET SUITE 310 CARMEL , IN 46032 ITEM 2(a). NAME OF PERSON FILING: Prudential Financial, Inc. ITEM 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE: 751 Broad Street Newark, New Jersey 07102-3777 ITEM 2(c). CITIZENSHIP: New Jersey ITEM 2(d). TITLE OF CLASS OF SECURITIES: Common Stock ITEM 2(e). CUSIP NUMBER: 045396108 ITEM 3. The Person filing this statement is a Parent Holding Company as defined in Section 240.13d-1(b)(1)(ii)(G) of the Securities Exchange Act of 1934. ITEM 4. OWNERSHIP: (a) Number of Shares Beneficially Owned: 2,123,900 See Exhibit A (b) Percent of Class: 10.6 (c) Powers No. Of Shares ----------- -------------------- Sole power to vote or 3,600 See Exhibit A to direct the vote Shared power to vote or 2,120,300 See Exhibit A to direct the vote Sole power to dispose or 3,600 See Exhibit A to direct disposition Shared power to dispose 2,120,300 See Exhibit A or to direct disposition ITEM 5. OWNERSHIP OF 5% OR LESS OF A CLASS: Not Applicable ITEM 6. OWNERSHIP OF MORE THAN 5% ON BEHALF OF ANOTHER PERSON: Our clients may have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities which are the subject of this filing. ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE ULTIMATE PARENT COMPANY: See Exhibit A ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP: Not Applicable ITEM 9. NOTICE OF DISSOLUTION OF GROUP: Not Applicable ITEM 10. CERTIFICATION:

By signing below, Prudential Financial, Inc. certifies that, to the best of its knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

The filing of this statement should not be construed as an admission that Prudential Financial, Inc. is, for purposes of Sections 13 or 16 of the Securities Exchange Act of 1934, the beneficial owner of such shares.

SIGNATURE After reasonable inquiry and to the best of its knowledge and belief, Prudential Financial, Inc. certifies that the information set forth in this statement is true, complete and correct. PRUDENTIAL FINANCIAL, INC. By: Richard Baker Second Vice President Date: 01/26/2018 As of: 12/31/2017 Exhibit A -------------- ITEM 4. OWNERSHIP: Through its parent/subsidiary relationship, Prudential Financial, Inc. may be deemed the beneficial owner of the same securities as the Item 7 listed subsidiaries and may have direct or indirect voting and/or investment discretion over 2,123,900 shares. These shares were acquired in the ordinary course of business, and not with the purpose or effect of changing or influencing control of the Issuer. The filing of this statement should not be construed as an admission that Prudential Financial, Inc. is, for the purposes of Sections 13 or 16 of the Securities Exchange Act of 1934, the beneficial owner of these shares. ITEM 7. IDENTIFICATION/CLASSIFICATION: Prudential Financial, Inc. is a Parent Holding Company and the indirect parent of the following subsidiaries, who are the beneficial owners of the number and percentage of securities which are the subject of this filing as set forth next to their names:

Subsidiaries		Number of Shares	Percentage
The Prudential Insurance Company of
America	IC	0	0
Prudential Retirement Insurance and Annuity Company	IC	0	0
Jennison Associates LLC	IA	2,120,300	10.53
PGIM, Inc.	IA	0	0
Quantitative Management Associates LLC	IA	3,600	0.02