IONIS PHARMACEUTICALS INC — Director's Dealing 2015

Mar 20, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2015-03-19

Reporting Person: HOUGEN ELIZABETH L (SVP, Finance & CFO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-03-19	Common Stock	M	10000	$11.27	Acquired	13387	Direct
2015-03-19	Common Stock	S	10000	$73.326	Disposed	3387	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2015-03-19	Employee Stock Option (right to buy)	$11.27	M	10000	Disposed	2017-01-03	Common Stock (10000)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 2/3/2015.