Lobe Sciences Ltd. — Regulatory Filings 2021

Dec 24, 2021

Form 52-109FV1

Certification of Annual Filings Venture Issuer Basic Certificate

I, Brian Zasitko , Chief Financial Officer of Lobe Sciences Ltd. , certify the following:

1. Review: I have reviewed the AIF, if any, annual financial statements and annual MD&A, including, for greater certainty, all documents and information that are incorporated by reference in the AIF (together, the “annual filings”) of Lobe Sciences Ltd. (the “issuer”) for the financial year ended August 31, 2021 .

2. No misrepresentations: Based on my knowledge, having exercised reasonable diligence, the annual filings do not contain any untrue statement of a material fact or omit to state a material fact required to be stated or that is necessary to make a statement not misleading in light of the circumstances under which it was made, for the period covered by the annual filings.

3. Fair presentation: Based on my knowledge, having exercised reasonable diligence, the annual financial statements together with the other financial information included in the annual filings fairly present in all material respects the financial condition, financial performance and cash flows of the issuer, as of the date of and for the periods presented in the annual filings.

Date: December 23[rd] , 2021

”Brian Zasitko” Brian Zasitko Chief Financial Officer

1