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IONIS PHARMACEUTICALS INC Director's Dealing 2012

Mar 7, 2012

30591_dirs_2012-03-07_733aed29-dc21-425e-af6d-47ac368490b4.zip

Director's Dealing

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SEC Form 3/A — Form 3/A

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2012-01-01

Reporting Person: Monia Brett P (Senior Vice President)

Holdings (Non-Derivative)

Security Shares Ownership
Common Stock 5073 Direct

Holdings (Derivative)

Security Exercise Price Expiration Underlying Shares Ownership
Employee Stock Option (right to buy) $6.81 2014-01-01 Common Stock (18240) Direct
Employee Stock Option (right to buy) $5.25 2013-01-02 Common Stock (12031) Direct
Employee Stock Option (right to buy) $11.12 2014-01-01 Common Stock (19500) Direct
Employee Stock Option (right to buy) $15.75 2014-12-31 Common Stock (10000) Direct
Employee Stock Option (right to buy) $15.38 2015-01-01 Common Stock (20000) Direct
Employee Stock Option (right to buy) $14.47 2016-01-01 Common Stock (22500) Direct
Employee Stock Option (right to buy) $14.65 2016-02-15 Common Stock (5000) Direct
Employee Stock Option (right to buy) $11.27 2017-01-03 Common Stock (22500) Direct
Employee Stock Option (right to buy) $10.29 2018-01-02 Common Stock (22600) Direct

Footnotes

F1: Grant of 1/2/08 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 2000 Broad-Based Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/09. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments, at the rate of 5,000 shares per year. The option is exercisable as to 19,583 shares on 1/1/12.

F2: Grant of 1/2/09 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/10. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments, at the rate of 5,625 shares per year. The option is exercisable as to 16,406 shares on 1/1/12.

F3: Grant of 2/16/09 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 2/16/10. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments, at the rate of 1,250 shares per year. The option is exercisable as to 3,541 shares on 1/1/12.

F4: Grant of 1/4/10 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/4/11. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments, at the rate of 5,625 shares per year. The option is exercisable as to 10,781 shares on 1/1/12.

F5: Grant of 1/3/11 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option will vest and become exercisable on 1/3/12. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 5,650 shares per year. The option is exercisable as to 0 shares on 1/1/12.