LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2009

Oct 26, 2009

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: LEXICON PHARMACEUTICALS, INC./DE (LXRX)
CIK: 0001062822
Period of Report: 2009-10-22

Reporting Person: BARKER SAM L (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2009-10-22	Common Stock	P	5500	$1.55	Acquired	17500	Direct
2009-10-22	Common Stock	P	8400	$1.56	Acquired	25900	Direct
2009-10-22	Common Stock	P	1500	$1.57	Acquired	27400	Direct
2009-10-22	Common Stock	P	3600	$1.58	Acquired	31000	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	35000	Indirect