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MorphoSys AG Annual Report 2005

Feb 28, 2006

291_10-k_2006-02-28_9ac7c8bd-a6e7-43b3-b4dd-96d186b203bf.pdf

Annual Report

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Consolidated Financial Statements (IFRS)

Group Management Report

Corporate Development 2005

Therapeutic Antibodies Segment

The Therapeutic Antibodies segment comprises MorphoSys' activities in the area of therapeutic antibodies, which includes its therapeutic antibody collaborations with pharmaceutical and biotech companies, as well as own antibody development programs. In 2005, the Therapeutic Antibodies segment was able to build upon the positive development of the prior years. Existing partnerships were extended or strengthened during the year, including those with Bayer, Boehringer Ingelheim, Bristol-Myers Squibb and ImmunoGen. At the same time, MorphoSys signed three new partnerships with pharmaceutical companies: Shionogi, Eli Lilly and Merck & Co. The Company ended the year with 29 active partner programs, and the first antibody from this group entered clinical trials. In total, the Therapeutic Antibodies segment generated sales of q 29.1 million in 2005, an increase of 37% compared to the previous year.

Research Antibodies Segment (AbD)

The Research Antibodies segment comprises all activities of MorphoSys' Antibodies by Design unit, as well as all activities of its subsidiaries Biogenesis Ltd. and Biogenesis, Inc. From 2006 onwards, the segment will be named AbD – Antibodies Direct. The AbD segment will comprise all activities of Antibodies by Design, Biogenesis, and the Serotec Group, which was acquired in January 2006. During the year 2005, MorphoSys also remained on a growth curve in the Research Antibodies segment. Following the acquisition of the Biogenesis Group in January, MorphoSys greatly expanded its customer base. Since then, the first HuCAL® antibodies have been marketed via the Biogenesis catalog. The Research Antibodies segment sales contributed q 4.3 million, representing about 13 % of total Company revenues.

Macroeconomic Development

Economic Development

The global economy grew by approximately 4% in 2005, nearly one percentage point less than in 2004. The slowdown was widespread, reaching virtually every economic region. It was precipitated by higher oil prices, resource-sector capacity constraints, tightening monetary policy in the United States and, in some countries, the maturation of the investment cycle following a year of very fast growth. Of these aforementioned effects, oil prices exerted a particularly strong pull on the economy. At year-end 2005, the price for Brent crude oil had risen to US \$ 58.16 per barrel, up 45% over the prior year.

In Europe, for instance, the growth slowdown was less pronounced. The relatively low oil intensity of European economies and relaxed macroeconomic policy stance helped explain why the slowdown in Europe was not more prominent. After a downturn in spring, the German economy posted stronger growth in the second half of 2005, totaling in an overall growth of approximately 1%.

In Asia, growth remained robust. In Japan, GDP was estimated to have increased by 2.3 %. Growth in China remained very strong despite a substantial slowing in both private consumption and investment demand.

With regard to interest rates, year-end European interest rates were slightly higher at 3.5%, compared to the prior year. In 2005, the U.S. Federal Reserve increased interest rates resulting largely from asset price inflation concerns. Related to these developments, the Euro ended the year at the rate of US \$ 1.18, weaker than at the end of the year before.

Development in the Global Capital Markets

Overall, growth in the German capital market was positive in 2005. The DAX closed with an increase of 27%. Although the American stock markets displayed a negative trend in the first six months, they witnessed a recovery in the second half of the year, and the S&P 500 Index registered an increase of 3% year on year. The Japanese Nikkei Index increased by 40 %, its best performance in years.

Within the technology sector, the U.S.-based NASDAQ Composite Index ended the year with an increase of 1%, while in comparison to its German counterpart, the Frankfurt Stock Exchange (FSE) TecDAX, it outperformed with an increase of 15% for the year.

Within the pharmaceutical and biotechnology sub-segments, the FSE Prime Biotechnology Performance Index increased by 21% and the Prime Pharma & Healthcare Index rose by 26%. The NASDAQ Biotechnology Index managed to recover from its low in May 2005, achieving an annual growth of 3%.

Development Within the Pharmaceutical and Biotechnology Sector

For the pharmaceutical and biotechnology sector, 2005 was a year of mixed messages. Data from industry analysts at IMS Health confirm that growth in the American pharmaceutical market was 6 to 7% in 2005 (2004: 8.3%). Ongoing discussions on drug safety, caused by the product recall of Vioxx by the U.S.-based Merck Group in 2004, hindered market growth. In the coming years, the U.S. Food and Drug Administration (FDA) is expected to adopt a more cautious approach toward the approval of new drugs. In light of this, few new drugs were approved

in 2005, while the number of so-called black box warning labels on drug packaging grew. In addition, a slew of fastselling drugs, such as the cholesterol-reducing Zocor from Merck, are losing their patent protection in 2006. This could have a negative effect on future sales growth, as cheaper imitation drugs (so-called generic drugs) can enter the market.

The financing window for biotechnology companies remained open in 2005 and enabled 18 biotechnology IPOs to be registered in the U.S. and 21 in Europe, including three in Germany. Many firms successfully refinanced in 2005. Worldwide, biotechnology companies raised approximately US \$ 20 billion in capital through IPOs and subsequent financings. As in previous years, numerous pharmaceutical and biotechnology mergers took place. The strong interest paid by pharmaceutical groups to this trend is evidenced by a range of significant deals. In June 2005, the pharmaceutical group Pfizer acquired the biopharmaceutical company Vicuron for US \$ 1.9 billion. In September, Novartis agreed to a long-term partnership with Alnylam Pharmaceuticals and acquired a 20 % stake in the company. In the same month, Biogen Idec licensed a portfolio of antibodies, which are currently in phase 2 clinical development, from Protein Design Labs.

In the antibodies sector, the unexpected product recall of the approved antibody Tysabri at the beginning of the year shook the industry. The monoclonal, humanized antibody developed by Biogen Idec and Elan had received approval in November 2004 for the treatment of multiple sclerosis. After cases of a rare and fatal neurological disease occurred in connection with the use of the drug, Biogen Idec and Elan decided to issue an immediate product recall. As a result, the stock prices of both companies fell dramatically, losing 40% and 70%, respectively. The resulting fallout also negatively affected antibody sector share prices.

Despite these setbacks, as the year progressed, a number of highly positive reports emerged from the sector. More specifically, Genentech, Inc., presented convincing phase 3 results for the therapeutic antibodies Herceptin and Avastin. In addition to various clinical results, other company reports uplifted sentiment in the antibody sector. As an example, Serono acquired the exclusive worldwide rights from Genmab to the fully human cancer antibody Humax-CD4, which is currently in phase 2 of clinical development.

Also fueling bullish speculation in the antibody sector were a few antibody company acquisitions. Of these, three relating to therapeutic antibody companies are particularly worthy of mention: in July 2005, the Roche Group acquired Swiss company GlycArt Biotechnology GmbH. Shortly afterwards, in August 2005, Pfizer announced the acquisition of the firm Bioren. Finally, in December 2005, Amgen announced a takeover bid for Abgenix for almost q 2.2 billion. Acquisitions and consolidation in the research antibodies sector also occurred in 2005. More specifically, Invitrogen acquired three providers of immunological reagents and antibodies in 2005 – Zymed Laboratories, BioSource and Caltag Laboratories.

On the whole, these developments helped to contribute to a positive price performance for the antibody sector. A peer group of listed antibody companies (source: BioCentury) displayed an average sector price increase of 30 % in 2005. MorphoSys shares gained 8 % in value during the year.

Financial Analysis

Revenues

Compared to the same period in the previous year, revenues for the full year 2005 increased by 52% to q 33.5 million (2004: q 22.0 million). Reasons for the increase included revenues arising from new deals and the inclusion of success-based payments from existing collaborations (comprising 21% of the reporting year's total revenues), which included clinical and research milestones achieved in 2005. The Group also recorded grant revenues, amounting to q 0.4 million (2004: q 0.1 million) during the reporting period. Approximately 64% of total Group revenues arose from MorphoSys's three largest alliances with Novartis, Centocor and Schering (2004: 71% from Centocor, Bayer and Novartis). Geographically, 56% of MorphoSys' commercial revenues were generated with biotechnology and pharmaceutical companies located in Europe and Asia compared to 42 % in North America (see also Notes to the Consolidated Financial Statements—section 2). This compares to 45% and 55% respectively, in the year 2004.

Therapeutic Antibodies Segment

Included in the Therapeutic Antibodies segment are all collaborations which have a strong therapeutic and licensing aspect to them. In 2005, this segment's revenues were generated with the following antibody collaborations: Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Centocor (Johnson & Johnson), Eli Lilly, F. Hoffmann-La Roche, GPC Biotech, ImmunoGen, Merck & Co., Novartis, Novoplant, Pfizer, Schering, Shionogi and XOMA. The Therapeutic Antibodies segment also includes all activities in the area of proprietary product development. Revenues arising from the Therapeutic Antibodies segment accounted for 87 % of total revenues (q 29.1 million) in 2005. This total comprises q 22.2 million funded research and paid license fees, as well as q 6.9 million success-based payments (which include clinical milestones).

  • Grants
  • Research Antibodies Segment
  • Success-Based Payments
  • License Fees & Funded Research

Research Antibodies Segment

The Research Antibodies segment, comprising MorphoSys's Antibodies by Design unit and the Biogenesis Group companies in the U.S.A. and the U.K., generated 13% (q 4.3 million) of total revenues. The Biogenesis Group, acquired in January 2005, contributed q 2.8 million in revenues, or 65% of the total segment revenues. The Antibodies by Design unit, based in Munich, contributed the remaining 35%, or q 1.5 million, of the total MorphoSys Research Antibodies segment revenues.

Operating Expenses

(in million E)

  • Costs of Goods Sold
  • Research and Development Expenses
  • Sales, General and Administrative Expenses
  • Stock-Based Compensation

Operating Expenses

For the year 2005, operating expenses including stock-based compensation expenses increased by 28% to q 27.3 million (2004: q 21.3 million), while operating profit increased by q 5.6 million to q 6.2 million (2004: q 0.6 million). The total increase in operating expenses of q 6.0 million was mainly due to higher personnel-related costs in conjunction with new collaborations and increased intangible expenses. The incorporation of the Biogenesis Group companies into Group accounts had the effect of increasing operating expenses by q 3.9 million.

Cost of Goods Sold (COGS)

COGS only arise in the Research Antibodies segment. This item is composed of the cost of goods sold for Antibodies by Design and Biogenesis, as well as amortization relating to the fair value adjustment of Biogenesis' stock identified at the time of the acquisition. For the year 2005, total COGS rose to q 2.5 million compared to q 0.9 million in the year 2004, which resulted largely from the q 1.5 million inclusion of Biogenesis COGS into consolidated Group accounts.

Research and Development Expenses

Costs for research and development increased by q 2.1 million to q 13.6 million (2004: q 11.5 million). This increase mainly resulted from higher success-based license fees and intangible costs. Costs for intangibles rose due to the Lilly patent settlement and increased payments to third-party licensors in conjunction with higher revenue levels. Impairment of assets acquired in 2005 in context with the Biogenesis transaction contributed additional cost of q 0.5 million.

Sales, General and Administrative Expenses

Sales, general and administrative expenses amounted to q 10.1 million compared to q 7.5 million in the previous year. This effect mainly resulted from increased costs for external services and higher personnel costs associated with Biogenesis. Biogenesis' total contribution to sales, general and administrative expenses amounted to q 1.6 million for the year 2005.

Stock-Based Compensation

Stock-based compensation in the amount of q 1.1 million for the year 2005 was recorded as a non-cash charge (2004: q 1.4 million), resulting from the application of IFRS 2 "Share-Based Payment" under IFRS accounting. The decrease in stock-based compensation was mainly due to declining expenses from options granted in prior periods.

Cost by Expenditure Type

For the year 2005, personnel costs (excluding expenses arising from stock-based compensation) amounted to q 10.8 million (2004: q 9.1 million) or 40% of total operating expenses, thus representing the largest cost block within operating expenses in the year 2005. The higher personnel costs arose from the increased head count in association with the Group's expanded operational activity.

Intangible costs, which include patent litigation costs and amortization of licenses and patents, amounted to q 5.4 million (2004: q 3.3 million) or 20% of total operating expenses in the year 2005. External consultancy costs amounted to q 2.9 million (2004: q 2.7 million) or 11% of total operating expenses and mainly consisted of marketing expenses, legal costs, costs for tax, auditing and accounting, and general consulting. Costs for infrastructure accounted for q 2.9 million, compared to q 2.1 million in the prior year.

Total Assets (in million E)*

  • Cash Equivalents, and Available-for-Sale Financial Assets
  • Accounts Receivable
  • Intangibles
  • Goodwill
  • Other Assets

Liabilities

(in million E)*

Current Liabilities

Non-Current Liabilities

Stockholders' Equity

* Differences due to rounding up/down, see balance sheet pages 30/31.

Non-Operating Items

Non-operating expenses amounted to q 1.5 million compared to non-operating expenses of q 0.4 million in the year 2004. In the last quarter of 2005, foreign exchange losses were reclassified into non-operating expenses in an amount of q 0.8 million. These foreign exchange losses relate to certain commercial contracts and are shared with the respective partners. Formerly, such shared losses were netted into revenues. Losses on foreign exchange (q 1.2 million in total), tax expenses (q 0.4 million) and interest expenses (q 0.3 million) were mainly offset by gains from available-for-sale securities (q 0.6 million) and interest income (q 0.1 million).

Net Profit/Loss

Continuing the positive trend established in 2004, the Company presented a net profit of q 4.7 million, compared to the prior year's net profit of q 0.3 million. The resulting profit per share for the entire MorphoSys Group for the year 2005 amounted to q 0.84 (2004: q 0.05).

Liquidity/Cash Flows

At the end of 2005, the Group held q 53.6 million in cash, cash equivalents and marketable securities compared to a q 37.2 million balance in the year 2004. The increased cash item mainly derived from higher cash inflows as a result of the expanded operational activity and from a capital increase successfully executed in March 2005. The cash inflow from operations contributed q 4.4 million to the same.

Assets

Total assets increased by q 24.3 million to q 80.1 million in the year 2005, compared to q 55.8 million in the year 2004, mainly as a result of the increased cash item and the acquisition of the Biogenesis Group's assets, including property and equipment in the amount of q 3.3 million, intangibles in the amount of q 2.4 million, and acquired goodwill in the amount of q 4.1 million. The purchase price allocation resulting from the application of IFRS 3 "Business Combinations" exercised is reflected in the Group accounts (see also Notes to the Consolidated Financial Statements – section 9).

Accounts Receivable

Accounts receivable increased by q 1.0 million to q 3.3 million in comparison to year-end 2004 (q 2.3 million). Accounts receivable attributable to the Therapeutic Antibodies segment (q 2.7 million) accounted for 82% of total accounts receivable. The Research Antibodies segment represented q 0.6 million or 18% of total accounts receivable, whereas the Biogenesis Group and the Antibodies by Design unit contributed q 0.2 million and q 0.4 million respectively to this item.

Liabilities

In the year 2005, current liabilities increased by q 0.9 million to q 11.0 million (2004: q 10.1 million). This was mainly due to increased provisions including income tax provisions for the fiscal year 2005, as well as increased license payable in connection with success-based thirdparty payments for higher revenue.

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Equity

At year-end 2005, the total number of shares issued was 6,025,863, of which 5,996,701 were outstanding, compared to 5,438,852 and 5,408,790 respectively in 2004. The increase arose from the issuance of 490,133 shares in connection with a capital increase in March 2005. An additional increase of 96,878 shares resulted from the exercise and conversion of options and bonds issued to related parties during the year 2005.

Capital Expenditure

MorphoSys' investment in property, plant and equipment amounted to q 0.6 million for the year 2005, compared to q 1.5 million for the prior year. Investment in intangibles amounted to q 0.1 million and q 0.2 million respectively in the years 2005 and 2004. Depreciation of property, plant and equipment for the year 2005 accounted for q 0.9 million compared to q 0.7 million in the year 2004. Amortization of intangibles amounted to q 2.7 million in 2005 (2004: q 2.0 million). The increase in amortization and depreciation was mainly due to the acquisition of the Biogenesis Group.

Organization/Subsidaries/Acquisitions

Acquisition of the Biogenesis Group

In January 2005, MorphoSys announced the acquisition of two privately held companies, Biogenesis Ltd. (Poole, U.K.) and its sister company Biogenesis, Inc. (Brentwood, New Hampshire, U.S.A.). With more than 20 years of experience in antibody development and manufacturing and a comprehensive antibody catalog, the combined Biogenesis Group represents one of the larger European suppliers of antibodies to the life sciences research community. The final agreements, signed on January 20, 2005, specify the purchase of 100 % ownership of Biogenesis Ltd. and Biogenesis, Inc., by MorphoSys. The two Biogenesis companies became wholly owned subsidiaries of MorphoSys AG. At the beginning of 2006, both subsidiaries have been renamed to MorphoSys UK Ltd., and MorphoSys US, Inc.

The acquisition of Biogenesis was an important strategic step for MorphoSys, one of the leading sources of next-generation antibody therapeutics, in establishing its innovative HuCAL technology in new antibody market segments. It followed the establishment of the Antibodies by Design unit in late 2003 to serve the research and diagnostics markets with custom monoclonal antibodies. The Biogenesis Group has a strong catalog and industrial antibody production business, providing clients in the research and diagnostics field with many different antibody services.

Biogenesis and Antibodies by Design have merged all marketing and commercial activities. Most importantly, the combined companies have been now organized along three markets: first, in the custom monoclonal antibodies segment, custom monoclonal antibodies are generated in Munich by Antibodies by Design using the HuCAL technology for global clients of both companies. Second, Biogenesis provides a comprehensive catalog of antibody products, which serves as a potential portal for the other segments of the business. An initial series of HuCALderived antibodies was added to the Biogenesis catalog during 2005. The third segment comprises a contract manufacturing business where antibodies are produced in a scale from 10 milligrams to 10 grams or more on behalf of customers.

Acquisition of the Serotec Group

In January 2006, the Research Antibodies segment was further strengthened through the acquisition of the Serotec Group. The acquisition of Serotec, a renowned and internationally active supplier of research antibodies, more than triples MorphoSys's existing Research Antibodies segment revenues and establishes the Company as the leading supplier of research antibodies and antibody research technologies in Europe. Serotec provides MorphoSys with a strong distribution network including subsidiaries and sales offices in the U.S., U.K., Germany, France and Scandinavia. Serotec (Serotec Ltd., Serotec, Inc., Serotec GmbH and Oxford Biotech Ltd.) has become a wholly owned subsidiary of MorphoSys AG and is being integrated within MorphoSys' existing Research Antibodies segment represented to date by the Biogenesis and Antibodies by Design brands.

The purchase price of approximately £ 20 million (approx. q 29.3 million) has been paid via approximately £ 14 million (approx. q 20.5 million) cash and through the issuance of 208,560 new MorphoSys shares from a capital increase against contribution in kind.

Business Development

Therapeutic Antibodies Segment

In 2005, the Company expanded existing partnerships and signed new collaborations. The following partnerships were either established or expanded in the 2005 fiscal year (in alphabetical order). For a detailed description of the partnerships, please refer to the Notes to the Consolidated Financial Statements—section 24.

Bayer Pharmaceuticals Corporation

In December 2005, MorphoSys extended its collaboration with Bayer Pharmaceuticals Corporation ("Bayer"). The collaboration was extended by five years, with a termination option after the first collaboration year.

Boehringer Ingelheim GmbH

Boehringer Ingelheim GmbH ("Boehringer Ingelheim") and MorphoSys expanded their existing cooperation involving both research and therapeutic applications in March 2005. Under the new contract, Boehringer Ingelheim has acquired an option to receive several exclusive licenses on new therapeutic antibody programs.

Bristol-Myers Squibb Company

In January 2005, MorphoSys signed a further expansion of its existing license agreement with Bristol-Myers Squibb Company ("Bristol-Myers Squibb"). Under the amended agreement, MorphoSys granted Bristol-Myers Squibb access to its HuCAL GOLD® library for use in Bristol-Myers Squibb's pharmaceutical discovery programs for target characterization and validation and for therapeutic and diagnostic antibody product development.

Eli Lilly & Company

In September 2005, MorphoSys announced a cross license agreement with Eli Lilly & Company ("Lilly") on the use of certain recombinant protein technologies. Under the agreement, MorphoSys received a license under the Kauffman patent estate to generate and screen certain recombinant peptide and protein libraries and to commercialize any resulting products. The agreement also provides Lilly access to the MorphoSys HuCAL GOLD technology for Lilly's internal research and development programs. The agreement was part of a settlement to resolve patent litigation initiated by Applied Molecular Evolution (AME), a wholly owned subsidiary of Lilly, involving several U.S. patents of the Kauffman patent family.

ImmunoGen, Inc.

MorphoSys announced in June 2005 that the U.S. biotechnology company, ImmunoGen, Inc., ("ImmunoGen") has extended its license to use the MorphoSys HuCAL GOLD library in ImmunoGen's internal target research programs for another year.

Merck & Co., Inc.

In December 2005, MorphoSys signed a five-year license agreement with the U.S. pharmaceutical company Merck & Co., Inc., ("Merck") for the use of MorphoSys' HuCAL GOLD and AutoCAL technologies in research and development of human therapeutic antibodies.

Shionogi & Co. Ltd.

MorphoSys and Shionogi & Co. Ltd. ("Shionogi") announced in September 2005 that they have signed a three-year license agreement on the use of MorphoSys' HuCAL technology. Under the terms of the agreement, MorphoSys grants Shionogi access to its HuCAL GOLD antibody library for use in Shionogi's pharmaceutical drug discovery programs.

Research Antibodies Segment

Armbruster Biotechnology GmbH

In March 2005, Antibodies by Design and Armbruster Biotechnology GmbH ("Armbruster") received a grant of approx. q 1 million from the German Federal Ministry of Education and Research (BMBF). The goal of this project is the research of new therapies against bone cancer metastasis, a life-threatening disease associated with various advanced cancers.

ProQinase/NMI

In June 2005, Antibodies by Design announced the start of a joint project with ProQinase, a division of KTB Tumorforschungs GmbH at the Tumor Biology Center, Freiburg, and the NMI Natural and Medical Sciences Institute at the University of Tübingen, which could transform the analysis of all human protein kinases—the human "kinome". The project combines the established protein kinase platform of ProQinase with the know-how of Antibodies by Design in the field of custom-made antibody generation and the experience of NMI with siRNA and biochip technologies. In the coming three years, the project will be supported by approximately q 2.0 million within the scope of the BioChancePLUS Program of the German Federal Ministry of Education and Research (BMBF).

Research and Development/Alliance Management

MorphoSys uses its own HuCAL technology for the development of therapeutic antibodies and research reagents. Its technology has been thoroughly tried and tested in numerous partnerships. The following represents the progress made in various existing collaborations throughout the year:

Therapeutic Antibodies Segment

In the course of the 2005 fiscal year, MorphoSys made significant progress in various existing collaborations. For a description of all existing partnerships, please see section 24 of the Notes to the Consolidated Financial Statements.

Centocor, Inc.

In September 2005, Centocor, Inc., ("Centocor"), a Johnson & Johnson company, elected a new target molecule involved in immune-mediated and inflammatory diseases, against which MorphoSys will generate antibodies using its proprietary HuCAL GOLD technology. Centocor will carry out pre-clinical and clinical development and the subsequent marketing of resulting products.

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GPC Biotech AG

In February 2005, MorphoSys announced that GPC Biotech AG has commenced a phase 1 clinical trial with a fully human cancer antibody generated using MorphoSys' HuCAL technology.

Novartis AG

In August 2005, MorphoSys successfully concluded an initial therapeutic antibody program with Novartis AG ("Novartis"). MorphoSys generated numerous fully human antibodies against a cancer disease-related target molecule from Novartis, fulfilling previously defined success criteria, and thus achieved the first performance-related milestone in the cooperation. The project work commenced in September 2004 and was completed within 11 months.

Schering AG

MorphoSys started three more therapeutic antibody programs within the scope of its collaboration with Schering AG ("Schering") in October 2005. Schering has selected three new target molecules, against which MorphoSys will generate antibodies using its proprietary HuCAL GOLD technology. Additionally, MorphoSys has granted Schering eight exclusive licenses for in vivo diagnostic applications.

MorphoSys' Proprietary Product Development

MorphoSys did not achieve its 2005 goal for presenting a commercial partner for at least one of its proprietary antibody candidates. Currently, the Company's proprietary pipeline of therapeutic antibody programs comprises four candidates, MOR101, MOR102, MOR103 and MOR202. To increase the future commercial success, MorphoSys is currently performing a strategic review of its own product pipeline. The results of this review will be presented at the Company's year-end press conference in February 2006.

MOR102

In April 2005, MorphoSys provided an update on its MOR102 antibody program for chronic in-flammatory diseases. As part of this program, MorphoSys commissioned a preclinical study to compare the effectiveness of MOR102 with that of the approved biologics Amevive® and Raptiva® in an animal model of psoriasis. Although therapeutic effects were observed for all tested compounds in several psoriatic skin samples, the indepth analysis showed that it is not possible to discriminate on a statistically valid basis between compoundmediated effects and spontaneous healing observed in the negative control group. Hence, this study did not enable conclusions to be drawn regarding the efficacy of MOR102 versus Amevive® or Raptiva®.

Research Antibodies Segment

Since the start of the Research Antibodies segment, various achievements within the identification and production process of research antibodies have been obtained. The overall goal is to create better research antibodies faster and more efficiently.

High Throughput in Generating Antibodies

Antibodies by Design unit concluded an extensive software project designed to allow increased antibody generation throughput via automated management of parallel projects. This new relational database system improves the efficiency of internal data administration relating to customers, processes, storage and shipment of materials. It includes establishment of a bar code system supporting the PSA (Panning & Screening Automation) software and is part of an ongoing comprehensive automation program by Antibodies by Design to increase the efficiency and speed of high-throughput antibody generation.

Introduction of Several HuCAL GOLD Recombinant Antibodies at Biogenesis

In September 2005, the Antibodies by Design unit introduced a series of fully human, recombinant research antibodies from the HuCAL GOLD antibody library into the sales catalog of the Biogenesis Group. These recombinant research antibodies were identified and developed as part of ongoing research cooperations and proactive projects at Biogenesis for targets with significant demand from potential new clients.

National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK)

In November 2005, Antibodies by Design announced the publication of a scientific research paper by a customer using antibodies generated from the MorphoSys HuCAL GOLD antibody library. Using its rapid, highthroughput antibody generation system, Antibodies by Design selected a set of eight monoclonal and fully human mini-antibodies targeted specifically against the HIV-1 protein gp41 antigens provided by Dr. G. Marius Clore. Scientists working in the team of Drs. Clore and Bewley at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) – part of the U.S. National Institutes of Health (NIH) – subsequently analyzed these antibodies in detail and published the results in the current edition of the Journal of Molecular Biology. The analysis demonstrates that the HuCAL-based antibody fragments provide a set of useful probes for studying HIV-1 envelope-mediated cell fusion and may act as fusion inhibitors preventing HIV-1 virus particles from entering their target cells.

Intellectual Property

Patent Litigation with AME/Eli Lilly Settled

In September 2005, MorphoSys signed a cross-licensing agreement with the pharmaceutical group Eli Lilly & Company concerning the use of certain recombinant protein technologies. The agreement allows MorphoSys rights to the Kauffman patents. At the same time, the agreement grants Lilly a license to use MorphoSys' HuCAL GOLD technology in its own internal research and development programs over a certain period of time. This agreement stems from the patent dispute with Applied Molecular Evolution (AME), a wholly owned subsidiary of the Lilly Group, initiated by AME against MorphoSys in 2001.

Information Technology

MorphoSys is experiencing rapid growth in head counts and operations, which demands management and IT infrastructures. MorphoSys will continuously improve and enhance its information and communication systems to ensure that all offices around the world are well coordinated and all employees can effectively communicate with the Company's growing customer base.

During 2005, MorphoSys implemented a new customer relationship management (CRM) system to improve the communication between customers and employees of MorphoSys. Additionally, the Biogenesis companies, which were acquired in January 2005, were integrated into the Company's network to ensure that all employees have access to all necessary information. Internally, the Company implemented management software for human resources to facilitate the management of the increased number of employees.

Financing

In March 2005, MorphoSys placed 490,133 shares in a private placement at a price of q 35.50 per share. The Company raised gross proceeds of approx. q 17.4 million. The issue proceeds will be used to capitalize on existing and future expansion opportunities to accelerate internal and external sales growth, primarily in MorphoSys' activities in the field of research antibodies. With the capital increase, the number of issued shares rose from 5,438,852 to 5,928,985 shares, corresponding to an increase of subscribed share capital in common stock from q 16,316,556 to q 17,786,955.

Production

To improve its production capabilities, MorphoSys has conducted a feasibility study with Wacker Biotech GmbH ("Wacker"). Wacker demonstrated that its proprietary E. coli secretion system can offer a far simpler and more cost-effective way of obtaining high yields of antibody fragments, which can be used for research, diagnostic and therapeutic applications. Under the joint agreement, MorphoSys obtains the right to use Wacker's secretion system for antibody fragment production in research quantities for therapeutic projects both on its own behalf and with its commercial partners.

Procurement

MorphoSys' procurement is focused on chemicals and laboratory supplies for R&D. The Company procures all needed material from international suppliers, and tends to place its purchase orders with the most favorably priced suppliers, taking into consideration all relevant quality aspects. One major goal is to secure sufficient supply at all times, at the lowest cost. In this vein, key global suppliers are being identified, in conjunction with recent acquisitions, in order to achieve maximum negotiating power with the Company's global vendors.

Human Resources

People at MorphoSys

MorphoSys is committed to building up a sustainable competitive advantage through the quality, the capability, the commitment and ultimately the performance of its employees. The Company's success is predicated on its ability to recruit and retain highly qualified and motivated people in all areas of the Company. During 2005, the fluctuation rate of employees was very low at 3.5%.

Performance-Related Compensation and Stock Option Programs

MorphoSys' success is based on the high motivation of its employees. In this vein, all employees take part in a "management by objectives" program. During 2005, MorphoSys implemented a new bonus scheme for all employees. The yearly bonus payments for each employee are dependent on the achievement of personal goals, as well as department and Company goals. For employees with management functions, the Company goals account for a higher percentage of the individual bonus payment. The new bonus payment is set up to support the future growth of the MorphoSys Group.

Additionally to the performance-related compensation, all employees have the chance to participate in a stock option or convertible bonds program as part of a long-term equity incentive scheme. The aim of this program is to give employees a long-term stake in the success of the Company.

Appointment of a New Member of the Management Board

On November 1, 2005, Dr. Marlies Sproll was appointed as Chief Scientific Officer and a member of the Management Board of MorphoSys AG. Dr. Sproll leads MorphoSys' research and development departments, as well as alliance management. Dr. Sproll joined MorphoSys in October 2000 as R&D department head. In September 2004, Dr. Sproll was promoted to Senior Vice President R&D, heading the complete research and development department of MorphoSys AG.

Number and Qualification of Employees

On December 31, 2005, the MorphoSys Group employed 172 people (December 31, 2004: 132). On average, the MorphoSys Group employed 170 people for the year 2005 (2004: 117).

Of the 172 employees, 123 worked in research and development and 49 in sales, general and administration. At the end of 2005, 46 of the employees of the MorphoSys Group had a Ph.D. degree (December 31, 2004: 45).

Of total employees, 27 worked for the Biogenesis Group, of whom 10 were engaged in research and development and 17 in sales, general and administration.

On December 31, 2005, MorphoSys employed 1 trainee as a technical information processor in the area of information technology (December 31, 2004: 2).

Numer of Employees
MorphoSys AG, Martinsried/Munich 145
MorphoSys, Inc., Charlotte, North Carolina, U.S.A.
MorphoSys IP GmbH, Martiensried/Munich
Biogenesis Ltd., Poole, U.K. 23
Biogenesis, Inc., Brentwood, New Hampshire, U.S.A. 4
Total 172

Employees of MorphoSys Group

Environment and Health Protection

MorphoSys carries out its research in safety level "Bio I" and "Bio II" laboratories and under observance of all relevant legal guidelines. Internal standards are more stringent than those guidelines which are legally required. One designated employee for work safety is part of the expert team of employees specifically responsible for work safety, biological safety and fire prevention. Employees are given regular training to inform them of the latest guidelines. To date, no official inspections have resulted in any requirement to change procedures. Due to regular maintenance by internal employees, all laboratory equipment adheres to the highest possible standard of safety. During 2005, no industrial accident was subject to mandatory reporting.

A detailed waste management concept has been extensively documented and ensures that disposal of laboratory waste is always in line with valid limits and guidelines.

Regular medical checks are carried out for all MorphoSys employees. An initial medical check is carried out for all new employees in the research department. Such checks are repeated yearly. Furthermore, employees are routinely vaccinated against hepatitis A and B.

Risk Report

MorphoSys AG operates on a global basis. Its business activities comprise different risks, which are relevant to many business functions. The business, financial condition and operating results of MorphoSys may be materially adversely affected by each of these risks. In line with the German "Corporate Sector Supervision and Transparency Act" ("Gesetz zur Kontrolle und Transparenz im Unternehmensbereich" – KonTraG), MorphoSys has established a comprehensive and effective system to identify, assess, communicate and manage risks across its functions and operations. Risk management has the goal of identifying risks as early as possible, limiting business losses by means of suitable measures, and avoiding risks that pose a threat to the Company's existence. Regular risk analyses at a corporate level are carried out in the following areas: Legal, Taxes and Insurance, Human Resources, Finance, Strategic Planning and Controlling, Business Development, Research and Development and Production.

General Business-Related Risks

MorphoSys is subject to the typical industry and market risks inherent to the development of fully human antibodies for use in research, diagnostics and therapy. It is known, that the development of drugs requires 10 to 15 years, with high attrition rates. MorphoSys is minimizing these risks by partnering its products with pharmaceutical and biotechnology companies, which are responsible for clinical development and marketing. In general, there is a risk that none of the antibody prod-ucts in MorphoSys's current antibody pipeline will be successfully developed.

Within its second operating segment, the MorphoSys Group generates antibodies for research applications and diagnostics applications. There is a risk that those products will not fulfill the requirements of the customers, or that other products will be more favorably priced.

Acquisition Risks

During 2005, MorphoSys acquired the Biogenesis Group, through which the Company has gained access to new distribution and sales channels. In the future, MorphoSys may acquire additional companies or technologies to increase market share and to complement existing business. Acquisition can expose the Company to risks associated with the assimilation of new technologies, operations, sites and personnel, the inability to generate sales to offset acquisition costs, the issuance of dilutive equity securities, the inability to maintain relationships with employees and customers and additional expenses associated with future amortization or impairment of acquired intangible assets or potential business. The failure to address the aforementioned risks may prevent the Company from achieving the anticipated benefits from the acquisition in a reasonable time frame.

Product Development Risks

MorphoSys is committed to generating therapeutic antibodies for its commercial partners and, more recently, on its own account. Thus, the Company's product pipeline comprises both partnered and proprietary therapeutic antibody development programs. These programs are subject to a number of risks of failure inherent in the development of medical therapies. Product candidates require pre-clinical studies and clinical trials in humans, as well as regulatory approval prior to commercialization. To date, none of the Company's licensees or partners has commercialized a product based on MorphoSys' HuCAL technology, and HuCAL-derived therapeutics are not expected to be commercially available for a number of years. In addition, none of the HuCAL-derived product candidates has successfully completed all stages of clinical testing and regulatory approval procedures. Pre-clinical studies may not predict and do not ensure safety or efficacy in humans, and are not necessarily indicative of the results that may be achieved in pivotal clinical trials with humans.

Competition and Technological Change

MorphoSys' business environment is characterized by rapid change and intense competition. Its competitors include major pharmaceutical, chemical and biotech companies possessing greater financial, technical and marketing resources than those available to MorphoSys. In addition, certain biotech companies have formed collaborations with large established companies to support the research, development and commercialization of products that may be competitive with those of MorphoSys. Moreover, certain research and academic institutions are also active in areas similar to MorphoSys. Some of MorphoSys' competitors are currently focusing their business efforts on gaining a share of the market and offer their technology at little or no cost to collaboration partners. The first pharmaceutical product to reach the market is often at a significant advantage to later entrants, particularly since subsequent potential entrants must prove an advantage of their product over products already in the market. There is a risk that MorphoSys' competitors could succeed in developing technologies and products that are safer, less costly and more effective than its technologies or products. In addition, there is a risk that these technologies could produce products that reach the market earlier and could be more successful than those developed by MorphoSys.

Product Risks

The marketing and sale of antibody products and services for certain applications entails a potential risk of product liability, and there can be no assurance that product liability claims will not be brought against the Company. MorphoSys currently carries product liability insurance coverage. There can be no assurance, however, that the Company will be able to maintain such insurance at a reasonable cost and on reasonable term or that such insurance will be adequate to protect MorphoSys against any or all potential claims or losses.

Dependence on Health Care and Pharmaceutical Spending

MorphoSys is dependent on various sources of income, including, in particular, fees, milestone payments and royalties from licensees and partners, the financial condition of public treasuries and the financial markets, the government and governmental health authorities, research institutions, private health insurers and other organizations. Part of MorphoSys' revenue is derived from entering into collaborations with partners, including pharmaceutical companies. Many collaborative and/or outlicensing agreements provide for milestone payments and fees to be paid subject to the satisfaction of specific criteria. MorphoSys has no control over whether its partners or licensees will be able to meet such milestones, nor will MorphoSys be able to control whether products derived from its technology are being developed at all by its partners. Moreover, certain pharmaceutical companies may be more likely to seek to inlicense products

which have already reached a relatively advanced stage of development, such as phase 2 compounds, as opposed to less advanced product candidates still in preclinical stages. Consequently, the products in MorphoSys' pipeline may not reach a sufficiently advanced stage of development to be of interest to these pharmaceutical companies for some time. Therefore, the Company can offer no assurance that there will be a guaranteed revenue stream from current or future collaborations.

IP Risks

MorphoSys is or has been involved in legal proceedings in Germany and certain foreign jurisdictions, including the United States. These involve claims brought by and against it for license or patent infringement, which arise in the ordinary course of business. After the settlement of the litigation with Applied Molecular Evolution/Eli Lilly in September 2005, no significant patent litigation is pending. However, the field of recombinant antibody libraries and phage display, in which the Company is active, is relatively new, and the intellectual property position of the various parties involved is complex and litigious. Therefore, MorphoSys can offer no assurance that further patent suits will not be brought by companies possessing existing patents or patents which have not yet been granted or which the Company is currently not aware of. Any such proceedings, if brought and subsequently decided against MorphoSys, could have an adverse material effect on the business, financial condition and operating results of MorphoSys.

Additional Funding Requirements

MorphoSys' future capital requirements will continue to be substantial and will be dependent on many factors, including its ability to find licensees and to enter into satisfactory collaboration agreements, as well as the success of such collaborations in generating revenues (e. g. licensing fees, milestone payments and royalties). The costs of the preclinical testing of MorphoSys' products and technologies and the costs associated with filing, defending and enforcing patent rights may exceed the returns from these products. MorphoSys may also need to raise additional funds in future years. The Company can offer no assurance that adequate funds will be available to MorphoSys when needed on satisfactory terms or at all. If adequate funds are not available or are not available on acceptable terms, MorphoSys may have to further reduce its expenditures for research and development, production or marketing. Any such development could have a material adverse effect on MorphoSys' business, financial condition and results of operations. If additional funds are raised by issuing shares, stockholders are likely to experience a dilution of their interests.

Currency Risks

The Group accounts are administered in euros. While the expenses of MorphoSys are predominantly paid in euros, a significant part of the revenues depends on the current exchange rate of U.S. dollars and euros. The Company examines the necessity of hedging foreign exchange transactions to minimize currency risk during the year and addresses this risk by employing derivative financial instruments.

Dependence on Key Personnel

MorphoSys has not experienced any difficulties in attracting or retaining key management or scientific staff, but the continued ability to recruit and retain qualified skilled personnel is critical to the Company's success. Due to the intense competition for experienced scientists from numerous pharmaceutical and biotechnology companies and academic and other research institutions, there can be no assurance that MorphoSys will be able to attract and retain such personnel on acceptable terms. Planned activities will also require additional personnel, including management, with expertise in different areas. The inability to recruit such personnel or develop such expertise could have an adverse material impact on the Company's operations.

Opportunities

MorphoSys is one of the world's leading biotechnology companies focusing on fully human antibodies. With its proprietary technologies, MorphoSys is developing not only the next generation of therapeutic antibodies, but also antibodies for research and diagnostics purposes. Antibodies represent the single fastest growing class of therapeutic agents in the pharmaceutical industry. The Company is well-positioned in this market and expects to continue its growth.

Therapeutic Antibodies

MorphoSys is a global player in the field of therapeutic antibodies. Only a few companies offer technologies to develop fully human antibodies, and MorphoSys offers one of the most advanced technologies in this field. MorphoSys owns several issued and pending patents on its core antibody technologies, which provide the Company with protection from competition. Due to high market entry barriers for new companies, as well as an increasing demand for antibody therapeutics, MorphoSys expects an increasing deal flow over the coming years. As can be seen from its partnership roster over the last 6-7 years, MorphoSys has a broad set of alliances with

pharmaceutical and biotechnology companies that have the know-how and resources to develop new therapeutics. Furthermore, the Company has been extremely successful in extending existing alliances. There may well be opportunities in the future not only to add new partnerships, but to extend and expand the scope of existing alliances.

By participating in drug development with multiple partners, MorphoSys has effectively lowered its risk profile. With currently between 25 and 30 active therapeutic antibody development programs ongoing with its partners, the chance that MorphoSys will participate financially in one or more marketed drugs is much higher than if fewer partnerships and fewer programmes were ongoing. As time goes on, and development projects advance, it is expected that both the number and magnitude of success-based payments will increase.

With regard to MorphoSys' proprietary antibody pipeline, the Company plans to increase its investments in own development programs, and intends to develop the antibody MOR103 for the treatment of rheumatoid arthritis at least as far as IND. By taking this programme forward without a partner, the Company stands to benefit from more lucrative financial terms at such time as an alliance for its further development is entered.

Research Antibodies

Through its acquisition of the Serotec Group, MorphoSys became Europe's leading provider of antibodies and antibody technology for research and diagnostic applications. With this, and the earlier acquisition of Biogenesis, the Company is establishing a strong base from which to commercialise HuCAL-derived antibodies in the research and diagnostics markets. These markets have traditionally been totally dominated by antibodies derived from animals. With its firstmover advantage, MorphoSys intends to lead the transition to new in vitro technologies for antibody generation. In contrast to animal-based methods, in vitro technologies, such as the HuCAL library, offer greater speed, throughput and flexibility in antibody generation.

The Company has demonstrated its ability to complete acquisitions in this segment of the industry and to use these transactions to accelerate its growth. MorphoSys intends to continue using a merger and acquisition strategy as a means of increasing its market share and achieving its growth objectives. From its current position as a leader in the European market, the Company expects to become one of the leading global players in this field.

Outlook and Forecast

Global Economic Outlook

In its September 2005 World Economic Outlook, the IMF (International Monetary Fund) continued to assume that the world economy – despite the renewed surge in oil prices in the third quarter of 2005 – will grow by 4.25% in 2006. The growth rate would thus remain well above the long-term average of 3.5%. The IMF forecast is based on the expectation that the growthdampening effects of higher oil prices will be offset by a continued accommodative monetary policy, favorable financial market conditions, especially low long-term interest rates, and a sustained improvement in corporate balance sheet structures.

Development of the Biotechnology Sector

For 2006, a continued positive development of the biotechnology sector is anticipated. According to Burrill & Company, in comparison to 2005, an increasing IPO market is expected, with more than 30 IPOs in the U.S. and an even a larger number internationally. It is intended that companies of the biotechnology industry will raise over US \$ 35 billion in 2006, with approximately US\$ 25 billion from the public equity markets capital and US\$ 10 billion in partnering. The trend towards consolidation through M&A activities is expected to continue with more deals than in 2005, especially among the larger companies.

Strategy

MorphoSys runs its business in two operating segments. One segment, the Therapeutic Antibodies unit, develops drug candidates for commercial partners and MorphoSys' own proprietary product pipeline. MorphoSys' second operating segment, the Research Antibodies segment, delivers antibodies to the research antibody market, under the brands "Antibodies by Design" and "Biogenesis" and from 2006 "Serotec". From 2006 onwards, the segment will be named AbD – Antibodies Direct.

In the future, MorphoSys expects further growth in both segments of its business. The Company anticipates signing further therapeutic and research antibody collaborations. Additionally, it is planned to invest in the development of its own proprietary antibody therapeutics. For the Research Antibodies segment (AbD), it is the stated goal of the Company to establish the HuCAL technology as an industry standard for the generation of antibodies within the life science industry. MorphoSys further endeavors to increase its worldwide market share through a combination of organic and inorganic growth. For both segments is intended to further expand to new geographical markets, e.g. the Asian-Pacific region.

Revenues

In line with growth expectations for a life sciences "growth" company, MorphoSys expects its long-term organic sales growth to average at least 15 % per annum. Over the last 5 years, annual revenue growth has averaged 36 %.

MorphoSys receives periodic license payments (both short and long term), funded research payments, performance-based success payments, and clinical milestone payments within the realm of its therapeutic antibody collaborations. In 2006, it is anticipated that milestones and successbased payments will contribute an increasing percentage of total revenues as compared to previous years. Such performance-based payments lend themselves to potentially higher upside, but also more volatility and unpredictability throughout the year.

Revenues from the Research Antibodies segment (AbD) are expected to further increase. Through the acquisition of Serotec in January 2006, revenues will at least triple in 2006. The acquisition of Biogenesis and Serotec provides MorphoSys with immediate access to new distribution channels and customers for its innovative HuCAL antibody technology. Revenues from the AbD segment comprise sales of ready made antibodies from the Biogenesis and Serotec antibody catalogs, revenues for services of the Antibodies by Design unit for custom monoclonal antibodies and revenues for contract manufacturing services.

Expenses

Expenses are expected to increase in 2006 compared to the prior year, mainly due to an increased full-year total average headcount of the MorphoSys Group as compared to the previous year. Additionally, personnel costs are expected to be impacted by higher stock-based compensation expenses resulting from stock options and convertible bonds granted at the beginning of 2006. Further increases in costs are expected to arise from further investment into development of the underlying HuCAL technology and higher levels of investment into product development.

Research and Development

Research and development is to remain the key focus in coming years. MorphoSys intends to maintain its technological leadership in the area of human antibodies and plans to invest money in further technology development. The Company continues to pursue further proprietary product development, and more specifically, focus these efforts on getting MOR103 for the treatment of rheumatoid arthritis at least as far as IND.

Financing

MorphoSys achieved profitability for the first time in 2004, and has been cash positive since 2003. The present business model is predicated on running operations independent of the capital market, i.e. at least cash neutral. Free cash flow and operating profits are intended to be reinvested into research and development, as well as in future growth opportunities in order to secure the long-term growth of the Company. On this basis, financings required for continuation of normal operations are currently not foreseen in 2006. However, a financing in conjunction with future acquisition would be on this basis not absolutely excluded per se.

Capital Expenditures

Investment in property and equipment is expected to increase in comparison to the previous year. Such investment is expected to focus increasing the efficiency of antibody generation at MorphoSys and maintaining the technological leadership using the HuCAL antibody library. For the newly acquired Serotec Group, investments for integration and exploitation of synergies are planned.

Human Resources

The average number of total employees of the MorphoSys Group is expected to be higher in 2006 due to the acquisition of Serotec, which adds approximately 80 employees to the corporate head count. New employees required beyond these levels are presently contingent upon new collaborations or expansions of existing business activities to support the same.

Supply Chain Management

In conjunction with the newly acquired affiliates in U.K. and U.S. (i.e. Biogenesis Group and the Serotec Group), MorphoSys is presently identifying common vendors across its various subsidiaries, in order to secure global agreements with these parties. It is expected that thereby additional critical mass could be gained in these agreements, which would help the Company to secure the most beneficial terms for Group Companies.

Future Legal Corporate Structure and Organization

The acquired Biogenesis Ltd. and Biogenesis, Inc., are now subsidiaries of MorphoSys AG and were renamed by the beginning of 2006 in MorphoSys UK Ltd. and MorphoSys US, Inc. The recently acquired Serotec Group, which includes Serotec Ltd., Serotec, Inc., Serotec GmbH and Oxford Biotechnology Ltd., also became affiliates of MorphoSys AG. A review is presently ongoing relating to corporate structure, with the ultimate purpose of making the present MorphoSys Group companies work as efficiently and smoothly as possible.

Dividends

Although MorphoSys achieved a net profit in 2005, the Company believes that the payment of dividends should be deferred until such time as its financial and liquidity position supports the same. As such, any profits generated by the business shall be reinvested into the operation of its business in order to create further growth opportunities for the future.

Financial Statements

  • Consolidated Statements of Operations (IFRS)
  • 30 Consolidated Balance Sheets (IFRS)
  • Consolidated Statements of Changes in Stockholders' Equity (IFRS)
  • 34 Consolidated Statements of Cash Flows (IFRS)

notes to the consolidated financial statements

  • Organization and Summary of Significant Accounting Policies
  • Segment Reporting
  • Cash and Cash Equivalents
  • Investments
  • Accounts Receivable
  • Other Receivables
  • Prepaid Expenses and Other Current Assets
  • Property and Equipment
  • Intangible Assets
  • Other Assets
  • Accounts Payable
  • Provisions
  • Stockholders' Equity
  • Convertible Bonds
  • Stock Options
  • Personnel Expenses
  • Income Taxes
  • Earnings Per Share
  • Financial Risk Management Objectives and Policies
  • Operating Leases
  • Contingencies
  • Related Parties
  • Corporate Governance
  • Research and Development Agreements
  • Events After the Balance Sheet Date
  • Summary of Significant Differences Between German GAAP and IFRS
  • Roll-Forward of Fixed Assets (Appendix 1)
  • Chart of Consolidated Equity (Appendix 2)
  • Audit Opinion

028 financial statements

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Consolidated Statements of Operations (IFRS)

in R Note 12/31/2005 12/31/2004
Revenues 1q 33,486,843 21,978,796
Operating Expenses
Cost of Goods Sold 2,514,172 943,817
Research and Development 2 11,447,478
Sales, General and Administrative 10,072,583 7,522,188
Stock-Based Compensation 14, 15 1,132,104 1,423,907
Total Operating Expenses 27,326,502 21,337,390
Profit from Operations 6,160,341 641,406
Interest Income 108,101 285,695
Interest Expense 277,228 338,469
Other Expenses, Net 879,259 306,520
Profit before Taxes 5,111,955 282,112
Income Tax 17 435,586
Net Profit 4,676,369 282,112
Basic Net Profit per Share 18 0.84 0.05
Diluted Net Profit per Share 18 0.83 0.05
Shares Used in Computing Basic Net Profit
per Share 18 5,578,865 5,131,467
Shares Used in Computing Diluted Net Profit
per Share 18 5,650,378 5,169,965

Consolidated Balance Sheets (IFRS)

in R Note 12/31/2005 12/31/2004
Assets
Current Assets
Cash and Cash Equivalents 3 4,017,029 12,531,198
Available-for-Sale Financial Assets 4 49,542,541 24,698,532
Accounts Receivable 5 3,345,812 2,304,778
Other Receivables 6 25,133 392,035
Prepaid Expenses and Other Current Assets 7 1,544,174 430,608
Total Current Assets 58,474,689 40,357,151
Non-Current Assets
Property, Plant and Equipment, Net 8 4,696,863 2,330,995
Patents, Net 9 2,361,005 2,790,091
License Fees, Net 9 8,457,091 9,671,131
Software, Net 9 131,506 288,115
Know How& Customer List, Net 9 1,485,567
Goodwill 9 4,137,349
Other Assets 10 372,574 358,210
Total Non-Current Assets 21,641,955 15,438,542
Total Assets 80,116,644 55,795,693

031

in R Note 12/31/2005 12/31/2004
Liabilities and Stockholders' Equity
Current Liabilities
Accounts Payable 11 4,321,591 3,838,144
Current Portion of License Payable 11 1,012,233 910,243
Provisions 12 978,719 600,607
Current Portion of Deferred Revenue 1q 4,735,208 4,757,249
Total Current Liabilities 11,047,751 10,106,243
Non-Current Liabilities
License Payable, Net of Current Portion 11 880,015
Provisions, Net of Current Portion 12 62,763
Deferred Revenue, Net of Current Portion 3,687,199 5,100,646
Convertible Bonds Due to Related Parties 14 50,214 109,692
Deferred Tax Liability 9, 17 1,260,946 220,611
Total Non-Current Liabilities 5,061,122 6,310,964
Stockholders' Equity 13, 14, 15
Common Stock, W
3.00 Par Value;
11,416,850 and 9,597,400 Ordinary Shares Authorized;
6,025,863 and 5,438,852 Ordinary Shares Issued;
5,996,701 and 5,408,790 Ordinary Shares Outstanding;
for 2005 and 2004 respectively
Treasury Stock (29,162 and 30,062 shares
for 2005 and 2004 respectively), at Cost 18,066,886 16,305,523
Additional Paid-In Capital 96,412,849 78,646,377
Accumulated Other Comprehensive Income 877,863 452,782
Accumulated Deficit
Total Stockholders' Equity 64,007,771 39,378,486
Total Liabilities and Stockholders' Equity 80,116,644 55,795,693

Consolidated Statements of Changes in Stockholders' Equity (IFRS)

Common Stock
Shares R
Balance as of January 1, 2004 4,901,332 14,703,996
Compensation Related to the Grant of Stock Options and Conv. Bonds
Equity Components of Convertible Bonds Granted to Employees
Exercise of Options and Convertible Bonds Issued to Related Parties 47,387 142,161
Exercise of Options from Treasury Stock Issued to Related Parties
Conversion of Convertible Bonds, Net of Issuance Cost of R 126,583 490,133 1,470,399
Other Comprehensive Income:
Change in Unrealized Gain on Avialable-for-Sale Securities,
Net of Deferred Tax Asset
Foreign Currency Gain from Consolidation
Net Profit for the Period
Comprehensive Income
Balance as of December 31, 2004 5,438,852 16,316,556
Compensation Related to the Grant of Stock Options and Conv. Bonds
Equity Components of Convertible Bonds Granted to Employees
Exercise of Options and Convertible Bonds Issued to Related Parties 96,878 290,634
Exercise of Options from Treasury Stock Issued to Related Parties
Capital Increase, Net of Issuance Cost of R 483,253 490,133 1,470,399
Other Comprehensive Income:
Change in Unrealized Gain on Avialable-for-Sale Securities,
Net of Deferred Tax Asset
Foreign Currency Gain from Consolidation
Net Profit for the Period
Comprehensive Income
Balance as of December 31, 2005 6,025,863 18,077,589

033

Treasury Stock Additional
Paid-In Capital
Revaluation
Reserve
Translation
Reserve
Accumulated
Deficit
Total Stock-
holders' Equity
Shares R R R R R R
59,762 (21,934) 68,632,990 244,930 50,826 (56,308,308) 27,302,500
1,423,908 1,423,908
7,405 7,405
715,476 857,637
(29,700) 10,901 508,850 519,751
7,357,748 8,828,147
158,299 158,299
(1,273) (1,273)
282,112 282,112
439,138
30,062 (11,033) 78,646,377 403,229 49,553 (56,026,196) 39,378,486
1,132,104 1,132,104
1,185,929 1,476,563
(900) 330 2,370 2,700
15,446,069 16,916,468
181,450 181,450
243,631 243,631
4,676,369 4,676,369
5,101,450
29,162 (10,703) 96,412,849 584,679 293,184 (51,349,827) 64,007,771

Consolidated Statements of Changes

in Stockholders' Equity (IFRS)

Consolidated Statements of Cash Flows (IFRS)

in R Note 12/31/2005 12/31/2004
Operating Activities
Net Profit 4,676,369 282,112
Adjustments to Reconcile Net Profit to Net Cash
Provided by (Used in) Operating Activities:
Depreciation 928,002 656,805
Amortization of Intangible Assets 2,696,560 1,980,243
Income Tax Benefit (344,817)
Net Gain on Sales of Financial Assets (611,187) (109,748)
Unrealized Net Loss (Gain) on Derivative Financial
Instruments 336,004 (233,459)
Loss (Gain) on Sale of Property and Equipment 26,396 (562)
Loss on Sale of Intangible Assets 3,792
Recognition of Deferred Revenue (11,669,191) (11,515,191)
Stock-Based Compensation 1,132,104 1,423,907
Changes in Operating Assets and Liabilities:
Accounts Receivable (624,172) (193,068)
Prepaid Expenses and Other Assets (909,014) 202,488
Accounts Payable and Provisions 869,890 1,381,447
Licenses Payable (1,006,679) (538,162)
Other Liabilities (1,520,771)
Deferred Revenue 10,233,703 11,014,632
Cash Generated from Operations 4,216,989 4,351,444
Interest Paid 228,654 325,011
Net Cash Provided by Operating Activities 4,445,643 4,676,455

035

in R Note 12/31/2005 12/31/2004
Investing Activities:
Purchases of Financial Assets (43,317,784) (16,638,219)
Proceeds from Sales of Financial Assets 19,611,985 9,055,420
Purchases of Property, Plant and Equipment (625,553) (1,505,102)
Proceeds from Disposals of Property,
Plant and Equipment 75,914 20,267
Additions to Intangibles (73,499) (221,644)
Acquisition of Biogenesis, Net of Cash Acquired (7,069,417)
Net Cash Used in Investing Activities 19 (31,398,354) (9,289,278)
Financing Activities:
Proceeds from the Issuance of Equity 17,399,722 8,954,730
Proceeds from the Exercise of Options and
Convertible Bonds 1,479,263 1,377,388
Interest Expense Due to the Issuance of
Convertible Bonds Granted to Related Parties 13,458
Net of Proceeds and Payments from the Issuance
of Convertible Bonds Granted to Related Parties (59,478) (47,508)
Purchases of Derivative Financial Instruments 6 (75,000) (186,647)
Proceeds from the Disposal of Derivatives 6 136,529 508,000
Net Cost of Share Issuance (483,253) (126,583)
Net Cash Provided by Financing Activities 19 18,397,783 10,492,838
Effect of Exchange Rate Differences on Cash 40,759 (1,273)
(Decrease)/Increase in Cash and Cash Equivalents (8,514,169) 5,878,742
Cash and Cash Equivalents at the Beginning
of the Period 12,531,198 6,652,456
Cash and Cash Equivalents at the End
of the Period 4,017,029 12,531,198

Notes to the Consolidated Financial Statements

1 Organization and Summary of Significant Accounting Policies

Business and Organization

MorphoSys AG ("the Company, MorphoSys") is a biotechnology company using combinatorial biology for drug discovery with the principal objective of developing and commercially exploiting new enabling technologies across a broad scientific spectrum. The Company was founded in July 1992 as a German limited liability company. In June 1998, MorphoSys AG became a German stock corporation. In March 1999, the Company went public on Germany's Neuer Markt, the stock exchange designated for high-growth enterprises. On January 15, 2003, MorphoSys AG was admitted to the Prime Standard segment of the Frankfurt Stock Exchange.

Consolidated Companies

The Company has four wholly owned subsidiaries (together referred to as "MorphoSys Group"):

MorphoSys U.S.A., Inc., was incorporated in the United States on February 16, 2000. The subsidiary's purpose was to assist the Company in the sale and licensing of MorphoSys AG products. MorphoSys U.S.A., Inc. substantially ceased its operations in November 2002.

MorphoSys IP GmbH was incorporated in Munich, Germany, on November 6, 2002. The subsidiary's purpose is to purchase, maintain and administer certain intangible assets of the MorphoSys Group. The company's operations are physically located on the premises of MorphoSys AG, and operations commenced on December 31, 2002.

Biogenesis Ltd. (Poole, U.K.) and its sister company Biogenesis, Inc., (Brentwood, New Hampshire, U.S.A.) were acquired by MorphoSys in January 2005. The final agreements specified the purchase of 100 % ownership of the two companies by MorphoSys AG for a total of £ 5,250,000, less net debt of approximately £ 0.7 million.

General Information

The consolidated financial statements for the year ended December 31, 2005, will be authorized for issue in accordance with a resolution of the Management Board on February 10, 2006. The Management Board is represented by: Dr. Simon E. Moroney (Chief Executive Officer), Mr. Dave Lemus (Executive Vice President and Chief Financial Officer) and Dr. Marlies Sproll (Chief Scientific Officer since November 1, 2005).

The Supervisory Board is represented by Dr. Gerald Möller (Chairman, Remuneration & Nomination Committee), Prof. Dr. Jürgen Drews (Deputy Chairman, Remuneration & Nomination Committee), Dr. Daniel Camus (Audit Committee), Dr. Metin Colpan (Remuneration & Nomination Committee), Prof. Dr. Andreas Plückthun and Dr. Geoffrey N. Vernon (Audit Committee).

The registered offices of MorphoSys AG are located at Lena-Christ-Str. 48 in 82152 Martinsried/Planegg, Germany.

Significant Accounting Policies

a) Basis of Adoption

The preparation of the consolidated financial statements in conformity with the International Financial Reporting Standards (IFRS) requires management to make certain estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates.

The accounting policies set out below have been applied consistently to all periods presented in these consolidated financial statements.

IFRS 2 "Share-Based Payment"

IFRS 2 "Share-Based Payment" requires an expense to be recognized where the Group buys goods or services in exchange for shares or rights over shares ("equity-settled transactions"), or in exchange for other assets equivalent in value to a given number of shares or rights over shares ("cash-settled transactions"). The main impact of IFRS 2 on the Group refers to the expense associated with employees' and directors' share options and other share-based incentives by using an optionpricing model.

In accordance with IFRS 2.54, the Group has applied IFRS 2 to equity-settled awards granted on or after January 1, 1999. In accordance with IFRS 2.56, options granted prior to January 1, 1999, are therefore not expensed. All information is nonetheless disclosed in line with IFRS 2.44 and 2.45. Further details are given in the Notes to the Consolidated Financial Statements—sections 14 and 15.

IFRS 3 "Business Combinations", IAS 36 "Impairment of Assets" and IAS 38 "Intangible Assets"

IFRS 3 applies to accounting for business combinations for which the agreement date is on or after March 31, 2004. IFRS 3 requires that all business combinations are accounted for using the purchase method, whereby identifiable assets and liabilities acquired are measured initially at their fair value. Any excess of the purchase price over the amounts allocated is recognized as goodwill. The goodwill is subject to a regular review for possible impairment.

The Company determined the accounting for business combinations in 2005 only provisionally. It is currently performing a purchase price allocation. The outcome may result in an adjustment of the goodwill following IFRS 3.62; any adjustments to the provisional values will be recognized within twelve months of the acquisition date (IFRS 3.69).

The useful economic life of intangible assets is generally assessed at the level of individual assets as having either a finite or an indefinite life. The Company has not identified any assets with an indefinite life. Intangible assets with a finite life have been amortized over their useful life. Amortization periods and methods for intangible assets with finite useful economic lives are reviewed annually or earlier where an indicator of impairment exists. In 2005, the Company identified impairments for assets acquired. Please see the Notes to the Consolidated Financial Statements – section 9 for detailed information.

Receivables, liabilities, provisions, income and expenses and profits between consolidated companies are eliminated on consolidation.

b) Statement of Compliance

The accompanying consolidated financial statements have been prepared in accordance with the International Financial Reporting Standards (IFRS) adopted by the International Accounting Standards Board (IASB), London, in consideration of interpretations of the Standing Interpretations Committee (SIC), the International Financial Reporting Interpretations Committee (IFRIC) and the IFRS adopted by the European Commission.

The consolidated financial statements of the Company for the year ended December 31, 2005, comprise the Company and its subsidiaries (together referred to as "MorphoSys Group").

c) Basis of Presentation

The financial statements are presented in euros unless otherwise stated. They are prepared on the historical cost basis except that the following assets and liabilities are stated at their fair value: derivative financial instruments, investments available-for-sale and certain licenses (Cambridge Antibody Technology Ltd. (CAT) and XOMA Ireland Ltd.). All figures in this report are rounded either to the nearest euro or thousands of euros.

IAS 27 "Consolidated and Separate Financial Statements" shall be applied for annual periods beginning on or after January 1, 2005. The Company decided to adopt IAS 27 for all financial statements beginning January 1, 2003. The accounting policies have been applied consistently by Group entities following IAS 27.28.

d) Basis of Consolidation

Intercompany balances and transactions and any unrealized gains arising from intercompany transactions are eliminated in preparing the consolidated financial statements following IAS 27.24. Unrealized losses are eliminated in the same way as unrealized gains. Please see the Notes to the Consolidated Financial Statements – section 1a "IFRS 3 "Business Combinations"..." for further details.

e) Foreign Currency Translation

IAS 21 ("The Effects of Changes in Foreign Exchange Rates") defines the accounting for transactions and balances in foreign currencies. Transactions in foreign currencies are translated at the foreign exchange rate as of the date of the transaction. Foreign exchange differences arising on these translations are recognized in the income statement. On the balance sheet date, assets and liabilities are translated at the closing rate, and income and expenses are translated at the average exchange rate for the period. Any foreign exchange differences deriving from these translations are recorded in the income statement. Any further foreign exchange differences on a Group level are recognized in other comprehensive income (equity).

f) Interest

MorphoSys uses interest rates to calculate fair values and discount certain liability. For stock-based compensation calculation, MorphoSys uses the interest rate of a German government bond with a duration of two years at grant date.

To discount certain obligations in connection with the settlement agreement with CAT, the Company uses a 13 % interest rate to discount its liability.

g) Derivative Financial Instruments

The Group uses derivative financial instruments to hedge its exposure to foreign exchange rate risks. In accordance with IAS 39.9, all derivative financial instruments are held for trading and recognized initially at cost. Subsequent to initial recognition, derivative financial instruments are stated at fair value, which is their quoted market price as of the balance

sheet date. Since the derivatives were not tested for hedge accounting, any resulting gain or loss is recognized in the income statement. According to the Group's foreign currency hedging policy, receivables which are definite and collectable within a twelve-month period will be hedged.

h) Cash and Cash Equivalents

The Company considers all cash at bank, in hand and shortterm deposits with an original maturity of three months or less to be cash and cash equivalents. The Company invests its cash in deposits with two major German financial institutions, namely HypoVereinsbank and Deutsche Bank.

i) Financial Assets

All financial assets are initially recognized at cost, being the fair value of the consideration given and including acquisition charges associated with the investment.

The Company accounts for its investments in debt and equity securities in accordance with IAS 39. The management determines the proper classifications of financial assets at the time of purchase and re-evaluates such designations as of each balance sheet date. As of December 31, 2005, and as of December 31, 2004, the financial assets held by the Group have been classified as available-for-sale. These financial assets are recognized or derecognized by the Group on the date it commits to purchase or sell the financial assets. After initial recognition, available-for-sale financial assets are measured at fair value, with any resulting gain or loss reported directly in other comprehensive income within equity until the financial assets are sold, collected or otherwise disposed of, or until the financial assets are determined to be impaired, at which time the cumulative loss is reported in the income statement.

The Company considers a decline in the fair value of available-for-sale financial assets which is longer than six months in duration to be deemed other than temporary unless specific facts and circumstances indicate otherwise. If, in a subsequent period, the fair value increases, the impairment loss is reversed, with the amount of reversal included in other comprehensive income for equity securities and in the income statement for debt securities.

j) Accounts Receivable

Accounts receivable are stated at their cost less any allowance for doubtful accounts (see below) and impairment losses (see accounting policy n).

The allowance for doubtful accounts is based on the management's assessment of the collectibility of specific customer accounts and the aging of the accounts receivable. If there is a deterioration in a major customer's creditworthiness or actual defaults are higher than the historical experience, the management's estimates of the recoverability of amounts due to the Company could be adversely affected. Based on management assessment, allowances in the amount of q 41,461 as of December 31, 2005, and q 36,456 as of December 31, 2004, were recognized. The Company does not require collateral from customers for accounts receivable.

k) Inventory

Inventories are stated on a FIFO basis at the manufacturing/ acquisition cost or net realizable value, whichever is the lower. Manufacturing cost of self-produced inventories comprises all costs which are directly attributable and an appropriate portion of the overhead costs.

l) Property, Plant and Equipment

Property, plant and equipment is stated at cost, less accumulated depreciation (see also the Notes to the Consolidated Financial Statements—section 8) and impairment losses (see accounting policy n). Replacements and improvements are capitalized while general repairs and maintenance are charged to expenses as incurred. Assets are depreciated over their expected useful lives using the straight-line method (three to five years). Leasehold improvements are depreciated over the estimated useful lives of the assets (ten to fifty years).

m) Intangible Assets

ma) Research and Development

Research costs are expensed as incurred. Development costs were expensed as incurred in accordance with IAS 38.5 and IAS 38.11-38.23.

mb) Patent Costs

Patents obtained by the Group are stated at cost less accumulated amortization (see below) and impairment losses (see accounting policy n). Capitalized costs principally relate to the costs of legal counsel. Patent costs are amortized on a straight-line basis over their estimated useful life (ten years) or the remaining patent term, whichever is the lower. Amortization commences when the patent is issued. The Company's patents covering its proprietary HuCAL technology were granted in Australia in October 2000, in the United States of America in October 2001 and in Europe in June 2002. Further patent applications are pending in Canada and Japan.

mc) License Rights

The Company acquired license rights by making up-front licensing payments, annual maintenance fees and sublicensing payments to third parties. The Company amortizes up-front licensing payments on a straight-line basis over the estimated useful life of the acquired license (ten years). The amortization period and method is reviewed at each balance sheet date (IAS 38.104). Annual maintenance fees are amortized over the term of each annual agreement. Sublicensing payments are amortized on a straight-line basis over the life of the contract or the estimated useful life of the collaboration for those contracts without a stipulated term.

md) Software

Software is stated at cost less accumulated amortization (see below) and impairment losses (see accounting policy n). Amortization is charged to the income statement on a straight-line basis over the estimated useful life of three years. Software is amortized from the date it is available for use.

me) Subsequent Expenditure

Subsequent expenditure on capitalized intangible assets is capitalized only when it increases the future economic benefits embodied in the specific asset to which it relates. All other expenditure is expensed as incurred.

n) Impairment

The management evaluates the carrying amount of the Group's assets for potential impairment at each balance sheet date or whenever events or changes in circumstances indicate that the carrying amount of such assets may not be recoverable. If any indication of impairment exists, the asset's recoverable amount is estimated. An impairment loss is recognized whenever the recoverable amount is less than the carrying amount of an asset. Impairment losses are recognized in the income statement.

The recoverable amount of an asset is its fair value less costs to sell or its value in use, whichever is the greater. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset. For an asset that does not generate independent cash inflows, the recoverable amount is determined for the cash-generating unit to which the asset belongs.

An impairment loss in respect of a receivable is reversed if the subsequent increase in the recoverable amount can be related objectively to an event occurring after the impairment loss was recognized. With respect to other assets, an impairment loss is reversed if there has been a change in the estimates used to determine the recoverable amount. An impairment loss is reversed only to the extent that the asset's carrying amount does not exceed the carrying amount that would have been determined, net of depreciation or amortization, if no impairment loss had been recognized. As of December 31, 2005, impairments in the amount of q 0.5 million were identified and recognized as R & D expenses (see also the Notes to the Consolidated Financial Statements—section 9).

o) Trade and Other Payables

Trade and other payables are stated at their repayment amounts. Payables with repayment dates exceeding one year are discounted to their net present values. Payables of uncertain timing or amount are shown as provisions.

p) Convertible Bonds

The Company issued convertible bonds to the Supervisory Board, Management Board and employees of the Group under application of IAS 32 and IAS 39. In accordance with IAS 32.28, the equity portion of the bond has to be separated and presented as additional-paid-in-capital. The equity component is deducted from the fair value of the bond. The remaining value is recognized as stock-based compensation. The Company applies the provisions of IFRS 2 "Share-Based Payment" for all convertible bonds granted to the Supervisory Board, Management Board and employees of the Group.

q) Revenue Recognition

The Company's revenues include technology access fees and fees derived from research and development collaboration agreements predominately with companies based in the United States.

Revenues related to non-refundable technology access fees, subscription fees and license fees are deferred and recognized on a straight-line basis over the relevant periods of the agreement, generally the research term or the estimated useful life of the collaboration for those contracts without a stipulated term unless a more accurate means of recognizing revenue is available. Research and development collaboration service fees are recognized in the period when the services are provided. Milestone revenues are recognized upon achievement of certain criteria.

Investment grants from governmental agencies for the support of specific research and development projects for which cash has been received are recorded as revenue to the extent the related expenses have been incurred. Under the terms of the investment grants, the governmental agencies generally have the right to audit the use of the payments received by the Company.

In accordance with IAS 18.21, 18.25 and IAS 20.18, the total consideration in revenue arrangements with multiple deliverables will be allocated among the separately identifiable components based on their respective fair values under application of IAS 18.20, and the applicable revenue recognition criteria will be considered separately for each of the separate components.

Deferred revenue represents revenues received but not yet earned per the terms of the contracts. Grant revenue in 2005 amounted to q 0.4 million (2004: q 0.1 million).

r) Expenses

ra) Cost of Goods Sold

Cost of goods sold comprises the cost of manufactured products and the acquisition cost of purchased goods which have been sold.

rb) Stock-Based Compensation

The Company applies the provisions of IFRS 2 "Share-Based Payment" which obligates the Company to record the estimated fair value for stock options and other awards at the measurement date as a compensation expense over the period in which the employees render the services associated with the award.

rc) Operating Lease Payments

Payments made under operating leases are recognized in the income statement on a straight-line basis over the term of the lease.

s) Interest Income

Interest income is recognized in the income statement as it occurs, taking into account the effective yield on the asset.

t) Interest Expense

Borrowing costs are expensed when incurred.

u) Income Taxes

Income tax on the profit or loss for the year comprises current and deferred tax. Income tax is recognized in the income statement except to the extent that it relates to items recognized directly in equity, in which case it is recognized in equity. Current tax is the expected tax payable on the taxable income for the year, using tax rates enacted or substantially enacted at the balance sheet date, and any adjustment to tax payable with respect to previous years.

Deferred tax is calculated using the balance sheet liability method, providing for temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for taxation purposes. The amount of deferred tax provided is based on the expected manner of realization or settlement of the carrying amount of assets and liabilities, using tax rates enacted or substantially enacted at the balance sheet date.

A deferred tax asset is recognized only to the extent that it is probable that future taxable profits will be available against which the asset can be utilized. Deferred tax assets are reduced to the extent that it is no longer probable that the related tax benefit will be realized.

2 Segment Reporting

A segment is a distinguishable component of the Group that is engaged in providing products or services and that is subject to risks and returns that are different from those of other segments.

Segment information is presented in respect of the Group's business and geographical segments. The primary format, business segments, is based on the Group's management and internal reporting structure. Segment results and assets include items directly attributable to a segment as well as those that can be allocated on a reasonable basis.

General and administrative expenses are allocated to the respective business segments by applying an allocation along the head count. Intangibles attributable to both segments are allocated along revenues.

The Group consists of the following main business segments:

Therapeutic Antibodies

MorphoSys possesses one of the leading technologies in the generation of human antibody therapeutics and bespoke antibody research projects. The Company makes use of its technology in collaborations with international pharmaceutical and biotech companies, as well as on its own account.

Research Antibodies Segment

The Research Antibodies segment leverages MorphoSys's core technological capabilities in the design and manufacture of antibodies for research purposes. It commercializes HuCAL technology focusing on the custom generation of research antibodies for partners on an individual basis.

Geographical Segments

In presenting information on the basis of geographical segments, segment revenue is based on the geographical location of the customers. Segment assets are based on the geographical location of the assets.

Therapeutic Antibodies Research Antibodies Unallocated Consolidated
in 000's R 2005 2004 2005 2004 2005 2004 2005 2004
Revenues 29,139 21,194 4,348 784 33,487 21,978
Cost of Goods Sold 2,514 944 2,514 944
Segment Result 12,121 6,094 (3,062) (2,372) (2,899) (3,081) 6,160 641
Interest Income 108 286
Interest Expense 277 338
Other Expenses, net 879 307
Total Profit Before
Taxes 5,112 282
Income Tax 436
Total Profit 4,676 282
Cash and Cash
Equivalents 215 3,802 12,531 4,017 12,531
Accounts Receivables 2,742 2,065 604 240 3,346 2,305
Prepaid Expenses and
Other Current Assets 542 1,002 431 1,544 431
Property, Plant and
Equipment, net 1,028 1,090 3,326 878 343 363 4,697 2,331
Software, net 93 210 8 8 31 70 132 288
Know How&
Customer List 1,485 1,485
Goodwill 4,137 4,137
Total Segment Assets 3,863 3,365 10,317 1,126 65,937 51,305 80,117 55,796
Accounts Payable 332 3,990 3,838 4,322 3,838
Deferred Revenue 8,391 9,815 31 43 8,422 9,858
Deferred Tax Liability 940 321 221 1,261 221
Total Segment Liabilities 8,391 9,815 1,303 43 6,415 6,560 16,109 16,418
Capital expenditure 505 728 124 777 70 699 1,505
Depreciation 537 461 391 145 51 928 657

The balance sheet items shown in the table above include segment allocation. The other items remain unallocated.

Segment result is defined as segment revenue less operating segment expenses.

The following table shows the split of the Company's consolidated sales by geographical markets:.

in 000's R 2005 2004
Europe and
Rest of the World 19,462 9,935
U.S.A. and & Canada 14,025 12,043
Total 33,487 21,978

The following table shows the split of the Company's assets by geographical segments:

in 000's R 2005 2004
Germany 77,639 55,796
U.K. 1,957 -
U.S.A. 581 -
Total Assets 80,117 55,796

The following table shows the split of the Company's capital expenditure by geographical segments:

in 000's R 2005 2004
Germany 630 1,727
U.K. 53 -
U.S.A. 16 -
Total 699 1,727

3 Cash and Cash Equivalents

in 000's R 2005 2004
Bank Balances and
Cash at Hand 3,590 12,281
Term Deposits 427 250
Cash and
Cash Equivalents 4,017 12,531

4 Financial Assets

Financial assets consist of the following as of December 31, 2005 and 2004:

Gross Unrealized
Holding
Realized
in 000's R Maturity Cost Gains Losses Holding
Gains
Market
Value
12/31/2005
DB Money Market Funds daily 48,637 905 49,542
Restricted Cash
49,542
12/31/2004
DB Money Market Funds daily 24,320 624 24,944
Restricted Cash 246
24,698

The gross unrealized holding gains of q 905,364 for the year ended December 31, 2005, and q 623,840 for the year ended December 31, 2004, were recorded as a separate component of stockholders' equity (revaluation reserve). In 2005 the Group recorded gains of q 611,187 in the income statement on the sale of financial assets, which had previously been recognized in equity (2004: q 109,748).

For further details on accounting for financial assets see also the Notes to the Consolidated Financial Statements—section 1i).

5 Accounts Receivable

All accounts receivable are non-interest bearing and are generally due on a 30- to 45-day term. On December 31, 2005 and 2004, accounts receivable included unbilled amounts of q 145,648 and q 116,037 respectively.

6 Other Receivables

According to the Company's hedging policy, definite foreign currency receivables which are collectable within a twelvemonth period are reviewed for hedging and shown as other receivables with their fair values. Starting 2003, MorphoSys entered into foreign currency options and forward contracts to hedge foreign exchange exposure related to U.S. dollar accounts receivable.

As of December 31, 2005, no options contracts were outstanding (2004: q 3,846,155 or US \$ 5,000,000). Therefore the fair market value as of December 31, 2005, was q 0 (2004: q 180,190). This was recorded in other receivables on the balance sheet, whereas it was classified as held-for-trading in 2004. Changes in fair value were recognized as other income and included in foreign exchange losses of q 1.2 million for the fiscal year 2005. As of December 31, 2005, the contract premium for derivatives entered into in February 2004 amounted to q 138,000 (2004: q 138,000).

7 Prepaid Expenses and Other Current Assets

Prepaid expenses mainly include prepaid sublicense fees of q 0.1 million as of December 31, 2005 (2004: q 0.1 million), and other prepayments in the amount of q 0.9 million as of December 31, 2005 (2004: q 0.3 million).

8 Property, Plant and Equipment, Net

in 000's R Land
and
Buildings
Office and
Laboratory
Equipment
Furniture
and Fixtures
Total
Cost
01/01/2005 4,986 1,345 6,331
Additions 2,247 629 536 3,412
Disposals 281 280
12/31/2005 2,247 5,334 1,881 9,462
Accumulated Depreciation
01/01/2005 3,274 726 4,000
Depreciation Charge for the Year 10 672 246 843
Disposals 163 163
12/31/2005 10 3,783 972 4,765
Carrying Amount
01/01/2005 1,712 619 2,331
12/31/2005 2,237 1,551 909 4,697

Property, Plant and Equipment of the two Biogenesis subsidiaries are included in additions and disposals, as these items were added to the MorphoSys Group on January 20, 2005.

The depreciation charge is included in the following line items of the statement of operations:

047

in 000's R 2005 2004
Research and
Development
568 493
Sales, General and
Administrative
321 164
Cost of Goods Sold 39 -
928 657

Currency translation effects for property, plant and equipment held in foreign currency were minor as of December 31, 2005 and therefore, these amounts were not shown separately. For more detailed information, see Appendix 1.

9 Intangible Assets, Net

in 000's R Patents License
Frees
Soft-
ware
Know
How and
Customer
Lists
Good
will
Total
Cost
01/01/2005 3,766 12,140 1,366 17,272
Additions 29 45 2,313 4,137 6,524
Disposals 19 19
12/31/2005 3,795 12,140 1,392 2,313 4,137 23,777
Accumulated Amortization
01/01/2005 976 2,469 1,078 4,523
Amortization for the Year * 458 1,214 198 827 2,697
Disposals 16 16
12/31/2005 1,434 3,683 1,260 827 7,204
Carrying Amount
01/01/2005 2,790 9,671 288 12,749
12/31/2005 2,361 8,457 132 1,486 4,137 16,573

*Including impairment losses of q 0.5 million

Intangibles of the Biogenesis Group are included in additions and disposals of the current year, since these items were acquired by the MorphoSys Group on January 20, 2005. Currency translation effects for intangibles held in foreign currency were minor as of December 31, 2005 and therefore, these amounts were not shown separately.

As of December 31, 2005, foreign exchange effects of q 0.2 million were recognized for the assets acquired and accounted for as other comprehensive income.

The amortization charge is included in the following line items of the income statement:

in 000's R 2005 2004
Research and
Development*
2,190 1,451
Sales, General and
Administrative
507 529
2,697 1,980

*Including impairment losses of q 0.5 million

Preliminary Goodwill Allocation

On January 20, 2005, MorphoSys acquired Biogenesis Ltd. (Poole, UK) and Biogenesis, Inc., (Brentwood, New Hampshire, U.S.A.). The final agreements specified the purchase of 100 % ownership of the two companies by MorphoSys AG for a total of £ 5,250,000, less net debt of approximately £ 0.7 million. The total cost for financial advisors, legal counsel and other advisors was q 0.7 million. The two Biogenesis companies became wholly owned subsidiaries of MorphoSys AG. In the year 2005, the subsidiaries contributed a net loss of q 0.8 million to the consolidated net profit. In accordance with IFRS 3.62

and 3.69, the group has applied a preliminary goodwill allocation since certain amounts can only be accounted for provisionally. All transactions are regularly reviewed with regard to triggering events for the impairment of acquired assets. The acquisition of Serotec was regarded a such triggering event. All assets recognized after the Biogenesis acquisition were analyzed accordingly and impairments ofq 0.5 million were recorded and shown separately as follows:

Net Assets as of January 20, 2005

Biogenesis Group

in 000's R Recog-
nized
Values
Fair
Value
Adjust-
ments
Impair-
ment
Fair
Value
Amounts
Cash and Cash Equivalents 206 206
Property, Plant and Equipment 1,788 898 2,686
Inventories 123 328 451
Trade and Other Receivables 425 425
Intangibles 2,230 (501) 1,729
Interest-Bearing Loans and Borrowings (990) (990)
Trade and Other Payables (543) (543)
Deferred Taxes (1,266) 175 (1,091)
Net Identifiable Assets and Liabilities 1,009 2,190 (326) 2,873
Goodwill on Acquisition 4,402
Consideration Paid, Satisfied in Cash * 7,275
Cash (acquired) 206
Net Cash Outflow 7,069

*Advisor fees amounting to q 0.7 million included

The Company has entered into the following license agreements covering certain patented technology which are capitalized (non-capitalized license agreements have not been disclosed in detail):

SCA Ventures, Inc., U.S.A.

In December 1999, the Company concluded a non-exclusive product-derived license agreement with SCA Ventures, Inc., U.S.A., in which the Company obtained a non-exclusive license from SCA Ventures in order to design, discover, develop, make, use, sell, offer for sale and import HuCAL-derived products under SCA Ventures' patent rights to single-chain antibodies. The Company may use SCA Ventures' licensed technologies for the research and discovery of novel therapeutic agents and targets and may sublicense the technology to its commercial partners. The Company may terminate this

agreement for any reason upon six months' prior written notice to SCA Ventures. The Company pays an up-front license fee, annual maintenance and transfer fees. As of December 31, 2005, the license had a remaining amortization period of four years.

Biosite Diagnostics, Inc., U.S.A.

In January 2000, the Company signed a collaboration agreement with Biosite Diagnostics, Inc., under which the Company receives a royalty-bearing, non-exclusive, worldwide license to patents owned by Biosite and XOMA Corporation covering certain technologies relating to the display and screening of multi-chain antibodies. The Company may use the licensed technologies for research and discovery of novel therapeutic agents and targets and may sublicense the technology to its commercial partners. Unless terminated earlier, the term of this agreement shall be until the expiration of the parties' respective obligations to pay royalties or the expiration of the last patent right licensed by one party to the other, whichever is the later. The Company pays an up-front technology access fee in addition to annual maintenance and transfer fees. As of December 31, 2005, the license had a remaining amortization period of four years.

Genentech, Inc., U.S.A.

In May 2000, the Company concluded a license agreement with Genentech, Inc., granting the Company rights under Genentech patents relating to monovalent phage display screening technology. The Company may use the licensed technologies for research and discovery of novel therapeutic agents and targets and may sublicense the technology to its commercial partners. The Company pays an up-front technology access fee in addition to annual maintenance and transfer fees. As of December 31, 2005, the license had a remaining amortization period of five years.

XOMA Ireland Ltd.

In February 2002, the Company concluded a cross-licensing agreement for antibody-related technologies with XOMA Ireland Ltd. Pursuant to the agreement, MorphoSys paid q 1.1 million to XOMA with a second payment of q 4.6 million due September 2002. At the Company's option, the second installment could be paid in cash or with new shares of the Company's common stock equivalent to q 5.5 million. The Company recorded q 2.5 million as a charge to research and development expenses in the year 2002. The remaining q 3.2 million represents the value of the license received and has been capitalized as an intangible asset and will be amortized over its expected useful life of ten years.

In October 2002, the Company exercised the option to pay the second installment with 363,466 new shares of its common stock, which was determined with reference to the market price of the Company's common stock at the time of the notice. The Company recorded a charge to interest expense of q 0.7 million at the time the shares were issued in May 2003 as a consequence of exercising this option.

As of December 31, 2005, the license had a remaining amortization period of seven years.

Cambridge Antibody Technology Ltd., Cambridge, U.K.

In December 2002 and effective July 2003, the Company entered into a licensing and settlement agreement with CAT. The settlement agreement covers MorphoSys's past, present and future use, the commercialization of all versions of its Hu-CAL libraries, and all patents in the ongoing disputes between the two companies. This includes the litigation in the United States regarding CAT's Griffiths, McCafferty, Winter II and Winter/Lerner/Huse patents, as well as oppositions launched by MorphoSys at the European Patent Office against CAT's Winter II and McCafferty patents.

As of December 31, 2005, the license had a remaining amortization period of eight years.

For further information, see Appendix 1.

10 Other Assets

The Company has classified certain items in other assets that are not available for use in its operations as restricted cash. As of December 31, 2005 and 2004, the Company had commitments of q 250,000 (unchanged) for guarantees issued and q 50,214 and q 59,778 respectively for convertible bonds issued to employees.

11 Accounts Payable

Accounts payable are non-interest bearing and are normally settled within 30 days. License payables are partly settled within 30 days. License payables which are expected to be settled after more than twelve months are discounted to their net present value applying with an interest rate of 13 %.

The residual maturity of liabilities is listed in the table below:

Accounts Payable in Euro

in 000's R 2005 2004
Accounts Payable 344 336
Accrued Expenses 3,617 2,588
Other Liabilities 361 914
Of which Taxes 143 731
Of which Related
to Social Security 154 157
Total 4,322 3,838

Accounts payable include accruals, which mainly contain accrued expenses for personnel payments of e 0.6 million (2004: q 1.0 million). Expenses for outstanding invoices include q 1.3 million mainly for license compensation (2004: q 0.9 million), q 0.2 million for Supervisory Board members' compensation (2004: q 0.1 million), q 0.1 million for audit fees and costs related thereto (2004: q 0.0 million) and q 0.5 million for legal services (2004: q 0.1 million).

At the Company's Annual Shareholders' Meeting in May 2005, the Company was authorized to appoint KPMG Deutsche Treuhand-Gesellschaft AG Wirtschaftsprüfungsgesellschaft as its auditor. In 2005, the auditing company and its partner companies within the international KPMG network were remunerated by MorphoSys AG in the amount of q 280,173 (thereof q 213,519 by KPMG Deutsche Treuhand-Gesellschaft AG Wirtschaftsprüfungsgesellschaft), including audit fees of q 121,363, fees for other confirmations and reviews of q 132,860, fees for tax consultancy of q 24,750 and fees for other services of q 1,200. Accrued expenses for audit fees in the amount of q 79,000 are included in these figures.

12 Provisions

As of December 31, 2005 and 2004, the Company recorded provisions of q 1,041,482 and q 600,607, respectively.

Provisions for taxes mainly comprise expenses for income tax, whereas other obligations mainly include provisions for legal disputes. Both items remain uncertain with respect to their amounts as of December 31, 2005.

Provisions changed during the year 2005 as follows:

in 000's R 01/01/2005 Additions Utilized Realeased 12/31/2005
Taxes 1,101 312 789
Obligations for Personnel and
Social Expenses
601 17 355 263
Other Obligations 252 252
Total 601 1,370 355 575 1,041

13 Stockholders' Equity

Common Stock

On December 31, 2005, the common stock of the Company was q 18,077,589. This represented an increase of q 1,761,033 compared to December 31, 2004, when the balance was q 16,316,556. Each share of common stock is entitled to one vote. An increase in the number of shares of q 1,470,399, or 490,133 shares, arose as a result of a capital increase executed on March 15, 2005. Through the conversion and exercise of 96,878 convertible bonds and options issued to employees, common stock increased by an additional q 290,634 in 2005. The increase of q 1,612,560 during the year ended December 31, 2004, arose as a result of the conversion of bonds issued to Novartis on May 19, 2004. The bond was converted into 490,133 MorphoSys shares on June 15, 2004. Through the conversion and exercise of 47,387 convertible bonds and options issued to employees, common stock increased by an additional q 142,161 in 2004.

Treasury shares totaling q 10,703 (29,162 shares) at December 31, 2005, compared to q 11,033 (30,062 shares) at December 31, 2004, were subtracted from the Company's common stock.

Authorized Capital

On May 11, 2005, the Annual Shareholders' Meeting authorized the Company to increase Authorized Capital I by 215,008 shares to create a maximum of 2,175,541 new shares of Authorized Capital I (December 31, 2004: 1,960,533 shares). Also approved was an increase to Authorized Capital II of 592,898 shares to create a maximum of 592,898 new shares of Authorized Capital II (December 31, 2004: 490,133 shares).

Unused Authorized Capital I equaled 2,175,541 and 1,960,533 shares at December 31, 2005 and 2004 respectively. Unused Authorized Capital II equaled 592,898 and 490,133 shares at December 31, 2005 and 2004 respectively.

Conditional Capital

In 2005, 1,400 shares were raised from Conditional Capital I through the exercise of the same number of options by employees, increasing the subscribed capital by q 4,200. Furthermore, 34,125 shares were raised from Conditional Capital II through the exercise of the same number of options by employees, increasing the subscribed capital by q 102,375, and 59,478 shares were raised from Conditional Capital IV through the exercise of the same number of convertible bonds by employees, increasing the subscribed capital by q 178,434. Finally, 1,875 shares were raised from Conditional Capital V through the exercise of the same number of options by employees, increasing the subscribed capital by q 5,625.

On May 16, 2003, the Annual Shareholders' Meeting authorized the Company to create additional shares for Conditional Capital III, IV and V, up to a maximum of 1,275,000, 450,269 and 111,447 shares respectively.

On May 11, 2004, the Annual Shareholders' Meeting authorized the Company to create an additional 58,816 shares for Conditional Capital V to create a maximum amount of q 510,789 (170,263 shares).

On May 19, 2004, MorphoSys issued a convertible bond (callable common shares) to Novartis, which was split into seven partial debentures and convertible into a total of 490,133 shares. On June 15, 2004, Novartis converted all debentures into 490,133 common shares from the Company's Conditional Capital III.

On May 11, 2005, the Annual Shareholders' Meeting authorized the Company to create additional shares for Conditional Capital III, IV and V, up to a maximum of 1,602,125, 513,938 and 242,405 shares respectively.

Dividends

Dividends may only be declared and paid from the accumulated retained earnings (after deduction of certain reserves) shown in the Company's annual German statutory accounts. Such amounts differ from the total of additional paid-in capital and accumulated deficit as shown in the accompanying consolidated financial statements as a result of the adjustments made to present the consolidated financial statements in accordance with IFRS. The Company's German statutory accounts showed taxable income in 2005; however, as of December 31, 2005 and 2004, they reflected no accumulated earnings available for distribution and the Company's ability to pay dividends will therefore depend upon its future earnings.

Additional Paid-In Capital

On December 31, 2005, additional paid-in capital amounted to q 96,412,849 (December 31, 2004: q 78,646,377). The increase of q 17.7 million is due to stock-based compensation provisions of q 1,132,104, q 15,446,069 including costs in connection with the transaction of q 767,068 as a result of the capital increase on March 15, 2005, netted by a deferred tax asset of q 283,815. A further increase of q 1,188,299 arose from exercise and conversion of options and convertible bonds in the year 2005.

In 2004, the additional paid-in capital was increased by q 10.0 million resulting from stock-based compensation provisions of q 1,431,313, q 7,357,748 from Novartis' capital increase through the grant of callable common shares in May 2004 and q 1,224,326 through the exercise of options and convertible bonds in the year 2004.

14 Convertible Bonds

At the Company's Annual Shareholders' Meeting in July 2002, the Company was authorized to issue up to 300,000 non-interest bearing convertible bonds with a par/nominal value of q 1.00 each to employees and members of the Management

Board of the Company and its affiliates until June 30, 2006. The preemptive rights of the stockholders were excluded. On May 16, 2003, the Annual Shareholders' Meeting authorized the Company to grant an additional 150,269 shares. At the Company's Annual Shareholders´ Meeting on May 11, 2005, the Company was authorized to grant an additional 150,269 convertible bonds until April 30, 2010.

On January 15, 2002, pursuant to a Management Board decision, the Company issued 91,500 convertible bonds to the Management Board and employees of the Company. The convertible bonds cannot be transferred or encumbered, other than through inheritance/death. In the event of inability to work, the Management Board can allow the transfer with good cause.

The conversion rights may only be exercised if the termination of the employment agreement with the owner of the convertible bonds has not been declared at the time of exercise and a mutual termination agreement has not been entered into. In the event of non-exercise of the conversion rights, beneficiaries are refunded the amount paid to acquire the convertible bonds (i.e., q 1.00 per bond/share).

The beneficiaries may only exercise the conversion rights after the expiration of a waiting period of one year after the grant date. Each convertible bond with a nominal value of q 1.00 can be exchanged for one share of ordinary no-par value common stock of the Company against payment of the exchange price. The convertible bonds cannot be exercised beyond December 31, 2004.

The exchange price for the convertible bonds issued on January 15, 2002, was q 57.56, representing the average closing price of a share in the Company in the final XETRA auction at the Frankfurt Stock Exchange during the last five trading days preceding the resolution of the Management Board to issue the convertible bonds.

The conversion rights can only be exercised if the stock exchange price on at least one day during the lifetime of the convertible bonds has amounted to q 63.31, or 110 % of the average stock exchange price in the final XETRA auction in the Frankfurt Stock Exchange during the five trading days prior to the resolution of the Management Board to issue the convertible bonds.

Shares which are issued by virtue of the conversion rights may participate in the profits of the Company for the first time in the business year for which no stockholders' resolution on the distribution of profits has been passed at the time of the issuance.

On December 31, 2004, all convertible bonds granted in 2002 expired. The nominal value of q 1.00 each was paid back to all those concerned.

In the year 2003, additional grants to employees were made under the 2002 Plan, with terms identical to the 2002 stock convertible bonds grants. 70,700, 8,500 and 14,000 convertible bonds were granted on April 1, 2003, May 17, 2003, and July 1, 2003, respectively to members of the Management and Supervisory Boards and employees of MorphoSys AG. The exercise prices for the convertible bonds were q 11.69, q 10.00 and q 10.88, respectively. In the year 2005, 59,478 bonds of the 2003 grant were converted into shares of ordinary no-par value common stock with the same amount by employees of the Company. Of these 43,000 bonds were exercised by members of the management and Supervisory Boards. Further details are given in the Notes to the Consolidated Financial Statements—section 22.

As of December 31, 2005 all convertible bonds granted in 2003 expired. The nominal value of q 1.00 each was paid back to all those concerned.

In the year 2004, an additional grant to board members and employees was made under the 2002 Plan, with terms identical to the 2002 stock convertible bonds grants. On December 9, 2004, 49,914 convertible bonds were granted to board members and employees of MorphoSys AG. The exercise price for the convertible bonds is q 38.40.

A summary of the activity under the Company's employee incentive convertible bonds plan for the years ended December 31, 2005 and 2004, is represented as follows:

Convertible
Bonds
Weighted
Average
Price R
Outstanding on
01/01/2004 151,800 30.68
Granted 49,914 38.40
Exercised (27,122) 11.69
Forfeited (24,200) 35.66
Expired (50,700) 57.56
Outstanding on
12/31/2004 99,692 24.83
Outstanding on
01/01/2005
99,692 24.83
Refunded 10,000 11.69
Exercised (59,478) 11.30
Forfeited (373) 38.40
Expired (300) 11.69
Outstanding on
12/31/2005
49,541 38.40

Convertible bonds exercisable on December 31, 2005 and 2004, amounted to 49,541 and 49,778 shares respectively. The weighted-average exercise prices of exercisable convertible bonds were q 38.40 and q 11.22 on December 31, 2005 and 2004 respectively. Furthermore, the weighted-average fair value of bonds granted during 2004 is estimated to be q 16.52. In the year 2005 no convertible bonds were granted.

As a result of a court decision, 10,000 forfeited convertible bonds in 2004 were refunded to all those concerned in 2005.

The following table presents the weighted-average price and information about the contractual life for significant convertible groups outstanding on December 31, 2005:

Range of Exercise Prices Number
Outstanding
Remaining
Contractual
Life (in Years)
Weighted-
Average
Exercise
Price
Number of
Exercisable
Weighted-
Average
Exercise
Price
E 10.00­ —
E 38.40
49,541
49,541
1.00 E 38.40 49,541
49,541
E 38.40

The Company accounts for stock-based compensation in accordance with the provisions of IFRS 2 and IAS 32.28. The equity portion of the bond has to be separated and presented as additional-paid-in-capital. The equity component is deducted from the fair value of the bond. The remaining value is recognized as stock-based compensation. The compensation expense recorded in 2005 and 2004 in connection with convertible bonds was q 757,965 and q 184,327 respectively. The fair value of the convertible bonds issued in 2004, the date of last issuance, was calculated using the Black-Scholes pricing model using the following assumptions: risk free interest rate of 2.74%; dividend yield of 0%; 78% expected volatility, based on historic data, and an expected life of 2.0 years.

Valuation models require the input of highly subjective assumptions. Because changes in the subjective input assumptions can materially affect the fair value estimate, the management does not consider that the existing models necessarily provide a reliable single measure of the fair value of its employee stock options.

15 Stock Options

1998 Employee Stock Option Program

Effective June 15, 1998, the Company introduced an incentive stock option plan ("1998 Plan") which provides for the grant of options to purchase shares of the Company's common stock to key employees and members of the Company's Management Board. The 1998 Plan authorized the grant of options to personnel for 96,075 shares of the Company's common stock in the form of 45,450 registered warrants, each equal to one share of common stock, and 50,625 shares deliverable upon exercise of nonwarrant option rights. The Company reserved 55,350 common shares plus 68,650 shares of treasury stock for stock options. All option rights granted under this 1998 Plan have a ten-year term. Each warrant entitles the holder to receive one share. Upon exercise of a warrant, the exercise price, which equals the fair value of the shares on the date of grant, is due and payable. Warrants holders can exercise up to the full amount of warrants six months after the date of grant. Warrants holders also have the right to sell them. The warrants or shares obtained upon exercise vest annually on a graded basis over three years.

The non-warrant option rights are granted by the Company to the employee by way of an option agreement. For all grants commencing after June 1998, a two-year holding period is required after the date of grant, after which the holder of nonwarrant option rights can exercise up to the amount of vested option rights.

For the full year 2005, 2,300 options from the 1998 Plan were exercised.

1999 Employee Stock Option Program

Effective July 21, 1999, the Company amended the incentive stock option plan ("1999 Plan") authorizing the additional grant of options to employees for up to 300,250 shares, arising from conditional capital, and deliverable upon exercise of non-warrant option rights. On October 31, 1999, a grant of 98,100 shares was made to Company employees, management and the Supervisory Board. The options rights are non-transferable, and have a maximum life of five years. Additionally, a two-year holding period is required after the date of grant, after which the holder of the option rights can exercise up to the amount of vested option rights, on condition that the value of the underlying stock has appreciated 10 % per annum, cumulatively, in the year of exercise.

In the year 2001, additional grants to employee were made under the 1999 Plan, with terms identical to the 1999 stock options grants. 15,250 options were granted on July 1, 2001, to employees of MorphoSys AG.

In the year 2002, additional grants to employees were made under the 1999 Plan, with terms identical to the 1999 stock options grants. 5,500 options were granted on January 15, 2002, to employees of MorphoSys AG.

In the year 2003, additional grants to Management Board members were made under the 1999 Plan, with terms identical to the 1999 stock options grants. 36,000 options were granted on July 1, 2003, to Management Board members of MorphoSys AG.

For the full year 2005, 34,125 options from the 1999 Plan were exercised.

2002 Employee Stock Option Program

Effective June 6, 2002 the Company amended the incentive stock option plan ("2002 Plan") authorizing the additional grant of options to employees for up to 74,556 shares, arising from conditional capital, and deliverable upon exercise of non-warrant option rights. On July 9, 2002, a grant of 7,500 shares was made to Company employees. The terms are very similar to those of the "1999 Employee Stock Option Program". On May 16, 2003, May 11, 2004 and May 11, 2005, the Annual Shareholders' Meeting authorized the Company to grant an additional 36,891, 58,816 and 74,017 shares respectively under the "2002 Employee Stock Option Program" with identical terms.

In the year 2003, grants to employees were made under the 2002 Plan, with terms identical to the 1999 and 2002 stock options grants. 2,500 options and 15,000 options were granted to employees of MorphoSys AG on January 15, 2003 and July 1, 2003 respectively.

On January 15, 2004, 35,000 options were granted to employees with terms identical to the 1999, 2002 and 2003 stock option grants.

In the year 2005, additional grants to Management Board members were made under the 2002 Plan, with terms identical to the 2002 stock options grants. 97,358 options were granted on July 1, 2005, to Management Board members of MorphoSys AG.

For the full year 2005, 1,875 options from the 2002 Plan were exercised.

A summary of the activity under the Company's employee incentive stock option plans for the years ended December 31, 2005 and 2004 is represented as follows:

Convertible
Bonds
Weighted
Average
Price R
Outstanding on
01/01/2004 271,745 26.40
Granted 35,750 11.72
Exercised (49,965) 21.11
Forfeited (63,600) 21.30
Outstanding on
12/31/2004
193,930 26.70
Outstanding on
01/01/2005
193,930 26.70
Refunded 21,000 20.80
Granted 97,358 31.35
Exercised (38,300) 21.41
Forfeited (15,529) 29.38
Expired (7,000) 217.60
Outstanding on
12/31/2005
251,459 23.34

Stock options exercisable on December 31, 2005 and 2004, amounted to 112,855 and 106,518 shares respectively. The weighted-average exercise prices of exercisable stock options were q 22.25 and q 36.51 on December 31, 2005 and 2004 respectively. Furthermore, the weighted-average fair value of options granted during 2005 and 2004 is estimated to be q 11.23 and q 6.99 respectively.

As a result of a court decision, 21,000 forfeited stock options in 2004 were refunded to all those concerned in 2005.

The following table presents the weighted-average price and information about the contractual life for significant option groups outstanding on December 31, 2005:

Range of Exercise Prices Number
Outstanding
Weighted-Av-
erage Remain-
ing Contractual
Life (in Years)
Weighted-
Average
Exercise
Price
Number
Exercisable
Weighted-
Average
Exercise
Price
E 10.88­ —
E 41.32
248,459 3.34 E 23.02 110,105 E 21.59
E 41.33
— E 59.51
3,000 0.68 E 49.81 2,750 E 48.93
251,459 112,855

The Company accounts for stock-based compensation in accordance with the provisions of IFRS 2 "Share-Based Payment". Compensation expense recorded in 2005 and 2004 in connection with stock options was q 374,138 and q 1,239,580 respectively. The fair value of the options issued in 2005 was calculated using the Black-Scholes option pricing model using the following assumptions: risk-free interest rate of 2.16 %, dividend yield of 0 %, 50 % expected volatility, based on historic data, and an expected option life of 3.0 years. For option grants in 2004, the following assumptions were used: risk free interest rate of 3.1 %, dividend yield of 0 %, 78 % expected volatility and of the same option life as in 2005.

Option valuation models require the input of highly subjective assumptions. Because changes in the subjective input assumptions can materially affect the fair value estimate, the management does not consider that the existing models necessarily provide a reliable single measure of the fair value of its employee stock options.

Stock Option Repricing

On September 1, 2001, the Company re-issued 94,100 options to employees, which were cancelled on July 5, 2001. The reissued options have similar characteristics and vesting provisions to the original options granted. In accordance with IFRS 2 "Share-Based Payment", the re-issued options were revalued at the date of re-issuance using the Black-Scholes option pricing model. An incremental fair market value of approximately q 5,950,000 was assigned to the re-issued options, which will be recognized over the vesting period of the re-issued options. During the years ended December 31, 2005 and 2004, the Company recognized approximately q 247,900 and q 535,741 respectively of stock-based compensation expense relating to these re-issued stock options.

Extension of 1999 Options

On October 31, 1999, 98,100 options were granted to employees, Supervisory Board members and Management Board members under the 1999 options plan. The options term originally anticipated was five years. On October 14, 2004 the Management and Supervisory Board decided to extend the exercise period of 54,900 options granted to employees and the Management Board until October 31, 2009. In accordance with IFRS 2 "Share-Based Payment", the extended options were revalued on October 14, 2004, using the Black-Scholes optionpricing model. Stock-based compensation in the amount of q 518,585 was recognized in full in the fourth quarter of 2004.

16 Personnel Expenses

in 000's R 2005 2004
Wages and Salaries 9,596 7,229
Social Security
Contributions
1,383 1,077
Stock-Based Com
pensation Expense
1,132 1,424
Temporary Staff
(External)
2 1
Other (161) 757
Total 11,952 10,488

The average number of employees during the year ended December 31, 2005, was 170 (2004: 117).

17 Income Taxes

The Company and its German subsidiary MorphoSys IP GmbH are subject to corporate tax, solidarity surcharge and trade tax. Since 2001, a corporate tax rate of 25 % plus 5.5 % solidarity surcharge applies. The corporate tax rate amounted to 26.5 % in 2003 only due to the one-off effect of the Flood Victims Solidarity Act applicable for 2003. Considering the multiplier rate ("Hebesatz") of 300 % for municipal trade tax, the trade tax rate amounts to approximately 13.04 % of the taxable income and is deductible in the calculation of the corporate tax income.

The income tax for the current fiscal year comprises as follows:

in 000's R 12/31/2005 12/31/2004
Current Tax Expense (Thereof Income Tax Expense Accounted Directly)
in Equity According to IAS 32.35: (283)) (816)
Current Tax Expense for Previous Yerars
Deferred Tax Expense/Benefit Resulting from the Existence or the Reversal
of Temporary Differences (537) (826)
Deferred Tax Benefit with Regard to the Recognition of DTA on Previously Unrecognized
DTA with Regard to Future Reversal of Cifferences Between IFRS and Tax Balance Sheet 917 826
Total Income Tax (436)
Total Amount of Deferred Taxes Resulting from Entries Directly Recognized in Equity (321) (221)

Deferred taxes are recognized only to the extent that it is more likely than not that the related tax benefits will be realized. Based on the income situation in the past and the business expectations for the foreseeable future valuation allowances are reported if this criterion is not fulfilled.

Valuation allowances on deferred tax assets were reduced by q 0.9 million (2004: q 0.8 million). The current assessment with regard to the usability of deferred tax assets can change dependent on the income situation of future years and may result in higher or lower valuation allowances.

The following table reconciles the statutory income tax expense to the actual income tax expense presented in the financial statements. For calculating the statutory income tax expense, in fiscal year 2005 the combined income tax rate of 36 % (2004: 36 %) was applied to income before taxes. The tax rate applied in the reconciliation statement includes corporate tax and solidarity surcharge and amounts to 26.38 % plus the effective trade tax rate based on the multiplier rate ("Hebesatz") of 300 % for municipal trade tax which amounts to 9.60 % taking into account that the trade tax is deductible in the calculation of the corporate tax income.

Reconciliation Statement

in 000's R 2005 2004
Profit Before Income Taxes 5,112 282
Expected Tax Rate 36 % 36 %
Expected Income Tax (1,840) (102)
Tax Effects Resulting From:
Deferred Income Tax Arising from the Recognition of DTA on Previously Unrecognized DTA
with Regard to Future Reversal of Differences Between IFRS and Tax Balance Sheet 917 826
Non-Recognition of DTA on Current Year Tax Losses (224)
Deferred Income Tax Arising From the Recognition of DTA on Previously Unrecognized DTA
on Tax Loss Carry Forwards 1,041
Stock-Based Compensation (SBC) (408) (513)
Expense of Cost/Capital Increase 46
Non Tax-Deductible Items in Germany (95) (29)
Other Effects (51) (4)
Actual Income Tax (436)

No deferred tax assets were reported for corporate tax loss carry-forwards in the amount of q 22.0 million and German trade tax loss carry-forwards in the amount of q 20.8 million. The loss carry-forwards may be carried forward indefinitely and in unlimited amounts. From 2004 onwards, German tax law restricts the offset of taxable income against existing tax loss carry-forwards to an amount of q 1.0 million plus 60 % of taxable income above q 1.0 million. The benefit from a previously unrecognized tax loss reduced the current tax expense by q 1.0 million in 2005. Deferred tax assets on assets and

liabilities of the German entities were only reported to the extent of existing deferred tax liabilities on assets and liabilities of the German entities. A valuation allowance for deferred tax assets with regard to future reversal of differences between IFRS and tax balance sheet in the amount of q 3.6 million (2004: q 4.5 million) exists.

Significant components of the deferred tax assets and liabilities are as follows:

in 000's R DTA 2005 DTA 2004 DTL 2005 DTL 2004
Intangible Assets 4,821 5,789 1,750 1,242
Valuation Allowance on Intangible Assets (3,592) (4,510)
Land 267
Buildings 71
Inventory 69 79 62
Advanced Payments 7
Receivables and Other Assets 870 36 121
Treasury Stock 4
Prepaid Expenses and Deferred Charges 4
Short-Term Securities Investments 4 325 225
Other Accruals 1 6
Trade Accounts Payable 47
Bonds there of Convertible 18
Deferred Income 110 2
Other Liabilities 2 979
1,316 2,348 2,576 2,569

18 Earnings per Share

The calculation of basic profit per share is based on the net profit for the year of q 4,676,369 (2004: q 282,112) and a weighted-average number of shares of common stock outstanding for the respective years (2005: 5,578,865; 2004: 5,131,467).

063

The weighted-average number of shares of common stock was calculated as follows:

2005 2004
Shares Issued at January 1 5,438,852 4,901,332
Effect of Treasury Shares Held (29,162) (30,062)
Effect of Shares Issued in January 2,260
Effect of Shares Issued in February 8,158
Effect of Shares Issued in March 143,043
Effect of Shares Issued in April 112 2,367
Effect of Shares Issued in May 13 5,671
Effect of Shares Issued in June 21 247,717
Effect of Shares Issued in July 897
Effect of Shares Issued in August 1,542 250
Effect of Shares Issued in September 10,417 583
Effect of Shares Issued in October 758 164
Effect of Shares Issued in November 1,858 2,204
Effect of Shares Issued in December 96 1,241
Weighted-Average Number of Shares of Common Stock 5,578,865 5,131,467

The diluted profit per share is calculated taking into account the Company's potential common shares from outstanding stock options and convertible bonds.

The table below illustrates the reconciliation from basic to diluted earnings per share (in thousands of euros, except per share data):

2005 2004
Numerator:
Net Profit 4,676 282
Denominator:
Weighted-Average Shares Used for Basic EPS 5,578,865 5,131,467
Dilutive Shares Arising from Stock Options 71,513 12,401
Dilutive Shares Arising from Convertible Bonds 26,097
Total Denominator: 5,650,378 5,169,965
Earnings per Share (in Euros):
Basic 0.84 0.05
Diluted 0.83 0.05

19 Financial Risk Management Objectives and Policies

In addition to the risks highlighted in the Management Report, the Company has identified the following:

Currency Risks

The Group accounts are administered in euros. While the expenses of MorphoSys are predominantly paid in euros, a significant part of the revenues depends on the current exchange rate of U.S. dollars and euros. The Company examines the necessity of hedging foreign exchange transactions to minimize currency risk during the year and addresses this risk by employing derivative financial instruments.

Interest Rate Risk

The exposure of the Group to changes in interest rates relates mainly to investments in available-for-sale debt securities. Changes in the general level of interest rates may lead to an increase or decrease in the fair value of these investments. With regard to the liabilities shown in the balance sheet, the Group is currently not subject to significant interest rate risks.

Credit and Liquidity Risk

Financial instruments that potentially subject the Company to concentrations of credit and liquidity risk consist primarily of

cash, cash equivalents, marketable securities and accounts receivable. The Company's cash and cash equivalents are principally denominated in euros and U.S. dollars. Marketable securities are placed in high-quality securities. Cash, cash equivalents and marketable securities are maintained principally with two high-quality financial institutions in Germany. The Company continually monitors its positions with, and the credit quality of, the financial institutions, which are counterparties to its financial instruments, and does not anticipate non-performance.

It is the Group's policy that all customers who wish to trade on credit terms are subject to credit verification procedures. However, the Company's revenues and accounts receivable are subject to credit risk as a result of customer concentrations. One customer individually accounted for approximately 44 % of the Company's 2005 accounts receivable balance. In addition, three customers individually accounted for 31 %, 19 % and 14 % of the Company's total revenues in the year 2005. On December 31, 2004, one customer accounted 52 % for prior year's accounts receivable balance and three customers individually accounted for 28 %, 26 % and 17 % of the Company's revenues in 2004. Based on the management's assessment, allowances of q 41,461 and q 36,456 in relation to the newly formed reagent business unit were necessary as of December 31, 2005 and 2004.

Fair Value of Financial Instruments

The carrying value of financial instruments such as cash and cash equivalents, accounts receivable and accounts payable approximates their fair value based upon the short-term maturities of these instruments. The fair value of marketable securities is based upon quoted market prices (see note 4). The fair value of license payables is determined by the effective interest method. Convertible bonds are recorded at their accreted values, which approximate the cash outlay that is due upon the note settlements.

20 Operating Leases

The Company leases facilities and equipment on long-term operating leases. Total rent expense amounted to q 880,173 and q 898,292 for the years ended December 31, 2005 and 2004, respectively. In January 2004, MorphoSys amended the existing lease agreement for its facilities. The new lease agreement expires in September 2009. Future minimum payments under non-cancelable operating leases, insurances and other services are as follows:

The Company's total expenses due to operating leases, insurances and other services in the years ended December 31, 2005 and 2004, totaled approximately q 1,185,515 and q 1,084,597 respectively.

21 Contingencies

In June 2001, a lawsuit was filed against the Company by Applied Molecular Evolution, Inc., ("AME") San Diego, California, U.S.A., (a wholly owned subsidiary of Eli Lilly & Company) at the United States District Court of Massachusetts in Boston/ U.S.A., alleging that the Company infringes the Kauffman-Ballivet patent family. These patents cover the stochastic production of proteins and were granted in the late 1990s. In January 2003 MorphoSys confirmed that it had received a positive "Report and Recommendation" from the Magistrate Judge to the District Judge for the District Court in Boston, Massachusetts, U.S.A., in the legal action filed by Applied Molecular Evolution. The Magistrate Judge recommended that MorphoSys' motion for summary judgment of non-infringement be allowed and that AME's motion for partial summary judgment of infringement be denied. In September 2004, the District Judge issued a "Memorandum and Order" wherein he declined to adopt the recommendation and denied the summary judgment motions. Instead he ordered that a Markman hearing, which took place on April 1, 2005, for claim construction should be held. In September 2005, MorphoSys announced a cross license agreement with Eli Lilly & Company ("Lilly") on the use of certain recombinant protein technologies. This agreement is part of a settlement to resolve the abovementioned patent litigation with AME. Under the agreement, MorphoSys receives a license under the Kauffman patent estate to generate and screen certain recombinant peptide and protein libraries and to commercialize any resulting products. The agreement also provides Lilly access to the Morpho-Sys HuCAL GOLD technology for Lilly's internal research and development programs. For any therapeutic antibodies Lilly develops under the agreement, it will pay MorphoSys exclusive licensing fees, success fees, milestone payments and royalties on end products. The settlement agreement covers MorphoSys's and its partners past, present and future use and commercialization of all versions of its HuCAL libraries, as well as its TRIM technology. The agreement also gives Lilly access under agreed terms to Antibodies by Design, Morpho-Sys's business unit focusing on development of custom monoclonal antibodies for non-therapeutic purposes.

The management is not aware of any other matters that could give rise to any material liability to the Company that would have a material adverse effect on the Company's financial condition or results of operations.

22 Related Parties

The Group has related party transactions with its Management and with members of the Supervisory Board. In addition to the cash remuneration, the Group has issued stock options and convertible bonds to the Management Board and members of the Supervisory Board.

The table below shows the shares, stock options and convertible bonds, and changes of ownership of the same, which were held by the Management and Supervisory Boards during the year 2005:

Shares

in 000's R 01/01/2005 Additions Forfeitures Expired Sales 12/31/2005
Management Board
Dr. Simon E. Moroney*
(held through a
controlled entity)
113,461 113,461
Dr. Simon E. Moroney 113,461 113,461
Dave Lemus
Dr. Marlies Sproll**
Total 113,461 113,461 113,461 113,461
Supervisory Board
Dr. Gerald Möller 2,500 2,500
Dr. Daniel Camus
Dr. Metin Colpan
Prof. Dr. Jürgen Drews
Prof. Dr. Andreas
Plückthun*
59,300 59,300
Dr. Geoffrey N. Vernon
Total 61,800 61,800

*   Shares were subject to share loan agreement as of March 31, 2005,

in connection with a capital increase and were retransferred on April 13, 2005

** Entered 11/01/2005

Stock Options

in 000's R 01/01/2005 Additions Forfeitures Expired Sales 12/31/2005
Management Board
Dr. Simon E. Moroney 47,000 36,000 83,000
Dave Lemus 21,000 27,000 48,000
Dr. Marlies Sproll** 10,000 7,500 2,500
Total 78,000 63,000 7,500 133,500
Supervisory Board
Dr. Gerald Möller 2,500 2,500
Dr. Daniel Camus
Dr. Metin Colpan
Prof. Dr. Jürgen Drews 3,930 1,500 2,430
Prof. Dr. Andreas
Plückthun 1,500 1,500
Dr. Geoffrey N. Vernon 1,500 1,500
Total 9,430 7,000 2,430

Convertible Bonds

in 000's R 01/01/2005 Additions Forfeitures Expired Sales 12/31/2005
Management Board
Dr. Simon E. Moroney 19,474 12,000 7,474
Dave Lemus 30,228 24,000 6,228
Dr. Marlies Sproll** 2,491 2,491
Total 52,193 36,000 16,193
Supervisory Board
Dr. Gerald Möller 2,500 2,500
Dr. Daniel Camus 1,500 1,500
Dr. Metin Colpan
Prof. Dr. Jürgen Drews
Prof. Dr. Andreas
Plückthun 1,500 1,500
Dr. Geoffrey N. Vernon 1,500 1,500
Total 7,000 7,000

** Entered 11/01/2005

Compensation for both the Management Board and the Supervisory Board consisted of fixed and variable components. Total compensation for the Supervisory Board excluding reimbursements of travel expenses in 2005 amounted to q 190,500 (2004: q 169,500). The tables below show the detailed compensation for the Management Board and Supervisory Board:

Management Board

Fixed Compensation Variable Compensation Other Compensatory
Benefits
Total Compensation
in R 2005 2004 2005 2004 2005 2004 2005 2004
Dr. Simon Moroney 257,453 227,052 136,231 63,630 66,789 59,051 460,473 349,733
Dave Lemus 184,174 170,824 102,495 74,993 106,779 101,072 393,448 346,889
Dr. Marlies Sproll* 27,500 6,543 34,043
Dr. Thomas von Rüden** 129,421 75,661 53,037 258,119
Total 469,127 527,297 238,726 214,284 180,111 213,160 887,964 954,741

* Entered 11/01/2005

** No longer with the company since 09/03/2004

Supervisory Board

Fixed Compensation Variable Compensation Total Compensation
in R 2005 2004 2005 2004 2005 2004
Dr. Gerald Möller 25,000 25,000 26,000 20,500 51,000 45,500
Dr. Daniel Camus 13,500 13,500 16,000 13,500 29,500 27,000
Prof. Jürgen Drews 18,500 18,500 14,000 7,000 32,500 25,500
Prof. Dr. Andreas Plückthun 12,000 12,000 7,500 7,500 19,500 19,500
Dr. Geoffrey N. Vernon 15,000 15,000 17,000 15,500 32,000 30,500
Dr. Metin Colpan 13,500 8,587 12,500 5,000 26,000 13,587
Dr. Jörg Reinhardt* 4,913 3,000 7,913
Total 97,500 97,500 93,000 72,000 190,500 169,500

* Retired 05/11/2004

23 Corporate Governance

The Company issued its statement according to Section 161 of the German Stock Corporation Act (Aktiengesetz). This declaration was published and made accessible to stockholders accordingly on December 22, 2005.

24 Research and Development Agreements

The Company has a significant number of research and development agreements relating to its discovery and development strategy. The following is a brief description of these agreements, which have had, or may have, a significant financial impact (in alphabetical order).

Bayer Corporation, Berkeley, U.S.A.

In December 1999, the Company announced a collaboration with Bayer AG ("Bayer") encompassing a research collaboration and license agreement for the application of the Company's proprietary technologies in a number of Bayer's research and development programs. The collaboration was extended by another four years in July 2001. The agreement specified four areas in which the two companies apply the Company's technologies. The Company's HuCAL (Human Combinatorial Antibody Library) technology is being used to generate fully human therapeutic antibodies against up to ten targets provided by Bayer. In addition, Bayer has an option to develop antibodies generated using the HuCAL technology as in vitro diagnostics. Furthermore, HuCAL is being used to identify antibodies for use in monitoring the progress of clinical trials with selected drugs. The fourth and last area of application is the use of MorphoSys technologies to identify and validate new targets emerging from Bayer's genomics program, which will be used by Bayer in screens for new drug candidates.

Under the terms of the agreement, Bayer made an up-front payment to the Company upon signing the agreement, and pays additional annual license fees and support for research and development funding at the Company. Furthermore, Bayer pays exclusivity fees for using the HuCAL technology on up to ten potential targets, as well as milestone fees on antibodies delivered by the Company that meet pre-agreed success criteria. Any antibody-based products developed in the collaboration trigger development-related milestone and royalty payments by Bayer to the Company. Over the course of the agreement, Bayer has thus far taken two exclusive licenses on antibodies from MorphoSys, and cross-licensed their HKB-11 cell line against the installation of HuCAL GOLD at selected Bayer sites.

In December 2005, the collaboration was extended by another five years, with a termination option after the first collaboration year. Under the terms of the extended agreement, MorphoSys grants Bayer access to its proprietary HuCAL GOLD antibody library for use in Bayer's drug discovery programs at its research site in West Haven, Connecticut, U.S.A. Additionally, the two parties undertake to commence up to 25 new therapeutic antibody programs should the collaboration run its full course.

Boehringer Ingelheim GmbH

In February 2003, MorphoSys and Boehringer Ingelheim GmbH ("Boehringer Ingelheim"), entered into a therapeutic antibody collaboration and cross-licensing agreements. Under the terms of the agreements, MorphoSys received an exclusive, worldwide license to patents owned or controlled by Boehringer Ingelheim to develop, make and sell therapeutic and diagnostic antibodies targeting the ICAM-1 molecule. Boehringer Ingelheim will receive exclusive commercial licenses to therapeutic antibodies against two undisclosed targets, which MorphoSys will generate utilizing its HuCAL GOLD antibody technology.

In November 2003, Boehringer Ingelheim exercised its first option for the development of a therapeutic antibody. As a result, MorphoSys will develop a therapeutic antibody for Boehringer Ingelheim against an undisclosed target molecule for the treatment of inflammatory diseases such as asthma and rheumatoid arthritis.

In August 2004, Boehringer Ingelheim exercised its second option for the development of a therapeutic antibody. Both parties initiated a new program for the development of a therapeutic antibody against an undisclosed target molecule involved in cardiovascular diseases. MorphoSys will generate this antibody using its proprietary HuCAL GOLD technology. Boehringer Ingelheim will be responsible for the pre-clinical and clinical development and subsequent marketing of any resultant products, on which MorphoSys could earn milestones and royalties.

In March 2005, Boehringer Ingelheim and MorphoSys signed an expansion of their existing cooperation involving both research and therapeutic applications. Boehringer Ingelheim has acquired an option to receive several exclusive licenses on new therapeutic antibody programs. Additionally, Boehringer Ingelheim will obtain access to MorphoSys' HuCAL GOLD library for research purposes at a number of the firm's research facilities. The first installation site is intended to be Boehringer Ingelheim's site in Vienna, Austria. MorphoSys will receive a technology access fee, annual license fees and optional R&D funding over the five-year collaboration term. For therapeutic antibodies emerging from the collaboration, Boehringer Ingelheim will pay milestone fees and royalties to MorphoSys.

Bristol-Myers Squibb

In August 1998, the Company and Bristol-Myers Squibb Company ("Bristol-Myers Squibb", formerly DuPont Pharmaceuticals Company) entered into a cooperation agreement under which Bristol-Myers Squibb acquired a non-exclusive license to MorphoSys' HuCAL antibody library technology. Under the agreement, Bristol-Myers Squibb applied HuCAL technology in its pharmaceutical discovery programs for target characterization and validation. In July 2000, the parties extended this research license and agreed to collaborate in developing a system for fully automated high-throughput antibody generation, called AutoCAL. The amended agreement provided for Bristol-Myers Squibb's continued use of the HuCAL libraries and for the installation of AutoCAL at Bristol-Myers Squibb's facilities in Wilmington, Delaware, U.S.A. Milestones were achieved in 2000 and 2001 with the successful generation of research antibodies against target molecules provided by Bristol-Myers Squibb using AutoCAL.

In January 2005, MorphoSys announced a further expansion of the existing license agreement to grant Bristol-Myers Squibb access to the HuCAL GOLD library.

Centocor, Inc., U.S.A.

In December 2000, the Company signed a subscription and license agreement with Centocor, Inc. ("Centocor"). The intention of the collaboration is to facilitate the research, discovery and development of novel antibody therapeutics. Centocor will have access to the HuCAL technology at various sites; in addition, the Company will generate antibodies against Centocor targets. Under the agreement, the Company will receive committed technology license fees, exclusivity fees, research and development funding, and milestone payments. Centocor will be responsible for development and marketing of any potential drugs. Should Centocor market any drugs as a result of the collaboration, the Company will receive royalty payments. The original contract had a duration of five years and was to end in December 2005. In December 2004, both parties extended their agreement until the end of 2007. The extension agreement provides for increased levels of research and development funding by Centocor to MorphoSys, and an up-front payment by Centocor to MorphoSys for the extension.

Eli Lilly & Company

MorphoSys and Eli Lilly & Company ("Lilly") signed a crosslicensing agreement in September 2005 for the use of their recombinant protein technologies. The agreement is part of a settlement to resolve the patent litigation with Applied Molecular Evolution (AME). Under the agreement, MorphoSys receives a license under the Kauffman patent estate to generate and screen certain recombinant peptide and protein libraries and to commercialize any resulting products. The agreement also provides Lilly access to the MorphoSys Hu-CAL GOLD technology for Lilly's internal research and development programs. For any therapeutic antibodies Lilly develops under the agreement, it will pay MorphoSys exclusive licensing fees, success fees, milestone payments and royalties on end products. The settlement agreement covers MorphoSys' and its partners past, present and future use and commercialization of all versions of its HuCAL libraries, as well as its TRIM technology. The agreement also gives Lilly access under agreed terms to Antibodies by Design, Morpho-Sys' business unit focusing on the development of custom monoclonal antibodies for non-therapeutic purposes.

F. Hoffmann-La Roche, Switzerland

In September 2000, MorphoSys entered into a collaboration and license agreement with F. Hoffman-La Roche ("Roche") for the development of human therapeutic antibodies against a Roche target. Under the terms of the agreement, the Company receives a license payment, development-related milestone payments, and royalties on marketed products. The Company will apply its (HuCAL) Fab technology to the generation and optimization of antibodies for the Roche target. Roche will be responsible for the clinical development, regulatory approval and worldwide marketing of any resulting

products. MorphoSys announced in Ianuary 2006, that Roche has filed all necessary applications to commence a European Phase 1 clinical trial with a HuCAL-derived antibody to treat Alzheimer's disease. The applications filing to commence clinical trials triggers a clinical milestone payment from Roche to MorphoSys.

GPC Biotech AG, Munich, Germany

In April 1999, the Company signed a collaboration and license agreement with GPC Biotech AG ("GPC"), Munich. The objective of the collaboration is to utilize the Company's technologies to generate human antibodies against GPC targets and to deliver such antibody products to GPC for confirmation of achievement of pre-defined success criteria. The Company received up-front research and development funding/exclusivity payments as well as the potential for milestone and royalty payments from GPC. In January 2005, GPC has started a Phase 1 clinical trial with a fully human cancer antibody (1D09C3) generated by MorphoSys, evaluating the antibody in patients with relapsed or refractory B-cell lymphomas, such as Hodgkin's and non-Hodgkin's lymphomas. The commencement of clinical trials triggers a clinical milestone payment from GPC Biotech to MorphoSys. The European Commission has granted orphan drug designation for the antibody for the treatment of chronic lymphocytic leukemia (CLL).

ImmunoGen, U.S.A.

In September 2000, the Company signed a collaboration and license agreement with ImmunoGen, U.S.A. ("ImmunoGen"). The parties will collaborate in the discovery and development of human monoclonal antibodies against certain specified targets. ImmunoGen will be responsible for developing one or more antibodies generated by the Company into a marketable product. Under the agreement, the Company will receive a license payment, as well as development-related milestone payments and royalties on marketed products.

The existing agreement between the two companies was expanded in June 2001. The new agreement provided for a research license from the Company to ImmunoGen for the Company's HuCAL antibody library technology for the generation of research antibodies for use in ImmunoGen´s functional genomics programs, in order to help validate new targets. The expanded agreement has a duration of four years.

In June 2005, the existing license agreement for ImmunoGen's internal target research programs was extended for another year.

Merck & Co., Inc.

In December 2005, MorphoSys signed a five-year license agreement with Merck & Co., Inc. ("Merck"). Under the terms of the agreement, MorphoSys grants Merck access to its proprietary technologies HuCAL GOLD and AutoCAL for use in Merck's drug discovery programs. Furthermore, the agreement enables Merck to develop HuCAL-derived therapeutic antibodies in a range of indications. MorphoSys receives an up-front payment, annual user fees and R&D funding. MorphoSys is also eligible to receive license and milestone payments on projects in clinical development, and royalties on any end products emerging from the collaboration.

Novartis AG

In May 2004, MorphoSys AG and Novartis AG ("Novartis") announced a collaboration to discover and develop antibody-based biopharmaceuticals as therapeutic agents, in order to address unmet medical need across a variety of diseases. MorphoSys brings validated and robust human antibody technologies (Hu-CAL GOLD) to Novartis' new strategic research directions, building a collaboration that will identify and develop novel therapeutic agents rapidly and efficiently. MorphoSys scientists will work directly with Novartis scientists across the global sites of the Novartis Institutes for BioMedical Research (NIBR), including the new world headquarters in Cambridge, MA, U. S.A. The MorphoSys HuCAL GOLD technology will be an integral part of Novartis' drug discovery and development efforts. During the three year term of the agreement, which may be extended up to a total of five years, Novartis will fund internal research at MorphoSys that will generate and optimize HuCAL GOLD antibodies against targets identified by Novartis. In addition, Novartis will have access to the current MorphoSys Hu-CAL GOLD library at two of its sites. Additionally, under the terms of this collaboration Novartis will be MorphoSys' first partner to receive a non-exclusive option on internalization of the entire MorphoSys technology platform, which would trigger an additional payment by Novartis to MorphoSys. Novartis made an approx. q 9 million investment in MorphoSys by purchasing non-interest bearing convertible bonds of MorphoSys. In addition, MorphoSys will receive over US \$ 30 million in committed R&D funding and technology license fees over the first three years. MorphoSys also stands to receive technology license payments, research and developmental milestones, as well as royalties on marketed antibody products.

Novoplant GmbH

MorphoSys AG and Novoplant GmbH ("Novoplant") announced in July 2004 the signing of a collaboration for the development of therapeutic antibodies in animal health applications. Under the three-year agreement Novoplant received a license for the development and commercialization of therapeutic antibodies as feed components for use in veterinary medicine. Novoplant will pay a technology access fee to MorphoSys in addition to annual licensing fees. Additionally, MorphoSys receives milestone fees and royalties for the subsequent development and marketing of any resulting products. In the context of the cooperation, Novoplant will use MorphoSys' HuCAL GOLD technology to generate antibodies against viruses, parasites and pathogenic microorganisms. The addition of such MorphoSys antibodies to animal feed stock may offer protection against infectious diseases in the respective animal's gastro-intestinal tract. MorphoSys retains all rights in any human therapeutics or diagnostics emerging from the collaboration.

Pfizer, Inc., U.S.A.

In December 2003, the Company announced a collaboration and license agreement with Pfizer, Inc. ("Pfizer"). The intention of the collaboration is to facilitate the research, discovery and development of novel antibody therapeutics. The Company will apply its HuCAL GOLD technology to the generation and optimization of antibodies for multiple Pfizer targets. Under the agreement, the Company received a committed up-front fee, research support, and, depending on collaboration progress, will receive milestone payments and royalties. Pfizer is responsible for the clinical development, regulatory approval and worldwide marketing of any resulting products.

Schering AG, Germany

In December 2001, the Company and Schering AG ("Schering") formed a strategic alliance for the development of antibody therapeutics and in-vivo diagnostics. As part of the agreement, Schering and the Company will combine their resources over the three year collaboration term to exclusively pursue a minimum of five therapeutic and several in-vivo diagnostic projects. Furthermore, the two partners will jointly undertake research to identify additional potential therapeutic and diagnostic targets emerging from Schering's genomics program.

Over the lifetime of the agreement, the Company will receive license fees, milestone payments and royalties on any end products emerging from the collaboration. Additionally, Schering purchased 357,880 shares at an average price of q 66.79 per share in February 2002 as part of their strategic commitment to the partnership.

In December 2004, both parties extended the collaboration agreement by at least two more years, until the end of 2006, with the option of a further extension period of one year beyond this time frame.

Shionogi & Co. Ltd.

In September 2005, MorphoSys signed a three year license agreement with Shionogi & Co., Ltd. ("Shionogi") on the use of MorphoSys' HuCAL technology. Under the terms of the agreement, MorphoSys grants Shionogi access to its HuCAL GOLD antibody library for use in Shionogi's pharmaceutical drug discovery programs. In return, MorphoSys stands to receive an up-front payment and annual user fees during the life span of the agreement.

XOMA Technology Ltd./XOMA Ireland Ltd.

In February 2002, MorphoSys and XOMA Technology Ltd./ XOMA Ireland Ltd. ("XOMA") concluded mutual license agreements for their antibody technologies. Under the terms of these agreements, MorphoSys received a license for its own and its collaboration partners' past and future use of XOMA antibody expression technology for the development of antibody products in connection with the phage display-based HuCAL antibody library (the "XOMA license"). In return, XOMA received a fiveyear license from MorphoSys to use the MorphoSys HuCAL GOLD antibody library, which XOMA will use for its own target molecule identification and for its research programs. Moreover, an option is included for the development of therapeutic antibodies. MorphoSys acquired the XOMA license by issuing 363,466 shares arising from a capital increase in 2003.

24 Events After the Balance Sheet Date

On January 12, 2006, MorphoSys announced the acquisition of the privately held Serotec Group. The acquisition of Serotec, a renowned and internationally-active supplier of research antibodies, more than triples the Group's existing Research Antibodies segment revenues and establishes MorphoSys as the leading supplier of research antibodies and antibody research technologies in Europe. The purchase price of approximately £ 20 million (approx. q 29.3 million) will be paid via approximately £ 14 million (approx. q 20.5 million) cash and through the issuance of 208,560 new MorphoSys shares from a capital increase against contribution in kind. Serotec provides Morpho-Sys with a strong distribution network including subsidiaries and sales offices in the U.S., the U.K., Germany, France and Scandinavia. It is intended that Serotec becomes a wholly owned subsidiary of MorphoSys AG and integrated within MorphoSys' existing research antibody business represented to date by the Biogenesis and Antibodies by Design brands. All three research antibody business units will operate under the umbrella brand AbD—Antibodies Direct.

In January 2005 MorphoSys announced the acquisition of the U.K.- and U.S.-based Biogenesis Group. The acquisition of Biogenesis was a first strategic step to expand the Research Antibodies unit by adding a comprehensive catalog antibody and contract antibody manufacturing business.

Serotec, founded in 1982, markets a substantial product portfolio of more than 4,600 research antibodies and reagents for use in research areas such as Immunology, Neurology, Cell Biology and Histology. Consolidated sales of Serotec group in 2005 amounted to approximately q 11 million. With this acquisition, MorphoSys adds sales offices in France and Scandinavia and bolsters its existing presence in Germany, the U.K. and U.S.A. The goal of the enlarged research antibody unit is to leverage its research and sales capabilities globally. MorphoSys sees potential for significant revenue and cost synergies.

MorphoSys' present Management Board will retain their present positions in the enlarged MorphoSys group. The research antibodies unit will be led by Dieter Lingelbach, Senior Vice President at MorphoSys AG, with former Serotec management remaining in place to support the integration process. Serotec group currently employs approximately 80 people, mostly in R&D and Sales & Marketing.

Summary of Significant Differences Between German GAAP and IFRS

In accordance with § 315a HGB, the Company has an exemption from publishing its financial statements in accordance with the German Commercial Code, which represents generally accepted accounting principles in Germany ("German GAAP"). The accompanying financial statements are in conformity with principles of consolidated financial statement of the European Union (principle 83/349/EWG). German GAAP varies in certain significant respects from IFRS. Accordingly, the Company has recorded certain adjustments, principally relating to revenue recognition and the recording of certain costs, in order to present the accompanying financial statements in accordance with IFRS.

The financial statements of the Company are prepared in accordance with International Financial Reporting Standards ("IFRS"), which differs in certain respects from German generally accepted accounting principles ("German GAAP") as prescribed by the German Commercial Code (HGB). The following is a summary of the significant differences between applied IFRS and German GAAP that may affect the Company's net income and equity for the periods presented.

Intangible assets — Under IFRS, certain expenses (i.e., internal costs associated with obtaining patents) are capitalized as intangible assets and amortized on a straight-line basis over their estimated useful lives. Under German GAAP, such costs are expensed as incurred. The capitalization of certain acquired license rights are accounted for according to an expert valuation under IFRS. Under German GAAP, the splits are based on the net present value or acquisition cost.

Amortization life of acquired license rights — Under IFRS, these rights are amortized over their estimated useful economic life of ten years. Under German GAAP, the amortization period of eight years follows the rates used for tax purposes.

Revenue recognition — Under IFRS, more stringent revenue recognition criteria exist which can result in differences in the periods in which revenue is recognized under German GAAP. Stock-based compensation – The Company accounts for stock option and convertible bonds grants in accordance with IFRS 2 and recognizes compensation expense. Under German GAAP compensation expense is not being recognized.

Private placement and initial public offering costs — Under IFRS, certain costs in connection with a private placement or an initial public offering of equity are recorded as a reduction of additional-paid-in-capital. Under German GAAP, such costs are expensed as incurred.

Unrealized holding gains and losses on derivative financial instruments — Under IFRS, unrealized gains and losses on derivatives are recorded as other income/expense. Under German GAAP, increased market value is not recorded.

Non-Current Liabilities — IFRS requires to record long-term liabilities with its present value of the future payments using an interest rate commensurate with the risk involved. Under German GAAP, the long-term liabilities are recorded with their repayment amounts.

Goodwill Allocation — IFRS requires to perform a purchase price allocation to identify assets and liabilities acquired. Under German GAAP, these amounts are shown as financial assets.

Roll-Forward of Fixed Assets (Appendix 1)

Acquisition and Production Cost
01/01/2005
R
Additions
R
Disposals
R
12/31/2005
R
I. Property and Equipment
Land and Buildings 2,247,115 2,247,115
Office and Laboratory Equipment 4,985,732 628,573 280,589 5,333,716
Furniture and Fixtures 1,345,543 536,188 1,881,731
6,331,275 3,411,876 280,589 9,462,562
II. Intangible Assets
Patents 3,765,756 28,805 3,794,561
License Rights 12,140,398 12,140,398
Software 1,366,441 44,694 19,500 1,391,635
Know How and Customer List 2,312,685 2,312,685
Goodwill 4,137,349 4,137,349
17,272,595 6,523,533 19,500 23,776,628

*including impairment losses of E 0.5 million

Chart of the Consolidated Entity as of December 31, 2005 (Appendix 2)

Name and Corporate Seat of the Company Currency Exchange Rate
At December 31,
2005 One Unit
of E
in Foreign
Currency
Company Consolidated (Apart from Parent Company)
MorphoSys USA, Inc., Charlotte, North Carolina, USA US \$ 1.18590
MorphoSys IP GmbH, Munich, Germany E
Biogenesis Ltd., Poole, UK £ 0.68430
Biogenesis, Inc., Brentwood, New Hampshire, USA US \$ 1.18590

*Before elimination of intercompany transactions.

Accumulated Depreciation Net Book Values
01/01/2005
Depreciation*
Disposals
12/31/2005
R
R
R
R
12/31/2005
12/31/2004
R
R

10,310

10,310
2,236,805
3,273,553
671,769
162,583
3,782,739
1,550,977
1,712,179
726,727
245,923

972,650
909,081
618,816
4,000,280
928,002
162,583
4,765,699
4,696,863
2,330,995
975,665
457,891

1,433,556
2,361,005
2,790,091
2,469,267
1,214,040

3,683,307
8,457,091
9,671,131
1,078,326
197,511
15,708
1,260,129
131,506
288,115

827,118

827,118
1,485,567



4,137,349
4,523,258
2,696,560
15,708
7,204,110
16,572,518
12,749,337
Share of Capital
%
Equity in
Foreign
Currency
Total Assets
in Foreign
Currency*
Total Liabilities
in Foreign
Currency*
Total Revenue
in Foreign
Currency*
Profit/Loss in
Foreign
Currency*
100 2,000 4,136 (1,345) (18,569)
100 25,000 16,818,787 18,816,912 6,989,479
100 200 1,363,390 514,053 1,658,032 29,420
100 100 698,996 467,416 1,007,166 (196,701)

Audit Opinion

We have issued the following unqualified auditor's report:

"Auditor's report

We have audited the consolidated financial statements prepared by the MorphoSys AG, Martinsried nearby Munich, –comprising the balance sheets, the statements of operations, the statements of cash flows, the statements of changes in stockholders' equity and the notes to the consolidated financial statements– together with the group management report for the business year from January 1 to December 31, 2005. The preparation of the consolidated financial statements and the group management report in accordance with IFRSs, as adopted by the EU, and the additional requirements of German commercial law pursuant to Section 315a Par. 1 HGB are the responsibility of the parent company's management. Our responsibility is to express an opinion on the consolidated financial statements and on the group management report based on our audit.

We conducted our audit of the consolidated financial statements in accordance with Section 317 HGB [Handelsgesetzbuch; "German Commercial Code"] and German generally accepted standards for the audit of financial statements promulgated by the Institut der Wirtschaftsprüfer (IDW). Those standards require that we plan and perform the audit such that misstatements materially affecting the presentation of the net assets, financial position and results of operations in the consolidated financial statements in accordance with the applicable financial reporting framework and in the group management report are detected with reasonable assurance. Knowledge of the business activities and the economic and legal environment of the Group and expectations as to possible misstatements are taken into account in the determination of audit procedures. The effectiveness of the accounting-related internal control system and the evidence supporting the disclosures in the consolidated financial statements and the group management report are examined primarily on a test basis within the framework of the audit. The audit includes assessing the annual financial statements of those entities included in consolidation, the determination of entities to be included in consolidation, the accounting and consolidation principles used and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements and group management report. We believe that our audit provides a reasonable basis for our opinion.

Our audit has not led to any reservations.

In our opinion, based on the findings of our audit, the consolidated financial statements comply with IFRSs, as adopted by the EU, the additional requirements of German commercial law pursuant to Section 315a Par. 1 HGB and give a true and fair view of the net assets, financial position and results of operations of the Group in accordance with these requirements. The group management report is consistent with the consolidated financial statements and as a whole provides a suitable view of the Group's position and suitably presents the opportunities and risks of future development."

Munich, February 3, 2006

KPMG Deutsche Treuhand-Gesellschaft Aktiengesellschaft Wirtschaftsprüfungsgesellschaft

Maurer Rahn

MorphoSys AG

Lena-Christ-Str. 48 82152 Martinsried/Planegg Germany Tel.: +49-89-89927-0 Fax: +49-89-89927-222