Strategic Partners A/S — Director's Dealing 2020

Jul 29, 2020

DK-2200 Copenhagen N

www.orphazyme.com Company Registration No. 32266355

Reporting of transactions in Orphazyme's shares made by persons discharging managerial responsibilities

Copenhagen, Denmark, July 29, 2020 – Pursuant to the Market Abuse Regulation article 19, Orphazyme A/S, CVR no. 32266355 ("Orphazyme"), hereby notifies receipt of information of the following transactions in Orphazyme's shares by persons discharging managerial responsibilities in Orphazyme:

1	Details of the Reporting Person / Closely Associated Person
a)	Name	Anders Vadsholt
2	Reason for the notification
a)	Position/status	Chief Financial Officer
b)	Initial notification/Amendment	Initial notification
3	Details of the Company, emission allowance market participant, auction platform, auctioneer
	or auction monitor
a)	Name	Orphazyme A/S
b)	LEI code	54930025OZD2GGSQ7L42
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each
	type of transaction; (iii) each date; and (iv) each place where transactions have been
	conducted
a)	Description of the financial instrument, type of	Shares
	instrument and identification code	ISIN DK0060910917
b)	Nature of the transaction	Purchase of shares
c)	Price(s) and volume(s)	Volume(s) Price (s)
		1 6,250 DKK
d)	Aggregated information	Aggregated volume: 6,250
		Aggregated price: DKK 6,250
		Price per share (volume weighted average): DKK 1
e)	Date of the transaction	July 29, 2020, 11:59 UTC
f)	Place of the transaction	Outside a trading venue

1	Details of the Reporting Person / Closely Associated Person
a) Name Thomas Blaettler
2	Reason for the notification

a)	Position/status	Chief Medical Officer
b)	Initial notification/Amendment	Initial notification
3	Details of the Company, emission allowance market participant, auction platform, auctioneer
	or auction monitor
a)	Name	Orphazyme A/S
b)	LEI code	54930025OZD2GGSQ7L42
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each
	type of transaction; (iii) each date; and (iv) each place where transactions have been
	conducted
a)	Description of the financial instrument, type of	Shares
	instrument and identification code	ISIN DK0060910917
b)	Nature of the transaction	Purchase of shares
c)	Price(s) and volume(s)	Volume(s) Price (s) 1 6,250 DKK
d)	Aggregated information	Aggregated volume: 6,250
		Aggregated price: DKK 6,250
		Price per share (volume weighted average): DKK 1
e)	Date of the transaction	July 29, 2020, 11:59 UTC
f)	Place of the transaction	Outside a trading venue

1	Details of the Reporting Person / Closely Associated Person
a)	Name	Thomas Kirkegaard Jensen
2	Reason for the notification
a)	Position/status	Chief Scientific Officer
b)	Initial notification/Amendment	Initial notification
3	Details of the Company, emission allowance market participant, auction platform, auctioneer
	or auction monitor
a)	Name	Orphazyme A/S
b)	LEI code	54930025OZD2GGSQ7L42
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each
	type of transaction; (iii) each date; and (iv) each place where transactions have been
	conducted
a)	Description of the financial instrument, type of	Shares
	instrument and identification code	ISIN DK0060910917
b)	Nature of the transaction	Purchase of shares

c)	Price(s) and volume(s)			Price (s)	1	Volume(s) 6,250
			DKK
d)	Aggregated information	Aggregated volume: 6,250
		Aggregated price: DKK 6,250
		Price per share (volume weighted average): DKK 1
e)	Date of the transaction	July 29, 2020, 11:59 UTC
f)	Place of the transaction	Outside a trading venue

For additional information, please contact

Orphazyme A/S

Anders Vadsholt, CFO +45 28 98 90 55

About Orphazyme A/S

Orphazyme is a biopharmaceutical company focused on bringing novel treatments to patients living with life-threatening or debilitating rare diseases. Our research focuses on developing therapies for diseases caused by misfolding of proteins, including lysosomal storage diseases. Arimoclomol, the company's lead candidate, is in clinical development for four orphan diseases: Niemann-Pick disease Type C, Gaucher disease, sporadic Inclusion Body Myositis, and Amyotrophic Lateral Sclerosis. The Denmark-based company is listed on Nasdaq Copenhagen (ORPHA.CO). For more information, please visit www.orphazyme.com.

Forward-looking statement

This company announcement may contain certain forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, all statements other than statements of historical fact included in this company announcement about future events are subject to (i) change without notice and (ii) factors beyond the Company's control. These statements may include, without limitation, any statements preceded by, followed by, or including words such as "target," "believe," "expect," "aim," "intend," "may," "anticipate," "estimate," "plan," "project," "will," "can have," "likely," "should," "would," "could", and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company's control that could cause the Company's actual results, performance, or achievements to be materially different from the expected results, performance, or achievements expressed or implied by such forward-looking statements. Except as required by law, the Company assumes no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future.